On a mouse monoclonal antibody that neutralizes all four dengue virus serotypes
Identifieur interne : 008186 ( Main/Exploration ); précédent : 008185; suivant : 008187On a mouse monoclonal antibody that neutralizes all four dengue virus serotypes
Auteurs : Ravikumar Rajamanonmani [Singapour] ; Celine Nkenfou [Singapour] ; Paula Clancy [Australie] ; YIN HOE YAU [Singapour] ; Susana Geifman Shochat [Singapour] ; Soila Sukupolvi-Petty [États-Unis] ; Wouter Schul [Singapour] ; Michael S. Diamond [États-Unis] ; Subhash G. Vasudevan [Singapour, Australie] ; Julien Lescar [Singapour, France]Source :
- Journal of general virology [ 0022-1317 ] ; 2009.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
The flavivirus envelope glycoprotein (E) is responsible for viral attachment and entry by membrane fusion. Its ectodomain is the primary target of the humoral immune response. In particular, the C-terminal Ig-like domain III of E, which is exposed at the surface of the viral particle, forms an attractive antigen for raising protective monoclonal antibodies (mAb). 9F12, a mouse mAb raised against a dengue virus (DENV) serotype 2 recombinant domain III, cross-reacts with corresponding domains from the other three DENV serotypes and also with West Nile virus. mAb 9F1 2 binds with nanomolar affinity to a conserved epitope that maps to the viral surface comprising residues 305, 307, 310 and 330 of the E protein. mAb 9F1 2 neutralizes all four DENV serotypes in plaque reduction assays. We expressed a single-chain Fv from 9F12 that retains the binding activity of the parent mAb. Adsorption and fusion inhibition assays indicate that mAb 9F1 2 prevents early steps of viral entry. Its virus inhibition activity and broad cross-reactivity makes mAb 9F12 a suitable candidate for optimization and humanization into a therapeutic antibody to treat severe infections by dengue.
Url:
Affiliations:
- Australie, France, Singapour, États-Unis
- Missouri (État), Provence-Alpes-Côte d'Azur
- Marseille, Saint-Louis (Missouri)
- Université Washington de Saint-Louis, École de médecine (Université Washington de Saint-Louis)
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 002E89
- to stream PascalFrancis, to step Curation: 003131
- to stream PascalFrancis, to step Checkpoint: 002963
- to stream Main, to step Merge: 008932
- to stream Pmc, to step Corpus: 001966
- to stream Pmc, to step Curation: 001825
- to stream Pmc, to step Checkpoint: 002750
- to stream Ncbi, to step Merge: 000546
- to stream Ncbi, to step Curation: 000546
- to stream Ncbi, to step Checkpoint: 000546
- to stream Main, to step Merge: 008238
- to stream Main, to step Curation: 008186
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">On a mouse monoclonal antibody that neutralizes all four dengue virus serotypes</title>
<author><name sortKey="Rajamanonmani, Ravikumar" sort="Rajamanonmani, Ravikumar" uniqKey="Rajamanonmani R" first="Ravikumar" last="Rajamanonmani">Ravikumar Rajamanonmani</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Biological Sciences, Nanyang Technological University</s1>
<s2>Biopolis</s2>
<s3>SGP</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>Biopolis</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Program in Emerging Infectious Diseases, Duke-NUS, Graduate Medical School</s1>
<s3>SGP</s3>
<sZ>1 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>Program in Emerging Infectious Diseases, Duke-NUS, Graduate Medical School</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nkenfou, Celine" sort="Nkenfou, Celine" uniqKey="Nkenfou C" first="Celine" last="Nkenfou">Celine Nkenfou</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Novartis Institute for Tropical Diseases</s1>
<s2>Biopolis</s2>
<s3>SGP</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>Novartis Institute for Tropical Diseases</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Clancy, Paula" sort="Clancy, Paula" uniqKey="Clancy P" first="Paula" last="Clancy">Paula Clancy</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Biochemistry and Molecular Biology, James Cook University</s1>
<s3>AUS</s3>
<sZ>3 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Department of Biochemistry and Molecular Biology, James Cook University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yin Hoe Yau" sort="Yin Hoe Yau" uniqKey="Yin Hoe Yau" last="Yin Hoe Yau">YIN HOE YAU</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Biological Sciences, Nanyang Technological University</s1>
<s2>Biopolis</s2>
