New Potent Membrane-Targeting Antibacterial Peptides from Viral Capsid Proteins
Identifieur interne : 000733 ( Main/Merge ); précédent : 000732; suivant : 000734New Potent Membrane-Targeting Antibacterial Peptides from Viral Capsid Proteins
Auteurs : Susana A. Dias [Portugal] ; João M. Freire [Portugal, France] ; Clara Pérez-Peinado [Espagne] ; Marco M. Domingues [Portugal] ; Diana Gaspar [Portugal] ; Nuno Vale [Portugal] ; Paula Gomes [Portugal] ; David Andreu [Espagne] ; S Nia T. Henriques [Australie] ; Miguel A. R. B. Castanho [Portugal] ; Ana S. Veiga [Portugal]Source :
- Frontiers in Microbiology [ 1664-302X ] ; 2017.
Abstract
The increasing prevalence of multidrug-resistant bacteria urges the development of new antibacterial agents. With a broad spectrum activity, antimicrobial peptides have been considered potential antibacterial drug leads. Using bioinformatic tools we have previously shown that viral structural proteins are a rich source for new bioactive peptide sequences, namely antimicrobial and cell-penetrating peptides. Here, we test the efficacy and mechanism of action of the most promising peptides among those previously identified against both Gram-positive and Gram-negative bacteria. Two cell-penetrating peptides, vCPP 0769 and vCPP 2319, have high antibacterial activity against
Url:
DOI: 10.3389/fmicb.2017.00775
PubMed: 28522994
PubMed Central: 5415599
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002498
- to stream Pmc, to step Curation: 002348
- to stream Pmc, to step Checkpoint: 000181
- to stream PubMed, to step Corpus: 000B93
- to stream PubMed, to step Curation: 000B90
- to stream PubMed, to step Checkpoint: 000B90
- to stream Ncbi, to step Merge: 004836
- to stream Ncbi, to step Curation: 004836
- to stream Ncbi, to step Checkpoint: 004836
Links to Exploration step
PMC:5415599Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">New Potent Membrane-Targeting Antibacterial Peptides from Viral Capsid Proteins</title><author><name sortKey="Dias, Susana A" sort="Dias, Susana A" uniqKey="Dias S" first="Susana A." last="Dias">Susana A. Dias</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa</institution><country>Lisbon, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Freire, Joao M" sort="Freire, Joao M" uniqKey="Freire J" first="João M." last="Freire">João M. Freire</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa</institution><country>Lisbon, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Virology, Institut Pasteur</institution><country>Paris, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Perez Peinado, Clara" sort="Perez Peinado, Clara" uniqKey="Perez Peinado C" first="Clara" last="Pérez-Peinado">Clara Pérez-Peinado</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona Biomedical Research Park</institution><country>Barcelona, Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Domingues, Marco M" sort="Domingues, Marco M" uniqKey="Domingues M" first="Marco M." last="Domingues">Marco M. Domingues</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa</institution><country>Lisbon, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Gaspar, Diana" sort="Gaspar, Diana" uniqKey="Gaspar D" first="Diana" last="Gaspar">Diana Gaspar</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa</institution><country>Lisbon, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Vale, Nuno" sort="Vale, Nuno" uniqKey="Vale N" first="Nuno" last="Vale">Nuno Vale</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>UCIBIO-REQUIMTE, Faculdade de Farmácia, Universidade do Porto</institution><country>Porto, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Gomes, Paula" sort="Gomes, Paula" uniqKey="Gomes P" first="Paula" last="Gomes">Paula Gomes</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto</institution><country>Porto, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Andreu, David" sort="Andreu, David" uniqKey="Andreu D" first="David" last="Andreu">David Andreu</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona Biomedical Research Park</institution><country>Barcelona, Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Henriques, S