AustralieFrV1, Main, Exploration, bibRecordById, pubmed:25385067

CD3bright signals on γδ T cells identify IL-17A-producing Vγ6Vδ1+ T cells.

Identifieur interne : 003093 ( Main/Exploration ); précédent : 003092; suivant : 003094

CD3bright signals on γδ T cells identify IL-17A-producing Vγ6Vδ1+ T cells.

Auteurs : C. Paget [France] ; M T Chow [Australie] ; N A Gherardin [Australie] ; P A Beavis [Australie] ; A P Uldrich [Australie] ; H. Duret [Australie] ; M. Hassane [France] ; F. Souza-Fonseca-Guimaraes [Australie] ; D A Mogilenko [France] ; D. Staumont-Sallé [France] ; N K Escalante [Canada] ; G R Hill [Australie] ; P. Neeson [Australie] ; D S Ritchie [Australie] ; D. Dombrowicz [France] ; T. Mallevaey [Canada] ; F. Trottein [France] ; G T Belz [Australie] ; D I Godfrey [Australie] ; M J Smyth [Australie]

Source :

Immunology and cell biology [ 1440-1711 ] ; 2015.

RBID : pubmed:25385067

Descripteurs français

English descriptors

KwdEn :
- Amino Acid Sequence, Aminoquinolines (pharmacology), Animals, Antigens, CD3 (chemistry), Antigens, CD3 (metabolism), Carrier Proteins (metabolism), Germ Cells (drug effects), Homeostasis (drug effects), Immunity, Inflammasomes (drug effects), Inflammasomes (metabolism), Interleukin-17 (biosynthesis), Interleukin-1beta (metabolism), Interleukin-23, Lung (drug effects), Lung (immunology), Lymphocyte Subsets (drug effects), Lymphocyte Subsets (immunology), Male, Mice, Inbred C57BL, Molecular Sequence Data, NLR Family, Pyrin Domain-Containing 3 Protein, Nuclear Receptor Subfamily 1, Group F, Member 3 (metabolism), Phenotype, Receptors, Antigen, T-Cell, gamma-delta (metabolism), Skin (drug effects), Skin (immunology), T-Lymphocytes (drug effects), T-Lymphocytes (immunology).
MESH :
- chemical , biosynthesis : Interleukin-17.
- chemical , chemistry : Antigens, CD3.
- chemical , drug effects : Inflammasomes.
- chemical , metabolism : Antigens, CD3, Carrier Proteins, Inflammasomes, Interleukin-1beta, Nuclear Receptor Subfamily 1, Group F, Member 3, Receptors, Antigen, T-Cell, gamma-delta.
- chemical , pharmacology : Aminoquinolines.
- drug effects : Germ Cells, Homeostasis, Lung, Lymphocyte Subsets, Skin, T-Lymphocytes.
- immunology : Lung, Lymphocyte Subsets, Skin, T-Lymphocytes.
- Amino Acid Sequence, Animals, Immunity, Interleukin-23, Male, Mice, Inbred C57BL, Molecular Sequence Data, NLR Family, Pyrin Domain-Containing 3 Protein, Phenotype.

Abstract

Interleukin-17A (IL-17A) is a pro-inflammatory cytokine that has an important role at mucosal sites in a wide range of immune responses including infection, allergy and auto-immunity. γδ T cells are recognized as IL-17 producers, but based on the level of CD3 expression, we now define the remarkable ability of a CD3(bright) γδ T-cell subset with an effector memory phenotype to rapidly produce IL-17A, but not interferon-γ. CD3(bright) γδ T cells uniformly express the canonical germline encoded Vγ6/Vδ1(+) T-cell receptor. They are widely distributed with a preferential representation in the lungs and skin are negatively impacted in the absence of retinoic acid receptor-related orphan receptor gammat expression or endogenous flora. This population responded rapidly to various stimuli in a mechanism involving IL-23 and NOD-like receptor family, pyrin domain containing 3 (NLRP3)-inflammasome-dependent IL-1β. Finally, we demonstrated that IL-17-producing CD3(bright) γδ T cells responded promptly and strongly to pneumococcal infection and during skin inflammation. Here, we propose a new way to specifically analyze IL-17-producing Vγ6/Vδ1(+) T cells based on the level of CD3 signals. Using this gating strategy, our data reinforce the crucial role of this γδ T-cell subset in respiratory and skin disorders.

