Rational design of rabies vaccine formulation for enhanced stability.
Identifieur interne : 000486 ( Main/Merge ); précédent : 000485; suivant : 000487Rational design of rabies vaccine formulation for enhanced stability.
Auteurs : Veysel Kayser [États-Unis] ; Alain Françon [France] ; Hervé Pinton [France] ; Jean-François Saluzzo [France] ; Bernhardt L. Trout [États-Unis]Source :
- Turkish journal of medical sciences [ 1300-0144 ] ; 2017.
Abstract
Vaccines are often lyophilized in order to retain their stability and efficacy for a longer period of time. However, the same lyophilization process may also cause a major degradation of the vaccine, especially during early phases of manufacturing, leading to a loss of potency of the product. Many viral diseases, such as rabies, are acute and fatal unless the vaccine is administered prior to exposure or the onset of symptoms in the case of postexposure treatment.
DOI: 10.3906/sag-1610-82
PubMed: 28618756
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pubmed:28618756Le document en format XML
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<front><div type="abstract" xml:lang="en">Vaccines are often lyophilized in order to retain their stability and efficacy for a longer period of time. However, the same lyophilization process may also cause a major degradation of the vaccine, especially during early phases of manufacturing, leading to a loss of potency of the product. Many viral diseases, such as rabies, are acute and fatal unless the vaccine is administered prior to exposure or the onset of symptoms in the case of postexposure treatment.</div>
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