Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant
Identifieur interne : 001942 ( Main/Exploration ); précédent : 001941; suivant : 001943Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant
Auteurs : Jun Li [Australie] ; Susan L. Woods [Australie] ; Sue Healey [Australie] ; Jonathan Beesley [Australie] ; Xiaoqing Chen [Australie] ; Jason S. Lee [Australie] ; Haran Sivakumaran [Australie] ; Nicci Wayte [Australie] ; Katia Nones [Australie] ; Joshua J. Waterfall [États-Unis] ; John Pearson [Australie] ; Anne-Marie Patch [Australie] ; Janine Senz [Canada] ; Manuel A. Ferreira [Australie] ; Pardeep Kaurah [Canada] ; Robertson Mackenzie [Canada] ; Alireza Heravi-Moussavi [Canada] ; Samantha Hansford [Canada] ; Tamsin R. M. Lannagan [Australie] ; Amanda B. Spurdle [Australie] ; Peter T. Simpson [Australie] ; Leonard Da Silva [Australie] ; Sunil R. Lakhani [Australie] ; Andrew D. Clouston [Australie] ; Mark Bettington [Australie] ; Florian Grimpen [Australie] ; Rita A. Busuttil [Australie] ; Natasha Di Costanzo [Australie] ; Alex Boussioutas [Australie] ; Marie Jeanjean [Canada] ; George Chong [Canada] ; Aurélie Fabre [France] ; Sylviane Olschwang [France] ; Geoffrey J. Faulkner [Australie] ; Evangelos Bellos [Australie, Royaume-Uni] ; Lachlan Coin [Australie] ; Kevin Rioux [Canada] ; Oliver F. Bathe [Canada] ; Xiaogang Wen [Portugal] ; Hilary C. Martin [Royaume-Uni] ; Deborah W. Neklason [États-Unis] ; Sean R. Davis [États-Unis] ; Robert L. Walker [États-Unis] ; Kathleen A. Calzone [États-Unis] ; Itzhak Avital [États-Unis] ; Theo Heller [États-Unis] ; Christopher Koh [États-Unis] ; Marbin Pineda [États-Unis] ; Udo Rudloff [États-Unis] ; Martha Quezado [États-Unis] ; Pavel N. Pichurin [États-Unis] ; Peter J. Hulick [États-Unis] ; Scott M. Weissman [États-Unis] ; Anna Newlin [États-Unis] ; Wendy S. Rubinstein [États-Unis] ; Jone E. Sampson [États-Unis] ; Kelly Hamman [États-Unis] ; David Goldgar [États-Unis] ; Nicola Poplawski [Australie] ; Kerry Phillips [Australie] ; Lyn Schofield [Australie] ; Jacqueline Armstrong [Australie] ; Cathy Kiraly-Borri [Australie] ; Graeme K. Suthers [Australie] ; David G. Huntsman [Canada] ; William D. Foulkes [Canada] ; Fatima Carneiro [Portugal] ; Noralane M. Lindor [États-Unis] ; Stacey L. Edwards [Australie] ; Juliet D. French [Australie] ; Nicola Waddell [Australie] ; Paul S. Meltzer [États-Unis] ; Daniel L. Worthley [Australie] ; Kasmintan A. Schrader [Canada] ; Georgia Chenevix-Trench [Australie]Source :
- American Journal of Human Genetics [ 0002-9297 ] ; 2016.
Descripteurs français
- KwdFr :
- Adénocarcinome (génétique), Déséquilibre allélique (génétique), Exome (génétique), Exons (génétique), Femelle, Humains, Liaison génétique (génétique), Muqueuse gastrique (métabolisme), Mutation ponctuelle (génétique), Mâle, Pedigree, Perte d'hétérozygotie, Polypes adénomateux (génétique), Polypose adénomateuse colique (génétique), Protéine de la polypose adénomateuse colique (génétique), Régions promotrices (génétique) (génétique), Séquençage nucléotidique à haut débit (), Tumeurs de l'estomac (génétique), Variations de nombre de copies de segment d'ADN (génétique).
- MESH :
- génétique : Adénocarcinome, Déséquilibre allélique, Exome, Exons, Liaison génétique, Mutation ponctuelle, Polypes adénomateux, Polypose adénomateuse colique, Protéine de la polypose adénomateuse colique, Régions promotrices (génétique), Tumeurs de l'estomac, Variations de nombre de copies de segment d'ADN.
- métabolisme : Muqueuse gastrique.
- Femelle, Humains, Mâle, Pedigree, Perte d'hétérozygotie, Séquençage nucléotidique à haut débit.
English descriptors
- KwdEn :
- Adenocarcinoma (genetics), Adenomatous Polyposis Coli (genetics), Adenomatous Polyposis Coli Protein (genetics), Adenomatous Polyps (genetics), Allelic Imbalance (genetics), DNA Copy Number Variations (genetics), Exome (genetics), Exons (genetics), Female, Gastric Mucosa (metabolism), Genetic Linkage (genetics), High-Throughput Nucleotide Sequencing (methods), Humans, Loss of Heterozygosity, Male, Pedigree, Point Mutation (genetics), Promoter Regions, Genetic (genetics), Stomach Neoplasms (genetics).
- MESH :
- chemical , genetics : Adenomatous Polyposis Coli Protein.
- genetics : Adenocarcinoma, Adenomatous Polyposis Coli, Adenomatous Polyps, Allelic Imbalance, DNA Copy Number Variations, Exome, Exons, Genetic Linkage, Point Mutation, Promoter Regions, Genetic, Stomach Neoplasms.
- metabolism : Gastric Mucosa.
- methods : High-Throughput Nucleotide Sequencing.
- Female, Humans, Loss of Heterozygosity, Male, Pedigree.
Abstract
Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) is an autosomal-dominant cancer-predisposition syndrome with a significant risk of gastric, but not colorectal, adenocarcinoma. We mapped the gene to 5q22 and found loss of the wild-type allele on 5q in fundic gland polyps from affected individuals. Whole-exome and -genome sequencing failed to find causal mutations but, through Sanger sequencing, we identified point mutations in
Url:
DOI: 10.1016/j.ajhg.2016.03.001
PubMed: 27087319
PubMed Central: 4863475
Affiliations:
- Australie, Canada, France, Portugal, Royaume-Uni, États-Unis
- Alberta, Arizona, Illinois, Maryland, Minnesota, New Jersey, Oregon, Provence-Alpes-Côte d'Azur, Québec, Utah, Victoria (État)
- Calgary, Marseille, Melbourne, Montréal, Portland
- Université McGill, Université d'Aix-Marseille, Université de Calgary, Université de Melbourne, Université des sciences et de la médecine de l'Oregon
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Le document en format XML
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Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant</title>
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<author><name sortKey="Clouston, Andrew D" sort="Clouston, Andrew D" uniqKey="Clouston A" first="Andrew D." last="Clouston">Andrew D. Clouston</name>
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<author><name sortKey="Bettington, Mark" sort="Bettington, Mark" uniqKey="Bettington M" first="Mark" last="Bettington">Mark Bettington</name>
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<affiliation wicri:level="1"><nlm:aff id="aff14">The Conjoint Gastroenterology Laboratory, QIMR Berghofer, Herston, QLD 4029, Australia</nlm:aff>
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<author><name sortKey="Grimpen, Florian" sort="Grimpen, Florian" uniqKey="Grimpen F" first="Florian" last="Grimpen">Florian Grimpen</name>
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<author><name sortKey="Busuttil, Rita A" sort="Busuttil, Rita A" uniqKey="Busuttil R" first="Rita A." last="Busuttil">Rita A. Busuttil</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Genetics and Genomics Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, Melbourne, VIC 8006</wicri:regionArea>
<wicri:noRegion>VIC 8006</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff17">Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff18">Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3010, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Di Costanzo, Natasha" sort="Di Costanzo, Natasha" uniqKey="Di Costanzo N" first="Natasha" last="Di Costanzo">Natasha Di Costanzo</name>
<affiliation wicri:level="1"><nlm:aff id="aff16">Cancer Genetics and Genomics Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, Melbourne, VIC 8006, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Genetics and Genomics Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, Melbourne, VIC 8006</wicri:regionArea>
<wicri:noRegion>VIC 8006</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Boussioutas, Alex" sort="Boussioutas, Alex" uniqKey="Boussioutas A" first="Alex" last="Boussioutas">Alex Boussioutas</name>
<affiliation wicri:level="1"><nlm:aff id="aff16">Cancer Genetics and Genomics Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, Melbourne, VIC 8006, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Genetics and Genomics Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, Melbourne, VIC 8006</wicri:regionArea>
<wicri:noRegion>VIC 8006</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff17">Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff18">Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3010, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff19">Department of Gastroenterology, Royal Melbourne Hospital, Parkville, VIC 3010, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Gastroenterology, Royal Melbourne Hospital, Parkville, VIC 3010</wicri:regionArea>
<wicri:noRegion>VIC 3010</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jeanjean, Marie" sort="Jeanjean, Marie" uniqKey="Jeanjean M" first="Marie" last="Jeanjean">Marie Jeanjean</name>
<affiliation wicri:level="1"><nlm:aff id="aff20">Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montreal, QC H3T 1E2, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montreal, QC H3T 1E2</wicri:regionArea>
<wicri:noRegion>QC H3T 1E2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chong, George" sort="Chong, George" uniqKey="Chong G" first="George" last="Chong">George Chong</name>
<affiliation wicri:level="1"><nlm:aff id="aff21">Molecular Pathology Centre, Department of Pathology, Jewish General Hospital - McGill University, Montreal, QC H3T 1E2, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Molecular Pathology Centre, Department of Pathology, Jewish General Hospital - McGill University, Montreal, QC H3T 1E2</wicri:regionArea>