DOI: 10.1038/icb.2014.94
PubMed: 25385067

Affiliations:

Le document en format XML

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<country xml:lang="fr">France</country>
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<author><name sortKey="Staumont Salle, D" sort="Staumont Salle, D" uniqKey="Staumont Salle D" first="D" last="Staumont-Sallé">D. Staumont-Sallé</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>1] University of Lille 2, Lille, France [2] INSERM U1011, Institut Pasteur de Lille, Lille, France [3] European Genomic Institute of Diabetes, Lille, France [4] Department of Dermatology, Claude Huriez Hospital, Lille</wicri:regionArea>
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<author><name sortKey="Escalante, N K" sort="Escalante, N K" uniqKey="Escalante N" first="N K" last="Escalante">N K Escalante</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>1] QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia [2] Department of Bone Marrow Transplantation, Royal Brisbane Hospital, Herston, Queensland</wicri:regionArea>
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<author><name sortKey="Neeson, P" sort="Neeson, P" uniqKey="Neeson P" first="P" last="Neeson">P. Neeson</name>
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<country xml:lang="fr">Australie</country>
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<author><name sortKey="Dombrowicz, D" sort="Dombrowicz, D" uniqKey="Dombrowicz D" first="D" last="Dombrowicz">D. Dombrowicz</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>1] University of Lille 2, Lille, France [2] INSERM U1011, Institut Pasteur de Lille, Lille, France [3] European Genomic Institute of Diabetes, Lille</wicri:regionArea>
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<author><name sortKey="Mallevaey, T" sort="Mallevaey, T" uniqKey="Mallevaey T" first="T" last="Mallevaey">T. Mallevaey</name>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Immunology, University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
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<author><name sortKey="Trottein, F" sort="Trottein, F" uniqKey="Trottein F" first="F" last="Trottein">F. Trottein</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>1] INSERM U1019, Centre d'Infection et d'Immunité de Lille, Institut Pasteur de Lille, Lille, France [2] University of Lille 2, Lille</wicri:regionArea>
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<author><name sortKey="Belz, G T" sort="Belz, G T" uniqKey="Belz G" first="G T" last="Belz">G T Belz</name>
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<author><name sortKey="Godfrey, D I" sort="Godfrey, D I" uniqKey="Godfrey D" first="D I" last="Godfrey">D I Godfrey</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>1] Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia [2] Australian Research Council Centre of Excellence in Advanced Medical Imaging at University of Melbourne, Parkville, Victoria</wicri:regionArea>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>1] Peter MacCallum Cancer Centre, Cancer Immunology Program, St Andrews Place, East Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology and Department of Pathology, University of Melbourne, Parkville, Victoria, Australia [3] QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia [4] School of Medicine, University of Queensland, Herston, Queensland</wicri:regionArea>
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<author><name sortKey="Gherardin, N A" sort="Gherardin, N A" uniqKey="Gherardin N" first="N A" last="Gherardin">N A Gherardin</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>1] Peter MacCallum Cancer Centre, Cancer Immunology Program, St Andrews Place, East Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology and Department of Pathology, University of Melbourne, Parkville, Victoria, Australia [3] Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beavis, P A" sort="Beavis, P A" uniqKey="Beavis P" first="P A" last="Beavis">P A Beavis</name>
