Effect of nivolumab on health-related quality of life in patients with treatment-naïve advanced melanoma: results from the phase III CheckMate 066 study
Identifieur interne : 002031 ( Main/Exploration ); précédent : 002030; suivant : 002032Effect of nivolumab on health-related quality of life in patients with treatment-naïve advanced melanoma: results from the phase III CheckMate 066 study
Auteurs : G. V. Long [Australie] ; V. Atkinson [Australie] ; P. A. Ascierto [Italie] ; C. Robert [France] ; J. C. Hassel [Allemagne] ; P. Rutkowski [Pologne] ; K. J. Savage [Canada] ; F. Taylor [États-Unis] ; C. Coon [États-Unis] ; I. Gilloteau [États-Unis] ; H. B. Dastani [États-Unis] ; I. M. Waxman [États-Unis] ; A. P. Abernethy [États-Unis]Source :
- Annals of Oncology [ 0923-7534 ] ; 2016.
Abstract
In patients with advanced melanoma in the CheckMate 066 study, baseline health-related quality of life (HRQoL) with nivolumab was maintained over time, with statistically significant and clinically meaningful improvements in some exploratory analyses, and no HRQoL improvements with dacarbazine. Added to the survival benefit of nivolumab, the benefit-to-risk ratio favors nivolumab over dacarbazine.
Url:
DOI: 10.1093/annonc/mdw265
PubMed: 27405322
PubMed Central: 5035785
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>In patients with advanced melanoma in the CheckMate 066 study, baseline health-related quality of life (HRQoL) with nivolumab was maintained over time, with statistically significant and clinically meaningful improvements in some exploratory analyses, and no HRQoL improvements with dacarbazine. Added to the survival benefit of nivolumab, the benefit-to-risk ratio favors nivolumab over dacarbazine.</p>
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<author><name sortKey="Stroyakovskiy, D" uniqKey="Stroyakovskiy D">D Stroyakovskiy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schadendorf, D" uniqKey="Schadendorf D">D Schadendorf</name>
</author>
<author><name sortKey="Dummer, R" uniqKey="Dummer R">R Dummer</name>
</author>
<author><name sortKey="Hauschild, A" uniqKey="Hauschild A">A Hauschild</name>
</author>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Pickard, As" uniqKey="Pickard A">AS Pickard</name>
</author>
<author><name sortKey="Neary, Mp" uniqKey="Neary M">MP Neary</name>
</author>
<author><name sortKey="Cella, D" uniqKey="Cella D">D Cella</name>
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</biblStruct>
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</div1>
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</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>France</li>
<li>Italie</li>
<li>Pologne</li>
<li>États-Unis</li>
</country>
<region><li>Massachusetts</li>
<li>New Jersey</li>
</region>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Long, G V" sort="Long, G V" uniqKey="Long G" first="G. V." last="Long">G. V. Long</name>
</noRegion>
<name sortKey="Atkinson, V" sort="Atkinson, V" uniqKey="Atkinson V" first="V." last="Atkinson">V. Atkinson</name>
</country>
<country name="Italie"><noRegion><name sortKey="Ascierto, P A" sort="Ascierto, P A" uniqKey="Ascierto P" first="P. A." last="Ascierto">P. A. Ascierto</name>
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<country name="France"><noRegion><name sortKey="Robert, C" sort="Robert, C" uniqKey="Robert C" first="C." last="Robert">C. Robert</name>
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<country name="Allemagne"><noRegion><name sortKey="Hassel, J C" sort="Hassel, J C" uniqKey="Hassel J" first="J. C." last="Hassel">J. C. Hassel</name>
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<country name="Pologne"><noRegion><name sortKey="Rutkowski, P" sort="Rutkowski, P" uniqKey="Rutkowski P" first="P." last="Rutkowski">P. Rutkowski</name>
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</country>
<country name="Canada"><noRegion><name sortKey="Savage, K J" sort="Savage, K J" uniqKey="Savage K" first="K. J." last="Savage">K. J. Savage</name>
</noRegion>
</country>
<country name="États-Unis"><region name="Massachusetts"><name sortKey="Taylor, F" sort="Taylor, F" uniqKey="Taylor F" first="F." last="Taylor">F. Taylor</name>
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<name sortKey="Abernethy, A P" sort="Abernethy, A P" uniqKey="Abernethy A" first="A. P." last="Abernethy">A. P. Abernethy</name>
<name sortKey="Coon, C" sort="Coon, C" uniqKey="Coon C" first="C." last="Coon">C. Coon</name>
<name sortKey="Dastani, H B" sort="Dastani, H B" uniqKey="Dastani H" first="H. B." last="Dastani">H. B. Dastani</name>
<name sortKey="Gilloteau, I" sort="Gilloteau, I" uniqKey="Gilloteau I" first="I." last="Gilloteau">I. Gilloteau</name>
<name sortKey="Waxman, I M" sort="Waxman, I M" uniqKey="Waxman I" first="I. M." last="Waxman">I. M. Waxman</name>
</country>
</tree>
</affiliations>
</record>
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