Efficacy and Tolerability of Evolocumab vs Ezetimibe in Patients With Muscle-Related Statin Intolerance: The GAUSS-3 Randomized Clinical Trial.
Identifieur interne : 002012 ( Main/Merge ); précédent : 002011; suivant : 002013Efficacy and Tolerability of Evolocumab vs Ezetimibe in Patients With Muscle-Related Statin Intolerance: The GAUSS-3 Randomized Clinical Trial.
Auteurs : Steven E. Nissen [États-Unis] ; Erik Stroes [Pays-Bas] ; Ricardo E. Dent-Acosta [États-Unis] ; Robert S. Rosenson [États-Unis] ; Sam J. Lehman [Australie] ; Naveed Sattar [Royaume-Uni] ; David Preiss [Royaume-Uni] ; Eric Bruckert [France] ; Richard Ceška [République tchèque] ; Norman Lepor [États-Unis] ; Christie M. Ballantyne [États-Unis] ; Ioanna Gouni-Berthold [Allemagne] ; Mary Elliott [États-Unis] ; Danielle M. Brennan [États-Unis] ; Scott M. Wasserman [États-Unis] ; Ransi Somaratne [États-Unis] ; Rob Scott [États-Unis] ; Evan A. Stein [États-Unis]Source :
- JAMA [ 1538-3598 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Anticholestérolémiants (effets indésirables), Anticholestérolémiants (usage thérapeutique), Anticorps monoclonaux (effets indésirables), Anticorps monoclonaux (usage thérapeutique), Atorvastatine de calcium (effets indésirables), Cholestérol LDL (sang), Creatine kinase (sang), Facteurs temps, Femelle, Humains, Hypercholestérolémie (sang), Hypercholestérolémie (traitement médicamenteux), Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (effets indésirables), Maladies musculaires (), Maladies musculaires (sang), Marqueurs biologiques (sang), Myalgie (), Myalgie (sang), Myosite (), Myosite (sang), Mâle, Méthode en double aveugle, Rhabdomyolyse (), Rhabdomyolyse (sang), Études croisées, Ézétimibe (effets indésirables), Ézétimibe (usage thérapeutique).
- MESH :
- effets indésirables : Anticholestérolémiants, Anticorps monoclonaux, Atorvastatine de calcium, Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase, Ézétimibe.
- sang : Cholestérol LDL, Creatine kinase, Hypercholestérolémie, Maladies musculaires, Marqueurs biologiques, Myalgie, Myosite, Rhabdomyolyse.
- traitement médicamenteux : Hypercholestérolémie.
- usage thérapeutique : Anticholestérolémiants, Anticorps monoclonaux, Ézétimibe.
- Adulte, Adulte d'âge moyen, Facteurs temps, Femelle, Humains, Maladies musculaires, Myalgie, Myosite, Mâle, Méthode en double aveugle, Rhabdomyolyse, Études croisées.
English descriptors
- KwdEn :
- Adult, Antibodies, Monoclonal (adverse effects), Antibodies, Monoclonal (therapeutic use), Anticholesteremic Agents (adverse effects), Anticholesteremic Agents (therapeutic use), Atorvastatin Calcium (adverse effects), Biomarkers (blood), Cholesterol, LDL (blood), Creatine Kinase (blood), Cross-Over Studies, Double-Blind Method, Ezetimibe (adverse effects), Ezetimibe (therapeutic use), Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors (adverse effects), Hypercholesterolemia (blood), Hypercholesterolemia (drug therapy), Male, Middle Aged, Muscular Diseases (blood), Muscular Diseases (chemically induced), Muscular Diseases (prevention & control), Myalgia (blood), Myalgia (chemically induced), Myalgia (prevention & control), Myositis (blood), Myositis (chemically induced), Myositis (prevention & control), Rhabdomyolysis (blood), Rhabdomyolysis (chemically induced), Rhabdomyolysis (prevention & control), Time Factors.
- MESH :
- chemical , adverse effects : Antibodies, Monoclonal, Anticholesteremic Agents, Atorvastatin Calcium, Ezetimibe, Hydroxymethylglutaryl-CoA Reductase Inhibitors.
- chemical , blood : Biomarkers, Cholesterol, LDL, Creatine Kinase.
- chemical , therapeutic use : Antibodies, Monoclonal, Anticholesteremic Agents, Ezetimibe.
- blood : Hypercholesterolemia, Muscular Diseases, Myalgia, Myositis, Rhabdomyolysis.
- chemically induced : Muscular Diseases, Myalgia, Myositis, Rhabdomyolysis.
- drug therapy : Hypercholesterolemia.
- prevention & control : Muscular Diseases, Myalgia, Myositis, Rhabdomyolysis.
- Adult, Cross-Over Studies, Double-Blind Method, Female, Humans, Male, Middle Aged, Time Factors.
Abstract
Muscle-related statin intolerance is reported by 5% to 20% of patients.
