The Salmonella Effector SteD Mediates MARCH8-Dependent Ubiquitination of MHC II Molecules and Inhibits T Cell Activation
Identifieur interne : 001647 ( Main/Merge ); précédent : 001646; suivant : 001648The Salmonella Effector SteD Mediates MARCH8-Dependent Ubiquitination of MHC II Molecules and Inhibits T Cell Activation
Auteurs : Ethel Bayer-Santos [Royaume-Uni] ; Charlotte H. Durkin [Royaume-Uni] ; Luciano A. Rigano [Royaume-Uni] ; Andreas Kupz [Allemagne, Australie] ; Eric Alix [Royaume-Uni] ; Ondrej Cerny [Royaume-Uni] ; Elliott Jennings [Royaume-Uni] ; Mei Liu [Royaume-Uni] ; Aindrias S. Ryan [Royaume-Uni] ; Nicolas Lapaque [France] ; Stefan H. E. Kaufmann [Allemagne] ; David W. Holden [Royaume-Uni]Source :
- Cell Host & Microbe [ 1931-3128 ] ; 2016.
Descripteurs français
- KwdFr :
- Activation des lymphocytes, Animaux, Antigènes d'histocompatibilité de classe II (métabolisme), Cellules dendritiques (immunologie), Cellules dendritiques (microbiologie), Humains, Interactions hôte-pathogène, Liaison aux protéines, Lignée cellulaire, Lymphocytes T (immunologie), Protéines bactériennes (métabolisme), Salmonella typhimurium (pathogénicité), Salmonelloses animales (immunologie), Salmonelloses animales (microbiologie), Souris, Ubiquitin-protein ligases (métabolisme), Ubiquitinylation, Échappement immunitaire.
- MESH :
- immunologie : Cellules dendritiques, Lymphocytes T, Salmonelloses animales.
- microbiologie : Cellules dendritiques, Salmonelloses animales.
- métabolisme : Antigènes d'histocompatibilité de classe II, Protéines bactériennes, Ubiquitin-protein ligases.
- pathogénicité : Salmonella typhimurium.
- Activation des lymphocytes, Animaux, Humains, Interactions hôte-pathogène, Liaison aux protéines, Lignée cellulaire, Souris, Ubiquitinylation, Échappement immunitaire.
English descriptors
- KwdEn :
- Animals, Bacterial Proteins (metabolism), Cell Line, Dendritic Cells (immunology), Dendritic Cells (microbiology), Histocompatibility Antigens Class II (metabolism), Host-Pathogen Interactions, Humans, Immune Evasion, Lymphocyte Activation, Mice, Protein Binding, Salmonella Infections, Animal (immunology), Salmonella Infections, Animal (microbiology), Salmonella typhimurium (pathogenicity), T-Lymphocytes (immunology), Ubiquitin-Protein Ligases (metabolism), Ubiquitination.
- MESH :
- chemical , metabolism : Bacterial Proteins, Histocompatibility Antigens Class II, Ubiquitin-Protein Ligases.
- immunology : Dendritic Cells, Salmonella Infections, Animal, T-Lymphocytes.
- microbiology : Dendritic Cells, Salmonella Infections, Animal.
- pathogenicity : Salmonella typhimurium.
- Animals, Cell Line, Host-Pathogen Interactions, Humans, Immune Evasion, Lymphocyte Activation, Mice, Protein Binding, Ubiquitination.
