Clinical efficacy and safety of achieving very low LDL-cholesterol concentrations with the PCSK9 inhibitor evolocumab: a prespecified secondary analysis of the FOURIER trial.
Identifieur interne : 000F82 ( Main/Exploration ); précédent : 000F81; suivant : 000F83Clinical efficacy and safety of achieving very low LDL-cholesterol concentrations with the PCSK9 inhibitor evolocumab: a prespecified secondary analysis of the FOURIER trial.
Auteurs : Robert P. Giugliano [États-Unis] ; Terje R. Pedersen [Norvège] ; Jeong-Gun Park [États-Unis] ; Gaetano M. De Ferrari [Italie] ; Zbigniew A. Gaciong [Pologne] ; Richard Ceska [République tchèque] ; Kalman Toth [Hongrie] ; Ioanna Gouni-Berthold [Allemagne] ; Jose Lopez-Miranda [Espagne] ; François Schiele [France] ; François Mach [Suisse] ; Brian R. Ott [États-Unis] ; Estella Kanevsky [États-Unis] ; Armando Lira Pineda [États-Unis] ; Ransi Somaratne [États-Unis] ; Scott M. Wasserman [États-Unis] ; Anthony C. Keech [Australie] ; Peter S. Sever [Royaume-Uni] ; Marc S. Sabatine [États-Unis]Source :
- Lancet (London, England) [ 1474-547X ] ; 2017.
Abstract
LDL cholesterol is a well established risk factor for atherosclerotic cardiovascular disease. How much one should or safely can lower this risk factor remains debated. We aimed to explore the relationship between progressively lower LDL-cholesterol concentrations achieved at 4 weeks and clinical efficacy and safety in the FOURIER trial of evolocumab, a monoclonal antibody to proprotein convertase subtilisin-kexin type 9 (PCSK9).
DOI: 10.1016/S0140-6736(17)32290-0
PubMed: 28859947
Affiliations:
- Allemagne, Australie, Espagne, France, Hongrie, Italie, Norvège, Pologne, Royaume-Uni, République tchèque, Suisse, États-Unis
- Angleterre, Bohême centrale, Bourgogne-Franche-Comté, Californie, Franche-Comté, Grand Londres, Massachusetts, Nouvelle-Galles du Sud, Rhode Island, Østlandet
- Besançon, Londres, Oslo, Prague, Sydney
- Université de Sydney
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Le document en format XML
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<author><name sortKey="Kanevsky, Estella" sort="Kanevsky, Estella" uniqKey="Kanevsky E" first="Estella" last="Kanevsky">Estella Kanevsky</name>
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</author>
<author><name sortKey="Wasserman, Scott M" sort="Wasserman, Scott M" uniqKey="Wasserman S" first="Scott M" last="Wasserman">Scott M. Wasserman</name>
<affiliation wicri:level="2"><nlm:affiliation>Amgen, Thousand Oaks, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Amgen, Thousand Oaks, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Keech, Anthony C" sort="Keech, Anthony C" uniqKey="Keech A" first="Anthony C" last="Keech">Anthony C. Keech</name>
<affiliation wicri:level="4"><nlm:affiliation>Sydney Medical School, National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sydney Medical School, National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, NSW</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sever, Peter S" sort="Sever, Peter S" uniqKey="Sever P" first="Peter S" last="Sever">Peter S. Sever</name>
<affiliation wicri:level="3"><nlm:affiliation>International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sabatine, Marc S" sort="Sabatine, Marc S" uniqKey="Sabatine M" first="Marc S" last="Sabatine">Marc S. Sabatine</name>
<affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Lancet (London, England)</title>
<idno type="eISSN">1474-547X</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">LDL cholesterol is a well established risk factor for atherosclerotic cardiovascular disease. How much one should or safely can lower this risk factor remains debated. We aimed to explore the relationship between progressively lower LDL-cholesterol concentrations achieved at 4 weeks and clinical efficacy and safety in the FOURIER trial of evolocumab, a monoclonal antibody to proprotein convertase subtilisin-kexin type 9 (PCSK9).</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Espagne</li>