<affiliation wicri:level="4"><nlm:affiliation>1] Peter MacCallum Cancer Centre, Cancer Immunology Program, St Andrews Place, East Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology and Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>1] Peter MacCallum Cancer Centre, Cancer Immunology Program, St Andrews Place, East Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology and Department of Pathology, University of Melbourne, Parkville, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Uldrich, A P" sort="Uldrich, A P" uniqKey="Uldrich A" first="A P" last="Uldrich">A P Uldrich</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Duret, H" sort="Duret, H" uniqKey="Duret H" first="H" last="Duret">H. Duret</name>
<affiliation wicri:level="4"><nlm:affiliation>1] Peter MacCallum Cancer Centre, Cancer Immunology Program, St Andrews Place, East Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology and Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>1] Peter MacCallum Cancer Centre, Cancer Immunology Program, St Andrews Place, East Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology and Department of Pathology, University of Melbourne, Parkville, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hassane, M" sort="Hassane, M" uniqKey="Hassane M" first="M" last="Hassane">M. Hassane</name>
<affiliation wicri:level="3"><nlm:affiliation>1] INSERM U1019, Centre d'Infection et d'Immunité de Lille, Institut Pasteur de Lille, Lille, France [2] University of Lille 2, Lille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>1] INSERM U1019, Centre d'Infection et d'Immunité de Lille, Institut Pasteur de Lille, Lille, France [2] University of Lille 2, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Souza Fonseca Guimaraes, F" sort="Souza Fonseca Guimaraes, F" uniqKey="Souza Fonseca Guimaraes F" first="F" last="Souza-Fonseca-Guimaraes">F. Souza-Fonseca-Guimaraes</name>
<affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mogilenko, D A" sort="Mogilenko, D A" uniqKey="Mogilenko D" first="D A" last="Mogilenko">D A Mogilenko</name>
<affiliation wicri:level="3"><nlm:affiliation>1] University of Lille 2, Lille, France [2] INSERM U1011, Institut Pasteur de Lille, Lille, France [3] European Genomic Institute of Diabetes, Lille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>1] University of Lille 2, Lille, France [2] INSERM U1011, Institut Pasteur de Lille, Lille, France [3] European Genomic Institute of Diabetes, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Staumont Salle, D" sort="Staumont Salle, D" uniqKey="Staumont Salle D" first="D" last="Staumont-Sallé">D. Staumont-Sallé</name>
<affiliation wicri:level="3"><nlm:affiliation>1] University of Lille 2, Lille, France [2] INSERM U1011, Institut Pasteur de Lille, Lille, France [3] European Genomic Institute of Diabetes, Lille, France [4] Department of Dermatology, Claude Huriez Hospital, Lille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>1] University of Lille 2, Lille, France [2] INSERM U1011, Institut Pasteur de Lille, Lille, France [3] European Genomic Institute of Diabetes, Lille, France [4] Department of Dermatology, Claude Huriez Hospital, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Escalante, N K" sort="Escalante, N K" uniqKey="Escalante N" first="N K" last="Escalante">N K Escalante</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Immunology, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Immunology, University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hill, G R" sort="Hill, G R" uniqKey="Hill G" first="G R" last="Hill">G R Hill</name>
<affiliation wicri:level="1"><nlm:affiliation>1] QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia [2] Department of Bone Marrow Transplantation, Royal Brisbane Hospital, Herston, Queensland, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>1] QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia [2] Department of Bone Marrow Transplantation, Royal Brisbane Hospital, Herston, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Neeson, P" sort="Neeson, P" uniqKey="Neeson P" first="P" last="Neeson">P. Neeson</name>
<affiliation wicri:level="4"><nlm:affiliation>1] Peter MacCallum Cancer Centre, Cancer Immunology Program, St Andrews Place, East Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology and Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>1] Peter MacCallum Cancer Centre, Cancer Immunology Program, St Andrews Place, East Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology and Department of Pathology, University of Melbourne, Parkville, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ritchie, D S" sort="Ritchie, D S" uniqKey="Ritchie D" first="D S" last="Ritchie">D S Ritchie</name>
