AustralieFrV1, Main, Exploration, bibRecordById, pubmed:28250806

Cancer: A disease at the crossroads of trade-offs.

Identifieur interne : 001051 ( Main/Exploration ); précédent : 001050; suivant : 001052

Cancer: A disease at the crossroads of trade-offs.

Auteurs : Camille Jacqueline ; Peter A. Biro ; Christa Beckmann ; Anders Pape Moller [France] ; François Renaud ; Gabriele Sorci ; Aurélie Tasiemski ; Beata Ujvari ; Frédéric Thomas

Source :

Evolutionary applications [ 1752-4571 ] ; 2017.

RBID : pubmed:28250806

Abstract

Central to evolutionary theory is the idea that living organisms face phenotypic and/or genetic trade-offs when allocating resources to competing life-history demands, such as growth, survival, and reproduction. These trade-offs are increasingly considered to be crucial to further our understanding of cancer. First, evidences suggest that neoplastic cells, as any living entities subject to natural selection, are governed by trade-offs such as between survival and proliferation. Second, selection might also have shaped trade-offs at the organismal level, especially regarding protective mechanisms against cancer. Cancer can also emerge as a consequence of additional trade-offs in organisms (e.g., eco-immunological trade-offs). Here, we review the wide range of trade-offs that occur at different scales and their relevance for understanding cancer dynamics. We also discuss how acknowledging these phenomena, in light of human evolutionary history, may suggest new guidelines for preventive and therapeutic strategies.

DOI: 10.1111/eva.12444
PubMed: 28250806

Affiliations:

France

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Cancer: A disease at the crossroads of trade-offs.

Cancer: A disease at the crossroads of trade-offs.

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