DOI: 10.1001/jama.2016.3608
PubMed: 27039291
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001F89
- to stream PubMed, to step Curation: 001F64
- to stream PubMed, to step Checkpoint: 001F64
- to stream Ncbi, to step Merge: 003356
- to stream Ncbi, to step Curation: 003356
- to stream Ncbi, to step Checkpoint: 003356
Links to Exploration step
pubmed:27039291Le document en format XML
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<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Amgen Inc, Thousand Oaks</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Scott, Rob" sort="Scott, Rob" uniqKey="Scott R" first="Rob" last="Scott">Rob Scott</name>
<affiliation wicri:level="2"><nlm:affiliation>Amgen Inc, Thousand Oaks, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Amgen Inc, Thousand Oaks</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Stein, Evan A" sort="Stein, Evan A" uniqKey="Stein E" first="Evan A" last="Stein">Evan A. Stein</name>
<affiliation wicri:level="2"><nlm:affiliation>Metabolic and Atherosclerosis Research Center, Cincinnati, Ohio.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Metabolic and Atherosclerosis Research Center, Cincinnati</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">JAMA</title>
<idno type="eISSN">1538-3598</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Antibodies, Monoclonal (adverse effects)</term>
<term>Antibodies, Monoclonal (therapeutic use)</term>
<term>Anticholesteremic Agents (adverse effects)</term>
<term>Anticholesteremic Agents (therapeutic use)</term>
<term>Atorvastatin Calcium (adverse effects)</term>
<term>Biomarkers (blood)</term>
<term>Cholesterol, LDL (blood)</term>
<term>Creatine Kinase (blood)</term>
<term>Cross-Over Studies</term>
<term>Double-Blind Method</term>
<term>Ezetimibe (adverse effects)</term>
<term>Ezetimibe (therapeutic use)</term>
<term>Female</term>
<term>Humans</term>
<term>Hydroxymethylglutaryl-CoA Reductase Inhibitors (adverse effects)</term>
<term>Hypercholesterolemia (blood)</term>
<term>Hypercholesterolemia (drug therapy)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Muscular Diseases (blood)</term>
<term>Muscular Diseases (chemically induced)</term>
<term>Muscular Diseases (prevention & control)</term>
<term>Myalgia (blood)</term>
<term>Myalgia (chemically induced)</term>
<term>Myalgia (prevention & control)</term>
<term>Myositis (blood)</term>
<term>Myositis (chemically induced)</term>
<term>Myositis (prevention & control)</term>
<term>Rhabdomyolysis (blood)</term>
<term>Rhabdomyolysis (chemically induced)</term>
<term>Rhabdomyolysis (prevention & control)</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Anticholestérolémiants (effets indésirables)</term>
<term>Anticholestérolémiants (usage thérapeutique)</term>
<term>Anticorps monoclonaux (effets indésirables)</term>
<term>Anticorps monoclonaux (usage thérapeutique)</term>
<term>Atorvastatine de calcium (effets indésirables)</term>
<term>Cholestérol LDL (sang)</term>
<term>Creatine kinase (sang)</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hypercholestérolémie (sang)</term>
<term>Hypercholestérolémie (traitement médicamenteux)</term>
<term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (effets indésirables)</term>
<term>Maladies musculaires ()</term>
<term>Maladies musculaires (sang)</term>
<term>Marqueurs biologiques (sang)</term>
<term>Myalgie ()</term>
<term>Myalgie (sang)</term>
<term>Myosite ()</term>
<term>Myosite (sang)</term>
<term>Mâle</term>
<term>Méthode en double aveugle</term>
<term>Rhabdomyolyse ()</term>
<term>Rhabdomyolyse (sang)</term>
<term>Études croisées</term>
<term>Ézétimibe (effets indésirables)</term>
<term>Ézétimibe (usage thérapeutique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Anticholesteremic Agents</term>
<term>Atorvastatin Calcium</term>
<term>Ezetimibe</term>
<term>Hydroxymethylglutaryl-CoA Reductase Inhibitors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term>
<term>Cholesterol, LDL</term>
<term>Creatine Kinase</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Anticholesteremic Agents</term>
<term>Ezetimibe</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Hypercholesterolemia</term>
<term>Muscular Diseases</term>
<term>Myalgia</term>
<term>Myositis</term>
<term>Rhabdomyolysis</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Muscular Diseases</term>
<term>Myalgia</term>
<term>Myositis</term>
<term>Rhabdomyolysis</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hypercholesterolemia</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Anticholestérolémiants</term>
<term>Anticorps monoclonaux</term>
<term>Atorvastatine de calcium</term>
<term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase</term>
<term>Ézétimibe</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Muscular Diseases</term>
<term>Myalgia</term>
<term>Myositis</term>
<term>Rhabdomyolysis</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Cholestérol LDL</term>
<term>Creatine kinase</term>
<term>Hypercholestérolémie</term>
<term>Maladies musculaires</term>
<term>Marqueurs biologiques</term>
<term>Myalgie</term>
<term>Myosite</term>
<term>Rhabdomyolyse</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hypercholestérolémie</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticholestérolémiants</term>
<term>Anticorps monoclonaux</term>
<term>Ézétimibe</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Cross-Over Studies</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Maladies musculaires</term>
<term>Myalgie</term>
<term>Myosite</term>
<term>Mâle</term>
<term>Méthode en double aveugle</term>
<term>Rhabdomyolyse</term>
<term>Études croisées</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Muscle-related statin intolerance is reported by 5% to 20% of patients.</div>
</front>
</TEI>
</record>
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