<affiliation wicri:level="4"><nlm:affiliation>1] Peter MacCallum Cancer Centre, Cancer Immunology Program, St Andrews Place, East Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology and Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>1] Peter MacCallum Cancer Centre, Cancer Immunology Program, St Andrews Place, East Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology and Department of Pathology, University of Melbourne, Parkville, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dombrowicz, D" sort="Dombrowicz, D" uniqKey="Dombrowicz D" first="D" last="Dombrowicz">D. Dombrowicz</name>
<affiliation wicri:level="3"><nlm:affiliation>1] University of Lille 2, Lille, France [2] INSERM U1011, Institut Pasteur de Lille, Lille, France [3] European Genomic Institute of Diabetes, Lille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>1] University of Lille 2, Lille, France [2] INSERM U1011, Institut Pasteur de Lille, Lille, France [3] European Genomic Institute of Diabetes, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mallevaey, T" sort="Mallevaey, T" uniqKey="Mallevaey T" first="T" last="Mallevaey">T. Mallevaey</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Immunology, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Immunology, University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Trottein, F" sort="Trottein, F" uniqKey="Trottein F" first="F" last="Trottein">F. Trottein</name>
<affiliation wicri:level="3"><nlm:affiliation>1] INSERM U1019, Centre d'Infection et d'Immunité de Lille, Institut Pasteur de Lille, Lille, France [2] University of Lille 2, Lille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>1] INSERM U1019, Centre d'Infection et d'Immunité de Lille, Institut Pasteur de Lille, Lille, France [2] University of Lille 2, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Belz, G T" sort="Belz, G T" uniqKey="Belz G" first="G T" last="Belz">G T Belz</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Godfrey, D I" sort="Godfrey, D I" uniqKey="Godfrey D" first="D I" last="Godfrey">D I Godfrey</name>
<affiliation wicri:level="4"><nlm:affiliation>1] Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia [2] Australian Research Council Centre of Excellence in Advanced Medical Imaging at University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>1] Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia [2] Australian Research Council Centre of Excellence in Advanced Medical Imaging at University of Melbourne, Parkville, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smyth, M J" sort="Smyth, M J" uniqKey="Smyth M" first="M J" last="Smyth">M J Smyth</name>
<affiliation wicri:level="4"><nlm:affiliation>1] Peter MacCallum Cancer Centre, Cancer Immunology Program, St Andrews Place, East Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology and Department of Pathology, University of Melbourne, Parkville, Victoria, Australia [3] QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia [4] School of Medicine, University of Queensland, Herston, Queensland, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>1] Peter MacCallum Cancer Centre, Cancer Immunology Program, St Andrews Place, East Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology and Department of Pathology, University of Melbourne, Parkville, Victoria, Australia [3] QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia [4] School of Medicine, University of Queensland, Herston, Queensland</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Immunology and cell biology</title>
<idno type="eISSN">1440-1711</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Aminoquinolines (pharmacology)</term>
<term>Animals</term>
<term>Antigens, CD3 (chemistry)</term>
<term>Antigens, CD3 (metabolism)</term>
<term>Carrier Proteins (metabolism)</term>
<term>Germ Cells (drug effects)</term>
<term>Homeostasis (drug effects)</term>
<term>Immunity</term>
<term>Inflammasomes (drug effects)</term>
<term>Inflammasomes (metabolism)</term>
<term>Interleukin-17 (biosynthesis)</term>
<term>Interleukin-1beta (metabolism)</term>
<term>Interleukin-23</term>
<term>Lung (drug effects)</term>
<term>Lung (immunology)</term>
<term>Lymphocyte Subsets (drug effects)</term>
<term>Lymphocyte Subsets (immunology)</term>
<term>Male</term>
<term>Mice, Inbred C57BL</term>
<term>Molecular Sequence Data</term>
<term>NLR Family, Pyrin Domain-Containing 3 Protein</term>