<wicri:noRegion>QC H3T 1E2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fabre, Aurelie" sort="Fabre, Aurelie" uniqKey="Fabre A" first="Aurélie" last="Fabre">Aurélie Fabre</name>
<affiliation wicri:level="1"><nlm:aff id="aff22">AP-HM Timone, Medical Genetics Department, 13385 Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>AP-HM Timone, Medical Genetics Department, 13385 Marseille</wicri:regionArea>
<wicri:noRegion>13385 Marseille</wicri:noRegion>
<placeName><settlement type="city">Marseille</settlement>
<region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff23">Aix Marseille Université, INSERM, GMGF UMR_S 910, 13385 Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Université, INSERM, GMGF UMR_S 910, 13385 Marseille</wicri:regionArea>
<wicri:noRegion>13385 Marseille</wicri:noRegion>
<placeName><settlement type="city">Marseille</settlement>
<region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff24">Oncology Unit, Generale de Sante, Clairval Hospital, 13009 Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Oncology Unit, Generale de Sante, Clairval Hospital, 13009 Marseille</wicri:regionArea>
<wicri:noRegion>13009 Marseille</wicri:noRegion>
<placeName><settlement type="city">Marseille</settlement>
<region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Olschwang, Sylviane" sort="Olschwang, Sylviane" uniqKey="Olschwang S" first="Sylviane" last="Olschwang">Sylviane Olschwang</name>
<affiliation wicri:level="1"><nlm:aff id="aff22">AP-HM Timone, Medical Genetics Department, 13385 Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>AP-HM Timone, Medical Genetics Department, 13385 Marseille</wicri:regionArea>
<wicri:noRegion>13385 Marseille</wicri:noRegion>
<placeName><settlement type="city">Marseille</settlement>
<region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff23">Aix Marseille Université, INSERM, GMGF UMR_S 910, 13385 Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Université, INSERM, GMGF UMR_S 910, 13385 Marseille</wicri:regionArea>
<wicri:noRegion>13385 Marseille</wicri:noRegion>
<placeName><settlement type="city">Marseille</settlement>
<region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff24">Oncology Unit, Generale de Sante, Clairval Hospital, 13009 Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Oncology Unit, Generale de Sante, Clairval Hospital, 13009 Marseille</wicri:regionArea>
<wicri:noRegion>13009 Marseille</wicri:noRegion>
<placeName><settlement type="city">Marseille</settlement>
<region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Faulkner, Geoffrey J" sort="Faulkner, Geoffrey J" uniqKey="Faulkner G" first="Geoffrey J." last="Faulkner">Geoffrey J. Faulkner</name>
<affiliation wicri:level="1"><nlm:aff id="aff25">Mater Research Institute, University of Queensland, TRI Building, Woolloongabba, QLD 4102, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Mater Research Institute, University of Queensland, TRI Building, Woolloongabba, QLD 4102</wicri:regionArea>
<wicri:noRegion>QLD 4102</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bellos, Evangelos" sort="Bellos, Evangelos" uniqKey="Bellos E" first="Evangelos" last="Bellos">Evangelos Bellos</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072</wicri:regionArea>
<wicri:noRegion>QLD 4072</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff26">Department of Genomics of Common Disease, Imperial College London, London W12 0NN, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Genomics of Common Disease, Imperial College London, London W12 0NN</wicri:regionArea>
<wicri:noRegion>London W12 0NN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Coin, Lachlan" sort="Coin, Lachlan" uniqKey="Coin L" first="Lachlan" last="Coin">Lachlan Coin</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072</wicri:regionArea>
<wicri:noRegion>QLD 4072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rioux, Kevin" sort="Rioux, Kevin" uniqKey="Rioux K" first="Kevin" last="Rioux">Kevin Rioux</name>
<affiliation wicri:level="4"><nlm:aff id="aff27">Department of Medicine, Division of Gastroenterology, Department of Microbiology and Infectious Diseases, Gastrointestinal Research Group, University of Calgary, Calgary, AB T2N 4N1, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine, Division of Gastroenterology, Department of Microbiology and Infectious Diseases, Gastrointestinal Research Group, University of Calgary, Calgary, AB T2N 4N1</wicri:regionArea>
<orgName type="university">Université de Calgary</orgName>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bathe, Oliver F" sort="Bathe, Oliver F" uniqKey="Bathe O" first="Oliver F." last="Bathe">Oliver F. Bathe</name>
<affiliation wicri:level="4"><nlm:aff id="aff28">Departments of Surgery and Oncology, University of Calgary, Calgary, AB T2N 4N1, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Departments of Surgery and Oncology, University of Calgary, Calgary, AB T2N 4N1</wicri:regionArea>
<orgName type="university">Université de Calgary</orgName>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff29">Division of Surgical Oncology, Tom Baker Cancer Centre, 1331 29<sup>th</sup>
St NW, Calgary, AB T2N 4N1, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> St NW, Calgary, AB T2N 4N1</wicri:regionArea>
<wicri:noRegion>AB T2N 4N1</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wen, Xiaogang" sort="Wen, Xiaogang" uniqKey="Wen X" first="Xiaogang" last="Wen">Xiaogang Wen</name>
<affiliation wicri:level="1"><nlm:aff id="aff30">Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP)/Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto 4200-135, Portugal</nlm:aff>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP)/Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto 4200-135</wicri:regionArea>
<wicri:noRegion>Porto 4200-135</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff31">Centro Hospitalar Vila Nova de Gaia/Espinho, Porto 4430-027, Portugal</nlm:aff>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Centro Hospitalar Vila Nova de Gaia/Espinho, Porto 4430-027</wicri:regionArea>
<wicri:noRegion>Porto 4430-027</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martin, Hilary C" sort="Martin, Hilary C" uniqKey="Martin H" first="Hilary C." last="Martin">Hilary C. Martin</name>
<affiliation wicri:level="1"><nlm:aff id="aff32">Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN</wicri:regionArea>
<wicri:noRegion>Oxford OX3 7BN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Neklason, Deborah W" sort="Neklason, Deborah W" uniqKey="Neklason D" first="Deborah W." last="Neklason">Deborah W. Neklason</name>
<affiliation wicri:level="2"><nlm:aff id="aff33">Department of Internal Medicine, Huntsman Cancer Institute at University of Utah, Salt Lake City, UT 84112, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Internal Medicine, Huntsman Cancer Institute at University of Utah, Salt Lake City, UT 84112</wicri:regionArea>
<placeName><region type="state">Utah</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Davis, Sean R" sort="Davis, Sean R" uniqKey="Davis S" first="Sean R." last="Davis">Sean R. Davis</name>
<affiliation wicri:level="2"><nlm:aff id="aff3">Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Walker, Robert L" sort="Walker, Robert L" uniqKey="Walker R" first="Robert L." last="Walker">Robert L. Walker</name>
<affiliation wicri:level="2"><nlm:aff id="aff3">Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Calzone, Kathleen A" sort="Calzone, Kathleen A" uniqKey="Calzone K" first="Kathleen A." last="Calzone">Kathleen A. Calzone</name>
<affiliation wicri:level="2"><nlm:aff id="aff3">Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Avital, Itzhak" sort="Avital, Itzhak" uniqKey="Avital I" first="Itzhak" last="Avital">Itzhak Avital</name>
<affiliation wicri:level="2"><nlm:aff id="aff34">Department of Surgery, Saint Peter’s University Hospital, Rutgers University, New Brunswick, NJ 08901, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, Saint Peter’s University Hospital, Rutgers University, New Brunswick, NJ 08901</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Heller, Theo" sort="Heller, Theo" uniqKey="Heller T" first="Theo" last="Heller">Theo Heller</name>
<affiliation wicri:level="2"><nlm:aff id="aff35">Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Disease (NIDDK), NIH, Bethesda, MD 20892, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Disease (NIDDK), NIH, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koh, Christopher" sort="Koh, Christopher" uniqKey="Koh C" first="Christopher" last="Koh">Christopher Koh</name>
<affiliation wicri:level="2"><nlm:aff id="aff35">Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Disease (NIDDK), NIH, Bethesda, MD 20892, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Disease (NIDDK), NIH, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pineda, Marbin" sort="Pineda, Marbin" uniqKey="Pineda M" first="Marbin" last="Pineda">Marbin Pineda</name>
<affiliation wicri:level="2"><nlm:aff id="aff3">Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rudloff, Udo" sort="Rudloff, Udo" uniqKey="Rudloff U" first="Udo" last="Rudloff">Udo Rudloff</name>
