Haemodiafiltration and mortality in end-stage kidney disease patients: a pooled individual participant data analysis from four randomized controlled trials.
Identifieur interne : 001D78 ( Main/Merge ); précédent : 001D77; suivant : 001D79Haemodiafiltration and mortality in end-stage kidney disease patients: a pooled individual participant data analysis from four randomized controlled trials.
Auteurs : Sanne A E. Peters [Pays-Bas] ; Michiel L. Bots [Pays-Bas] ; Bernard Canaud [France] ; Andrew Davenport [Royaume-Uni] ; Muriel P C. Grooteman [Pays-Bas] ; Fatih Kircelli [Turquie] ; Francesco Locatelli [Italie] ; Francisco Maduell [Espagne] ; Marion Morena [France] ; Menso J. Nubé [Pays-Bas] ; Ercan Ok [Turquie] ; Ferran Torres [Espagne] ; Mark Woodward [États-Unis] ; Peter J. Blankestijn [Pays-Bas]Source :
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association [ 1460-2385 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Cause de décès (tendances), Dialyse rénale (), Défaillance rénale chronique (), Défaillance rénale chronique (mortalité), Europe (épidémiologie), Facteurs de risque, Femelle, Humains, Hémodiafiltration (), Modèles de hasards proportionnels, Mâle, Sujet âgé, Taux de survie (tendances).
- MESH :
- mortalité : Défaillance rénale chronique.
- tendances : Cause de décès, Taux de survie.
- épidémiologie : Europe.
- Adulte d'âge moyen, Dialyse rénale, Défaillance rénale chronique, Facteurs de risque, Femelle, Humains, Hémodiafiltration, Modèles de hasards proportionnels, Mâle, Sujet âgé.
English descriptors
- KwdEn :
- MESH :
- epidemiology : Europe.
- methods : Hemodiafiltration, Renal Dialysis.
- mortality : Kidney Failure, Chronic.
- therapy : Kidney Failure, Chronic.
- trends : Cause of Death, Survival Rate.
- Aged, Female, Humans, Male, Middle Aged, Proportional Hazards Models, Risk Factors.
Abstract
Mortality rates remain high for haemodialysis (HD) patients and simply increasing the HD dose to remove more small solutes does not improve survival. Online haemodiafiltration (HDF) provides additional clearance of larger toxins compared with standard HD. Randomized controlled trials (RCTs) comparing HDF with conventional HD on all-cause and cause-specific mortality in end-stage kidney disease (ESKD) patients reported inconsistent results and were at high risk of bias. We conducted a pooled individual participant data analysis of RCTs to provide the most reliable evidence to date on the effects of HDF on mortality outcomes in ESKD patients.
DOI: 10.1093/ndt/gfv349
PubMed: 26492924
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pubmed:26492924Le document en format XML
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<region type="old region">Languedoc-Roussillon</region>
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<author><name sortKey="Nube, Menso J" sort="Nube, Menso J" uniqKey="Nube M" first="Menso J" last="Nubé">Menso J. Nubé</name>
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<author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name>
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<author><name sortKey="Blankestijn, Peter J" sort="Blankestijn, Peter J" uniqKey="Blankestijn P" first="Peter J" last="Blankestijn">Peter J. Blankestijn</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
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<series><title level="j">Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association</title>
<idno type="eISSN">1460-2385</idno>
<imprint><date when="2016" type="published">2016</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Cause of Death (trends)</term>
<term>Europe (epidemiology)</term>
<term>Female</term>
<term>Hemodiafiltration (methods)</term>
<term>Humans</term>
<term>Kidney Failure, Chronic (mortality)</term>
<term>Kidney Failure, Chronic (therapy)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Proportional Hazards Models</term>
<term>Renal Dialysis (methods)</term>
<term>Risk Factors</term>
<term>Survival Rate (trends)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Cause de décès (tendances)</term>
<term>Dialyse rénale ()</term>
<term>Défaillance rénale chronique ()</term>
<term>Défaillance rénale chronique (mortalité)</term>
<term>Europe (épidémiologie)</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hémodiafiltration ()</term>
<term>Modèles de hasards proportionnels</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Taux de survie (tendances)</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Europe</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Hemodiafiltration</term>
<term>Renal Dialysis</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Kidney Failure, Chronic</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Défaillance rénale chronique</term>
</keywords>
<keywords scheme="MESH" qualifier="tendances" xml:lang="fr"><term>Cause de décès</term>
<term>Taux de survie</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Kidney Failure, Chronic</term>
</keywords>
<keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Cause of Death</term>
<term>Survival Rate</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Europe</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Proportional Hazards Models</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Dialyse rénale</term>
<term>Défaillance rénale chronique</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hémodiafiltration</term>
<term>Modèles de hasards proportionnels</term>
<term>Mâle</term>
<term>Sujet âgé</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Mortality rates remain high for haemodialysis (HD) patients and simply increasing the HD dose to remove more small solutes does not improve survival. Online haemodiafiltration (HDF) provides additional clearance of larger toxins compared with standard HD. Randomized controlled trials (RCTs) comparing HDF with conventional HD on all-cause and cause-specific mortality in end-stage kidney disease (ESKD) patients reported inconsistent results and were at high risk of bias. We conducted a pooled individual participant data analysis of RCTs to provide the most reliable evidence to date on the effects of HDF on mortality outcomes in ESKD patients.</div>
</front>
</TEI>
</record>
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