Nia T" sort="Henriques, S Nia T" uniqKey="Henriques S" first="S Nia T." last="Henriques">S Nia T. Henriques</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Institute for Molecular Bioscience, The University of Queensland, Brisbane</institution><country>QLD, Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Castanho, Miguel A R B" sort="Castanho, Miguel A R B" uniqKey="Castanho M" first="Miguel A. R. B." last="Castanho">Miguel A. R. B. Castanho</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa</institution><country>Lisbon, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Veiga, Ana S" sort="Veiga, Ana S" uniqKey="Veiga A" first="Ana S." last="Veiga">Ana S. Veiga</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa</institution><country>Lisbon, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28522994</idno><idno type="pmc">5415599</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415599</idno><idno type="RBID">PMC:5415599</idno><idno type="doi">10.3389/fmicb.2017.00775</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">002498</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002498</idno><idno type="wicri:Area/Pmc/Curation">002348</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002348</idno><idno type="wicri:Area/Pmc/Checkpoint">000181</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000181</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000B93</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B93</idno><idno type="wicri:Area/PubMed/Curation">000B90</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000B90</idno><idno type="wicri:Area/PubMed/Checkpoint">000B90</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000B90</idno><idno type="wicri:Area/Ncbi/Merge">004836</idno><idno type="wicri:Area/Ncbi/Curation">004836</idno><idno type="wicri:Area/Ncbi/Checkpoint">004836</idno><idno type="wicri:Area/Main/Merge">000733</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">New Potent Membrane-Targeting Antibacterial Peptides from Viral Capsid Proteins</title><author><name sortKey="Dias, Susana A" sort="Dias, Susana A" uniqKey="Dias S" first="Susana A." last="Dias">Susana A. Dias</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa</institution><country>Lisbon, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Freire, Joao M" sort="Freire, Joao M" uniqKey="Freire J" first="João M." last="Freire">João M. Freire</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa</institution><country>Lisbon, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Virology, Institut Pasteur</institution><country>Paris, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Perez Peinado, Clara" sort="Perez Peinado, Clara" uniqKey="Perez Peinado C" first="Clara" last="Pérez-Peinado">Clara Pérez-Peinado</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona Biomedical Research Park</institution><country>Barcelona, Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Domingues, Marco M" sort="Domingues, Marco M" uniqKey="Domingues M" first="Marco M." last="Domingues">Marco M. Domingues</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa</institution><country>Lisbon, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Gaspar, Diana" sort="Gaspar, Diana" uniqKey="Gaspar D" first="Diana" last="Gaspar">Diana Gaspar</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa</institution><country>Lisbon, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Vale, Nuno" sort="Vale, Nuno" uniqKey="Vale N" first="Nuno" last="Vale">Nuno Vale</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>UCIBIO-REQUIMTE, Faculdade de Farmácia, Universidade do Porto</institution><country>Porto, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Gomes, Paula" sort="Gomes, Paula" uniqKey="Gomes P" first="Paula" last="Gomes">Paula Gomes</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto</institution><country>Porto, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Andreu, David" sort="Andreu, David" uniqKey="Andreu D" first="David" last="Andreu">David Andreu</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona Biomedical