Abstract
The SPI-2 type III secretion system (T3SS) of intracellular
Url:
DOI: 10.1016/j.chom.2016.10.007
PubMed: 27832589
PubMed Central: 5104694
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002369
- to stream Pmc, to step Curation: 002219
- to stream Pmc, to step Checkpoint: 000580
- to stream PubMed, to step Corpus: 001648
- to stream PubMed, to step Curation: 001626
- to stream PubMed, to step Checkpoint: 001626
- to stream Ncbi, to step Merge: 003E48
- to stream Ncbi, to step Curation: 003E48
- to stream Ncbi, to step Checkpoint: 003E48
Links to Exploration step
PMC:5104694Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The <italic>Salmonella</italic>
Effector SteD Mediates MARCH8-Dependent Ubiquitination of MHC II Molecules and Inhibits T Cell Activation</title>
<author><name sortKey="Bayer Santos, Ethel" sort="Bayer Santos, Ethel" uniqKey="Bayer Santos E" first="Ethel" last="Bayer-Santos">Ethel Bayer-Santos</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ</wicri:regionArea>
<wicri:noRegion>London SW7 2AZ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Durkin, Charlotte H" sort="Durkin, Charlotte H" uniqKey="Durkin C" first="Charlotte H." last="Durkin">Charlotte H. Durkin</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ</wicri:regionArea>
<wicri:noRegion>London SW7 2AZ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rigano, Luciano A" sort="Rigano, Luciano A" uniqKey="Rigano L" first="Luciano A." last="Rigano">Luciano A. Rigano</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ</wicri:regionArea>
<wicri:noRegion>London SW7 2AZ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kupz, Andreas" sort="Kupz, Andreas" uniqKey="Kupz A" first="Andreas" last="Kupz">Andreas Kupz</name>
<affiliation wicri:level="3"><nlm:aff id="aff2">Department of Immunology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Immunology, Max Planck Institute for Infection Biology, 10117 Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5">Centre for Biosecurity and Tropical Infectious Diseases, Australian Institute of Tropical Health and Medicine, James Cook University, McGregor Road, Cairns, QLD 4878, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Biosecurity and Tropical Infectious Diseases, Australian Institute of Tropical Health and Medicine, James Cook University, McGregor Road, Cairns, QLD 4878</wicri:regionArea>
<wicri:noRegion>QLD 4878</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alix, Eric" sort="Alix, Eric" uniqKey="Alix E" first="Eric" last="Alix">Eric Alix</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ</wicri:regionArea>
<wicri:noRegion>London SW7 2AZ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cerny, Ondrej" sort="Cerny, Ondrej" uniqKey="Cerny O" first="Ondrej" last="Cerny">Ondrej Cerny</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ</wicri:regionArea>
<wicri:noRegion>London SW7 2AZ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jennings, Elliott" sort="Jennings, Elliott" uniqKey="Jennings E" first="Elliott" last="Jennings">Elliott Jennings</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ</wicri:regionArea>
<wicri:noRegion>London SW7 2AZ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Mei" sort="Liu, Mei" uniqKey="Liu M" first="Mei" last="Liu">Mei Liu</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ</wicri:regionArea>
<wicri:noRegion>London SW7 2AZ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ryan, Aindrias S" sort="Ryan, Aindrias S" uniqKey="Ryan A" first="Aindrias S." last="Ryan">Aindrias S. Ryan</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ</wicri:regionArea>
<wicri:noRegion>London SW7 2AZ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lapaque, Nicolas" sort="Lapaque, Nicolas" uniqKey="Lapaque N" first="Nicolas" last="Lapaque">Nicolas Lapaque</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">INRA, UMR 1319 Micalis, Domaine de Vilvert, Jouy-en-Josas 78352, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INRA, UMR 1319 Micalis, Domaine de Vilvert, Jouy-en-Josas 78352</wicri:regionArea>