<affiliation wicri:level="2"><nlm:aff id="aff36">Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Quezado, Martha" sort="Quezado, Martha" uniqKey="Quezado M" first="Martha" last="Quezado">Martha Quezado</name>
<affiliation wicri:level="2"><nlm:aff id="aff37">Laboratory of Pathology, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Pathology, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pichurin, Pavel N" sort="Pichurin, Pavel N" uniqKey="Pichurin P" first="Pavel N." last="Pichurin">Pavel N. Pichurin</name>
<affiliation wicri:level="2"><nlm:aff id="aff38">Department of Medical Genetics, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Genetics, Mayo Clinic, Rochester, MN 55905</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hulick, Peter J" sort="Hulick, Peter J" uniqKey="Hulick P" first="Peter J." last="Hulick">Peter J. Hulick</name>
<affiliation wicri:level="2"><nlm:aff id="aff39">Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL 60201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL 60201</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weissman, Scott M" sort="Weissman, Scott M" uniqKey="Weissman S" first="Scott M." last="Weissman">Scott M. Weissman</name>
<affiliation wicri:level="2"><nlm:aff id="aff40">GeneDx, 207 Perry Parkway, Gaithersburg, MD 20877, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>GeneDx, 207 Perry Parkway, Gaithersburg, MD 20877</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Newlin, Anna" sort="Newlin, Anna" uniqKey="Newlin A" first="Anna" last="Newlin">Anna Newlin</name>
<affiliation wicri:level="2"><nlm:aff id="aff39">Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL 60201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL 60201</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rubinstein, Wendy S" sort="Rubinstein, Wendy S" uniqKey="Rubinstein W" first="Wendy S." last="Rubinstein">Wendy S. Rubinstein</name>
<affiliation wicri:level="2"><nlm:aff id="aff41">National Center for Biotechnology Information (NCBI), National Library of Medicine (NLM), NIH, Bethesda, MD 20892, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Center for Biotechnology Information (NCBI), National Library of Medicine (NLM), NIH, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sampson, Jone E" sort="Sampson, Jone E" uniqKey="Sampson J" first="Jone E." last="Sampson">Jone E. Sampson</name>
<affiliation wicri:level="4"><nlm:aff id="aff42">Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Hamman, Kelly" sort="Hamman, Kelly" uniqKey="Hamman K" first="Kelly" last="Hamman">Kelly Hamman</name>
<affiliation wicri:level="4"><nlm:aff id="aff42">Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Goldgar, David" sort="Goldgar, David" uniqKey="Goldgar D" first="David" last="Goldgar">David Goldgar</name>
<affiliation wicri:level="2"><nlm:aff id="aff43">Department of Dermatology and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Dermatology and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84112</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Poplawski, Nicola" sort="Poplawski, Nicola" uniqKey="Poplawski N" first="Nicola" last="Poplawski">Nicola Poplawski</name>
<affiliation wicri:level="1"><nlm:aff id="aff44">Adult Genetics Unit, SA Pathology at the Women’s and Children’s Hospital, North Adelaide, SA 5006, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Adult Genetics Unit, SA Pathology at the Women’s and Children’s Hospital, North Adelaide, SA 5006</wicri:regionArea>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff45">University Department of Paediatrics, University of Adelaide, Adelaide, SA 5005, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University Department of Paediatrics, University of Adelaide, Adelaide, SA 5005</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Phillips, Kerry" sort="Phillips, Kerry" uniqKey="Phillips K" first="Kerry" last="Phillips">Kerry Phillips</name>
<affiliation wicri:level="1"><nlm:aff id="aff44">Adult Genetics Unit, SA Pathology at the Women’s and Children’s Hospital, North Adelaide, SA 5006, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Adult Genetics Unit, SA Pathology at the Women’s and Children’s Hospital, North Adelaide, SA 5006</wicri:regionArea>
<wicri:noRegion>SA 5006</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff45">University Department of Paediatrics, University of Adelaide, Adelaide, SA 5005, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University Department of Paediatrics, University of Adelaide, Adelaide, SA 5005</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Schofield, Lyn" sort="Schofield, Lyn" uniqKey="Schofield L" first="Lyn" last="Schofield">Lyn Schofield</name>
<affiliation wicri:level="1"><nlm:aff id="aff46">Genetic Services of Western Australia, King Edward Memorial Hospital, Subiaco, WA 6008, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Services of Western Australia, King Edward Memorial Hospital, Subiaco, WA 6008</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Armstrong, Jacqueline" sort="Armstrong, Jacqueline" uniqKey="Armstrong J" first="Jacqueline" last="Armstrong">Jacqueline Armstrong</name>
<affiliation wicri:level="1"><nlm:aff id="aff44">Adult Genetics Unit, SA Pathology at the Women’s and Children’s Hospital, North Adelaide, SA 5006, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Adult Genetics Unit, SA Pathology at the Women’s and Children’s Hospital, North Adelaide, SA 5006</wicri:regionArea>
<wicri:noRegion>SA 5006</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kiraly Borri, Cathy" sort="Kiraly Borri, Cathy" uniqKey="Kiraly Borri C" first="Cathy" last="Kiraly-Borri">Cathy Kiraly-Borri</name>
<affiliation wicri:level="1"><nlm:aff id="aff46">Genetic Services of Western Australia, King Edward Memorial Hospital, Subiaco, WA 6008, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Services of Western Australia, King Edward Memorial Hospital, Subiaco, WA 6008</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Suthers, Graeme K" sort="Suthers, Graeme K" uniqKey="Suthers G" first="Graeme K." last="Suthers">Graeme K. Suthers</name>
<affiliation wicri:level="1"><nlm:aff id="aff45">University Department of Paediatrics, University of Adelaide, Adelaide, SA 5005, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University Department of Paediatrics, University of Adelaide, Adelaide, SA 5005</wicri:regionArea>
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</author>
<author><name sortKey="Huntsman, David G" sort="Huntsman, David G" uniqKey="Huntsman D" first="David G." last="Huntsman">David G. Huntsman</name>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, BC V5Z 1L3</wicri:regionArea>
<wicri:noRegion>BC V5Z 1L3</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff47">Department of Pathology and Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC V6Z 2K5, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Pathology and Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC V6Z 2K5</wicri:regionArea>
<wicri:noRegion>BC V6Z 2K5</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Foulkes, William D" sort="Foulkes, William D" uniqKey="Foulkes W" first="William D." last="Foulkes">William D. Foulkes</name>
<affiliation wicri:level="1"><nlm:aff id="aff20">Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montreal, QC H3T 1E2, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montreal, QC H3T 1E2</wicri:regionArea>
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</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff48">Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montreal, QC H3A 1B1</wicri:regionArea>
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<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Carneiro, Fatima" sort="Carneiro, Fatima" uniqKey="Carneiro F" first="Fatima" last="Carneiro">Fatima Carneiro</name>
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<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP)/Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto 4200-135</wicri:regionArea>
<wicri:noRegion>Porto 4200-135</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff49">Medical Faculty of the University of Porto/Centro Hospitalar São João, Porto 4200-319, Portugal</nlm:aff>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Medical Faculty of the University of Porto/Centro Hospitalar São João, Porto 4200-319</wicri:regionArea>
<wicri:noRegion>Porto 4200-319</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M." last="Lindor">Noralane M. Lindor</name>
<affiliation wicri:level="2"><nlm:aff id="aff50">Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ 85259, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ 85259</wicri:regionArea>
<placeName><region type="state">Arizona</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Edwards, Stacey L" sort="Edwards, Stacey L" uniqKey="Edwards S" first="Stacey L." last="Edwards">Stacey L. Edwards</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="French, Juliet D" sort="French, Juliet D" uniqKey="French J" first="Juliet D." last="French">Juliet D. French</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Waddell, Nicola" sort="Waddell, Nicola" uniqKey="Waddell N" first="Nicola" last="Waddell">Nicola Waddell</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029</wicri:regionArea>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4">Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Meltzer, Paul S" sort="Meltzer, Paul S" uniqKey="Meltzer P" first="Paul S." last="Meltzer">Paul S. Meltzer</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Worthley, Daniel L" sort="Worthley, Daniel L" uniqKey="Worthley D" first="Daniel L." last="Worthley">Daniel L. Worthley</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">School of Medicine, University of Adelaide and Cancer Theme, SAHMRI, Adelaide, SA 5000, Australia</nlm:aff>
