Promoting macrophage survival delays progression of pre-existing atherosclerotic lesions through macrophage-derived apoE.
Identifieur interne : 002955 ( Main/Exploration ); précédent : 002954; suivant : 002956Promoting macrophage survival delays progression of pre-existing atherosclerotic lesions through macrophage-derived apoE.
Auteurs : Laura Bouchareychas [France] ; John Pirault [France] ; Flora Saint-Charles [France] ; Virginie Deswaerte [France] ; Tiphaine Le Roy [France] ; Wendy Jessup [Australie] ; Philippe Giral [France] ; Wilfried Le Goff [France] ; Thierry Huby [France] ; Emmanuel L. Gautier [France] ; Philippe Lesnik [France]Source :
- Cardiovascular research [ 1755-3245 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Antigènes Ly (physiologie), Apolipoprotéines E (physiologie), Apoptose, Athérosclérose (étiologie), Cholestérol (métabolisme), Macrophages (physiologie), Mâle, Protéines proto-oncogènes c-bcl-2 (analyse), Récepteurs aux lipoprotéines LDL (physiologie), Souris, Survie cellulaire, Évolution de la maladie.
- MESH :
- analyse : Protéines proto-oncogènes c-bcl-2.
- métabolisme : Cholestérol.
- physiologie : Antigènes Ly, Apolipoprotéines E, Macrophages, Récepteurs aux lipoprotéines LDL.
- étiologie : Athérosclérose.
- Animaux, Apoptose, Mâle, Souris, Survie cellulaire, Évolution de la maladie.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Proto-Oncogene Proteins c-bcl-2.
- chemical , metabolism : Cholesterol.
- chemical , physiology : Antigens, Ly, Apolipoproteins E, Receptors, LDL.
- etiology : Atherosclerosis.
- physiology : Macrophages.
- Animals, Apoptosis, Cell Survival, Disease Progression, Male, Mice.
Abstract
Macrophage apoptosis is a prominent feature of atherosclerosis, yet whether cell death-protected macrophages would favour the resolution of already established atherosclerotic lesions, and thus hold therapeutic potential, remains unknown.
DOI: 10.1093/cvr/cvv177
PubMed: 26092098
Affiliations:
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Le document en format XML
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<author><name sortKey="Gautier, Emmanuel L" sort="Gautier, Emmanuel L" uniqKey="Gautier E" first="Emmanuel L" last="Gautier">Emmanuel L. Gautier</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013, France philippe.lesnik@upmc.fr emmanuel-laurent.gautier@inserm.fr.</nlm:affiliation>
<country wicri:rule="url">France</country>
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<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
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</author>
<author><name sortKey="Lesnik, Philippe" sort="Lesnik, Philippe" uniqKey="Lesnik P" first="Philippe" last="Lesnik">Philippe Lesnik</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013, France philippe.lesnik@upmc.fr emmanuel-laurent.gautier@inserm.fr.</nlm:affiliation>
<country wicri:rule="url">France</country>
<wicri:regionArea>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Cardiovascular research</title>
<idno type="eISSN">1755-3245</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
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</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antigens, Ly (physiology)</term>
<term>Apolipoproteins E (physiology)</term>
<term>Apoptosis</term>
<term>Atherosclerosis (etiology)</term>
<term>Cell Survival</term>
<term>Cholesterol (metabolism)</term>
<term>Disease Progression</term>
<term>Macrophages (physiology)</term>
<term>Male</term>
<term>Mice</term>
<term>Proto-Oncogene Proteins c-bcl-2 (analysis)</term>
<term>Receptors, LDL (physiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Antigènes Ly (physiologie)</term>
<term>Apolipoprotéines E (physiologie)</term>
<term>Apoptose</term>
<term>Athérosclérose (étiologie)</term>
<term>Cholestérol (métabolisme)</term>
<term>Macrophages (physiologie)</term>
<term>Mâle</term>
<term>Protéines proto-oncogènes c-bcl-2 (analyse)</term>
<term>Récepteurs aux lipoprotéines LDL (physiologie)</term>
<term>Souris</term>
<term>Survie cellulaire</term>
<term>Évolution de la maladie</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Proto-Oncogene Proteins c-bcl-2</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cholesterol</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Antigens, Ly</term>
<term>Apolipoproteins E</term>
<term>Receptors, LDL</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Protéines proto-oncogènes c-bcl-2</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Atherosclerosis</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cholestérol</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Antigènes Ly</term>
<term>Apolipoprotéines E</term>
<term>Macrophages</term>
<term>Récepteurs aux lipoprotéines LDL</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Athérosclérose</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Apoptosis</term>
<term>Cell Survival</term>
<term>Disease Progression</term>
<term>Male</term>
<term>Mice</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Apoptose</term>
<term>Mâle</term>
<term>Souris</term>
<term>Survie cellulaire</term>
<term>Évolution de la maladie</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Macrophage apoptosis is a prominent feature of atherosclerosis, yet whether cell death-protected macrophages would favour the resolution of already established atherosclerotic lesions, and thus hold therapeutic potential, remains unknown.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
<region><li>Nouvelle-Galles du Sud</li>
<li>Île-de-France</li>
</region>
<settlement><li>Sydney</li>
</settlement>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Bouchareychas, Laura" sort="Bouchareychas, Laura" uniqKey="Bouchareychas L" first="Laura" last="Bouchareychas">Laura Bouchareychas</name>
</region>
<name sortKey="Deswaerte, Virginie" sort="Deswaerte, Virginie" uniqKey="Deswaerte V" first="Virginie" last="Deswaerte">Virginie Deswaerte</name>
<name sortKey="Gautier, Emmanuel L" sort="Gautier, Emmanuel L" uniqKey="Gautier E" first="Emmanuel L" last="Gautier">Emmanuel L. Gautier</name>
<name sortKey="Giral, Philippe" sort="Giral, Philippe" uniqKey="Giral P" first="Philippe" last="Giral">Philippe Giral</name>
<name sortKey="Huby, Thierry" sort="Huby, Thierry" uniqKey="Huby T" first="Thierry" last="Huby">Thierry Huby</name>
<name sortKey="Le Goff, Wilfried" sort="Le Goff, Wilfried" uniqKey="Le Goff W" first="Wilfried" last="Le Goff">Wilfried Le Goff</name>
<name sortKey="Le Roy, Tiphaine" sort="Le Roy, Tiphaine" uniqKey="Le Roy T" first="Tiphaine" last="Le Roy">Tiphaine Le Roy</name>
<name sortKey="Lesnik, Philippe" sort="Lesnik, Philippe" uniqKey="Lesnik P" first="Philippe" last="Lesnik">Philippe Lesnik</name>
<name sortKey="Pirault, John" sort="Pirault, John" uniqKey="Pirault J" first="John" last="Pirault">John Pirault</name>
<name sortKey="Saint Charles, Flora" sort="Saint Charles, Flora" uniqKey="Saint Charles F" first="Flora" last="Saint-Charles">Flora Saint-Charles</name>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Jessup, Wendy" sort="Jessup, Wendy" uniqKey="Jessup W" first="Wendy" last="Jessup">Wendy Jessup</name>
</region>
</country>
</tree>
</affiliations>
</record>
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