<term>Nuclear Receptor Subfamily 1, Group F, Member 3 (metabolism)</term>
<term>Phenotype</term>
<term>Receptors, Antigen, T-Cell, gamma-delta (metabolism)</term>
<term>Skin (drug effects)</term>
<term>Skin (immunology)</term>
<term>T-Lymphocytes (drug effects)</term>
<term>T-Lymphocytes (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Aminoquinoléines (pharmacologie)</term>
<term>Animaux</term>
<term>Antigènes CD3 ()</term>
<term>Antigènes CD3 (métabolisme)</term>
<term>Cellules germinales ()</term>
<term>Données de séquences moléculaires</term>
<term>Homéostasie ()</term>
<term>Immunité</term>
<term>Inflammasomes ()</term>
<term>Inflammasomes (métabolisme)</term>
<term>Interleukine-1 bêta (métabolisme)</term>
<term>Interleukine-17 (biosynthèse)</term>
<term>Interleukine-23</term>
<term>Lymphocytes T ()</term>
<term>Lymphocytes T (immunologie)</term>
<term>Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires (métabolisme)</term>
<term>Mâle</term>
<term>Peau ()</term>
<term>Peau (immunologie)</term>
<term>Phénotype</term>
<term>Poumon ()</term>
<term>Poumon (immunologie)</term>
<term>Protéine-3 de la famille des NLR contenant un domaine pyrine</term>
<term>Protéines de transport (métabolisme)</term>
<term>Récepteur lymphocytaire T antigène, gamma-delta (métabolisme)</term>
<term>Souris de lignée C57BL</term>
<term>Sous-populations de lymphocytes ()</term>
<term>Sous-populations de lymphocytes (immunologie)</term>
<term>Séquence d'acides aminés</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interleukin-17</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antigens, CD3</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Inflammasomes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, CD3</term>
<term>Carrier Proteins</term>
<term>Inflammasomes</term>
<term>Interleukin-1beta</term>
<term>Nuclear Receptor Subfamily 1, Group F, Member 3</term>
<term>Receptors, Antigen, T-Cell, gamma-delta</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Aminoquinolines</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Interleukine-17</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Germ Cells</term>
<term>Homeostasis</term>
<term>Lung</term>
<term>Lymphocyte Subsets</term>
<term>Skin</term>
<term>T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphocytes T</term>
<term>Peau</term>
<term>Poumon</term>
<term>Sous-populations de lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Lung</term>
<term>Lymphocyte Subsets</term>
<term>Skin</term>
<term>T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigènes CD3</term>
<term>Inflammasomes</term>
<term>Interleukine-1 bêta</term>
<term>Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires</term>
<term>Protéines de transport</term>
<term>Récepteur lymphocytaire T antigène, gamma-delta</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Aminoquinoléines</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Immunity</term>
<term>Interleukin-23</term>
<term>Male</term>
<term>Mice, Inbred C57BL</term>
<term>Molecular Sequence Data</term>
<term>NLR Family, Pyrin Domain-Containing 3 Protein</term>
<term>Phenotype</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Antigènes CD3</term>
<term>Cellules germinales</term>
<term>Données de séquences moléculaires</term>
<term>Homéostasie</term>
<term>Immunité</term>
<term>Inflammasomes</term>
<term>Interleukine-23</term>
<term>Lymphocytes T</term>
<term>Mâle</term>
<term>Peau</term>
<term>Phénotype</term>
<term>Poumon</term>
<term>Protéine-3 de la famille des NLR contenant un domaine pyrine</term>
<term>Souris de lignée C57BL</term>
<term>Sous-populations de lymphocytes</term>
<term>Séquence d'acides aminés</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">Interleukin-17A (IL-17A) is a pro-inflammatory cytokine that has an important role at mucosal sites in a wide range of immune responses including infection, allergy and auto-immunity. γδ T cells are recognized as IL-17 producers, but based on the level of CD3 expression, we now define the remarkable ability of a CD3(bright) γδ T-cell subset with an effector memory phenotype to rapidly produce IL-17A, but not interferon-γ. CD3(bright) γδ T cells uniformly express the canonical germline encoded Vγ6/Vδ1(+) T-cell receptor. They are widely distributed with a preferential representation in the lungs and skin are negatively impacted in the