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<wicri:regionArea>School of Medicine, University of Adelaide and Cancer Theme, SAHMRI, Adelaide, SA 5000</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Schrader, Kasmintan A" sort="Schrader, Kasmintan A" uniqKey="Schrader K" first="Kasmintan A." last="Schrader">Kasmintan A. Schrader</name>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medical Genetics, University of British Columbia, Vancouver, BC V6H 3N1</wicri:regionArea>
<wicri:noRegion>BC V6H 3N1</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff7">Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, BC V5Z 1L3</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029</wicri:regionArea>
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</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Point Mutations in Exon 1B of <italic>APC</italic>
Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant</title>
<author><name sortKey="Li, Jun" sort="Li, Jun" uniqKey="Li J" first="Jun" last="Li">Jun Li</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Woods, Susan L" sort="Woods, Susan L" uniqKey="Woods S" first="Susan L." last="Woods">Susan L. Woods</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">School of Medicine, University of Adelaide and Cancer Theme, SAHMRI, Adelaide, SA 5000, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Medicine, University of Adelaide and Cancer Theme, SAHMRI, Adelaide, SA 5000</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029</wicri:regionArea>
<wicri:noRegion>QLD 4029</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Jason S" sort="Lee, Jason S" uniqKey="Lee J" first="Jason S." last="Lee">Jason S. Lee</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Sivakumaran, Haran" sort="Sivakumaran, Haran" uniqKey="Sivakumaran H" first="Haran" last="Sivakumaran">Haran Sivakumaran</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029</wicri:regionArea>
<wicri:noRegion>QLD 4029</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wayte, Nicci" sort="Wayte, Nicci" uniqKey="Wayte N" first="Nicci" last="Wayte">Nicci Wayte</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029</wicri:regionArea>
<wicri:noRegion>QLD 4029</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nones, Katia" sort="Nones, Katia" uniqKey="Nones K" first="Katia" last="Nones">Katia Nones</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029</wicri:regionArea>
<wicri:noRegion>QLD 4029</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Waterfall, Joshua J" sort="Waterfall, Joshua J" uniqKey="Waterfall J" first="Joshua J." last="Waterfall">Joshua J. Waterfall</name>
<affiliation wicri:level="2"><nlm:aff id="aff3">Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pearson, John" sort="Pearson, John" uniqKey="Pearson J" first="John" last="Pearson">John Pearson</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029</wicri:regionArea>
<wicri:noRegion>QLD 4029</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4">Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072</wicri:regionArea>
<wicri:noRegion>QLD 4072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Patch, Anne Marie" sort="Patch, Anne Marie" uniqKey="Patch A" first="Anne-Marie" last="Patch">Anne-Marie Patch</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Senz, Janine" sort="Senz, Janine" uniqKey="Senz J" first="Janine" last="Senz">Janine Senz</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5</wicri:regionArea>
<wicri:noRegion>BC V6T 2B5</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ferreira, Manuel A" sort="Ferreira, Manuel A" uniqKey="Ferreira M" first="Manuel A." last="Ferreira">Manuel A. Ferreira</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029</wicri:regionArea>
<wicri:noRegion>QLD 4029</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kaurah, Pardeep" sort="Kaurah, Pardeep" uniqKey="Kaurah P" first="Pardeep" last="Kaurah">Pardeep Kaurah</name>
<affiliation wicri:level="1"><nlm:aff id="aff6">Department of Medical Genetics, University of British Columbia, Vancouver, BC V6H 3N1, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medical Genetics, University of British Columbia, Vancouver, BC V6H 3N1</wicri:regionArea>
<wicri:noRegion>BC V6H 3N1</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mackenzie, Robertson" sort="Mackenzie, Robertson" uniqKey="Mackenzie R" first="Robertson" last="Mackenzie">Robertson Mackenzie</name>
<affiliation wicri:level="1"><nlm:aff id="aff7">Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, BC V5Z 1L3</wicri:regionArea>
<wicri:noRegion>BC V5Z 1L3</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Heravi Moussavi, Alireza" sort="Heravi Moussavi, Alireza" uniqKey="Heravi Moussavi A" first="Alireza" last="Heravi-Moussavi">Alireza Heravi-Moussavi</name>
<affiliation wicri:level="1"><nlm:aff id="aff8">Canada’s Michael Smith Genome Sciences Centre, Vancouver, BC V5Z 4S6, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canada’s Michael Smith Genome Sciences Centre, Vancouver, BC V5Z 4S6</wicri:regionArea>
<wicri:noRegion>BC V5Z 4S6</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hansford, Samantha" sort="Hansford, Samantha" uniqKey="Hansford S" first="Samantha" last="Hansford">Samantha Hansford</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5</wicri:regionArea>
<wicri:noRegion>BC V6T 2B5</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lannagan, Tamsin R M" sort="Lannagan, Tamsin R M" uniqKey="Lannagan T" first="Tamsin R. M." last="Lannagan">Tamsin R. M. Lannagan</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">School of Medicine, University of Adelaide and Cancer Theme, SAHMRI, Adelaide, SA 5000, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Medicine, University of Adelaide and Cancer Theme, SAHMRI, Adelaide, SA 5000</wicri:regionArea>
<wicri:noRegion>SA 5000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029</wicri:regionArea>
<wicri:noRegion>QLD 4029</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Simpson, Peter T" sort="Simpson, Peter T" uniqKey="Simpson P" first="Peter T." last="Simpson">Peter T. Simpson</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD 4029</wicri:regionArea>
<wicri:noRegion>QLD 4029</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff10">School of Medicine, The University of Queensland, Brisbane, QLD 4006, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Medicine, The University of Queensland, Brisbane, QLD 4006</wicri:regionArea>
<wicri:noRegion>QLD 4006</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Da Silva, Leonard" sort="Da Silva, Leonard" uniqKey="Da Silva L" first="Leonard" last="Da Silva">Leonard Da Silva</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD 4029</wicri:regionArea>
<wicri:noRegion>QLD 4029</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff10">School of Medicine, The University of Queensland, Brisbane, QLD 4006, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Medicine, The University of Queensland, Brisbane, QLD 4006</wicri:regionArea>
<wicri:noRegion>QLD 4006</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lakhani, Sunil R" sort="Lakhani, Sunil R" uniqKey="Lakhani S" first="Sunil R." last="Lakhani">Sunil R. Lakhani</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD 4029</wicri:regionArea>
<wicri:noRegion>QLD 4029</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff10">School of Medicine, The University of Queensland, Brisbane, QLD 4006, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Medicine, The University of Queensland, Brisbane, QLD 4006</wicri:regionArea>
<wicri:noRegion>QLD 4006</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff11">Anatomical Pathology, Pathology Queensland, Royal Brisbane and Women’s Hospital, Brisbane, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Anatomical Pathology, Pathology Queensland, Royal Brisbane and Women’s Hospital, Brisbane, QLD 4029</wicri:regionArea>
<wicri:noRegion>QLD 4029</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Clouston, Andrew D" sort="Clouston, Andrew D" uniqKey="Clouston A" first="Andrew D." last="Clouston">Andrew D. Clouston</name>
<affiliation wicri:level="1"><nlm:aff id="aff12">Centre for Liver Disease Research, TRI Building, University of Queensland, Woolloongabba, QLD 4102, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Liver Disease Research, TRI Building, University of Queensland, Woolloongabba, QLD 4102</wicri:regionArea>
<wicri:noRegion>QLD 4102</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff13">Envoi Specialist Pathologists, Bishop Street, Kelvin Grove, QLD 4059, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Envoi Specialist Pathologists, Bishop Street, Kelvin Grove, QLD 4059</wicri:regionArea>
<wicri:noRegion>QLD 4059</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bettington, Mark" sort="Bettington, Mark" uniqKey="Bettington M" first="Mark" last="Bettington">Mark Bettington</name>
