Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis: A global survey of physicians' practice
Identifieur interne : 000F51 ( Main/Merge ); précédent : 000F50; suivant : 000F52Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis: A global survey of physicians' practice
Auteurs : Shomron Ben-Horin ; Jane M. Andrews ; Konstantinos H. Katsanos ; Florian Rieder ; Flavio Steinwurz ; Konstantinos Karmiris ; Jae Hee Cheon ; Gordon William Moran ; Monica Cesarini ; Christian D. Stone ; Doron Schwartz ; Marijana Protic ; Xavier Roblin ; Giulia Roda ; Min-Hu Chen ; Ofir Har-Noy ; Charles N. BernsteinSource :
- World Journal of Gastroenterology [ 1007-9327 ] ; 2017.
Abstract
To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates (5ASA) with corticosteroids (CS) versus corticosteroids alone for patients with active ulcerative colitis (UC).
A cross-sectional questionnaire exploring physicians’ attitude toward 5ASA + CS combination therapy
Six hundred and sixty-four questionnaires were distributed and 349 received (52.6% response rate). Of 340 eligible respondents, 221 (65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108 (32%) would stop the 5ASA (
Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients.
Url:
DOI: 10.3748/wjg.v23.i16.2995
PubMed: 28522918
PubMed Central: 5413795
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Katsanos</name></author><author><name sortKey="Rieder, Florian" sort="Rieder, Florian" uniqKey="Rieder F" first="Florian" last="Rieder">Florian Rieder</name></author><author><name sortKey="Steinwurz, Flavio" sort="Steinwurz, Flavio" uniqKey="Steinwurz F" first="Flavio" last="Steinwurz">Flavio Steinwurz</name></author><author><name sortKey="Karmiris, Konstantinos" sort="Karmiris, Konstantinos" uniqKey="Karmiris K" first="Konstantinos" last="Karmiris">Konstantinos Karmiris</name></author><author><name sortKey="Cheon, Jae Hee" sort="Cheon, Jae Hee" uniqKey="Cheon J" first="Jae Hee" last="Cheon">Jae Hee Cheon</name></author><author><name sortKey="Moran, Gordon William" sort="Moran, Gordon William" uniqKey="Moran G" first="Gordon William" last="Moran">Gordon William Moran</name></author><author><name sortKey="Cesarini, Monica" sort="Cesarini, Monica" uniqKey="Cesarini M" first="Monica" last="Cesarini">Monica Cesarini</name></author><author><name sortKey="Stone, Christian D" sort="Stone, Christian D" uniqKey="Stone C" first="Christian D" last="Stone">Christian D. 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Andrews</name></author><author><name sortKey="Katsanos, Konstantinos H" sort="Katsanos, Konstantinos H" uniqKey="Katsanos K" first="Konstantinos H" last="Katsanos">Konstantinos H. Katsanos</name></author><author><name sortKey="Rieder, Florian" sort="Rieder, Florian" uniqKey="Rieder F" first="Florian" last="Rieder">Florian Rieder</name></author><author><name sortKey="Steinwurz, Flavio" sort="Steinwurz, Flavio" uniqKey="Steinwurz F" first="Flavio" last="Steinwurz">Flavio Steinwurz</name></author><author><name sortKey="Karmiris, Konstantinos" sort="Karmiris, Konstantinos" uniqKey="Karmiris K" first="Konstantinos" last="Karmiris">Konstantinos Karmiris</name></author><author><name sortKey="Cheon, Jae Hee" sort="Cheon, Jae Hee" uniqKey="Cheon J" first="Jae Hee" last="Cheon">Jae Hee Cheon</name></author><author><name sortKey="Moran, Gordon William" sort="Moran, Gordon William" uniqKey="Moran G" first="Gordon William" last="Moran">Gordon William Moran</name></author><author><name sortKey="Cesarini, Monica" sort="Cesarini, Monica" uniqKey="Cesarini M" first="Monica" last="Cesarini">Monica Cesarini</name></author><author><name sortKey="Stone, Christian D" sort="Stone, Christian D" uniqKey="Stone C" first="Christian D" last="Stone">Christian D. Stone</name></author><author><name