absence of retinoic acid receptor-related orphan receptor gammat expression or endogenous flora. This population responded rapidly to various stimuli in a mechanism involving IL-23 and NOD-like receptor family, pyrin domain containing 3 (NLRP3)-inflammasome-dependent IL-1β. Finally, we demonstrated that IL-17-producing CD3(bright) γδ T cells responded promptly and strongly to pneumococcal infection and during skin inflammation. Here, we propose a new way to specifically analyze IL-17-producing Vγ6/Vδ1(+) T cells based on the level of CD3 signals. Using this gating strategy, our data reinforce the crucial role of this γδ T-cell subset in respiratory and skin disorders.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Canada</li>
<li>France</li>
</country>
<region><li>Hauts-de-France</li>
<li>Nord-Pas-de-Calais</li>
<li>Ontario</li>
<li>Victoria (État)</li>
</region>
<settlement><li>Lille</li>
<li>Melbourne</li>
<li>Toronto</li>
</settlement>
<orgName><li>Université de Melbourne</li>
<li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="France"><region name="Hauts-de-France"><name sortKey="Paget, C" sort="Paget, C" uniqKey="Paget C" first="C" last="Paget">C. Paget</name>
</region>
<name sortKey="Dombrowicz, D" sort="Dombrowicz, D" uniqKey="Dombrowicz D" first="D" last="Dombrowicz">D. Dombrowicz</name>
<name sortKey="Hassane, M" sort="Hassane, M" uniqKey="Hassane M" first="M" last="Hassane">M. Hassane</name>
<name sortKey="Mogilenko, D A" sort="Mogilenko, D A" uniqKey="Mogilenko D" first="D A" last="Mogilenko">D A Mogilenko</name>
<name sortKey="Staumont Salle, D" sort="Staumont Salle, D" uniqKey="Staumont Salle D" first="D" last="Staumont-Sallé">D. Staumont-Sallé</name>
<name sortKey="Trottein, F" sort="Trottein, F" uniqKey="Trottein F" first="F" last="Trottein">F. Trottein</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Chow, M T" sort="Chow, M T" uniqKey="Chow M" first="M T" last="Chow">M T Chow</name>
</region>
<name sortKey="Beavis, P A" sort="Beavis, P A" uniqKey="Beavis P" first="P A" last="Beavis">P A Beavis</name>
<name sortKey="Belz, G T" sort="Belz, G T" uniqKey="Belz G" first="G T" last="Belz">G T Belz</name>
<name sortKey="Duret, H" sort="Duret, H" uniqKey="Duret H" first="H" last="Duret">H. Duret</name>
<name sortKey="Gherardin, N A" sort="Gherardin, N A" uniqKey="Gherardin N" first="N A" last="Gherardin">N A Gherardin</name>
<name sortKey="Godfrey, D I" sort="Godfrey, D I" uniqKey="Godfrey D" first="D I" last="Godfrey">D I Godfrey</name>
<name sortKey="Hill, G R" sort="Hill, G R" uniqKey="Hill G" first="G R" last="Hill">G R Hill</name>
<name sortKey="Neeson, P" sort="Neeson, P" uniqKey="Neeson P" first="P" last="Neeson">P. Neeson</name>
<name sortKey="Ritchie, D S" sort="Ritchie, D S" uniqKey="Ritchie D" first="D S" last="Ritchie">D S Ritchie</name>
<name sortKey="Smyth, M J" sort="Smyth, M J" uniqKey="Smyth M" first="M J" last="Smyth">M J Smyth</name>
<name sortKey="Souza Fonseca Guimaraes, F" sort="Souza Fonseca Guimaraes, F" uniqKey="Souza Fonseca Guimaraes F" first="F" last="Souza-Fonseca-Guimaraes">F. Souza-Fonseca-Guimaraes</name>
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<country name="Canada"><region name="Ontario"><name sortKey="Escalante, N K" sort="Escalante, N K" uniqKey="Escalante N" first="N K" last="Escalante">N K Escalante</name>
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<name sortKey="Mallevaey, T" sort="Mallevaey, T" uniqKey="Mallevaey T" first="T" last="Mallevaey">T. Mallevaey</name>
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Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003093 | SxmlIndent | more

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Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:25385067
   |texte=   CD3bright signals on γδ T cells identify IL-17A-producing Vγ6Vδ1+ T cells.
}}

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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:25385067" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

CD3bright signals on γδ T cells identify IL-17A-producing Vγ6Vδ1+ T cells.

CD3bright signals on γδ T cells identify IL-17A-producing Vγ6Vδ1+ T cells.

Source :

Descripteurs français

English descriptors

Abstract

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Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
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