Research Park</institution><country>Barcelona, Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Henriques, S Nia T" sort="Henriques, S Nia T" uniqKey="Henriques S" first="S Nia T." last="Henriques">S Nia T. Henriques</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Institute for Molecular Bioscience, The University of Queensland, Brisbane</institution><country>QLD, Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Castanho, Miguel A R B" sort="Castanho, Miguel A R B" uniqKey="Castanho M" first="Miguel A. R. B." last="Castanho">Miguel A. R. B. Castanho</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa</institution><country>Lisbon, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author><author><name sortKey="Veiga, Ana S" sort="Veiga, Ana S" uniqKey="Veiga A" first="Ana S." last="Veiga">Ana S. Veiga</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa</institution><country>Lisbon, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Medical Microbiology and Virology, National Health Laboratory Service/University of the Free State, Bloemfontein 9301</wicri:regionArea><wicri:noRegion>Bloemfontein 9301</wicri:noRegion></affiliation></author></analytic><series><title level="j">Frontiers in Microbiology</title><idno type="eISSN">1664-302X</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The increasing prevalence of multidrug-resistant bacteria urges the development of new antibacterial agents. With a broad spectrum activity, antimicrobial peptides have been considered potential antibacterial drug leads. Using bioinformatic tools we have previously shown that viral structural proteins are a rich source for new bioactive peptide sequences, namely antimicrobial and cell-penetrating peptides. Here, we test the efficacy and mechanism of action of the most promising peptides among those previously identified against both Gram-positive and Gram-negative bacteria. Two cell-penetrating peptides, vCPP 0769 and vCPP 2319, have high antibacterial activity against <italic>Staphylococcus aureus</italic>, MRSA, <italic>Escherichia coli</italic>, and <italic>Pseudomonas aeruginosa</italic>, being thus multifunctional. The antibacterial mechanism of action of the two most active viral protein-derived peptides, vAMP 059 and vCPP 2319, was studied in detail. Both peptides act on both Gram-positive <italic>S. aureus</italic> and Gram-negative <italic>P. aeruginosa</italic>, with bacterial cell death occurring within minutes. Also, these peptides cause bacterial membrane permeabilization and damage of the bacterial envelope of <italic>P. aeruginosa</italic> cells. Overall, the results show that structural viral proteins are an abundant source for membrane-active peptides sequences with strong antibacterial properties.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Alves, C S" uniqKey="Alves C">C. S. Alves</name></author><author><name sortKey="Melo, M N" uniqKey="Melo M">M. N. Melo</name></author><author><name sortKey="Franquelim, H G" uniqKey="Franquelim H">H. G. Franquelim</name></author><author><name sortKey="Ferre, R" uniqKey="Ferre R">R. Ferre</name></author><author><name sortKey="Planas, M" uniqKey="Planas M">M. Planas</name></author><author><name sortKey="Feliu, L" uniqKey="Feliu L">L. Feliu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bahar, A A" uniqKey="Bahar A">A. A. Bahar</name></author><author><name sortKey="Ren, D" uniqKey="Ren D">D. Ren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bahnsen, J S" uniqKey="Bahnsen J">J. S. Bahnsen</name></author><author><name sortKey="Franzyk, H" uniqKey="Franzyk H">H. Franzyk</name></author><author><name sortKey="Sandberg Schaal, A" uniqKey="Sandberg Schaal A">A. Sandberg-Schaal</name></author><author><name sortKey="Nielsen, H M" uniqKey="Nielsen H">H. M. Nielsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baltzer, S A" uniqKey="Baltzer S">S. A. Baltzer</name></author><author><name sortKey="Brown, M H" uniqKey="Brown M">M. H. Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barbosa, M" uniqKey="Barbosa M">M. Barbosa</name></author><author><name sortKey="Vale, N" uniqKey="Vale N">N. Vale</name></author><author><name sortKey="Costa, F M T A" uniqKey="Costa F">F. M. T. A. Costa</name></author><author><name sortKey="Martins, M C L" uniqKey="Martins M">M. C. L. Martins</name></author><author><name sortKey="Gomes, P" uniqKey="Gomes P">P. Gomes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barry, A L" uniqKey="Barry A">A. L. Barry</name></author><author><name sortKey="Craig, W A" uniqKey="Craig W">W. A. Craig</name></author><author><name sortKey="Nadler, H" uniqKey="Nadler H">H. Nadler</name></author><author><name sortKey="Reller, L B" uniqKey="Reller L">L. B. Reller</name></author><author><name sortKey="Sanders, C C" uniqKey="Sanders C">C. C. Sanders</name></author><author><name sortKey="Swenson, J M" uniqKey="Swenson J">J. M. Swenson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beveridge, T J" uniqKey="Beveridge T">T. J. Beveridge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bobone, S" uniqKey="Bobone S">S. Bobone</name></author><author><name sortKey="Piazzon, A" uniqKey="Piazzon A">A. Piazzon</name></author><author><name sortKey="Orioni, B" uniqKey="Orioni B">B. Orioni</name></author><author><name sortKey="Pedersen, J Z" uniqKey="Pedersen J">J. Z. Pedersen</name></author><author><name sortKey="Nan, Y H" uniqKey="Nan Y">Y. H. Nan</name></author><author><name sortKey="Hahm, K S" uniqKey="Hahm K">K. S. Hahm</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brogden, K A" uniqKey="Brogden K">K. A. Brogden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brogden, N K" uniqKey="Brogden N">N. K. Brogden</name></author><author><name sortKey="Brogden, K A" uniqKey="Brogden K">K. A. Brogden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, D" uniqKey="Brown D">D. Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bulet, P" uniqKey="Bulet P">P. Bulet</name></author><author><name sortKey="Stocklin, R" uniqKey="Stocklin R">R. Stöcklin</name></author><author><name sortKey="Menin, L" uniqKey="Menin L">L. Menin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, H L" uniqKey="Chen H">H. L. Chen</name></author><author><name sortKey="Su, P" uniqKey="Su P">P. Su</name></author><author><name sortKey="Chang, Y" uniqKey="Chang Y">Y. Chang</name></author><author><name sortKey="Wu, S" uniqKey="Wu S">S. Wu</name></author><author><name sortKey="Liao, Y" uniqKey="Liao Y">Y. Liao</name></author><author><name sortKey="Yu, H" uniqKey="Yu H">H. Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clement, S" uniqKey="Clement S">S. Clement</name></author><author><name sortKey="Vaudaux, P" uniqKey="Vaudaux P">P. Vaudaux</name></author><author><name sortKey="Francois, P" uniqKey="Francois P">P. Francois</name></author><author><name sortKey="Schrenzel, J" uniqKey="Schrenzel J">J. Schrenzel</name></author><author><name sortKey="Huggler, E" uniqKey="Huggler E">E. Huggler</name></author><author><name sortKey="Kampf, S" uniqKey="Kampf S">S. Kampf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Domingues, M M" uniqKey="Domingues M">M. M. Domingues</name></author><author><name sortKey="Castanho, M A R B" uniqKey="Castanho M">M. A. R. B. Castanho</name></author><author><name sortKey="Santos, N C" uniqKey="Santos N">N. C. Santos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ernst, R K" uniqKey="Ernst R">R. K. Ernst</name></author><author><name sortKey="Guina, T" uniqKey="Guina T">T. Guina</name></author><author><name sortKey="Miller, S I" uniqKey="Miller S">S. I. Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freire, J M" uniqKey="Freire J">J. M. Freire</name></author><author><name sortKey="Dias, S A" uniqKey="Dias S">S. A. Dias</name></author><author><name sortKey="Flores, L" uniqKey="Flores L">L. Flores</name></author><author><name sortKey="Veiga, A S" uniqKey="Veiga A">A. S. Veiga</name></author><author><name sortKey="Castanho, M A R B" uniqKey="Castanho M">M. A. R. B. Castanho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freire, J M" uniqKey="Freire J">J. M. Freire</name></author><author><name sortKey="Santos, N C" uniqKey="Santos N">N. C. Santos</name></author><author><name sortKey="Veiga, A S" uniqKey="Veiga A">A. S. Veiga</name></author><author><name sortKey="Da