<wicri:noRegion>78352</wicri:noRegion>
<wicri:noRegion>78352</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4">AgroParisTech, UMR Micalis, Jouy-en-Josas 78350, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>AgroParisTech, UMR Micalis, Jouy-en-Josas 78350</wicri:regionArea>
<wicri:noRegion>78350</wicri:noRegion>
<wicri:noRegion>78350</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kaufmann, Stefan H E" sort="Kaufmann, Stefan H E" uniqKey="Kaufmann S" first="Stefan H. E." last="Kaufmann">Stefan H. E. Kaufmann</name>
<affiliation wicri:level="3"><nlm:aff id="aff2">Department of Immunology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Immunology, Max Planck Institute for Infection Biology, 10117 Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Holden, David W" sort="Holden, David W" uniqKey="Holden D" first="David W." last="Holden">David W. Holden</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ</wicri:regionArea>
<wicri:noRegion>London SW7 2AZ</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">27832589</idno>
<idno type="pmc">5104694</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104694</idno>
<idno type="RBID">PMC:5104694</idno>
<idno type="doi">10.1016/j.chom.2016.10.007</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">002369</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002369</idno>
<idno type="wicri:Area/Pmc/Curation">002219</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002219</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000580</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000580</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001648</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001648</idno>
<idno type="wicri:Area/PubMed/Curation">001626</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001626</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001626</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001626</idno>
<idno type="wicri:Area/Ncbi/Merge">003E48</idno>
<idno type="wicri:Area/Ncbi/Curation">003E48</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003E48</idno>
<idno type="wicri:Area/Main/Merge">001647</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The <italic>Salmonella</italic>
Effector SteD Mediates MARCH8-Dependent Ubiquitination of MHC II Molecules and Inhibits T Cell Activation</title>
<author><name sortKey="Bayer Santos, Ethel" sort="Bayer Santos, Ethel" uniqKey="Bayer Santos E" first="Ethel" last="Bayer-Santos">Ethel Bayer-Santos</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ</wicri:regionArea>
<wicri:noRegion>London SW7 2AZ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Durkin, Charlotte H" sort="Durkin, Charlotte H" uniqKey="Durkin C" first="Charlotte H." last="Durkin">Charlotte H. Durkin</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ</wicri:regionArea>
<wicri:noRegion>London SW7 2AZ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rigano, Luciano A" sort="Rigano, Luciano A" uniqKey="Rigano L" first="Luciano A." last="Rigano">Luciano A. Rigano</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ</wicri:regionArea>
<wicri:noRegion>London SW7 2AZ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kupz, Andreas" sort="Kupz, Andreas" uniqKey="Kupz A" first="Andreas" last="Kupz">Andreas Kupz</name>
<affiliation wicri:level="3"><nlm:aff id="aff2">Department of Immunology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Immunology, Max Planck Institute for Infection Biology, 10117 Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5">Centre for Biosecurity and Tropical Infectious Diseases, Australian Institute of Tropical Health and Medicine, James Cook University, McGregor Road, Cairns, QLD 4878, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Biosecurity and Tropical Infectious Diseases, Australian Institute of Tropical Health and Medicine, James Cook University, McGregor Road, Cairns, QLD 4878</wicri:regionArea>