<affiliation wicri:level="1"><nlm:aff id="aff10">School of Medicine, The University of Queensland, Brisbane, QLD 4006, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Medicine, The University of Queensland, Brisbane, QLD 4006</wicri:regionArea>
<wicri:noRegion>QLD 4006</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff13">Envoi Specialist Pathologists, Bishop Street, Kelvin Grove, QLD 4059, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Envoi Specialist Pathologists, Bishop Street, Kelvin Grove, QLD 4059</wicri:regionArea>
<wicri:noRegion>QLD 4059</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff14">The Conjoint Gastroenterology Laboratory, QIMR Berghofer, Herston, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Conjoint Gastroenterology Laboratory, QIMR Berghofer, Herston, QLD 4029</wicri:regionArea>
<wicri:noRegion>QLD 4029</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grimpen, Florian" sort="Grimpen, Florian" uniqKey="Grimpen F" first="Florian" last="Grimpen">Florian Grimpen</name>
<affiliation wicri:level="1"><nlm:aff id="aff15">Departments of Gastroenterology and Hepatology, Royal Brisbane and Women’s Hospital, Brisbane, QLD 4006, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Departments of Gastroenterology and Hepatology, Royal Brisbane and Women’s Hospital, Brisbane, QLD 4006</wicri:regionArea>
<wicri:noRegion>QLD 4006</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Busuttil, Rita A" sort="Busuttil, Rita A" uniqKey="Busuttil R" first="Rita A." last="Busuttil">Rita A. Busuttil</name>
<affiliation wicri:level="1"><nlm:aff id="aff16">Cancer Genetics and Genomics Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, Melbourne, VIC 8006, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Genetics and Genomics Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, Melbourne, VIC 8006</wicri:regionArea>
<wicri:noRegion>VIC 8006</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff17">Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff18">Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3010, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Di Costanzo, Natasha" sort="Di Costanzo, Natasha" uniqKey="Di Costanzo N" first="Natasha" last="Di Costanzo">Natasha Di Costanzo</name>
<affiliation wicri:level="1"><nlm:aff id="aff16">Cancer Genetics and Genomics Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, Melbourne, VIC 8006, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Genetics and Genomics Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, Melbourne, VIC 8006</wicri:regionArea>
<wicri:noRegion>VIC 8006</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Boussioutas, Alex" sort="Boussioutas, Alex" uniqKey="Boussioutas A" first="Alex" last="Boussioutas">Alex Boussioutas</name>
<affiliation wicri:level="1"><nlm:aff id="aff16">Cancer Genetics and Genomics Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, Melbourne, VIC 8006, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Genetics and Genomics Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, Melbourne, VIC 8006</wicri:regionArea>
<wicri:noRegion>VIC 8006</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff17">Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff18">Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3010, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff19">Department of Gastroenterology, Royal Melbourne Hospital, Parkville, VIC 3010, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Gastroenterology, Royal Melbourne Hospital, Parkville, VIC 3010</wicri:regionArea>
<wicri:noRegion>VIC 3010</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jeanjean, Marie" sort="Jeanjean, Marie" uniqKey="Jeanjean M" first="Marie" last="Jeanjean">Marie Jeanjean</name>
<affiliation wicri:level="1"><nlm:aff id="aff20">Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montreal, QC H3T 1E2, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montreal, QC H3T 1E2</wicri:regionArea>
<wicri:noRegion>QC H3T 1E2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chong, George" sort="Chong, George" uniqKey="Chong G" first="George" last="Chong">George Chong</name>
<affiliation wicri:level="1"><nlm:aff id="aff21">Molecular Pathology Centre, Department of Pathology, Jewish General Hospital - McGill University, Montreal, QC H3T 1E2, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Molecular Pathology Centre, Department of Pathology, Jewish General Hospital - McGill University, Montreal, QC H3T 1E2</wicri:regionArea>
<wicri:noRegion>QC H3T 1E2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fabre, Aurelie" sort="Fabre, Aurelie" uniqKey="Fabre A" first="Aurélie" last="Fabre">Aurélie Fabre</name>
<affiliation wicri:level="1"><nlm:aff id="aff22">AP-HM Timone, Medical Genetics Department, 13385 Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>AP-HM Timone, Medical Genetics Department, 13385 Marseille</wicri:regionArea>
<wicri:noRegion>13385 Marseille</wicri:noRegion>
<placeName><settlement type="city">Marseille</settlement>
<region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff23">Aix Marseille Université, INSERM, GMGF UMR_S 910, 13385 Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Université, INSERM, GMGF UMR_S 910, 13385 Marseille</wicri:regionArea>
<wicri:noRegion>13385 Marseille</wicri:noRegion>
<placeName><settlement type="city">Marseille</settlement>
<region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff24">Oncology Unit, Generale de Sante, Clairval Hospital, 13009 Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Oncology Unit, Generale de Sante, Clairval Hospital, 13009 Marseille</wicri:regionArea>
<wicri:noRegion>13009 Marseille</wicri:noRegion>
<placeName><settlement type="city">Marseille</settlement>
<region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Olschwang, Sylviane" sort="Olschwang, Sylviane" uniqKey="Olschwang S" first="Sylviane" last="Olschwang">Sylviane Olschwang</name>
<affiliation wicri:level="1"><nlm:aff id="aff22">AP-HM Timone, Medical Genetics Department, 13385 Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>AP-HM Timone, Medical Genetics Department, 13385 Marseille</wicri:regionArea>
<wicri:noRegion>13385 Marseille</wicri:noRegion>
<placeName><settlement type="city">Marseille</settlement>
<region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff23">Aix Marseille Université, INSERM, GMGF UMR_S 910, 13385 Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Université, INSERM, GMGF UMR_S 910, 13385 Marseille</wicri:regionArea>
<wicri:noRegion>13385 Marseille</wicri:noRegion>
<placeName><settlement type="city">Marseille</settlement>
<region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff24">Oncology Unit, Generale de Sante, Clairval Hospital, 13009 Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Oncology Unit, Generale de Sante, Clairval Hospital, 13009 Marseille</wicri:regionArea>
<wicri:noRegion>13009 Marseille</wicri:noRegion>
<placeName><settlement type="city">Marseille</settlement>
<region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Faulkner, Geoffrey J" sort="Faulkner, Geoffrey J" uniqKey="Faulkner G" first="Geoffrey J." last="Faulkner">Geoffrey J. Faulkner</name>
<affiliation wicri:level="1"><nlm:aff id="aff25">Mater Research Institute, University of Queensland, TRI Building, Woolloongabba, QLD 4102, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Mater Research Institute, University of Queensland, TRI Building, Woolloongabba, QLD 4102</wicri:regionArea>
<wicri:noRegion>QLD 4102</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bellos, Evangelos" sort="Bellos, Evangelos" uniqKey="Bellos E" first="Evangelos" last="Bellos">Evangelos Bellos</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072</wicri:regionArea>
<wicri:noRegion>QLD 4072</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff26">Department of Genomics of Common Disease, Imperial College London, London W12 0NN, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Genomics of Common Disease, Imperial College London, London W12 0NN</wicri:regionArea>
<wicri:noRegion>London W12 0NN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Coin, Lachlan" sort="Coin, Lachlan" uniqKey="Coin L" first="Lachlan" last="Coin">Lachlan Coin</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072</wicri:regionArea>
<wicri:noRegion>QLD 4072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rioux, Kevin" sort="Rioux, Kevin" uniqKey="Rioux K" first="Kevin" last="Rioux">Kevin Rioux</name>
<affiliation wicri:level="4"><nlm:aff id="aff27">Department of Medicine, Division of Gastroenterology, Department of Microbiology and Infectious Diseases, Gastrointestinal Research Group, University of Calgary, Calgary, AB T2N 4N1, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine, Division of Gastroenterology, Department of Microbiology and Infectious Diseases, Gastrointestinal Research Group, University of Calgary, Calgary, AB T2N 4N1</wicri:regionArea>
<orgName type="university">Université de Calgary</orgName>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bathe, Oliver F" sort="Bathe, Oliver F" uniqKey="Bathe O" first="Oliver F." last="Bathe">Oliver F. Bathe</name>
<affiliation wicri:level="4"><nlm:aff id="aff28">Departments of Surgery and Oncology, University of Calgary, Calgary, AB T2N 4N1, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Departments of Surgery and Oncology, University of Calgary, Calgary, AB T2N 4N1</wicri:regionArea>
<orgName type="university">Université de Calgary</orgName>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff29">Division of Surgical Oncology, Tom Baker Cancer Centre, 1331 29<sup>th</sup>
St NW, Calgary, AB T2N 4N1, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> St NW, Calgary, AB T2N 4N1</wicri:regionArea>
<wicri:noRegion>AB T2N 4N1</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wen, Xiaogang" sort="Wen, Xiaogang" uniqKey="Wen X" first="Xiaogang" last="Wen">Xiaogang Wen</name>
<affiliation wicri:level="1"><nlm:aff id="aff30">Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP)/Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto 4200-135, Portugal</nlm:aff>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP)/Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto 4200-135</wicri:regionArea>
<wicri:noRegion>Porto 4200-135</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff31">Centro Hospitalar Vila Nova de Gaia/Espinho, Porto 4430-027, Portugal</nlm:aff>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Centro Hospitalar Vila Nova de Gaia/Espinho, Porto 4430-027</wicri:regionArea>
<wicri:noRegion>Porto 4430-027</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martin, Hilary C" sort="Martin, Hilary C" uniqKey="Martin H" first="Hilary C." last="Martin">Hilary C. Martin</name>
<affiliation wicri:level="1"><nlm:aff id="aff32">Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN</wicri:regionArea>
<wicri:noRegion>Oxford OX3 7BN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Neklason, Deborah W" sort="Neklason, Deborah W" uniqKey="Neklason D" first="Deborah W." last="Neklason">Deborah W. Neklason</name>
<affiliation wicri:level="2"><nlm:aff id="aff33">Department of Internal Medicine, Huntsman Cancer Institute at University of Utah, Salt Lake City, UT 84112, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Internal Medicine, Huntsman Cancer Institute at University of Utah, Salt Lake City, UT 84112</wicri:regionArea>
<placeName><region type="state">Utah</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Davis, Sean R" sort="Davis, Sean R" uniqKey="Davis S" first="Sean R." last="Davis">Sean R. Davis</name>
<affiliation wicri:level="2"><nlm:aff id="aff3">Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Walker, Robert L" sort="Walker, Robert L" uniqKey="Walker R" first="Robert L." last="Walker">Robert L. Walker</name>
<affiliation wicri:level="2"><nlm:aff id="aff3">Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Calzone, Kathleen A" sort="Calzone, Kathleen A" uniqKey="Calzone K" first="Kathleen A." last="Calzone">Kathleen A. Calzone</name>
<affiliation wicri:level="2"><nlm:aff id="aff3">Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Avital, Itzhak" sort="Avital, Itzhak" uniqKey="Avital I" first="Itzhak" last="Avital">Itzhak Avital</name>
<affiliation wicri:level="2"><nlm:aff id="aff34">Department of Surgery, Saint Peter’s University Hospital, Rutgers University, New Brunswick, NJ 08901, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, Saint Peter’s University Hospital, Rutgers University, New Brunswick, NJ 08901</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Heller, Theo" sort="Heller, Theo" uniqKey="Heller T" first="Theo" last="Heller">Theo Heller</name>
<affiliation wicri:level="2"><nlm:aff id="aff35">Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Disease (NIDDK), NIH, Bethesda, MD 20892, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Disease (NIDDK), NIH, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koh, Christopher" sort="Koh, Christopher" uniqKey="Koh C" first="Christopher" last="Koh">Christopher Koh</name>
<affiliation wicri:level="2"><nlm:aff id="aff35">Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Disease (NIDDK), NIH, Bethesda, MD 20892, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Disease (NIDDK), NIH, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pineda, Marbin" sort="Pineda, Marbin" uniqKey="Pineda M" first="Marbin" last="Pineda">Marbin Pineda</name>
<affiliation wicri:level="2"><nlm:aff id="aff3">Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rudloff, Udo" sort="Rudloff, Udo" uniqKey="Rudloff U" first="Udo" last="Rudloff">Udo Rudloff</name>
<affiliation wicri:level="2"><nlm:aff id="aff36">Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Quezado, Martha" sort="Quezado, Martha" uniqKey="Quezado M" first="Martha" last="Quezado">Martha Quezado</name>
<affiliation wicri:level="2"><nlm:aff id="aff37">Laboratory of Pathology, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Pathology, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pichurin, Pavel N" sort="Pichurin, Pavel N" uniqKey="Pichurin P" first="Pavel N." last="Pichurin">Pavel N. Pichurin</name>
<affiliation wicri:level="2"><nlm:aff id="aff38">Department of Medical Genetics, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Genetics, Mayo Clinic, Rochester, MN 55905</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hulick, Peter J" sort="Hulick, Peter J" uniqKey="Hulick P" first="Peter J." last="Hulick">Peter J. Hulick</name>
<affiliation wicri:level="2"><nlm:aff id="aff39">Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL 60201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL 60201</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weissman, Scott M" sort="Weissman, Scott M" uniqKey="Weissman S" first="Scott M." last="Weissman">Scott M. Weissman</name>
<affiliation wicri:level="2"><nlm:aff id="aff40">GeneDx, 207 Perry Parkway, Gaithersburg, MD 20877, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>GeneDx, 207 Perry Parkway, Gaithersburg, MD 20877</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Newlin, Anna" sort="Newlin, Anna" uniqKey="Newlin A" first="Anna" last="Newlin">Anna Newlin</name>
<affiliation wicri:level="2"><nlm:aff id="aff39">Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL 60201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL 60201</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rubinstein, Wendy S" sort="Rubinstein, Wendy S" uniqKey="Rubinstein W" first="Wendy S." last="Rubinstein">Wendy S. Rubinstein</name>
<affiliation wicri:level="2"><nlm:aff id="aff41">National Center for Biotechnology Information (NCBI), National Library of Medicine (NLM), NIH, Bethesda, MD 20892, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Center for Biotechnology Information (NCBI), National Library of Medicine (NLM), NIH, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sampson, Jone E" sort="Sampson, Jone E" uniqKey="Sampson J" first="Jone E." last="Sampson">Jone E. Sampson</name>
<affiliation wicri:level="4"><nlm:aff id="aff42">Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Hamman, Kelly" sort="Hamman, Kelly" uniqKey="Hamman K" first="Kelly" last="Hamman">Kelly Hamman</name>
<affiliation wicri:level="4"><nlm:aff id="aff42">Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239</wicri:regionArea>
<placeName><region type="state">Oregon</region>
<settlement type="city">Portland</settlement>
</placeName>
<orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName>
</affiliation>
</author>
<author><name sortKey="Goldgar, David" sort="Goldgar, David" uniqKey="Goldgar D" first="David" last="Goldgar">David Goldgar</name>
<affiliation wicri:level="2"><nlm:aff id="aff43">Department of Dermatology and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Dermatology and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84112</wicri:regionArea>
<placeName><region type="state">Utah</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Poplawski, Nicola" sort="Poplawski, Nicola" uniqKey="Poplawski N" first="Nicola" last="Poplawski">Nicola Poplawski</name>
<affiliation wicri:level="1"><nlm:aff id="aff44">Adult Genetics Unit, SA Pathology at the Women’s and Children’s Hospital, North Adelaide, SA 5006, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Adult Genetics Unit, SA Pathology at the Women’s and Children’s Hospital, North Adelaide, SA 5006</wicri:regionArea>
<wicri:noRegion>SA 5006</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff45">University Department of Paediatrics, University of Adelaide, Adelaide, SA 5005, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University Department of Paediatrics, University of Adelaide, Adelaide, SA 5005</wicri:regionArea>
<wicri:noRegion>SA 5005</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Phillips, Kerry" sort="Phillips, Kerry" uniqKey="Phillips K" first="Kerry" last="Phillips">Kerry Phillips</name>
<affiliation wicri:level="1"><nlm:aff id="aff44">Adult Genetics Unit, SA Pathology at the Women’s and Children’s Hospital, North Adelaide, SA 5006, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Adult Genetics Unit, SA Pathology at the Women’s and Children’s Hospital, North Adelaide, SA 5006</wicri:regionArea>
<wicri:noRegion>SA 5006</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff45">University Department of Paediatrics, University of Adelaide, Adelaide, SA 5005, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University Department of Paediatrics, University of Adelaide, Adelaide, SA 5005</wicri:regionArea>
<wicri:noRegion>SA 5005</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schofield, Lyn" sort="Schofield, Lyn" uniqKey="Schofield L" first="Lyn" last="Schofield">Lyn Schofield</name>
<affiliation wicri:level="1"><nlm:aff id="aff46">Genetic Services of Western Australia, King Edward Memorial Hospital, Subiaco, WA 6008, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Services of Western Australia, King Edward Memorial Hospital, Subiaco, WA 6008</wicri:regionArea>
<wicri:noRegion>WA 6008</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Armstrong, Jacqueline" sort="Armstrong, Jacqueline" uniqKey="Armstrong J" first="Jacqueline" last="Armstrong">Jacqueline Armstrong</name>
<affiliation wicri:level="1"><nlm:aff id="aff44">Adult Genetics Unit, SA Pathology at the Women’s and Children’s Hospital, North Adelaide, SA 5006, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Adult Genetics Unit, SA Pathology at the Women’s and Children’s Hospital, North Adelaide, SA 5006</wicri:regionArea>
<wicri:noRegion>SA 5006</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kiraly Borri, Cathy" sort="Kiraly Borri, Cathy" uniqKey="Kiraly Borri C" first="Cathy" last="Kiraly-Borri">Cathy Kiraly-Borri</name>
<affiliation wicri:level="1"><nlm:aff id="aff46">Genetic Services of Western Australia, King Edward Memorial Hospital, Subiaco, WA 6008, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Services of Western Australia, King Edward Memorial Hospital, Subiaco, WA 6008</wicri:regionArea>
<wicri:noRegion>WA 6008</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Suthers, Graeme K" sort="Suthers, Graeme K" uniqKey="Suthers G" first="Graeme K." last="Suthers">Graeme K. Suthers</name>
<affiliation wicri:level="1"><nlm:aff id="aff45">University Department of Paediatrics, University of Adelaide, Adelaide, SA 5005, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University Department of Paediatrics, University of Adelaide, Adelaide, SA 5005</wicri:regionArea>
<wicri:noRegion>SA 5005</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huntsman, David G" sort="Huntsman, David G" uniqKey="Huntsman D" first="David G." last="Huntsman">David G. Huntsman</name>
<affiliation wicri:level="1"><nlm:aff id="aff7">Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, BC V5Z 1L3</wicri:regionArea>
<wicri:noRegion>BC V5Z 1L3</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff47">Department of Pathology and Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC V6Z 2K5, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Pathology and Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC V6Z 2K5</wicri:regionArea>
<wicri:noRegion>BC V6Z 2K5</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Foulkes, William D" sort="Foulkes, William D" uniqKey="Foulkes W" first="William D." last="Foulkes">William D. Foulkes</name>
<affiliation wicri:level="1"><nlm:aff id="aff20">Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montreal, QC H3T 1E2, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montreal, QC H3T 1E2</wicri:regionArea>
<wicri:noRegion>QC H3T 1E2</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff48">Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montreal, QC H3A 1B1</wicri:regionArea>
<orgName type="university">Université McGill</orgName>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Carneiro, Fatima" sort="Carneiro, Fatima" uniqKey="Carneiro F" first="Fatima" last="Carneiro">Fatima Carneiro</name>
<affiliation wicri:level="1"><nlm:aff id="aff30">Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP)/Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto 4200-135, Portugal</nlm:aff>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP)/Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto 4200-135</wicri:regionArea>
<wicri:noRegion>Porto 4200-135</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff49">Medical Faculty of the University of Porto/Centro Hospitalar São João, Porto 4200-319, Portugal</nlm:aff>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Medical Faculty of the University of Porto/Centro Hospitalar São João, Porto 4200-319</wicri:regionArea>
<wicri:noRegion>Porto 4200-319</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M." last="Lindor">Noralane M. Lindor</name>
<affiliation wicri:level="2"><nlm:aff id="aff50">Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ 85259, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ 85259</wicri:regionArea>
<placeName><region type="state">Arizona</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Edwards, Stacey L" sort="Edwards, Stacey L" uniqKey="Edwards S" first="Stacey L." last="Edwards">Stacey L. Edwards</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029</wicri:regionArea>
<wicri:noRegion>QLD 4029</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="French, Juliet D" sort="French, Juliet D" uniqKey="French J" first="Juliet D." last="French">Juliet D. French</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029</wicri:regionArea>
<wicri:noRegion>QLD 4029</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Waddell, Nicola" sort="Waddell, Nicola" uniqKey="Waddell N" first="Nicola" last="Waddell">Nicola Waddell</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029</wicri:regionArea>
<wicri:noRegion>QLD 4029</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4">Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072</wicri:regionArea>
<wicri:noRegion>QLD 4072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meltzer, Paul S" sort="Meltzer, Paul S" uniqKey="Meltzer P" first="Paul S." last="Meltzer">Paul S. Meltzer</name>
<affiliation wicri:level="2"><nlm:aff id="aff3">Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Worthley, Daniel L" sort="Worthley, Daniel L" uniqKey="Worthley D" first="Daniel L." last="Worthley">Daniel L. Worthley</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">School of Medicine, University of Adelaide and Cancer Theme, SAHMRI, Adelaide, SA 5000, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Medicine, University of Adelaide and Cancer Theme, SAHMRI, Adelaide, SA 5000</wicri:regionArea>
<wicri:noRegion>SA 5000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schrader, Kasmintan A" sort="Schrader, Kasmintan A" uniqKey="Schrader K" first="Kasmintan A." last="Schrader">Kasmintan A. Schrader</name>
<affiliation wicri:level="1"><nlm:aff id="aff6">Department of Medical Genetics, University of British Columbia, Vancouver, BC V6H 3N1, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medical Genetics, University of British Columbia, Vancouver, BC V6H 3N1</wicri:regionArea>
<wicri:noRegion>BC V6H 3N1</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff7">Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, BC V5Z 1L3</wicri:regionArea>
<wicri:noRegion>BC V5Z 1L3</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029</wicri:regionArea>
<wicri:noRegion>QLD 4029</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">American Journal of Human Genetics</title>
<idno type="ISSN">0002-9297</idno>
<idno type="eISSN">1537-6605</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenocarcinoma (genetics)</term>
<term>Adenomatous Polyposis Coli (genetics)</term>
<term>Adenomatous Polyposis Coli Protein (genetics)</term>
<term>Adenomatous Polyps (genetics)</term>
<term>Allelic Imbalance (genetics)</term>
<term>DNA Copy Number Variations (genetics)</term>
<term>Exome (genetics)</term>
<term>Exons (genetics)</term>
<term>Female</term>
<term>Gastric Mucosa (metabolism)</term>
<term>Genetic Linkage (genetics)</term>
<term>High-Throughput Nucleotide Sequencing (methods)</term>
<term>Humans</term>
<term>Loss of Heterozygosity</term>
<term>Male</term>
<term>Pedigree</term>
<term>Point Mutation (genetics)</term>
<term>Promoter Regions, Genetic (genetics)</term>
<term>Stomach Neoplasms (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adénocarcinome (génétique)</term>
<term>Déséquilibre allélique (génétique)</term>
<term>Exome (génétique)</term>
<term>Exons (génétique)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Liaison génétique (génétique)</term>
<term>Muqueuse gastrique (métabolisme)</term>
<term>Mutation ponctuelle (génétique)</term>
<term>Mâle</term>
<term>Pedigree</term>
<term>Perte d'hétérozygotie</term>
<term>Polypes adénomateux (génétique)</term>
<term>Polypose adénomateuse colique (génétique)</term>
<term>Protéine de la polypose adénomateuse colique (génétique)</term>
<term>Régions promotrices (génétique) (génétique)</term>
<term>Séquençage nucléotidique à haut débit ()</term>
<term>Tumeurs de l'estomac (génétique)</term>
<term>Variations de nombre de copies de segment d'ADN (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Adenomatous Polyposis Coli Protein</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenocarcinoma</term>
<term>Adenomatous Polyposis Coli</term>
<term>Adenomatous Polyps</term>
<term>Allelic Imbalance</term>
<term>DNA Copy Number Variations</term>
<term>Exome</term>
<term>Exons</term>
<term>Genetic Linkage</term>
<term>Point Mutation</term>
<term>Promoter Regions, Genetic</term>
<term>Stomach Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adénocarcinome</term>
<term>Déséquilibre allélique</term>
<term>Exome</term>
<term>Exons</term>
<term>Liaison génétique</term>
<term>Mutation ponctuelle</term>
<term>Polypes adénomateux</term>
<term>Polypose adénomateuse colique</term>
<term>Protéine de la polypose adénomateuse colique</term>
<term>Régions promotrices (génétique)</term>
<term>Tumeurs de l'estomac</term>
<term>Variations de nombre de copies de segment d'ADN</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Gastric Mucosa</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>High-Throughput Nucleotide Sequencing</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Muqueuse gastrique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Humans</term>
<term>Loss of Heterozygosity</term>
<term>Male</term>
<term>Pedigree</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Pedigree</term>
<term>Perte d'hétérozygotie</term>
<term>Séquençage nucléotidique à haut débit</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) is an autosomal-dominant cancer-predisposition syndrome with a significant risk of gastric, but not colorectal, adenocarcinoma. We mapped the gene to 5q22 and found loss of the wild-type allele on 5q in fundic gland polyps from affected individuals. Whole-exome and -genome sequencing failed to find causal mutations but, through Sanger sequencing, we identified point mutations in <italic>APC</italic>
promoter 1B that co-segregated with disease in all six families. The mutations reduced binding of the YY1 transcription factor and impaired activity of the <italic>APC</italic>
promoter 1B in luciferase assays. Analysis of blood and saliva from carriers showed allelic imbalance of <italic>APC</italic>
, suggesting that these mutations lead to decreased allele-specific expression in vivo. Similar mutations in <italic>APC</italic>
promoter 1B occur in rare families with familial adenomatous polyposis (FAP). Promoter 1A is methylated in GAPPS and sporadic FGPs and in normal stomach, which suggests that 1B transcripts are more important than 1A in gastric mucosa. This might explain why all known GAPPS-affected families carry promoter 1B point mutations but only rare FAP-affected families carry similar mutations, the colonic cells usually being protected by the expression of the 1A isoform. Gastric polyposis and cancer have been previously described in some FAP-affected individuals with large deletions around promoter 1B. Our finding that GAPPS is caused by point mutations in the same promoter suggests that families with mutations affecting the promoter 1B are at risk of gastric adenocarcinoma, regardless of whether or not colorectal polyps are present.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Canada</li>
<li>France</li>
<li>Portugal</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Alberta</li>
<li>Arizona</li>
<li>Illinois</li>
<li>Maryland</li>
<li>Minnesota</li>
<li>New Jersey</li>
<li>Oregon</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Québec</li>
<li>Utah</li>
<li>Victoria (État)</li>
</region>
<settlement><li>Calgary</li>
<li>Marseille</li>
<li>Melbourne</li>
<li>Montréal</li>
<li>Portland</li>
</settlement>
<orgName><li>Université McGill</li>
<li>Université d'Aix-Marseille</li>
<li>Université de Calgary</li>
<li>Université de Melbourne</li>
<li>Université des sciences et de la médecine de l'Oregon</li>
</orgName>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Li, Jun" sort="Li, Jun" uniqKey="Li J" first="Jun" last="Li">Jun Li</name>
</noRegion>
<name sortKey="Armstrong, Jacqueline" sort="Armstrong, Jacqueline" uniqKey="Armstrong J" first="Jacqueline" last="Armstrong">Jacqueline Armstrong</name>
<name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name>
<name sortKey="Bellos, Evangelos" sort="Bellos, Evangelos" uniqKey="Bellos E" first="Evangelos" last="Bellos">Evangelos Bellos</name>
<name sortKey="Bettington, Mark" sort="Bettington, Mark" uniqKey="Bettington M" first="Mark" last="Bettington">Mark Bettington</name>
<name sortKey="Bettington, Mark" sort="Bettington, Mark" uniqKey="Bettington M" first="Mark" last="Bettington">Mark Bettington</name>
<name sortKey="Bettington, Mark" sort="Bettington, Mark" uniqKey="Bettington M" first="Mark" last="Bettington">Mark Bettington</name>
<name sortKey="Boussioutas, Alex" sort="Boussioutas, Alex" uniqKey="Boussioutas A" first="Alex" last="Boussioutas">Alex Boussioutas</name>
<name sortKey="Boussioutas, Alex" sort="Boussioutas, Alex" uniqKey="Boussioutas A" first="Alex" last="Boussioutas">Alex Boussioutas</name>
<name sortKey="Boussioutas, Alex" sort="Boussioutas, Alex" uniqKey="Boussioutas A" first="Alex" last="Boussioutas">Alex Boussioutas</name>
<name sortKey="Boussioutas, Alex" sort="Boussioutas, Alex" uniqKey="Boussioutas A" first="Alex" last="Boussioutas">Alex Boussioutas</name>
<name sortKey="Busuttil, Rita A" sort="Busuttil, Rita A" uniqKey="Busuttil R" first="Rita A." last="Busuttil">Rita A. Busuttil</name>
<name sortKey="Busuttil, Rita A" sort="Busuttil, Rita A" uniqKey="Busuttil R" first="Rita A." last="Busuttil">Rita A. Busuttil</name>
<name sortKey="Busuttil, Rita A" sort="Busuttil, Rita A" uniqKey="Busuttil R" first="Rita A." last="Busuttil">Rita A. Busuttil</name>
<name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name>
<name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<name sortKey="Clouston, Andrew D" sort="Clouston, Andrew D" uniqKey="Clouston A" first="Andrew D." last="Clouston">Andrew D. Clouston</name>
<name sortKey="Clouston, Andrew D" sort="Clouston, Andrew D" uniqKey="Clouston A" first="Andrew D." last="Clouston">Andrew D. Clouston</name>
<name sortKey="Coin, Lachlan" sort="Coin, Lachlan" uniqKey="Coin L" first="Lachlan" last="Coin">Lachlan Coin</name>
<name sortKey="Da Silva, Leonard" sort="Da Silva, Leonard" uniqKey="Da Silva L" first="Leonard" last="Da Silva">Leonard Da Silva</name>
<name sortKey="Da Silva, Leonard" sort="Da Silva, Leonard" uniqKey="Da Silva L" first="Leonard" last="Da Silva">Leonard Da Silva</name>
<name sortKey="Di Costanzo, Natasha" sort="Di Costanzo, Natasha" uniqKey="Di Costanzo N" first="Natasha" last="Di Costanzo">Natasha Di Costanzo</name>
<name sortKey="Edwards, Stacey L" sort="Edwards, Stacey L" uniqKey="Edwards S" first="Stacey L." last="Edwards">Stacey L. Edwards</name>
<name sortKey="Faulkner, Geoffrey J" sort="Faulkner, Geoffrey J" uniqKey="Faulkner G" first="Geoffrey J." last="Faulkner">Geoffrey J. Faulkner</name>
<name sortKey="Ferreira, Manuel A" sort="Ferreira, Manuel A" uniqKey="Ferreira M" first="Manuel A." last="Ferreira">Manuel A. Ferreira</name>
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<name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name>
<name sortKey="Kiraly Borri, Cathy" sort="Kiraly Borri, Cathy" uniqKey="Kiraly Borri C" first="Cathy" last="Kiraly-Borri">Cathy Kiraly-Borri</name>
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<name sortKey="Lakhani, Sunil R" sort="Lakhani, Sunil R" uniqKey="Lakhani S" first="Sunil R." last="Lakhani">Sunil R. Lakhani</name>
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<name sortKey="Lee, Jason S" sort="Lee, Jason S" uniqKey="Lee J" first="Jason S." last="Lee">Jason S. Lee</name>
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<name sortKey="Pearson, John" sort="Pearson, John" uniqKey="Pearson J" first="John" last="Pearson">John Pearson</name>
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<name sortKey="Simpson, Peter T" sort="Simpson, Peter T" uniqKey="Simpson P" first="Peter T." last="Simpson">Peter T. Simpson</name>
<name sortKey="Simpson, Peter T" sort="Simpson, Peter T" uniqKey="Simpson P" first="Peter T." last="Simpson">Peter T. Simpson</name>
<name sortKey="Sivakumaran, Haran" sort="Sivakumaran, Haran" uniqKey="Sivakumaran H" first="Haran" last="Sivakumaran">Haran Sivakumaran</name>
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<name sortKey="Suthers, Graeme K" sort="Suthers, Graeme K" uniqKey="Suthers G" first="Graeme K." last="Suthers">Graeme K. Suthers</name>
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<name sortKey="Waddell, Nicola" sort="Waddell, Nicola" uniqKey="Waddell N" first="Nicola" last="Waddell">Nicola Waddell</name>
<name sortKey="Wayte, Nicci" sort="Wayte, Nicci" uniqKey="Wayte N" first="Nicci" last="Wayte">Nicci Wayte</name>
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<name sortKey="Worthley, Daniel L" sort="Worthley, Daniel L" uniqKey="Worthley D" first="Daniel L." last="Worthley">Daniel L. Worthley</name>
</country>
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</region>
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<name sortKey="Olschwang, Sylviane" sort="Olschwang, Sylviane" uniqKey="Olschwang S" first="Sylviane" last="Olschwang">Sylviane Olschwang</name>
<name sortKey="Olschwang, Sylviane" sort="Olschwang, Sylviane" uniqKey="Olschwang S" first="Sylviane" last="Olschwang">Sylviane Olschwang</name>
<name sortKey="Olschwang, Sylviane" sort="Olschwang, Sylviane" uniqKey="Olschwang S" first="Sylviane" last="Olschwang">Sylviane Olschwang</name>
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</country>
<country name="Portugal"><noRegion><name sortKey="Wen, Xiaogang" sort="Wen, Xiaogang" uniqKey="Wen X" first="Xiaogang" last="Wen">Xiaogang Wen</name>
</noRegion>
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<name sortKey="Wen, Xiaogang" sort="Wen, Xiaogang" uniqKey="Wen X" first="Xiaogang" last="Wen">Xiaogang Wen</name>
</country>
</tree>
</affiliations>
</record>
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