<li>France</li>
<li>Hongrie</li>
<li>Italie</li>
<li>Norvège</li>
<li>Pologne</li>
<li>Royaume-Uni</li>
<li>République tchèque</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Bohême centrale</li>
<li>Bourgogne-Franche-Comté</li>
<li>Californie</li>
<li>Franche-Comté</li>
<li>Grand Londres</li>
<li>Massachusetts</li>
<li>Nouvelle-Galles du Sud</li>
<li>Rhode Island</li>
<li>Østlandet</li>
</region>
<settlement><li>Besançon</li>
<li>Londres</li>
<li>Oslo</li>
<li>Prague</li>
<li>Sydney</li>
</settlement>
<orgName><li>Université de Sydney</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Giugliano, Robert P" sort="Giugliano, Robert P" uniqKey="Giugliano R" first="Robert P" last="Giugliano">Robert P. Giugliano</name>
</region>
<name sortKey="Kanevsky, Estella" sort="Kanevsky, Estella" uniqKey="Kanevsky E" first="Estella" last="Kanevsky">Estella Kanevsky</name>
<name sortKey="Ott, Brian R" sort="Ott, Brian R" uniqKey="Ott B" first="Brian R" last="Ott">Brian R. Ott</name>
<name sortKey="Park, Jeong Gun" sort="Park, Jeong Gun" uniqKey="Park J" first="Jeong-Gun" last="Park">Jeong-Gun Park</name>
<name sortKey="Pineda, Armando Lira" sort="Pineda, Armando Lira" uniqKey="Pineda A" first="Armando Lira" last="Pineda">Armando Lira Pineda</name>
<name sortKey="Sabatine, Marc S" sort="Sabatine, Marc S" uniqKey="Sabatine M" first="Marc S" last="Sabatine">Marc S. Sabatine</name>
<name sortKey="Somaratne, Ransi" sort="Somaratne, Ransi" uniqKey="Somaratne R" first="Ransi" last="Somaratne">Ransi Somaratne</name>
<name sortKey="Wasserman, Scott M" sort="Wasserman, Scott M" uniqKey="Wasserman S" first="Scott M" last="Wasserman">Scott M. Wasserman</name>
</country>
<country name="Norvège"><region name="Østlandet"><name sortKey="Pedersen, Terje R" sort="Pedersen, Terje R" uniqKey="Pedersen T" first="Terje R" last="Pedersen">Terje R. Pedersen</name>
</region>
</country>
<country name="Italie"><noRegion><name sortKey="De Ferrari, Gaetano M" sort="De Ferrari, Gaetano M" uniqKey="De Ferrari G" first="Gaetano M" last="De Ferrari">Gaetano M. De Ferrari</name>
</noRegion>
</country>
<country name="Pologne"><noRegion><name sortKey="Gaciong, Zbigniew A" sort="Gaciong, Zbigniew A" uniqKey="Gaciong Z" first="Zbigniew A" last="Gaciong">Zbigniew A. Gaciong</name>
</noRegion>
</country>
<country name="République tchèque"><region name="Bohême centrale"><name sortKey="Ceska, Richard" sort="Ceska, Richard" uniqKey="Ceska R" first="Richard" last="Ceska">Richard Ceska</name>
</region>
</country>
<country name="Hongrie"><noRegion><name sortKey="Toth, Kalman" sort="Toth, Kalman" uniqKey="Toth K" first="Kalman" last="Toth">Kalman Toth</name>
</noRegion>
</country>
<country name="Allemagne"><noRegion><name sortKey="Gouni Berthold, Ioanna" sort="Gouni Berthold, Ioanna" uniqKey="Gouni Berthold I" first="Ioanna" last="Gouni-Berthold">Ioanna Gouni-Berthold</name>
</noRegion>
</country>
<country name="Espagne"><noRegion><name sortKey="Lopez Miranda, Jose" sort="Lopez Miranda, Jose" uniqKey="Lopez Miranda J" first="Jose" last="Lopez-Miranda">Jose Lopez-Miranda</name>
</noRegion>
</country>
<country name="France"><region name="Bourgogne-Franche-Comté"><name sortKey="Schiele, Francois" sort="Schiele, Francois" uniqKey="Schiele F" first="François" last="Schiele">François Schiele</name>
</region>
</country>
<country name="Suisse"><noRegion><name sortKey="Mach, Francois" sort="Mach, Francois" uniqKey="Mach F" first="François" last="Mach">François Mach</name>
</noRegion>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Keech, Anthony C" sort="Keech, Anthony C" uniqKey="Keech A" first="Anthony C" last="Keech">Anthony C. Keech</name>
</region>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Sever, Peter S" sort="Sever, Peter S" uniqKey="Sever P" first="Peter S" last="Sever">Peter S. Sever</name>
</region>
</country>
</tree>
</affiliations>
</record>
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