<wicri:noRegion>QLD 4878</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alix, Eric" sort="Alix, Eric" uniqKey="Alix E" first="Eric" last="Alix">Eric Alix</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ</wicri:regionArea>
<wicri:noRegion>London SW7 2AZ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cerny, Ondrej" sort="Cerny, Ondrej" uniqKey="Cerny O" first="Ondrej" last="Cerny">Ondrej Cerny</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ</wicri:regionArea>
<wicri:noRegion>London SW7 2AZ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jennings, Elliott" sort="Jennings, Elliott" uniqKey="Jennings E" first="Elliott" last="Jennings">Elliott Jennings</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ</wicri:regionArea>
<wicri:noRegion>London SW7 2AZ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Mei" sort="Liu, Mei" uniqKey="Liu M" first="Mei" last="Liu">Mei Liu</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ</wicri:regionArea>
<wicri:noRegion>London SW7 2AZ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ryan, Aindrias S" sort="Ryan, Aindrias S" uniqKey="Ryan A" first="Aindrias S." last="Ryan">Aindrias S. Ryan</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ</wicri:regionArea>
<wicri:noRegion>London SW7 2AZ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lapaque, Nicolas" sort="Lapaque, Nicolas" uniqKey="Lapaque N" first="Nicolas" last="Lapaque">Nicolas Lapaque</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">INRA, UMR 1319 Micalis, Domaine de Vilvert, Jouy-en-Josas 78352, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INRA, UMR 1319 Micalis, Domaine de Vilvert, Jouy-en-Josas 78352</wicri:regionArea>
<wicri:noRegion>78352</wicri:noRegion>
<wicri:noRegion>78352</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4">AgroParisTech, UMR Micalis, Jouy-en-Josas 78350, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>AgroParisTech, UMR Micalis, Jouy-en-Josas 78350</wicri:regionArea>
<wicri:noRegion>78350</wicri:noRegion>
<wicri:noRegion>78350</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kaufmann, Stefan H E" sort="Kaufmann, Stefan H E" uniqKey="Kaufmann S" first="Stefan H. E." last="Kaufmann">Stefan H. E. Kaufmann</name>
<affiliation wicri:level="3"><nlm:aff id="aff2">Department of Immunology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Immunology, Max Planck Institute for Infection Biology, 10117 Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Holden, David W" sort="Holden, David W" uniqKey="Holden D" first="David W." last="Holden">David W. Holden</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ</wicri:regionArea>
<wicri:noRegion>London SW7 2AZ</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Cell Host & Microbe</title>
<idno type="ISSN">1931-3128</idno>
<idno type="eISSN">1934-6069</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Bacterial Proteins (metabolism)</term>
<term>Cell Line</term>
<term>Dendritic Cells (immunology)</term>
<term>Dendritic Cells (microbiology)</term>
<term>Histocompatibility Antigens Class II (metabolism)</term>
<term>Host-Pathogen Interactions</term>
<term>Humans</term>
<term>Immune Evasion</term>
<term>Lymphocyte Activation</term>
<term>Mice</term>
<term>Protein Binding</term>
<term>Salmonella Infections, Animal (immunology)</term>
<term>Salmonella Infections, Animal (microbiology)</term>
<term>Salmonella typhimurium (pathogenicity)</term>
<term>T-Lymphocytes (immunology)</term>
<term>Ubiquitin-Protein Ligases (metabolism)</term>