sortKey="Schwartz, Doron" sort="Schwartz, Doron" uniqKey="Schwartz D" first="Doron" last="Schwartz">Doron Schwartz</name></author><author><name sortKey="Protic, Marijana" sort="Protic, Marijana" uniqKey="Protic M" first="Marijana" last="Protic">Marijana Protic</name></author><author><name sortKey="Roblin, Xavier" sort="Roblin, Xavier" uniqKey="Roblin X" first="Xavier" last="Roblin">Xavier Roblin</name></author><author><name sortKey="Roda, Giulia" sort="Roda, Giulia" uniqKey="Roda G" first="Giulia" last="Roda">Giulia Roda</name></author><author><name sortKey="Chen, Min Hu" sort="Chen, Min Hu" uniqKey="Chen M" first="Min-Hu" last="Chen">Min-Hu Chen</name></author><author><name sortKey="Har Noy, Ofir" sort="Har Noy, Ofir" uniqKey="Har Noy O" first="Ofir" last="Har-Noy">Ofir Har-Noy</name></author><author><name sortKey="Bernstein, Charles N" sort="Bernstein, Charles N" uniqKey="Bernstein C" first="Charles N" last="Bernstein">Charles N. Bernstein</name></author></analytic><series><title level="j">World Journal of Gastroenterology</title><idno type="ISSN">1007-9327</idno><idno type="eISSN">2219-2840</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>AIM</title><p>To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates (5ASA) with corticosteroids (CS) versus corticosteroids alone for patients with active ulcerative colitis (UC).</p></sec><sec><title>METHODS</title><p>A cross-sectional questionnaire exploring physicians’ attitude toward 5ASA + CS combination therapy <italic>vs</italic> CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents’ agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses.</p></sec><sec><title>RESULTS</title><p>Six hundred and sixty-four questionnaires were distributed and 349 received (52.6% response rate). Of 340 eligible respondents, 221 (65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108 (32%) would stop the 5ASA (<italic>P</italic> < 0.001), and 11 (3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340 (41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most (94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS.</p></sec><sec><title>CONCLUSION</title><p>Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Truelove, Sc" uniqKey="Truelove S">SC Truelove</name></author><author><name sortKey="Witts, Lj" uniqKey="Witts L">LJ Witts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dignass, A" uniqKey="Dignass A">A Dignass</name></author><author><name sortKey="Lindsay, Jo" uniqKey="Lindsay J">JO Lindsay</name></author><author><name sortKey="Sturm, A" uniqKey="Sturm A">A Sturm</name></author><author><name sortKey="Windsor, A" uniqKey="Windsor A">A Windsor</name></author><author><name sortKey="Colombel, Jf" uniqKey="Colombel J">JF Colombel</name></author><author><name sortKey="Allez, M" uniqKey="Allez M">M Allez</name></author><author><name sortKey="D Aens, G" uniqKey="D Aens G">G D’Haens</name></author><author><name sortKey="D Oore, A" uniqKey="D Oore A">A 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Forbes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Har Noy, O" uniqKey="Har Noy O">O Har-Noy</name></author><author><name sortKey="Kim, B" uniqKey="Kim B">B Kim</name></author><author><name sortKey="Haiat, R" uniqKey="Haiat R">R Haiat</name></author><author><name sortKey="Engel, T" uniqKey="Engel T">T Engel</name></author><author><name sortKey="Ungar, B" uniqKey="Ungar B">B Ungar</name></author><author><name sortKey="Eliakim, R" uniqKey="Eliakim R">R Eliakim</name></author><author><name sortKey="Kim, Wh" uniqKey="Kim W">WH Kim</name></author><author><name sortKey="Cheon, Jh" uniqKey="Cheon J">JH Cheon</name></author><author><name sortKey="Ben Horin, S" uniqKey="Ben Horin S">S Ben-Horin</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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