Poian, A T" uniqKey="Da Poian A">A. T. Da Poian</name></author><author><name sortKey="Castanho, M A R B" uniqKey="Castanho M">M. A. R. B. Castanho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gautam, A" uniqKey="Gautam A">A. Gautam</name></author><author><name sortKey="Chaudhary, K" uniqKey="Chaudhary K">K. Chaudhary</name></author><author><name sortKey="Kumar, R" uniqKey="Kumar R">R. Kumar</name></author><author><name sortKey="Sharma, A" uniqKey="Sharma A">A. Sharma</name></author><author><name sortKey="Kapoor, P" uniqKey="Kapoor P">P. Kapoor</name></author><author><name sortKey="Tyagi, A" uniqKey="Tyagi A">A. Tyagi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gr Slund, A" uniqKey="Gr Slund A">A. Gräslund</name></author><author><name sortKey="Madani, F" uniqKey="Madani F">F. Madani</name></author><author><name sortKey="Lindberg, S" uniqKey="Lindberg S">S. Lindberg</name></author><author><name sortKey="Langel, U" uniqKey="Langel U">Ü Langel</name></author><author><name sortKey="Futaki, S" uniqKey="Futaki S">S. Futaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hancock, R E W" uniqKey="Hancock R">R. E. W. Hancock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Henriques, S T" uniqKey="Henriques S">S. T. Henriques</name></author><author><name sortKey="Melo, M N" uniqKey="Melo M">M. N. Melo</name></author><author><name sortKey="Castanho, M A R B" uniqKey="Castanho M">M. A. R. B. Castanho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jenssen, H" uniqKey="Jenssen H">H. Jenssen</name></author><author><name sortKey="Hamill, P" uniqKey="Hamill P">P. Hamill</name></author><author><name sortKey="Hancock, R E W" uniqKey="Hancock R">R. E. W. Hancock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaplan, C W" uniqKey="Kaplan C">C. W. Kaplan</name></author><author><name sortKey="Sim, J H" uniqKey="Sim J">J. H. Sim</name></author><author><name sortKey="Shah, K R" uniqKey="Shah K">K. R. Shah</name></author><author><name sortKey="Kolesnikova Kaplan, A" uniqKey="Kolesnikova Kaplan A">A. Kolesnikova-Kaplan</name></author><author><name sortKey="Shi, W" uniqKey="Shi W">W. Shi</name></author><author><name sortKey="Eckert, R" uniqKey="Eckert R">R. Eckert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levison, M E" uniqKey="Levison M">M. E. Levison</name></author><author><name sortKey="Levison, J H" uniqKey="Levison J">J. H. Levison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mahlapuu, M" uniqKey="Mahlapuu M">M. Mahlapuu</name></author><author><name sortKey="H Kansson, J" uniqKey="H Kansson J">J. Håkansson</name></author><author><name sortKey="Ringstad, L" uniqKey="Ringstad L">L. Ringstad</name></author><author><name sortKey="Bjorn, C" uniqKey="Bjorn C">C. Björn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Melo, M" uniqKey="Melo M">M. Melo</name></author><author><name sortKey="Ferre, R" uniqKey="Ferre R">R. Ferre</name></author><author><name sortKey="Castanho, M" uniqKey="Castanho M">M. Castanho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Melo, M N" uniqKey="Melo M">M. N. Melo</name></author><author><name sortKey="Castanho, M A R B" uniqKey="Castanho M">M. A. R. B. Castanho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mileykovskaya, E" uniqKey="Mileykovskaya E">E. Mileykovskaya</name></author><author><name sortKey="Dowhan, W" uniqKey="Dowhan W">W. Dowhan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mogi, T" uniqKey="Mogi T">T. Mogi</name></author><author><name sortKey="Kita, K" uniqKey="Kita K">K. Kita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Monteiro, C" uniqKey="Monteiro C">C. Monteiro</name></author><author><name sortKey="Fernandes, M" uniqKey="Fernandes M">M. Fernandes</name></author><author><name sortKey="Pinheiro, M" uniqKey="Pinheiro M">M. Pinheiro</name></author><author><name sortKey="Maia, S" uniqKey="Maia S">S. Maia</name></author><author><name sortKey="Seabra, C L" uniqKey="Seabra C">C. L. Seabra</name></author><author><name sortKey="Ferreira Da Silva, F" uniqKey="Ferreira Da Silva F">F. Ferreira-Da-Silva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nekhotiaeva, N" uniqKey="Nekhotiaeva