<term>Ubiquitination</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Animaux</term>
<term>Antigènes d'histocompatibilité de classe II (métabolisme)</term>
<term>Cellules dendritiques (immunologie)</term>
<term>Cellules dendritiques (microbiologie)</term>
<term>Humains</term>
<term>Interactions hôte-pathogène</term>
<term>Liaison aux protéines</term>
<term>Lignée cellulaire</term>
<term>Lymphocytes T (immunologie)</term>
<term>Protéines bactériennes (métabolisme)</term>
<term>Salmonella typhimurium (pathogénicité)</term>
<term>Salmonelloses animales (immunologie)</term>
<term>Salmonelloses animales (microbiologie)</term>
<term>Souris</term>
<term>Ubiquitin-protein ligases (métabolisme)</term>
<term>Ubiquitinylation</term>
<term>Échappement immunitaire</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Bacterial Proteins</term>
<term>Histocompatibility Antigens Class II</term>
<term>Ubiquitin-Protein Ligases</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules dendritiques</term>
<term>Lymphocytes T</term>
<term>Salmonelloses animales</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Dendritic Cells</term>
<term>Salmonella Infections, Animal</term>
<term>T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Cellules dendritiques</term>
<term>Salmonelloses animales</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Dendritic Cells</term>
<term>Salmonella Infections, Animal</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigènes d'histocompatibilité de classe II</term>
<term>Protéines bactériennes</term>
<term>Ubiquitin-protein ligases</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Salmonella typhimurium</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Salmonella typhimurium</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Line</term>
<term>Host-Pathogen Interactions</term>
<term>Humans</term>
<term>Immune Evasion</term>
<term>Lymphocyte Activation</term>
<term>Mice</term>
<term>Protein Binding</term>
<term>Ubiquitination</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Animaux</term>
<term>Humains</term>
<term>Interactions hôte-pathogène</term>
<term>Liaison aux protéines</term>
<term>Lignée cellulaire</term>
<term>Souris</term>
<term>Ubiquitinylation</term>
<term>Échappement immunitaire</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p>The SPI-2 type III secretion system (T3SS) of intracellular <italic>Salmonella enterica</italic>
translocates effector proteins into mammalian cells. Infection of antigen-presenting cells results in SPI-2 T3SS-dependent ubiquitination and reduction of surface-localized mature MHC class II (mMHCII). We identify the effector SteD as required and sufficient for this process. In Mel Juso cells, SteD localized to the Golgi network and vesicles containing the E3 ubiquitin ligase MARCH8 and mMHCII. SteD caused MARCH8-dependent ubiquitination and depletion of surface mMHCII. One of two transmembrane domains and the C-terminal cytoplasmic region of SteD mediated binding to MARCH8 and mMHCII, respectively. Infection of dendritic cells resulted in SteD-dependent depletion of surface MHCII, the co-stimulatory molecule B7.2, and suppression of T cell activation. SteD also accounted for suppression of T cell activation during <italic>Salmonella</italic>
infection of mice. We propose that SteD is an adaptor, forcing inappropriate ubiquitination of mMHCII by MARCH8 and thereby suppressing T cell activation.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ashida, H" uniqKey="Ashida H">H. Ashida</name>
</author>
<author><name sortKey="Kim, M" uniqKey="Kim M">M. Kim</name>
</author>
<author><name sortKey="Sasakawa, C" uniqKey="Sasakawa C">C. Sasakawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bartee, E" uniqKey="Bartee E">E. Bartee</name>
</author>
<author><name sortKey="Mansouri, M" uniqKey="Mansouri M">M. Mansouri</name>
</author>
