The "Efficacy-Effectiveness Gap": Historical Background and Current Conceptualization.
Identifieur interne : 001650 ( Main/Merge ); précédent : 001649; suivant : 001651The "Efficacy-Effectiveness Gap": Historical Background and Current Conceptualization.
Auteurs : Clementine Nordon [France] ; Helene Karcher [Royaume-Uni] ; Rolf H H. Groenwold [Pays-Bas] ; Mikkel Zöllner Ankarfeldt [Danemark] ; Franz Pichler [Australie] ; Helene Chevrou-Severac [Suisse] ; Michel Rossignol [Canada] ; Adeline Abbe [France] ; Lucien Abenhaim [Royaume-Uni]Source :
- Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research [ 1524-4733 ] ; 2016.
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Abstract
The concept of the "efficacy-effectiveness gap" (EEG) has started to challenge confidence in decisions made for drugs when based on randomized controlled trials alone. Launched by the Innovative Medicines Initiative, the GetReal project aims to improve understanding of how to reconcile evidence to support efficacy and effectiveness and at proposing operational solutions.
DOI: 10.1016/j.jval.2015.09.2938
PubMed: 26797239
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sort="Pichler, Franz" uniqKey="Pichler F" first="Franz" last="Pichler">Franz Pichler</name><affiliation wicri:level="1"><nlm:affiliation>Eli Lilly and Company, Melrose Park, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Eli Lilly and Company, Melrose Park</wicri:regionArea><wicri:noRegion>Melrose Park</wicri:noRegion></affiliation></author><author><name sortKey="Chevrou Severac, Helene" sort="Chevrou Severac, Helene" uniqKey="Chevrou Severac H" first="Helene" last="Chevrou-Severac">Helene Chevrou-Severac</name><affiliation wicri:level="1"><nlm:affiliation>Takeda Pharmaceuticals International, Glattpark-Opfikon, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Takeda Pharmaceuticals International, Glattpark-Opfikon</wicri:regionArea><wicri:noRegion>Glattpark-Opfikon</wicri:noRegion></affiliation></author><author><name sortKey="Rossignol, Michel" sort="Rossignol, Michel" uniqKey="Rossignol M" first="Michel" last="Rossignol">Michel Rossignol</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Abbe, Adeline" sort="Abbe, Adeline" uniqKey="Abbe A" first="Adeline" last="Abbe">Adeline Abbe</name><affiliation wicri:level="1"><nlm:affiliation>Sanofi R&D, Chilly Mazarin, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Sanofi R&D, Chilly Mazarin</wicri:regionArea><wicri:noRegion>Chilly Mazarin</wicri:noRegion><wicri:noRegion>Chilly Mazarin</wicri:noRegion></affiliation></author><author><name sortKey="Abenhaim, Lucien" sort="Abenhaim, Lucien" uniqKey="Abenhaim L" first="Lucien" last="Abenhaim">Lucien Abenhaim</name><affiliation wicri:level="3"><nlm:affiliation>LASER Analytica, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>LASER Analytica, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research</title><idno type="eISSN">1524-4733</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Clinical Trials as Topic</term><term>Drug Therapy</term><term>Health Knowledge, Attitudes, Practice</term><term>Humans</term><term>Product Surveillance, Postmarketing</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Connaissances, attitudes et pratiques en santé</term><term>Essais cliniques comme sujet</term><term>Humains</term><term>Résultat thérapeutique</term><term>Surveillance post-commercialisation des produits de santé</term><term>Traitement médicamenteux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Clinical Trials as Topic</term><term>Drug Therapy</term><term>Health Knowledge, Attitudes, Practice</term><term>Humans</term><term>Product Surveillance, Postmarketing</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Connaissances, attitudes et pratiques en santé</term><term>Essais cliniques comme sujet</term><term>Humains</term><term>Résultat thérapeutique</term><term>Surveillance post-commercialisation des produits de santé</term><term>Traitement médicamenteux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The concept of the "efficacy-effectiveness gap" (EEG) has started to challenge confidence in decisions made for drugs when based on randomized controlled trials alone. Launched by the Innovative Medicines Initiative, the GetReal project aims to improve understanding of how to reconcile evidence to support efficacy and effectiveness and at proposing operational solutions.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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