N">N. Nekhotiaeva</name></author><author><name sortKey="Elmquist, A" uniqKey="Elmquist A">A. Elmquist</name></author><author><name sortKey="Rajarao, G K" uniqKey="Rajarao G">G. K. Rajarao</name></author><author><name sortKey="H Llbrink, M" uniqKey="H Llbrink M">M. Hällbrink</name></author><author><name sortKey="Langel, U" uniqKey="Langel U">U. Langel</name></author><author><name sortKey="Good, L" uniqKey="Good L">L. Good</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nguyen, L T" uniqKey="Nguyen L">L. T. Nguyen</name></author><author><name sortKey="Haney, E F" uniqKey="Haney E">E. F. Haney</name></author><author><name sortKey="Vogel, H J" uniqKey="Vogel H">H. J. Vogel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, C B" uniqKey="Park C">C. B. Park</name></author><author><name sortKey="Yi, K S" uniqKey="Yi K">K. S. Yi</name></author><author><name sortKey="Matsuzaki, K" uniqKey="Matsuzaki K">K. Matsuzaki</name></author><author><name sortKey="Kim, M S" uniqKey="Kim M">M. S. Kim</name></author><author><name sortKey="Kim, S C" uniqKey="Kim S">S. C. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peters, B M" uniqKey="Peters B">B. M. Peters</name></author><author><name sortKey="Shirtliff, M E" uniqKey="Shirtliff M">M. E. Shirtliff</name></author><author><name sortKey="Jabra Rizk, M A" uniqKey="Jabra Rizk M">M. A. Jabra-Rizk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Piers, K L" uniqKey="Piers K">K. L. Piers</name></author><author><name sortKey="Brown, M H" uniqKey="Brown M">M. H. Brown</name></author><author><name sortKey="Hancock, R E W" uniqKey="Hancock R">R. E. W. Hancock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Powers, J P S" uniqKey="Powers J">J. P. S. Powers</name></author><author><name sortKey="Hancock, R E W" uniqKey="Hancock R">R. E. W. Hancock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roth, B L" uniqKey="Roth B">B. L. Roth</name></author><author><name sortKey="Poot, M" uniqKey="Poot M">M. Poot</name></author><author><name sortKey="Yue, S T" uniqKey="Yue S">S. T. Yue</name></author><author><name sortKey="Millard, P J" uniqKey="Millard P">P. J. Millard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rozek, A" uniqKey="Rozek A">A. Rozek</name></author><author><name sortKey="Powers, J P S" uniqKey="Powers J">J. P. S. Powers</name></author><author><name sortKey="Friedrich, C L" uniqKey="Friedrich C">C. L. Friedrich</name></author><author><name sortKey="Hancock, R E W" uniqKey="Hancock R">R. E. W. Hancock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sancho Vaello, E" uniqKey="Sancho Vaello E">E. Sancho-Vaello</name></author><author><name sortKey="Zeth, K" uniqKey="Zeth K">K. Zeth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sandri, A M" uniqKey="Sandri A">A. M. Sandri</name></author><author><name sortKey="Landersdorfer, C B" uniqKey="Landersdorfer C">C. B. Landersdorfer</name></author><author><name sortKey="Jacob, J" uniqKey="Jacob J">J. Jacob</name></author><author><name sortKey="Boniatti, M M" uniqKey="Boniatti M">M. M. Boniatti</name></author><author><name sortKey="Dalarosa, M G" uniqKey="Dalarosa M">M. G. Dalarosa</name></author><author><name sortKey="Falci, D R" uniqKey="Falci D">D. R. Falci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sani, M A" uniqKey="Sani M">M. A. Sani</name></author><author><name sortKey="Henriques, S T" uniqKey="Henriques S">S. T. Henriques</name></author><author><name sortKey="Weber, D" uniqKey="Weber D">D. Weber</name></author><author><name sortKey="Separovic, F" uniqKey="Separovic F">F. Separovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shai, Y" uniqKey="Shai Y">Y. Shai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Splith, K" uniqKey="Splith K">K. Splith</name></author><author><name sortKey="Neundorf, I" uniqKey="Neundorf I">I. Neundorf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takeshima, K" uniqKey="Takeshima K">K. Takeshima</name></author><author><name sortKey="Chikushi, A" uniqKey="Chikushi A">A. Chikushi</name></author><author><name sortKey="Lee, K K" uniqKey="Lee K">K. K. Lee</name></author><author><name sortKey="Yonehara, S" uniqKey="Yonehara