<s3>SGP</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>Biopolis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Geifman Shochat, Susana" sort="Geifman Shochat, Susana" uniqKey="Geifman Shochat S" first="Susana" last="Geifman Shochat">Susana Geifman Shochat</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Biological Sciences, Nanyang Technological University</s1>
<s2>Biopolis</s2>
<s3>SGP</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>Biopolis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sukupolvi Petty, Soila" sort="Sukupolvi Petty, Soila" uniqKey="Sukupolvi Petty S" first="Soila" last="Sukupolvi-Petty">Soila Sukupolvi-Petty</name>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Departments of Medicine, Molecular Microbiology, Pathology and Immunology, Washington University School of Medicine</s1>
<s2>St Louis</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<orgName type="institution">Université Washington de Saint-Louis</orgName>
</affiliation>
</author>
<author><name sortKey="Schul, Wouter" sort="Schul, Wouter" uniqKey="Schul W" first="Wouter" last="Schul">Wouter Schul</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Novartis Institute for Tropical Diseases</s1>
<s2>Biopolis</s2>
<s3>SGP</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>Novartis Institute for Tropical Diseases</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Diamond, Michael S" sort="Diamond, Michael S" uniqKey="Diamond M" first="Michael S." last="Diamond">Michael S. Diamond</name>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Departments of Medicine, Molecular Microbiology, Pathology and Immunology, Washington University School of Medicine</s1>
<s2>St Louis</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<orgName type="institution">Université Washington de Saint-Louis</orgName>
</affiliation>
</author>
<author><name sortKey="Vasudevan, Subhash G" sort="Vasudevan, Subhash G" uniqKey="Vasudevan S" first="Subhash G." last="Vasudevan">Subhash G. Vasudevan</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Program in Emerging Infectious Diseases, Duke-NUS, Graduate Medical School</s1>
<s3>SGP</s3>
<sZ>1 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>Program in Emerging Infectious Diseases, Duke-NUS, Graduate Medical School</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Biochemistry and Molecular Biology, James Cook University</s1>
<s3>AUS</s3>
<sZ>3 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Department of Biochemistry and Molecular Biology, James Cook University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lescar, Julien" sort="Lescar, Julien" uniqKey="Lescar J" first="Julien" last="Lescar">Julien Lescar</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Biological Sciences, Nanyang Technological University</s1>
<s2>Biopolis</s2>
<s3>SGP</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>Biopolis</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>AFMB CNRS UMR6098</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">09-0162365</idno>
<date when="2009">2009</date>
<idno type="stanalyst">PASCAL 09-0162365 INIST</idno>
<idno type="RBID">Pascal:09-0162365</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">002E89</idno>
<idno type="wicri:Area/PascalFrancis/Curation">003131</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">002963</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">002963</idno>
<idno type="wicri:doubleKey">0022-1317:2009:Rajamanonmani R:on:a:mouse</idno>
<idno type="wicri:Area/Main/Merge">008932</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889437</idno>
<idno type="RBID">PMC:2889437</idno>
<idno type="wicri:Area/Pmc/Corpus">001966</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001966</idno>
<idno type="wicri:Area/Pmc/Curation">001825</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001825</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002750</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002750</idno>
<idno type="wicri:Area/Ncbi/Merge">000546</idno>
<idno type="wicri:Area/Ncbi/Curation">000546</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000546</idno>
<idno type="wicri:doubleKey">0022-1317:2009:Rajamanonmani R:on:a:mouse</idno>
<idno type="wicri:Area/Main/Merge">008238</idno>
<idno type="wicri:Area/Main/Curation">008186</idno>
<idno type="wicri:Area/Main/Exploration">008186</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">On a mouse monoclonal antibody that neutralizes all four dengue virus serotypes</title>
<author><name sortKey="Rajamanonmani, Ravikumar" sort="Rajamanonmani, Ravikumar" uniqKey="Rajamanonmani R" first="Ravikumar" last="Rajamanonmani">Ravikumar Rajamanonmani</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Biological Sciences, Nanyang Technological University</s1>
<s2>Biopolis</s2>
<s3>SGP</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>Biopolis</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Program in Emerging Infectious Diseases, Duke-NUS, Graduate Medical School</s1>
<s3>SGP</s3>
<sZ>1 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>Program in Emerging Infectious Diseases, Duke-NUS, Graduate Medical School</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nkenfou, Celine" sort="Nkenfou, Celine" uniqKey="Nkenfou C" first="Celine" last="Nkenfou">Celine Nkenfou</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Novartis Institute for Tropical Diseases</s1>
<s2>Biopolis</s2>
<s3>SGP</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>Novartis Institute for Tropical Diseases</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Clancy, Paula" sort="Clancy, Paula" uniqKey="Clancy P" first="Paula" last="Clancy">Paula Clancy</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Biochemistry and Molecular Biology, James Cook University</s1>
<s3>AUS</s3>
<sZ>3 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Department of Biochemistry and Molecular Biology, James Cook University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yin Hoe Yau" sort="Yin Hoe Yau" uniqKey="Yin Hoe Yau" last="Yin Hoe Yau">YIN HOE YAU</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Biological Sciences, Nanyang Technological University</s1>
<s2>Biopolis</s2>
<s3>SGP</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>Biopolis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Geifman Shochat, Susana" sort="Geifman Shochat, Susana" uniqKey="Geifman Shochat S" first="Susana" last="Geifman Shochat">Susana Geifman Shochat</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Biological Sciences, Nanyang Technological University</s1>
<s2>Biopolis</s2>
<s3>SGP</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>Biopolis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sukupolvi Petty, Soila" sort="Sukupolvi Petty, Soila" uniqKey="Sukupolvi Petty S" first="Soila" last="Sukupolvi-Petty">Soila Sukupolvi-Petty</name>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Departments of Medicine, Molecular Microbiology, Pathology and Immunology, Washington University School of Medicine</s1>
<s2>St Louis</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<orgName type="institution">Université Washington de Saint-Louis</orgName>
</affiliation>
</author>
<author><name sortKey="Schul, Wouter" sort="Schul, Wouter" uniqKey="Schul W" first="Wouter" last="Schul">Wouter Schul</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Novartis Institute for Tropical Diseases</s1>
<s2>Biopolis</s2>
<s3>SGP</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>Novartis Institute for Tropical Diseases</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Diamond, Michael S" sort="Diamond, Michael S" uniqKey="Diamond M" first="Michael S." last="Diamond">Michael S. Diamond</name>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Departments of Medicine, Molecular Microbiology, Pathology and Immunology, Washington University School of Medicine</s1>
<s2>St Louis</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<orgName type="institution">Université Washington de Saint-Louis</orgName>
</affiliation>
</author>
<author><name sortKey="Vasudevan, Subhash G" sort="Vasudevan, Subhash G" uniqKey="Vasudevan S" first="Subhash G." last="Vasudevan">Subhash G. Vasudevan</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Program in Emerging Infectious Diseases, Duke-NUS, Graduate Medical School</s1>
<s3>SGP</s3>
<sZ>1 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>Program in Emerging Infectious Diseases, Duke-NUS, Graduate Medical School</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Biochemistry and Molecular Biology, James Cook University</s1>
<s3>AUS</s3>
<sZ>3 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Department of Biochemistry and Molecular Biology, James Cook University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lescar, Julien" sort="Lescar, Julien" uniqKey="Lescar J" first="Julien" last="Lescar">Julien Lescar</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Biological Sciences, Nanyang Technological University</s1>
<s2>Biopolis</s2>
<s3>SGP</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>Biopolis</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>AFMB CNRS UMR6098</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of general virology</title>
<title level="j" type="abbreviated">J. gen. virol.</title>
<idno type="ISSN">0022-1317</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of general virology</title>
<title level="j" type="abbreviated">J. gen. virol.</title>
<idno type="ISSN">0022-1317</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Dengue virus</term>
<term>Microbiology</term>
<term>Monoclonal antibody</term>
<term>Mouse</term>
<term>Serotype</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Souris</term>
<term>Virus dengue</term>
<term>Animal</term>
<term>Anticorps monoclonal</term>
<term>Sérotype</term>
<term>Microbiologie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The flavivirus envelope glycoprotein (E) is responsible for viral attachment and entry by membrane fusion. Its ectodomain is the primary target of the humoral immune response. In particular, the C-terminal Ig-like domain III of E, which is exposed at the surface of the viral particle, forms an attractive antigen for raising protective monoclonal antibodies (mAb). 9F12, a mouse mAb raised against a dengue virus (DENV) serotype 2 recombinant domain III, cross-reacts with corresponding domains from the other three DENV serotypes and also with West Nile virus. mAb 9F1 2 binds with nanomolar affinity to a conserved epitope that maps to the viral surface comprising residues 305, 307, 310 and 330 of the E protein. mAb 9F1 2 neutralizes all four DENV serotypes in plaque reduction assays. We expressed a single-chain Fv from 9F12 that retains the binding activity of the parent mAb. Adsorption and fusion inhibition assays indicate that mAb 9F1 2 prevents early steps of viral entry. Its virus inhibition activity and broad cross-reactivity makes mAb 9F12 a suitable candidate for optimization and humanization into a therapeutic antibody to treat severe infections by dengue.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Singapour</li>
<li>États-Unis</li>
</country>
<region><li>Missouri (État)</li>
<li>Provence-Alpes-Côte d'Azur</li>
</region>
<settlement><li>Marseille</li>
<li>Saint-Louis (Missouri)</li>
</settlement>
<orgName><li>Université Washington de Saint-Louis</li>
<li>École de médecine (Université Washington de Saint-Louis)</li>
</orgName>
</list>
<tree><country name="Singapour"><noRegion><name sortKey="Rajamanonmani, Ravikumar" sort="Rajamanonmani, Ravikumar" uniqKey="Rajamanonmani R" first="Ravikumar" last="Rajamanonmani">Ravikumar Rajamanonmani</name>
</noRegion>
<name sortKey="Geifman Shochat, Susana" sort="Geifman Shochat, Susana" uniqKey="Geifman Shochat S" first="Susana" last="Geifman Shochat">Susana Geifman Shochat</name>
<name sortKey="Lescar, Julien" sort="Lescar, Julien" uniqKey="Lescar J" first="Julien" last="Lescar">Julien Lescar</name>
<name sortKey="Nkenfou, Celine" sort="Nkenfou, Celine" uniqKey="Nkenfou C" first="Celine" last="Nkenfou">Celine Nkenfou</name>
<name sortKey="Rajamanonmani, Ravikumar" sort="Rajamanonmani, Ravikumar" uniqKey="Rajamanonmani R" first="Ravikumar" last="Rajamanonmani">Ravikumar Rajamanonmani</name>
<name sortKey="Schul, Wouter" sort="Schul, Wouter" uniqKey="Schul W" first="Wouter" last="Schul">Wouter Schul</name>
<name sortKey="Vasudevan, Subhash G" sort="Vasudevan, Subhash G" uniqKey="Vasudevan S" first="Subhash G." last="Vasudevan">Subhash G. Vasudevan</name>
<name sortKey="Yin Hoe Yau" sort="Yin Hoe Yau" uniqKey="Yin Hoe Yau" last="Yin Hoe Yau">YIN HOE YAU</name>
</country>
<country name="Australie"><noRegion><name sortKey="Clancy, Paula" sort="Clancy, Paula" uniqKey="Clancy P" first="Paula" last="Clancy">Paula Clancy</name>
</noRegion>
<name sortKey="Vasudevan, Subhash G" sort="Vasudevan, Subhash G" uniqKey="Vasudevan S" first="Subhash G." last="Vasudevan">Subhash G. Vasudevan</name>
</country>
<country name="États-Unis"><region name="Missouri (État)"><name sortKey="Sukupolvi Petty, Soila" sort="Sukupolvi Petty, Soila" uniqKey="Sukupolvi Petty S" first="Soila" last="Sukupolvi-Petty">Soila Sukupolvi-Petty</name>
</region>
<name sortKey="Diamond, Michael S" sort="Diamond, Michael S" uniqKey="Diamond M" first="Michael S." last="Diamond">Michael S. Diamond</name>
</country>
<country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Lescar, Julien" sort="Lescar, Julien" uniqKey="Lescar J" first="Julien" last="Lescar">Julien Lescar</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 008186 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 008186 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Main |étape= Exploration |type= RBID |clé= Pascal:09-0162365 |texte= On a mouse monoclonal antibody that neutralizes all four dengue virus serotypes }}
![]() | This area was generated with Dilib version V0.6.33. | ![]() |