<author><name sortKey="Hovey Nerenberg, B T" uniqKey="Hovey Nerenberg B">B.T. Hovey Nerenberg</name>
</author>
<author><name sortKey="Gouveia, K" uniqKey="Gouveia K">K. Gouveia</name>
</author>
<author><name sortKey="Fruh, K" uniqKey="Fruh K">K. Früh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bijlmakers, M J" uniqKey="Bijlmakers M">M.J. Bijlmakers</name>
</author>
<author><name sortKey="Benaroch, P" uniqKey="Benaroch P">P. Benaroch</name>
</author>
<author><name sortKey="Ploegh, H L" uniqKey="Ploegh H">H.L. Ploegh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cheminay, C" uniqKey="Cheminay C">C. Cheminay</name>
</author>
<author><name sortKey="Mohlenbrink, A" uniqKey="Mohlenbrink A">A. Möhlenbrink</name>
</author>
<author><name sortKey="Hensel, M" uniqKey="Hensel M">M. Hensel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cho, K J" uniqKey="Cho K">K.J. Cho</name>
</author>
<author><name sortKey="Walseng, E" uniqKey="Walseng E">E. Walseng</name>
</author>
<author><name sortKey="Ishido, S" uniqKey="Ishido S">S. Ishido</name>
</author>
<author><name sortKey="Roche, P A" uniqKey="Roche P">P.A. Roche</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Datsenko, K A" uniqKey="Datsenko K">K.A. Datsenko</name>
</author>
<author><name sortKey="Wanner, B L" uniqKey="Wanner B">B.L. Wanner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Gassart, A" uniqKey="De Gassart A">A. De Gassart</name>
</author>
<author><name sortKey="Camosseto, V" uniqKey="Camosseto V">V. Camosseto</name>
</author>
<author><name sortKey="Thibodeau, J" uniqKey="Thibodeau J">J. Thibodeau</name>
</author>
<author><name sortKey="Ceppi, M" uniqKey="Ceppi M">M. Ceppi</name>
</author>
<author><name sortKey="Catalan, N" uniqKey="Catalan N">N. Catalan</name>
</author>
<author><name sortKey="Pierre, P" uniqKey="Pierre P">P. Pierre</name>
</author>
<author><name sortKey="Gatti, E" uniqKey="Gatti E">E. Gatti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fujita, H" uniqKey="Fujita H">H. Fujita</name>
</author>
<author><name sortKey="Iwabu, Y" uniqKey="Iwabu Y">Y. Iwabu</name>
</author>
<author><name sortKey="Tokunaga, K" uniqKey="Tokunaga K">K. Tokunaga</name>
</author>
<author><name sortKey="Tanaka, Y" uniqKey="Tanaka Y">Y. Tanaka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Furuta, K" uniqKey="Furuta K">K. Furuta</name>
</author>
<author><name sortKey="Walseng, E" uniqKey="Walseng E">E. Walseng</name>
</author>
<author><name sortKey="Roche, P A" uniqKey="Roche P">P.A. Roche</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Goto, E" uniqKey="Goto E">E. Goto</name>
</author>
<author><name sortKey="Ishido, S" uniqKey="Ishido S">S. Ishido</name>
</author>
<author><name sortKey="Sato, Y" uniqKey="Sato Y">Y. Sato</name>
</author>
<author><name sortKey="Ohgimoto, S" uniqKey="Ohgimoto S">S. Ohgimoto</name>
</author>
<author><name sortKey="Ohgimoto, K" uniqKey="Ohgimoto K">K. Ohgimoto</name>
</author>
<author><name sortKey="Nagano Fujii, M" uniqKey="Nagano Fujii M">M. Nagano-Fujii</name>
</author>
<author><name sortKey="Hotta, H" uniqKey="Hotta H">H. Hotta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Halici, S" uniqKey="Halici S">S. Halici</name>
</author>
<author><name sortKey="Zenk, S F" uniqKey="Zenk S">S.F. Zenk</name>
</author>
<author><name sortKey="Jantsch, J" uniqKey="Jantsch J">J. Jantsch</name>
</author>
<author><name sortKey="Hensel, M" uniqKey="Hensel M">M. Hensel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jackson, N P" uniqKey="Jackson N">N.P. Jackson</name>
</author>
<author><name sortKey="Kang, Y H" uniqKey="Kang Y">Y.H. Kang</name>
</author>
<author><name sortKey="Lapaque, N" uniqKey="Lapaque N">N. Lapaque</name>
</author>
<author><name sortKey="Janssen, H" uniqKey="Janssen H">H. Janssen</name>
</author>
<author><name sortKey="Trowsdale, J" uniqKey="Trowsdale J">J. Trowsdale</name>