S">S. Yonehara</name></author><author><name sortKey="Matsuzaki, K" uniqKey="Matsuzaki K">K. Matsuzaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tanwar, J" uniqKey="Tanwar J">J. Tanwar</name></author><author><name sortKey="Das, S" uniqKey="Das S">S. Das</name></author><author><name sortKey="Fatima, Z" uniqKey="Fatima Z">Z. Fatima</name></author><author><name sortKey="Hameed, S" uniqKey="Hameed S">S. Hameed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teixeira, V" uniqKey="Teixeira V">V. Teixeira</name></author><author><name sortKey="Feio, M J" uniqKey="Feio M">M. J. Feio</name></author><author><name sortKey="Bastos, M" uniqKey="Bastos M">M. Bastos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Torcato, I M" uniqKey="Torcato I">I. M. Torcato</name></author><author><name sortKey="Huang, Y H" uniqKey="Huang Y">Y. H. Huang</name></author><author><name sortKey="Franquelim, H G" uniqKey="Franquelim H">H. G. Franquelim</name></author><author><name sortKey="Gaspar, D D" uniqKey="Gaspar D">D. D. Gaspar</name></author><author><name sortKey="Craik, D J" uniqKey="Craik D">D. J. Craik</name></author><author><name sortKey="Castanho, M A R B" uniqKey="Castanho M">M. A. R. B. Castanho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Torrent, M" uniqKey="Torrent M">M. Torrent</name></author><author><name sortKey="Di Tommaso, P" uniqKey="Di Tommaso P">P. Di Tommaso</name></author><author><name sortKey="Pulido, D" uniqKey="Pulido D">D. Pulido</name></author><author><name sortKey="Nogues, M V" uniqKey="Nogues M">M. V. Nogués</name></author><author><name sortKey="Notredame, C" uniqKey="Notredame C">C. Notredame</name></author><author><name sortKey="Boix, E" uniqKey="Boix E">E. Boix</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ventola, C L" uniqKey="Ventola C">C. L. Ventola</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wiegand, I" uniqKey="Wiegand I">I. Wiegand</name></author><author><name sortKey="Hilpert, K" uniqKey="Hilpert K">K. Hilpert</name></author><author><name sortKey="Hancock, R E W" uniqKey="Hancock R">R. E. W. Hancock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wikler, M A" uniqKey="Wikler M">M. A. Wikler</name></author><author><name sortKey="Low, D E" uniqKey="Low D">D. E. Low</name></author><author><name sortKey="Cockerill, F R" uniqKey="Cockerill F">F. R. Cockerill</name></author><author><name sortKey="Sheehan, D J" uniqKey="Sheehan D">D. J. Sheehan</name></author><author><name sortKey="Craig, W A" uniqKey="Craig W">W. A. Craig</name></author><author><name sortKey="Tenover, F C" uniqKey="Tenover F">F. C. Tenover</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, M" uniqKey="Wu M">M. Wu</name></author><author><name sortKey="Hancock, R E W" uniqKey="Hancock R">R. E. W. Hancock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xia, G" uniqKey="Xia G">G. Xia</name></author><author><name sortKey="Kohler, T" uniqKey="Kohler T">T. Kohler</name></author><author><name sortKey="Peschel, A" uniqKey="Peschel A">A. Peschel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yeaman, M R" uniqKey="Yeaman M">M. R. Yeaman</name></author><author><name sortKey="Yount, N Y" uniqKey="Yount N">N. Y. Yount</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zasloff, M" uniqKey="Zasloff M">M. Zasloff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, W L" uniqKey="Zhu W">W. L. Zhu</name></author><author><name sortKey="Lan, H" uniqKey="Lan H">H. Lan</name></author><author><name sortKey="Park, I S" uniqKey="Park I">I. S. Park</name></author><author><name sortKey="Kim, J" uniqKey="Kim J">J. Kim</name></author><author><name sortKey="Jin, H Z" uniqKey="Jin H">H. Z. Jin</name></author><author><name sortKey="Hahm, K S" uniqKey="Hahm K">K. S. Hahm</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000733 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000733 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Merge
|type= RBID
|clé= PMC:5415599
|texte= New Potent Membrane-Targeting Antibacterial Peptides from Viral Capsid Proteins
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:28522994" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |