Predictive factors of bleeding events in adults undergoing extracorporeal membrane oxygenation
Identifieur interne : 001914 ( Main/Exploration ); précédent : 001913; suivant : 001915Predictive factors of bleeding events in adults undergoing extracorporeal membrane oxygenation
Auteurs : Cécile Aubron [Australie, France] ; Joris Depuydt [Australie, Belgique] ; François Belon [France] ; Michael Bailey [Australie] ; Matthieu Schmidt [Australie, France] ; Jayne Sheldrake [Australie] ; Deirdre Murphy [Australie] ; Carlos Scheinkestel [Australie] ; D Jamie Cooper [Australie] ; Gilles Capellier [France] ; Vincent Pellegrino [Australie] ; David Pilcher [Australie] ; Zoe Mcquilten [Australie]Source :
- Annals of Intensive Care [ 2110-5820 ] ; 2016.
Abstract
Bleeding is the most frequent complication associated with extracorporeal membrane oxygenation (ECMO) support in critically ill patients. Nonetheless, risk factors for bleeding have been poorly described especially those associated with coagulation anomalies and anticoagulant therapy during ECMO support. The aim of this study is to describe bleeding complications in critically ill patients undergoing ECMO and to identify risk factors for bleeding events.
We retrospectively analysed ICU charts of adults who received either veno-venous (VV) or veno-arterial (VA) ECMO support in two participating ICUs between 2010 and 2013. Characteristics of patients with and without bleeding complications, as per the Extracorporeal Life Support Organisation (ELSO) definition, were compared, and the impact of bleeding complications on patient outcomes was assessed using survival analysis. Variables that were independently associated with bleeding, including daily clinical and biological variables during ECMO courses, were modelled.
Of the 149 ECMO episodes (111 VA ECMO and 38 VV ECMO) performed in 147 adults, 89 episodes (60 %) were complicated by at least one bleeding event. The most common bleeding sources were: ECMO cannula (37 %), haemothorax or cardiac tamponade (17 %) and ear–nose and throat (16 %). Intra-cranial haemorrhage occurred in five (2.2 %) patients. Bleeding complications were independently associated with worse survival [adjusted hazard ratio (HR) 2.17, 95 % confidence interval (CI) 1.07–4.41,
Bleeding events based on the ELSO bleeding definition occurred in more than 60 % of ECMO episodes and were associated with hospital mortality. We identified higher aPTT prior bleeding as an independent risk factor for bleeding event, suggesting that better control of the aPTT (through a better control of either coagulopathy or anticoagulation) may improve patients’ outcome.
Url:
DOI: 10.1186/s13613-016-0196-7
PubMed: 27714705
PubMed Central: 5053950
Affiliations:
- Australie, Belgique, France
- Bourgogne-Franche-Comté, Franche-Comté, Province d'Anvers, Région Bretagne, Victoria (État), Île-de-France
- Anvers, Besançon, Brest, Melbourne, Paris
- Université de Bretagne Occidentale
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Le document en format XML
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<author><name sortKey="Murphy, Deirdre" sort="Murphy, Deirdre" uniqKey="Murphy D" first="Deirdre" last="Murphy">Deirdre Murphy</name>
<affiliation wicri:level="3"><nlm:aff id="Aff3">The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Intensive Care Unit, The Alfred Hospital, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff6">School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Public Health and Preventive Medicine, Monash University, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Scheinkestel, Carlos" sort="Scheinkestel, Carlos" uniqKey="Scheinkestel C" first="Carlos" last="Scheinkestel">Carlos Scheinkestel</name>
<affiliation wicri:level="3"><nlm:aff id="Aff3">The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Intensive Care Unit, The Alfred Hospital, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff6">School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Public Health and Preventive Medicine, Monash University, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cooper, D Jamie" sort="Cooper, D Jamie" uniqKey="Cooper D" first="D Jamie" last="Cooper">D Jamie Cooper</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff3">The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Intensive Care Unit, The Alfred Hospital, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Capellier, Gilles" sort="Capellier, Gilles" uniqKey="Capellier G" first="Gilles" last="Capellier">Gilles Capellier</name>
<affiliation wicri:level="3"><nlm:aff id="Aff5">The Intensive Care Unit, Jean Minjoz Hospital, 25030 Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>The Intensive Care Unit, Jean Minjoz Hospital, 25030 Besançon</wicri:regionArea>
<placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region>
<region type="old region" nuts="2">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pellegrino, Vincent" sort="Pellegrino, Vincent" uniqKey="Pellegrino V" first="Vincent" last="Pellegrino">Vincent Pellegrino</name>
<affiliation wicri:level="3"><nlm:aff id="Aff3">The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Intensive Care Unit, The Alfred Hospital, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff6">School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Public Health and Preventive Medicine, Monash University, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pilcher, David" sort="Pilcher, David" uniqKey="Pilcher D" first="David" last="Pilcher">David Pilcher</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff3">The Intensive Care Unit, The Alfred Hospital, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Intensive Care Unit, The Alfred Hospital, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcquilten, Zoe" sort="Mcquilten, Zoe" uniqKey="Mcquilten Z" first="Zoe" last="Mcquilten">Zoe Mcquilten</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff2">The Transfusion Research Unit, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Transfusion Research Unit, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Annals of Intensive Care</title>
<idno type="eISSN">2110-5820</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Bleeding is the most frequent complication associated with extracorporeal membrane oxygenation (ECMO) support in critically ill patients. Nonetheless, risk factors for bleeding have been poorly described especially those associated with coagulation anomalies and anticoagulant therapy during ECMO support. The aim of this study is to describe bleeding complications in critically ill patients undergoing ECMO and to identify risk factors for bleeding events.</p>
</sec>
<sec><title>Methods</title>
<p>We retrospectively analysed ICU charts of adults who received either veno-venous (VV) or veno-arterial (VA) ECMO support in two participating ICUs between 2010 and 2013. Characteristics of patients with and without bleeding complications, as per the Extracorporeal Life Support Organisation (ELSO) definition, were compared, and the impact of bleeding complications on patient outcomes was assessed using survival analysis. Variables that were independently associated with bleeding, including daily clinical and biological variables during ECMO courses, were modelled.</p>
</sec>
<sec><title>Results</title>
<p>Of the 149 ECMO episodes (111 VA ECMO and 38 VV ECMO) performed in 147 adults, 89 episodes (60 %) were complicated by at least one bleeding event. The most common bleeding sources were: ECMO cannula (37 %), haemothorax or cardiac tamponade (17 %) and ear–nose and throat (16 %). Intra-cranial haemorrhage occurred in five (2.2 %) patients. Bleeding complications were independently associated with worse survival [adjusted hazard ratio (HR) 2.17, 95 % confidence interval (CI) 1.07–4.41, <italic>P</italic>
= 0.03]. Higher activated partial thromboplastin time (aPTT) [adjusted odds ratio (OR) 3.00, 95 % CI 1.64–5.47, <italic>P</italic>
< 0.01], APACHE III score [adjusted OR 1.01, 95 % CI 1.01–1.02, <italic>P</italic>
= 0.01] and ECMO following surgery [adjusted OR 3.04, 95 % CI 1.62–5.69, <italic>P</italic>
< 0.01] were independently associated with greater risk of bleeding occurrence. A similar association between bleeding and higher aPTT was found when non-post-surgical VA ECMO was considered separately.</p>
</sec>
<sec><title>Conclusions</title>
<p>Bleeding events based on the ELSO bleeding definition occurred in more than 60 % of ECMO episodes and were associated with hospital mortality. We identified higher aPTT prior bleeding as an independent risk factor for bleeding event, suggesting that better control of the aPTT (through a better control of either coagulopathy or anticoagulation) may improve patients’ outcome.</p>
</sec>
</div>
</front>
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</back>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Belgique</li>
<li>France</li>
</country>
<region><li>Bourgogne-Franche-Comté</li>
<li>Franche-Comté</li>
<li>Province d'Anvers</li>
<li>Région Bretagne</li>
<li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Anvers</li>
<li>Besançon</li>
<li>Brest</li>
<li>Melbourne</li>
<li>Paris</li>
</settlement>
<orgName><li>Université de Bretagne Occidentale</li>
</orgName>
</list>
<tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Aubron, Cecile" sort="Aubron, Cecile" uniqKey="Aubron C" first="Cécile" last="Aubron">Cécile Aubron</name>
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<name sortKey="Aubron, Cecile" sort="Aubron, Cecile" uniqKey="Aubron C" first="Cécile" last="Aubron">Cécile Aubron</name>
<name sortKey="Bailey, Michael" sort="Bailey, Michael" uniqKey="Bailey M" first="Michael" last="Bailey">Michael Bailey</name>
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<name sortKey="Depuydt, Joris" sort="Depuydt, Joris" uniqKey="Depuydt J" first="Joris" last="Depuydt">Joris Depuydt</name>
<name sortKey="Mcquilten, Zoe" sort="Mcquilten, Zoe" uniqKey="Mcquilten Z" first="Zoe" last="Mcquilten">Zoe Mcquilten</name>
<name sortKey="Mcquilten, Zoe" sort="Mcquilten, Zoe" uniqKey="Mcquilten Z" first="Zoe" last="Mcquilten">Zoe Mcquilten</name>
<name sortKey="Murphy, Deirdre" sort="Murphy, Deirdre" uniqKey="Murphy D" first="Deirdre" last="Murphy">Deirdre Murphy</name>
<name sortKey="Murphy, Deirdre" sort="Murphy, Deirdre" uniqKey="Murphy D" first="Deirdre" last="Murphy">Deirdre Murphy</name>
<name sortKey="Pellegrino, Vincent" sort="Pellegrino, Vincent" uniqKey="Pellegrino V" first="Vincent" last="Pellegrino">Vincent Pellegrino</name>
<name sortKey="Pellegrino, Vincent" sort="Pellegrino, Vincent" uniqKey="Pellegrino V" first="Vincent" last="Pellegrino">Vincent Pellegrino</name>
<name sortKey="Pilcher, David" sort="Pilcher, David" uniqKey="Pilcher D" first="David" last="Pilcher">David Pilcher</name>
<name sortKey="Pilcher, David" sort="Pilcher, David" uniqKey="Pilcher D" first="David" last="Pilcher">David Pilcher</name>
<name sortKey="Scheinkestel, Carlos" sort="Scheinkestel, Carlos" uniqKey="Scheinkestel C" first="Carlos" last="Scheinkestel">Carlos Scheinkestel</name>
<name sortKey="Scheinkestel, Carlos" sort="Scheinkestel, Carlos" uniqKey="Scheinkestel C" first="Carlos" last="Scheinkestel">Carlos Scheinkestel</name>
<name sortKey="Schmidt, Matthieu" sort="Schmidt, Matthieu" uniqKey="Schmidt M" first="Matthieu" last="Schmidt">Matthieu Schmidt</name>
<name sortKey="Sheldrake, Jayne" sort="Sheldrake, Jayne" uniqKey="Sheldrake J" first="Jayne" last="Sheldrake">Jayne Sheldrake</name>
</country>
<country name="France"><region name="Région Bretagne"><name sortKey="Aubron, Cecile" sort="Aubron, Cecile" uniqKey="Aubron C" first="Cécile" last="Aubron">Cécile Aubron</name>
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<name sortKey="Aubron, Cecile" sort="Aubron, Cecile" uniqKey="Aubron C" first="Cécile" last="Aubron">Cécile Aubron</name>
<name sortKey="Belon, Francois" sort="Belon, Francois" uniqKey="Belon F" first="François" last="Belon">François Belon</name>
<name sortKey="Capellier, Gilles" sort="Capellier, Gilles" uniqKey="Capellier G" first="Gilles" last="Capellier">Gilles Capellier</name>
<name sortKey="Schmidt, Matthieu" sort="Schmidt, Matthieu" uniqKey="Schmidt M" first="Matthieu" last="Schmidt">Matthieu Schmidt</name>
</country>
<country name="Belgique"><region name="Province d'Anvers"><name sortKey="Depuydt, Joris" sort="Depuydt, Joris" uniqKey="Depuydt J" first="Joris" last="Depuydt">Joris Depuydt</name>
</region>
</country>
</tree>
</affiliations>
</record>
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