</author>
<author><name sortKey="Kelly, A P" uniqKey="Kelly A">A.P. Kelly</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jantsch, J" uniqKey="Jantsch J">J. Jantsch</name>
</author>
<author><name sortKey="Cheminay, C" uniqKey="Cheminay C">C. Cheminay</name>
</author>
<author><name sortKey="Chakravortty, D" uniqKey="Chakravortty D">D. Chakravortty</name>
</author>
<author><name sortKey="Lindig, T" uniqKey="Lindig T">T. Lindig</name>
</author>
<author><name sortKey="Hein, J" uniqKey="Hein J">J. Hein</name>
</author>
<author><name sortKey="Hensel, M" uniqKey="Hensel M">M. Hensel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Krogh, A" uniqKey="Krogh A">A. Krogh</name>
</author>
<author><name sortKey="Larsson, B" uniqKey="Larsson B">B. Larsson</name>
</author>
<author><name sortKey="Von Heijne, G" uniqKey="Von Heijne G">G. von Heijne</name>
</author>
<author><name sortKey="Sonnhammer, E L" uniqKey="Sonnhammer E">E.L. Sonnhammer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lapaque, N" uniqKey="Lapaque N">N. Lapaque</name>
</author>
<author><name sortKey="Hutchinson, J L" uniqKey="Hutchinson J">J.L. Hutchinson</name>
</author>
<author><name sortKey="Jones, D C" uniqKey="Jones D">D.C. Jones</name>
</author>
<author><name sortKey="Meresse, S" uniqKey="Meresse S">S. Méresse</name>
</author>
<author><name sortKey="Holden, D W" uniqKey="Holden D">D.W. Holden</name>
</author>
<author><name sortKey="Trowsdale, J" uniqKey="Trowsdale J">J. Trowsdale</name>
</author>
<author><name sortKey="Kelly, A P" uniqKey="Kelly A">A.P. Kelly</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lapaque, N" uniqKey="Lapaque N">N. Lapaque</name>
</author>
<author><name sortKey="Jahnke, M" uniqKey="Jahnke M">M. Jahnke</name>
</author>
<author><name sortKey="Trowsdale, J" uniqKey="Trowsdale J">J. Trowsdale</name>
</author>
<author><name sortKey="Kelly, A P" uniqKey="Kelly A">A.P. Kelly</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Leon, S" uniqKey="Leon S">S. Léon</name>
</author>
<author><name sortKey="Haguenauer Tsapis, R" uniqKey="Haguenauer Tsapis R">R. Haguenauer-Tsapis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcguire, V A" uniqKey="Mcguire V">V.A. McGuire</name>
</author>
<author><name sortKey="Arthur, J S" uniqKey="Arthur J">J.S. Arthur</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mitchell, E K" uniqKey="Mitchell E">E.K. Mitchell</name>
</author>
<author><name sortKey="Mastroeni, P" uniqKey="Mastroeni P">P. Mastroeni</name>
</author>
<author><name sortKey="Kelly, A P" uniqKey="Kelly A">A.P. Kelly</name>
</author>
<author><name sortKey="Trowsdale, J" uniqKey="Trowsdale J">J. Trowsdale</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Neefjes, J" uniqKey="Neefjes J">J. Neefjes</name>
</author>
<author><name sortKey="Jongsma, M L" uniqKey="Jongsma M">M.L. Jongsma</name>
</author>
<author><name sortKey="Paul, P" uniqKey="Paul P">P. Paul</name>
</author>
<author><name sortKey="Bakke, O" uniqKey="Bakke O">O. Bakke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Niemann, G S" uniqKey="Niemann G">G.S. Niemann</name>
</author>
<author><name sortKey="Brown, R N" uniqKey="Brown R">R.N. Brown</name>
</author>
<author><name sortKey="Gustin, J K" uniqKey="Gustin J">J.K. Gustin</name>
</author>
<author><name sortKey="Stufkens, A" uniqKey="Stufkens A">A. Stufkens</name>
</author>
<author><name sortKey="Shaikh Kidwai, A S" uniqKey="Shaikh Kidwai A">A.S. Shaikh-Kidwai</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J. Li</name>
</author>
<author><name sortKey="Mcdermott, J E" uniqKey="Mcdermott J">J.E. McDermott</name>
</author>
<author><name sortKey="Brewer, H M" uniqKey="Brewer H">H.M. Brewer</name>
</author>
<author><name sortKey="Schepmoes, A" uniqKey="Schepmoes A">A. Schepmoes</name>
</author>
<author><name sortKey="Smith, R D" uniqKey="Smith R">R.D. Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Omasits, U" uniqKey="Omasits U">U. Omasits</name>
</author>
<author><name sortKey="Ahrens, C H" uniqKey="Ahrens C">C.H. Ahrens</name>
</author>
<author><name sortKey="Muller, S" uniqKey="Muller S">S. Müller</name>
</author>
<author><name sortKey="Wollscheid, B" uniqKey="Wollscheid B">B. Wollscheid</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Quah, B J" uniqKey="Quah B">B.J. Quah</name>
</author>
<author><name sortKey="Parish, C R" uniqKey="Parish C">C.R. Parish</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Randow, F" uniqKey="Randow F">F. Randow</name>
</author>
<author><name sortKey="Sale, J E" uniqKey="Sale J">J.E. Sale</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roche, P A" uniqKey="Roche P">P.A. Roche</name>
</author>
<author><name sortKey="Furuta, K" uniqKey="Furuta K">K. Furuta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schroeder, N" uniqKey="Schroeder N">N. Schroeder</name>
</author>
<author><name sortKey="Henry, T" uniqKey="Henry T">T. Henry</name>
</author>
<author><name sortKey="De Chastellier, C" uniqKey="De Chastellier C">C. de Chastellier</name>
</author>
<author><name sortKey="Zhao, W" uniqKey="Zhao W">W. Zhao</name>
</author>
<author><name sortKey="Guilhon, A A" uniqKey="Guilhon A">A.A. Guilhon</name>
</author>
<author><name sortKey="Gorvel, J P" uniqKey="Gorvel J">J.P. Gorvel</name>
</author>
<author><name sortKey="Meresse, S" uniqKey="Meresse S">S. Méresse</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tam, M A" uniqKey="Tam M">M.A. Tam</name>
</author>
<author><name sortKey="Rydstrom, A" uniqKey="Rydstrom A">A. Rydström</name>
</author>
<author><name sortKey="Sundquist, M" uniqKey="Sundquist M">M. Sundquist</name>
</author>
<author><name sortKey="Wick, M J" uniqKey="Wick M">M.J. Wick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tobar, J A" uniqKey="Tobar J">J.A. Tobar</name>
</author>
<author><name sortKey="Gonzalez, P A" uniqKey="Gonzalez P">P.A. González</name>
</author>
<author><name sortKey="Kalergis, A M" uniqKey="Kalergis A">A.M. Kalergis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tobar, J A" uniqKey="Tobar J">J.A. Tobar</name>
</author>
<author><name sortKey="Carre O, L J" uniqKey="Carre O L">L.J. Carreño</name>
</author>
<author><name sortKey="Bueno, S M" uniqKey="Bueno S">S.M. Bueno</name>
</author>
<author><name sortKey="Gonzalez, P A" uniqKey="Gonzalez P">P.A. González</name>
</author>
<author><name sortKey="Mora, J E" uniqKey="Mora J">J.E. Mora</name>
</author>
<author><name sortKey="Quezada, S A" uniqKey="Quezada S">S.A. Quezada</name>
</author>
<author><name sortKey="Kalergis, A M" uniqKey="Kalergis A">A.M. Kalergis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van De Kooij, B" uniqKey="Van De Kooij B">B. van de Kooij</name>
</author>
<author><name sortKey="Verbrugge, I" uniqKey="Verbrugge I">I. Verbrugge</name>
</author>
<author><name sortKey="De Vries, E" uniqKey="De Vries E">E. de Vries</name>
</author>
<author><name sortKey="Gijsen, M" uniqKey="Gijsen M">M. Gijsen</name>
</author>
<author><name sortKey="Montserrat, V" uniqKey="Montserrat V">V. Montserrat</name>
</author>
<author><name sortKey="Maas, C" uniqKey="Maas C">C. Maas</name>
</author>
<author><name sortKey="Neefjes, J" uniqKey="Neefjes J">J. Neefjes</name>
</author>
<author><name sortKey="Borst, J" uniqKey="Borst J">J. Borst</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001647 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 001647 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Main |étape= Merge |type= RBID |clé= PMC:5104694 |texte= The Salmonella Effector SteD Mediates MARCH8-Dependent Ubiquitination of MHC II Molecules and Inhibits T Cell Activation }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:27832589" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |