AustralieFrV1, Main, Exploration, bibRecordById, PMC:3898474

Combined Targeting of JAK2 and Bcl-2/Bcl-xL to Cure Mutant JAK2-Driven Malignancies and Overcome Acquired Resistance to JAK2 Inhibitors

Identifieur interne : 004785 ( Main/Exploration ); précédent : 004784; suivant : 004786

Combined Targeting of JAK2 and Bcl-2/Bcl-xL to Cure Mutant JAK2-Driven Malignancies and Overcome Acquired Resistance to JAK2 Inhibitors

Auteurs : Michaela Waibel [Australie] ; Vanessa S. Solomon [Australie] ; Deborah A. Knight [Australie] ; Rachael A. Ralli [Australie] ; Sang-Kyu Kim [Australie] ; Kellie-Marie Banks [Australie] ; Eva Vidacs [Australie] ; Clemence Virely [France] ; Keith C. S. Sia [Australie] ; Lauryn S. Bracken [Australie] ; Racquel Collins-Underwood [États-Unis] ; Christina Drenberg [États-Unis] ; Laura B. Ramsey [États-Unis] ; Sara C. Meyer [États-Unis] ; Megumi Takiguchi [Australie] ; Ross A. Dickins [Australie] ; Ross Levine [États-Unis] ; Jacques Ghysdael [France] ; Mark A. Dawson [Royaume-Uni] ; Richard B. Lock [Australie] ; Charles G. Mullighan [États-Unis] ; Ricky W. Johnstone [Australie]

Source :

Cell Reports [ 2211-1247 ] ; 2013.

RBID : PMC:3898474

Descripteurs français

English descriptors

KwdEn :
- Animals, Apoptosis (drug effects), Apoptosis Regulatory Proteins (genetics), Bcl-2-Like Protein 11, Biphenyl Compounds (pharmacology), Cell Line, Tumor, Cell Survival, Drug Resistance, Neoplasm, Gene Expression Profiling, Humans, Janus Kinase 2 (antagonists & inhibitors), Janus Kinase 2 (genetics), Membrane Proteins (genetics), Mice, Mice, Inbred C57BL, Mice, Inbred NOD, Mice, SCID, Neoplasm Transplantation, Nitrophenols (pharmacology), Piperazines (pharmacology), Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (drug therapy), Proto-Oncogene Proteins (genetics), Pyrazoles (pharmacology), Pyrimidines (pharmacology), Signal Transduction (drug effects), Sulfonamides (pharmacology), Transplantation, Heterologous, bcl-X Protein (antagonists & inhibitors), bcl-X Protein (genetics).
MESH :
- chemical , antagonists & inhibitors : Janus Kinase 2, bcl-X Protein.
- chemical , genetics : Apoptosis Regulatory Proteins, Janus Kinase 2, Membrane Proteins, Proto-Oncogene Proteins, bcl-X Protein.
- drug effects : Apoptosis, Signal Transduction.
- drug therapy : Precursor T-Cell Lymphoblastic Leukemia-Lymphoma.
- chemical , pharmacology : Biphenyl Compounds, Nitrophenols, Piperazines, Pyrazoles, Pyrimidines, Sulfonamides.
- Animals, Bcl-2-Like Protein 11, Cell Line, Tumor, Cell Survival, Drug Resistance, Neoplasm, Gene Expression Profiling, Humans, Mice, Mice, Inbred C57BL, Mice, Inbred NOD, Mice, SCID, Neoplasm Transplantation, Transplantation, Heterologous.

Abstract

Summary

To design rational therapies for JAK2-driven hematological malignancies, we functionally dissected the key survival pathways downstream of hyperactive JAK2. In tumors driven by mutant JAK2, Stat1, Stat3, Stat5, and the Pi3k and Mek/Erk pathways were constitutively active, and gene expression profiling of TEL-JAK2 T-ALL cells revealed the upregulation of prosurvival Bcl-2 family genes. Combining the Bcl-2/Bcl-xL inhibitor ABT-737 with JAK2 inhibitors mediated prolonged disease regressions and cures in mice bearing primary human and mouse JAK2 mutant tumors. Moreover, combined targeting of JAK2 and Bcl-2/Bcl-xL was able to circumvent and overcome acquired resistance to single-agent JAK2 inhibitor treatment. Thus, inhibiting the oncogenic JAK2 signaling network at two nodal points, at the initiating stage (JAK2) and the effector stage (Bcl-2/Bcl-xL), is highly effective and provides a clearly superior therapeutic benefit than targeting just one node. Therefore, we have defined a potentially curative treatment for hematological malignancies expressing constitutively active JAK2.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898474

DOI: 10.1016/j.celrep.2013.10.038
PubMed: 24268771
PubMed Central: 3898474

Affiliations:

Le document en format XML

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<author><name sortKey="Virely, Clemence" sort="Virely, Clemence" uniqKey="Virely C" first="Clemence" last="Virely">Clemence Virely</name>
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<author><name sortKey="Sia, Keith C S" sort="Sia, Keith C S" uniqKey="Sia K" first="Keith C. S." last="Sia">Keith C. S. Sia</name>
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<author><name sortKey="Bracken, Lauryn S" sort="Bracken, Lauryn S" uniqKey="Bracken L" first="Lauryn S." last="Bracken">Lauryn S. Bracken</name>
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<author><name sortKey="Collins Underwood, Racquel" sort="Collins Underwood, Racquel" uniqKey="Collins Underwood R" first="Racquel" last="Collins-Underwood">Racquel Collins-Underwood</name>
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<wicri:regionArea>Department of Pathology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105</wicri:regionArea>
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<author><name sortKey="Drenberg, Christina" sort="Drenberg, Christina" uniqKey="Drenberg C" first="Christina" last="Drenberg">Christina Drenberg</name>
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<author><name sortKey="Ramsey, Laura B" sort="Ramsey, Laura B" uniqKey="Ramsey L" first="Laura B." last="Ramsey">Laura B. Ramsey</name>
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</placeName>
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<author><name sortKey="Meyer, Sara C" sort="Meyer, Sara C" uniqKey="Meyer S" first="Sara C." last="Meyer">Sara C. Meyer</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10065</wicri:regionArea>
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</placeName>
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<author><name sortKey="Takiguchi, Megumi" sort="Takiguchi, Megumi" uniqKey="Takiguchi M" first="Megumi" last="Takiguchi">Megumi Takiguchi</name>
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<author><name sortKey="Dickins, Ross A" sort="Dickins, Ross A" uniqKey="Dickins R" first="Ross A." last="Dickins">Ross A. Dickins</name>
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<author><name sortKey="Levine, Ross" sort="Levine, Ross" uniqKey="Levine R" first="Ross" last="Levine">Ross Levine</name>
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</placeName>
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<author><name sortKey="Ghysdael, Jacques" sort="Ghysdael, Jacques" uniqKey="Ghysdael J" first="Jacques" last="Ghysdael">Jacques Ghysdael</name>
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</placeName>
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<author><name sortKey="Dawson, Mark A" sort="Dawson, Mark A" uniqKey="Dawson M" first="Mark A." last="Dawson">Mark A. Dawson</name>
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<wicri:regionArea>Gurdon Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN</wicri:regionArea>
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<affiliation wicri:level="4"><nlm:aff id="aff11">Department of Haematology, Cambridge Institute for Medical Research and Addenbrooke’s Hospital, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Haematology, Cambridge Institute for Medical Research and Addenbrooke’s Hospital, University of Cambridge, Hills Road, Cambridge CB2 0XY</wicri:regionArea>
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<author><name sortKey="Lock, Richard B" sort="Lock, Richard B" uniqKey="Lock R" first="Richard B." last="Lock">Richard B. Lock</name>
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<author><name sortKey="Johnstone, Ricky W" sort="Johnstone, Ricky W" uniqKey="Johnstone R" first="Ricky W." last="Johnstone">Ricky W. Johnstone</name>
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<affiliation wicri:level="4"><nlm:aff id="aff12">Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, 3052 VIC, Australia</nlm:aff>
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<wicri:regionArea>Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, 3052 VIC</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Combined Targeting of JAK2 and Bcl-2/Bcl-xL to Cure Mutant JAK2-Driven Malignancies and Overcome Acquired Resistance to JAK2 Inhibitors</title>
<author><name sortKey="Waibel, Michaela" sort="Waibel, Michaela" uniqKey="Waibel M" first="Michaela" last="Waibel">Michaela Waibel</name>
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<author><name sortKey="Solomon, Vanessa S" sort="Solomon, Vanessa S" uniqKey="Solomon V" first="Vanessa S." last="Solomon">Vanessa S. Solomon</name>
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<author><name sortKey="Knight, Deborah A" sort="Knight, Deborah A" uniqKey="Knight D" first="Deborah A." last="Knight">Deborah A. Knight</name>
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</author>
<author><name sortKey="Ralli, Rachael A" sort="Ralli, Rachael A" uniqKey="Ralli R" first="Rachael A." last="Ralli">Rachael A. Ralli</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Cancer Therapeutics Program, The Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, 3002 VIC, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Therapeutics Program, The Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, 3002 VIC</wicri:regionArea>
<wicri:noRegion>3002 VIC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Sang Kyu" sort="Kim, Sang Kyu" uniqKey="Kim S" first="Sang-Kyu" last="Kim">Sang-Kyu Kim</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Cancer Therapeutics Program, The Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, 3002 VIC, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Therapeutics Program, The Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, 3002 VIC</wicri:regionArea>
<wicri:noRegion>3002 VIC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Banks, Kellie Marie" sort="Banks, Kellie Marie" uniqKey="Banks K" first="Kellie-Marie" last="Banks">Kellie-Marie Banks</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Cancer Therapeutics Program, The Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, 3002 VIC, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Therapeutics Program, The Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, 3002 VIC</wicri:regionArea>
<wicri:noRegion>3002 VIC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vidacs, Eva" sort="Vidacs, Eva" uniqKey="Vidacs E" first="Eva" last="Vidacs">Eva Vidacs</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Cancer Therapeutics Program, The Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, 3002 VIC, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Therapeutics Program, The Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, 3002 VIC</wicri:regionArea>
<wicri:noRegion>3002 VIC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Virely, Clemence" sort="Virely, Clemence" uniqKey="Virely C" first="Clemence" last="Virely">Clemence Virely</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Institut Curie, Centre Universitaire, Bat 110, 91405 Orsay, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Curie, Centre Universitaire, Bat 110, 91405 Orsay</wicri:regionArea>
<wicri:noRegion>91405 Orsay</wicri:noRegion>
<wicri:noRegion>91405 Orsay</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3">Centre National de la Recherche Scientifique, Unite Mixte de Recherche 3306, Centre Universitaire, Bat 110, 91405 Orsay, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de la Recherche Scientifique, Unite Mixte de Recherche 3306, Centre Universitaire, Bat 110, 91405 Orsay</wicri:regionArea>
<wicri:noRegion>91405 Orsay</wicri:noRegion>
<wicri:noRegion>91405 Orsay</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4">Institut National de la Sante et al Recherche Medicale, Unite 1005, Centre Universitaire, Bat 110, 91405 Orsay, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Sante et al Recherche Medicale, Unite 1005, Centre Universitaire, Bat 110, 91405 Orsay</wicri:regionArea>
<wicri:noRegion>91405 Orsay</wicri:noRegion>
<wicri:noRegion>91405 Orsay</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sia, Keith C S" sort="Sia, Keith C S" uniqKey="Sia K" first="Keith C. S." last="Sia">Keith C. S. Sia</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW, Sydney, 2052 NSW, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW, Sydney, 2052 NSW</wicri:regionArea>
<wicri:noRegion>2052 NSW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bracken, Lauryn S" sort="Bracken, Lauryn S" uniqKey="Bracken L" first="Lauryn S." last="Bracken">Lauryn S. Bracken</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW, Sydney, 2052 NSW, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW, Sydney, 2052 NSW</wicri:regionArea>
<wicri:noRegion>2052 NSW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Collins Underwood, Racquel" sort="Collins Underwood, Racquel" uniqKey="Collins Underwood R" first="Racquel" last="Collins-Underwood">Racquel Collins-Underwood</name>
<affiliation wicri:level="2"><nlm:aff id="aff6">Department of Pathology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Drenberg, Christina" sort="Drenberg, Christina" uniqKey="Drenberg C" first="Christina" last="Drenberg">Christina Drenberg</name>
<affiliation wicri:level="2"><nlm:aff id="aff7">Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ramsey, Laura B" sort="Ramsey, Laura B" uniqKey="Ramsey L" first="Laura B." last="Ramsey">Laura B. Ramsey</name>
<affiliation wicri:level="2"><nlm:aff id="aff7">Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meyer, Sara C" sort="Meyer, Sara C" uniqKey="Meyer S" first="Sara C." last="Meyer">Sara C. Meyer</name>
<affiliation wicri:level="2"><nlm:aff id="aff8">Department of Medicine, Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10065</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Takiguchi, Megumi" sort="Takiguchi, Megumi" uniqKey="Takiguchi M" first="Megumi" last="Takiguchi">Megumi Takiguchi</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Molecular Medicine Division, Walter and Eliza Hall Institute of Medical Research, Parkville, 3052 VIC, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Molecular Medicine Division, Walter and Eliza Hall Institute of Medical Research, Parkville, 3052 VIC</wicri:regionArea>
<wicri:noRegion>3052 VIC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dickins, Ross A" sort="Dickins, Ross A" uniqKey="Dickins R" first="Ross A." last="Dickins">Ross A. Dickins</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Molecular Medicine Division, Walter and Eliza Hall Institute of Medical Research, Parkville, 3052 VIC, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Molecular Medicine Division, Walter and Eliza Hall Institute of Medical Research, Parkville, 3052 VIC</wicri:regionArea>
<wicri:noRegion>3052 VIC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Levine, Ross" sort="Levine, Ross" uniqKey="Levine R" first="Ross" last="Levine">Ross Levine</name>
<affiliation wicri:level="2"><nlm:aff id="aff8">Department of Medicine, Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10065</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ghysdael, Jacques" sort="Ghysdael, Jacques" uniqKey="Ghysdael J" first="Jacques" last="Ghysdael">Jacques Ghysdael</name>
<affiliation wicri:level="3"><nlm:aff id="aff2">Institut Curie, Centre Universitaire, Bat 110, 91405 Orsay, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Curie, Centre Universitaire, Bat 110, 91405 Orsay</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Orsay</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff3">Centre National de la Recherche Scientifique, Unite Mixte de Recherche 3306, Centre Universitaire, Bat 110, 91405 Orsay, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de la Recherche Scientifique, Unite Mixte de Recherche 3306, Centre Universitaire, Bat 110, 91405 Orsay</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Orsay</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff4">Institut National de la Sante et al Recherche Medicale, Unite 1005, Centre Universitaire, Bat 110, 91405 Orsay, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Sante et al Recherche Medicale, Unite 1005, Centre Universitaire, Bat 110, 91405 Orsay</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Orsay</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dawson, Mark A" sort="Dawson, Mark A" uniqKey="Dawson M" first="Mark A." last="Dawson">Mark A. Dawson</name>
<affiliation wicri:level="4"><nlm:aff id="aff10">Gurdon Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Gurdon Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff11">Department of Haematology, Cambridge Institute for Medical Research and Addenbrooke’s Hospital, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Haematology, Cambridge Institute for Medical Research and Addenbrooke’s Hospital, University of Cambridge, Hills Road, Cambridge CB2 0XY</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lock, Richard B" sort="Lock, Richard B" uniqKey="Lock R" first="Richard B." last="Lock">Richard B. Lock</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW, Sydney, 2052 NSW, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW, Sydney, 2052 NSW</wicri:regionArea>
<wicri:noRegion>2052 NSW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mullighan, Charles G" sort="Mullighan, Charles G" uniqKey="Mullighan C" first="Charles G." last="Mullighan">Charles G. Mullighan</name>
<affiliation wicri:level="2"><nlm:aff id="aff6">Department of Pathology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johnstone, Ricky W" sort="Johnstone, Ricky W" uniqKey="Johnstone R" first="Ricky W." last="Johnstone">Ricky W. Johnstone</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Cancer Therapeutics Program, The Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, 3002 VIC, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Therapeutics Program, The Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, 3002 VIC</wicri:regionArea>
<wicri:noRegion>3002 VIC</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff12">Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, 3052 VIC, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, 3052 VIC</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Cell Reports</title>
<idno type="eISSN">2211-1247</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Apoptosis (drug effects)</term>
<term>Apoptosis Regulatory Proteins (genetics)</term>
<term>Bcl-2-Like Protein 11</term>
<term>Biphenyl Compounds (pharmacology)</term>
<term>Cell Line, Tumor</term>
<term>Cell Survival</term>
<term>Drug Resistance, Neoplasm</term>
<term>Gene Expression Profiling</term>
<term>Humans</term>
<term>Janus Kinase 2 (antagonists & inhibitors)</term>
<term>Janus Kinase 2 (genetics)</term>
<term>Membrane Proteins (genetics)</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Inbred NOD</term>
<term>Mice, SCID</term>
<term>Neoplasm Transplantation</term>
<term>Nitrophenols (pharmacology)</term>
<term>Piperazines (pharmacology)</term>
<term>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (drug therapy)</term>
<term>Proto-Oncogene Proteins (genetics)</term>
<term>Pyrazoles (pharmacology)</term>
<term>Pyrimidines (pharmacology)</term>
<term>Signal Transduction (drug effects)</term>
<term>Sulfonamides (pharmacology)</term>
<term>Transplantation, Heterologous</term>
<term>bcl-X Protein (antagonists & inhibitors)</term>
<term>bcl-X Protein (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term>
<term>Animaux</term>
<term>Apoptose ()</term>
<term>Dérivés du biphényle (pharmacologie)</term>
<term>Humains</term>
<term>Kinase Janus-2 (antagonistes et inhibiteurs)</term>
<term>Kinase Janus-2 (génétique)</term>
<term>Leucémie-lymphome lymphoblastique à précurseurs T (traitement médicamenteux)</term>
<term>Lignée cellulaire tumorale</term>
<term>Nitrophénols (pharmacologie)</term>
<term>Pipérazines (pharmacologie)</term>
<term>Protéine bcl-X (antagonistes et inhibiteurs)</term>
<term>Protéine bcl-X (génétique)</term>
<term>Protéine-11 analogue à Bcl-2</term>
<term>Protéines membranaires (génétique)</term>
<term>Protéines proto-oncogènes (génétique)</term>
<term>Protéines régulatrices de l'apoptose (génétique)</term>
<term>Pyrazoles (pharmacologie)</term>
<term>Pyrimidines (pharmacologie)</term>
<term>Résistance aux médicaments antinéoplasiques</term>
<term>Souris</term>
<term>Souris SCID</term>
<term>Souris de lignée C57BL</term>
<term>Souris de lignée NOD</term>
<term>Sulfonamides (pharmacologie)</term>
<term>Survie cellulaire</term>
<term>Transduction du signal ()</term>
<term>Transplantation hétérologue</term>
<term>Transplantation tumorale</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Janus Kinase 2</term>
<term>bcl-X Protein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apoptosis Regulatory Proteins</term>
<term>Janus Kinase 2</term>
<term>Membrane Proteins</term>
<term>Proto-Oncogene Proteins</term>
<term>bcl-X Protein</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Kinase Janus-2</term>
<term>Protéine bcl-X</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Kinase Janus-2</term>
<term>Protéine bcl-X</term>
<term>Protéines membranaires</term>
<term>Protéines proto-oncogènes</term>
<term>Protéines régulatrices de l'apoptose</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Dérivés du biphényle</term>
<term>Nitrophénols</term>
<term>Pipérazines</term>
<term>Pyrazoles</term>
<term>Pyrimidines</term>
<term>Sulfonamides</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Biphenyl Compounds</term>
<term>Nitrophenols</term>
<term>Piperazines</term>
<term>Pyrazoles</term>
<term>Pyrimidines</term>
<term>Sulfonamides</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Leucémie-lymphome lymphoblastique à précurseurs T</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Bcl-2-Like Protein 11</term>
<term>Cell Line, Tumor</term>
<term>Cell Survival</term>
<term>Drug Resistance, Neoplasm</term>
<term>Gene Expression Profiling</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Inbred NOD</term>
<term>Mice, SCID</term>
<term>Neoplasm Transplantation</term>
<term>Transplantation, Heterologous</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term>
<term>Animaux</term>
<term>Apoptose</term>
<term>Humains</term>
<term>Lignée cellulaire tumorale</term>
<term>Protéine-11 analogue à Bcl-2</term>
<term>Résistance aux médicaments antinéoplasiques</term>
<term>Souris</term>
<term>Souris SCID</term>
<term>Souris de lignée C57BL</term>
<term>Souris de lignée NOD</term>
<term>Survie cellulaire</term>
<term>Transduction du signal</term>
<term>Transplantation hétérologue</term>
<term>Transplantation tumorale</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p>To design rational therapies for JAK2-driven hematological malignancies, we functionally dissected the key survival pathways downstream of hyperactive JAK2. In tumors driven by mutant JAK2, Stat1, Stat3, Stat5, and the Pi3k and Mek/Erk pathways were constitutively active, and gene expression profiling of TEL-JAK2 T-ALL cells revealed the upregulation of prosurvival Bcl-2 family genes. Combining the Bcl-2/Bcl-xL inhibitor ABT-737 with JAK2 inhibitors mediated prolonged disease regressions and cures in mice bearing primary human and mouse JAK2 mutant tumors. Moreover, combined targeting of JAK2 and Bcl-2/Bcl-xL was able to circumvent and overcome acquired resistance to single-agent JAK2 inhibitor treatment. Thus, inhibiting the oncogenic JAK2 signaling network at two nodal points, at the initiating stage (JAK2) and the effector stage (Bcl-2/Bcl-xL), is highly effective and provides a clearly superior therapeutic benefit than targeting just one node. Therefore, we have defined a potentially curative treatment for hematological malignancies expressing constitutively active JAK2.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Atallah, E" uniqKey="Atallah E">E. Atallah</name>
</author>
<author><name sortKey="Verstovsek, S" uniqKey="Verstovsek S">S. Verstovsek</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baxter, E J" uniqKey="Baxter E">E.J. Baxter</name>
</author>
<author><name sortKey="Scott, L M" uniqKey="Scott L">L.M. Scott</name>
</author>
<author><name sortKey="Campbell, P J" uniqKey="Campbell P">P.J. Campbell</name>
</author>
<author><name sortKey="East, C" uniqKey="East C">C. East</name>
</author>
<author><name sortKey="Fourouclas, N" uniqKey="Fourouclas N">N. Fourouclas</name>
</author>
<author><name sortKey="Swanton, S" uniqKey="Swanton S">S. Swanton</name>
</author>
<author><name sortKey="Vassiliou, G S" uniqKey="Vassiliou G">G.S. Vassiliou</name>
</author>
<author><name sortKey="Bench, A J" uniqKey="Bench A">A.J. Bench</name>
</author>
<author><name sortKey="Boyd, E M" uniqKey="Boyd E">E.M. Boyd</name>
</author>
<author><name sortKey="Curtin, N" uniqKey="Curtin N">N. Curtin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carron, C" uniqKey="Carron C">C. Carron</name>
</author>
<author><name sortKey="Cormier, F" uniqKey="Cormier F">F. Cormier</name>
</author>
<author><name sortKey="Janin, A" uniqKey="Janin A">A. Janin</name>
</author>
<author><name sortKey="Lacronique, V" uniqKey="Lacronique V">V. Lacronique</name>
</author>
<author><name sortKey="Giovannini, M" uniqKey="Giovannini M">M. Giovannini</name>
</author>
<author><name sortKey="Daniel, M T" uniqKey="Daniel M">M.T. Daniel</name>
</author>
<author><name sortKey="Bernard, O" uniqKey="Bernard O">O. Bernard</name>
</author>
<author><name sortKey="Ghysdael, J" uniqKey="Ghysdael J">J. Ghysdael</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cragg, M S" uniqKey="Cragg M">M.S. Cragg</name>
</author>
<author><name sortKey="Harris, C" uniqKey="Harris C">C. Harris</name>
</author>
<author><name sortKey="Strasser, A" uniqKey="Strasser A">A. Strasser</name>
</author>
<author><name sortKey="Scott, C L" uniqKey="Scott C">C.L. Scott</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dai, C" uniqKey="Dai C">C. Dai</name>
</author>
<author><name sortKey="Chung, I J" uniqKey="Chung I">I.J. Chung</name>
</author>
<author><name sortKey="Krantz, S B" uniqKey="Krantz S">S.B. Krantz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dawson, M A" uniqKey="Dawson M">M.A. Dawson</name>
</author>
<author><name sortKey="Bannister, A J" uniqKey="Bannister A">A.J. Bannister</name>
</author>
<author><name sortKey="Gottgens, B" uniqKey="Gottgens B">B. Göttgens</name>
</author>
<author><name sortKey="Foster, S D" uniqKey="Foster S">S.D. Foster</name>
</author>
<author><name sortKey="Bartke, T" uniqKey="Bartke T">T. Bartke</name>
</author>
<author><name sortKey="Green, A R" uniqKey="Green A">A.R. Green</name>
</author>
<author><name sortKey="Kouzarides, T" uniqKey="Kouzarides T">T. Kouzarides</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fiskus, W" uniqKey="Fiskus W">W. Fiskus</name>
</author>
<author><name sortKey="Verstovsek, S" uniqKey="Verstovsek S">S. Verstovsek</name>
</author>
<author><name sortKey="Manshouri, T" uniqKey="Manshouri T">T. Manshouri</name>
</author>
<author><name sortKey="Smith, J E" uniqKey="Smith J">J.E. Smith</name>
</author>
<author><name sortKey="Peth, K" uniqKey="Peth K">K. Peth</name>
</author>
<author><name sortKey="Abhyankar, S" uniqKey="Abhyankar S">S. Abhyankar</name>
</author>
<author><name sortKey="Mcguirk, J" uniqKey="Mcguirk J">J. McGuirk</name>
</author>
<author><name sortKey="Bhalla, K N" uniqKey="Bhalla K">K.N. Bhalla</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ghoreschi, K" uniqKey="Ghoreschi K">K. Ghoreschi</name>
</author>
<author><name sortKey="Laurence, A" uniqKey="Laurence A">A. Laurence</name>
</author>
<author><name sortKey="O Hea, J J" uniqKey="O Hea J">J.J. O’Shea</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Harvey, R C" uniqKey="Harvey R">R.C. Harvey</name>
</author>
<author><name sortKey="Mullighan, C G" uniqKey="Mullighan C">C.G. Mullighan</name>
</author>
<author><name sortKey="Chen, I M" uniqKey="Chen I">I.M. Chen</name>
</author>
<author><name sortKey="Wharton, W" uniqKey="Wharton W">W. Wharton</name>
</author>
<author><name sortKey="Mikhail, F M" uniqKey="Mikhail F">F.M. Mikhail</name>
</author>
<author><name sortKey="Carroll, A J" uniqKey="Carroll A">A.J. Carroll</name>
</author>
<author><name sortKey="Kang, H" uniqKey="Kang H">H. Kang</name>
</author>
<author><name sortKey="Liu, W" uniqKey="Liu W">W. Liu</name>
</author>
<author><name sortKey="Dobbin, K K" uniqKey="Dobbin K">K.K. Dobbin</name>
</author>
<author><name sortKey="Smith, M A" uniqKey="Smith M">M.A. Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hertzberg, L" uniqKey="Hertzberg L">L. Hertzberg</name>
</author>
<author><name sortKey="Vendramini, E" uniqKey="Vendramini E">E. Vendramini</name>
</author>
<author><name sortKey="Ganmore, I" uniqKey="Ganmore I">I. Ganmore</name>
</author>
<author><name sortKey="Cazzaniga, G" uniqKey="Cazzaniga G">G. Cazzaniga</name>
</author>
<author><name sortKey="Schmitz, M" uniqKey="Schmitz M">M. Schmitz</name>
</author>
<author><name sortKey="Chalker, J" uniqKey="Chalker J">J. Chalker</name>
</author>
<author><name sortKey="Shiloh, R" uniqKey="Shiloh R">R. Shiloh</name>
</author>
<author><name sortKey="Iacobucci, I" uniqKey="Iacobucci I">I. Iacobucci</name>
</author>
<author><name sortKey="Shochat, C" uniqKey="Shochat C">C. Shochat</name>
</author>
<author><name sortKey="Zeligson, S" uniqKey="Zeligson S">S. Zeligson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ho, J M" uniqKey="Ho J">J.M. Ho</name>
</author>
<author><name sortKey="Nguyen, M H" uniqKey="Nguyen M">M.H. Nguyen</name>
</author>
<author><name sortKey="Dierov, J K" uniqKey="Dierov J">J.K. Dierov</name>
</author>
<author><name sortKey="Badger, K M" uniqKey="Badger K">K.M. Badger</name>
</author>
<author><name sortKey="Beattie, B K" uniqKey="Beattie B">B.K. Beattie</name>
</author>
<author><name sortKey="Tartaro, P" uniqKey="Tartaro P">P. Tartaro</name>
</author>
<author><name sortKey="Haq, R" uniqKey="Haq R">R. Haq</name>
</author>
<author><name sortKey="Zanke, B W" uniqKey="Zanke B">B.W. Zanke</name>
</author>
<author><name sortKey="Carroll, M P" uniqKey="Carroll M">M.P. Carroll</name>
</author>
<author><name sortKey="Barber, D L" uniqKey="Barber D">D.L. Barber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="James, C" uniqKey="James C">C. James</name>
</author>
<author><name sortKey="Ugo, V" uniqKey="Ugo V">V. Ugo</name>
</author>
<author><name sortKey="Le Couedic, J P" uniqKey="Le Couedic J">J.P. Le Couédic</name>
</author>
<author><name sortKey="Staerk, J" uniqKey="Staerk J">J. Staerk</name>
</author>
<author><name sortKey="Delhommeau, F" uniqKey="Delhommeau F">F. Delhommeau</name>
</author>
<author><name sortKey="Lacout, C" uniqKey="Lacout C">C. Lacout</name>
</author>
<author><name sortKey="Garcon, L" uniqKey="Garcon L">L. Garçon</name>
</author>
<author><name sortKey="Raslova, H" uniqKey="Raslova H">H. Raslova</name>
</author>
<author><name sortKey="Berger, R" uniqKey="Berger R">R. Berger</name>
</author>
<author><name sortKey="Bennaceur Griscelli, A" uniqKey="Bennaceur Griscelli A">A. Bennaceur-Griscelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Knight, Z A" uniqKey="Knight Z">Z.A. Knight</name>
</author>
<author><name sortKey="Lin, H" uniqKey="Lin H">H. Lin</name>
</author>
<author><name sortKey="Shokat, K M" uniqKey="Shokat K">K.M. Shokat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Konopleva, M" uniqKey="Konopleva M">M. Konopleva</name>
</author>
<author><name sortKey="Contractor, R" uniqKey="Contractor R">R. Contractor</name>
</author>
<author><name sortKey="Tsao, T" uniqKey="Tsao T">T. Tsao</name>
</author>
<author><name sortKey="Samudio, I" uniqKey="Samudio I">I. Samudio</name>
</author>
<author><name sortKey="Ruvolo, P P" uniqKey="Ruvolo P">P.P. Ruvolo</name>
</author>
<author><name sortKey="Kitada, S" uniqKey="Kitada S">S. Kitada</name>
</author>
<author><name sortKey="Deng, X" uniqKey="Deng X">X. Deng</name>
</author>
<author><name sortKey="Zhai, D" uniqKey="Zhai D">D. Zhai</name>
</author>
<author><name sortKey="Shi, Y X" uniqKey="Shi Y">Y.X. Shi</name>
</author>
<author><name sortKey="Sneed, T" uniqKey="Sneed T">T. Sneed</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Koppikar, P" uniqKey="Koppikar P">P. Koppikar</name>
</author>
<author><name sortKey="Bhagwat, N" uniqKey="Bhagwat N">N. Bhagwat</name>
</author>
<author><name sortKey="Kilpivaara, O" uniqKey="Kilpivaara O">O. Kilpivaara</name>
</author>
<author><name sortKey="Manshouri, T" uniqKey="Manshouri T">T. Manshouri</name>
</author>
<author><name sortKey="Adli, M" uniqKey="Adli M">M. Adli</name>
</author>
<author><name sortKey="Hricik, T" uniqKey="Hricik T">T. Hricik</name>
</author>
<author><name sortKey="Liu, F" uniqKey="Liu F">F. Liu</name>
</author>
<author><name sortKey="Saunders, L M" uniqKey="Saunders L">L.M. Saunders</name>
</author>
<author><name sortKey="Mullally, A" uniqKey="Mullally A">A. Mullally</name>
</author>
<author><name sortKey="Abdel Wahab, O" uniqKey="Abdel Wahab O">O. Abdel-Wahab</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kralovics, R" uniqKey="Kralovics R">R. Kralovics</name>
</author>
<author><name sortKey="Passamonti, F" uniqKey="Passamonti F">F. Passamonti</name>
</author>
<author><name sortKey="Buser, A S" uniqKey="Buser A">A.S. Buser</name>
</author>
<author><name sortKey="Teo, S S" uniqKey="Teo S">S.S. Teo</name>
</author>
<author><name sortKey="Tiedt, R" uniqKey="Tiedt R">R. Tiedt</name>
</author>
<author><name sortKey="Passweg, J R" uniqKey="Passweg J">J.R. Passweg</name>
</author>
<author><name sortKey="Tichelli, A" uniqKey="Tichelli A">A. Tichelli</name>
</author>
<author><name sortKey="Cazzola, M" uniqKey="Cazzola M">M. Cazzola</name>
</author>
<author><name sortKey="Skoda, R C" uniqKey="Skoda R">R.C. Skoda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lacronique, V" uniqKey="Lacronique V">V. Lacronique</name>
</author>
<author><name sortKey="Boureux, A" uniqKey="Boureux A">A. Boureux</name>
</author>
<author><name sortKey="Valle, V D" uniqKey="Valle V">V.D. Valle</name>
</author>
<author><name sortKey="Poirel, H" uniqKey="Poirel H">H. Poirel</name>
</author>
<author><name sortKey="Quang, C T" uniqKey="Quang C">C.T. Quang</name>
</author>
<author><name sortKey="Mauchauffe, M" uniqKey="Mauchauffe M">M. Mauchauffé</name>
</author>
<author><name sortKey="Berthou, C" uniqKey="Berthou C">C. Berthou</name>
</author>
<author><name sortKey="Lessard, M" uniqKey="Lessard M">M. Lessard</name>
</author>
<author><name sortKey="Berger, R" uniqKey="Berger R">R. Berger</name>
</author>
<author><name sortKey="Ghysdael, J" uniqKey="Ghysdael J">J. Ghysdael</name>
</author>
<author><name sortKey="Bernard, O A" uniqKey="Bernard O">O.A. Bernard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lessene, G" uniqKey="Lessene G">G. Lessene</name>
</author>
<author><name sortKey="Czabotar, P E" uniqKey="Czabotar P">P.E. Czabotar</name>
</author>
<author><name sortKey="Sleebs, B E" uniqKey="Sleebs B">B.E. Sleebs</name>
</author>
<author><name sortKey="Zobel, K" uniqKey="Zobel K">K. Zobel</name>
</author>
<author><name sortKey="Lowes, K N" uniqKey="Lowes K">K.N. Lowes</name>
</author>
<author><name sortKey="Adams, J M" uniqKey="Adams J">J.M. Adams</name>
</author>
<author><name sortKey="Baell, J B" uniqKey="Baell J">J.B. Baell</name>
</author>
<author><name sortKey="Colman, P M" uniqKey="Colman P">P.M. Colman</name>
</author>
<author><name sortKey="Deshayes, K" uniqKey="Deshayes K">K. Deshayes</name>
</author>
<author><name sortKey="Fairbrother, W J" uniqKey="Fairbrother W">W.J. Fairbrother</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Levine, R L" uniqKey="Levine R">R.L. Levine</name>
</author>
<author><name sortKey="Wadleigh, M" uniqKey="Wadleigh M">M. Wadleigh</name>
</author>
<author><name sortKey="Cools, J" uniqKey="Cools J">J. Cools</name>
</author>
<author><name sortKey="Ebert, B L" uniqKey="Ebert B">B.L. Ebert</name>
</author>
<author><name sortKey="Wernig, G" uniqKey="Wernig G">G. Wernig</name>
</author>
<author><name sortKey="Huntly, B J" uniqKey="Huntly B">B.J. Huntly</name>
</author>
<author><name sortKey="Boggon, T J" uniqKey="Boggon T">T.J. Boggon</name>
</author>
<author><name sortKey="Wlodarska, I" uniqKey="Wlodarska I">I. Wlodarska</name>
</author>
<author><name sortKey="Clark, J J" uniqKey="Clark J">J.J. Clark</name>
</author>
<author><name sortKey="Moore, S" uniqKey="Moore S">S. Moore</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marty, C" uniqKey="Marty C">C. Marty</name>
</author>
<author><name sortKey="Lacout, C" uniqKey="Lacout C">C. Lacout</name>
</author>
<author><name sortKey="Martin, A" uniqKey="Martin A">A. Martin</name>
</author>
<author><name sortKey="Hasan, S" uniqKey="Hasan S">S. Hasan</name>
</author>
<author><name sortKey="Jacquot, S" uniqKey="Jacquot S">S. Jacquot</name>
</author>
<author><name sortKey="Birling, M C" uniqKey="Birling M">M.C. Birling</name>
</author>
<author><name sortKey="Vainchenker, W" uniqKey="Vainchenker W">W. Vainchenker</name>
</author>
<author><name sortKey="Villeval, J L" uniqKey="Villeval J">J.L. Villeval</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maude, S L" uniqKey="Maude S">S.L. Maude</name>
</author>
<author><name sortKey="Tasian, S K" uniqKey="Tasian S">S.K. Tasian</name>
</author>
<author><name sortKey="Vincent, T" uniqKey="Vincent T">T. Vincent</name>
</author>
<author><name sortKey="Hall, J W" uniqKey="Hall J">J.W. Hall</name>
</author>
<author><name sortKey="Sheen, C" uniqKey="Sheen C">C. Sheen</name>
</author>
<author><name sortKey="Roberts, K G" uniqKey="Roberts K">K.G. Roberts</name>
</author>
<author><name sortKey="Seif, A E" uniqKey="Seif A">A.E. Seif</name>
</author>
<author><name sortKey="Barrett, D M" uniqKey="Barrett D">D.M. Barrett</name>
</author>
<author><name sortKey="Chen, I M" uniqKey="Chen I">I.M. Chen</name>
</author>
<author><name sortKey="Collins, J R" uniqKey="Collins J">J.R. Collins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Merino, D" uniqKey="Merino D">D. Mérino</name>
</author>
<author><name sortKey="Khaw, S L" uniqKey="Khaw S">S.L. Khaw</name>
</author>
<author><name sortKey="Glaser, S P" uniqKey="Glaser S">S.P. Glaser</name>
</author>
<author><name sortKey="Anderson, D J" uniqKey="Anderson D">D.J. Anderson</name>
</author>
<author><name sortKey="Belmont, L D" uniqKey="Belmont L">L.D. Belmont</name>
</author>
<author><name sortKey="Wong, C" uniqKey="Wong C">C. Wong</name>
</author>
<author><name sortKey="Yue, P" uniqKey="Yue P">P. Yue</name>
</author>
<author><name sortKey="Robati, M" uniqKey="Robati M">M. Robati</name>
</author>
<author><name sortKey="Phipson, B" uniqKey="Phipson B">B. Phipson</name>
</author>
<author><name sortKey="Fairlie, W D" uniqKey="Fairlie W">W.D. Fairlie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mullally, A" uniqKey="Mullally A">A. Mullally</name>
</author>
<author><name sortKey="Lane, S W" uniqKey="Lane S">S.W. Lane</name>
</author>
<author><name sortKey="Ball, B" uniqKey="Ball B">B. Ball</name>
</author>
<author><name sortKey="Megerdichian, C" uniqKey="Megerdichian C">C. Megerdichian</name>
</author>
<author><name sortKey="Okabe, R" uniqKey="Okabe R">R. Okabe</name>
</author>
<author><name sortKey="Al Shahrour, F" uniqKey="Al Shahrour F">F. Al-Shahrour</name>
</author>
<author><name sortKey="Paktinat, M" uniqKey="Paktinat M">M. Paktinat</name>
</author>
<author><name sortKey="Haydu, J E" uniqKey="Haydu J">J.E. Haydu</name>
</author>
<author><name sortKey="Housman, E" uniqKey="Housman E">E. Housman</name>
</author>
<author><name sortKey="Lord, A M" uniqKey="Lord A">A.M. Lord</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mullighan, C G" uniqKey="Mullighan C">C.G. Mullighan</name>
</author>
<author><name sortKey="Collins Underwood, J R" uniqKey="Collins Underwood J">J.R. Collins-Underwood</name>
</author>
<author><name sortKey="Phillips, L A" uniqKey="Phillips L">L.A. Phillips</name>
</author>
<author><name sortKey="Loudin, M G" uniqKey="Loudin M">M.G. Loudin</name>
</author>
<author><name sortKey="Liu, W" uniqKey="Liu W">W. Liu</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name>
</author>
<author><name sortKey="Ma, J" uniqKey="Ma J">J. Ma</name>
</author>
<author><name sortKey="Coustan Smith, E" uniqKey="Coustan Smith E">E. Coustan-Smith</name>
</author>
<author><name sortKey="Harvey, R C" uniqKey="Harvey R">R.C. Harvey</name>
</author>
<author><name sortKey="Willman, C L" uniqKey="Willman C">C.L. Willman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mullighan, C G" uniqKey="Mullighan C">C.G. Mullighan</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name>
</author>
<author><name sortKey="Harvey, R C" uniqKey="Harvey R">R.C. Harvey</name>
</author>
<author><name sortKey="Collins Underwood, J R" uniqKey="Collins Underwood J">J.R. Collins-Underwood</name>
</author>
<author><name sortKey="Schulman, B A" uniqKey="Schulman B">B.A. Schulman</name>
</author>
<author><name sortKey="Phillips, L A" uniqKey="Phillips L">L.A. Phillips</name>
</author>
<author><name sortKey="Tasian, S K" uniqKey="Tasian S">S.K. Tasian</name>
</author>
<author><name sortKey="Loh, M L" uniqKey="Loh M">M.L. Loh</name>
</author>
<author><name sortKey="Su, X" uniqKey="Su X">X. Su</name>
</author>
<author><name sortKey="Liu, W" uniqKey="Liu W">W. Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nguyen, M H" uniqKey="Nguyen M">M.H. Nguyen</name>
</author>
<author><name sortKey="Ho, J M" uniqKey="Ho J">J.M. Ho</name>
</author>
<author><name sortKey="Beattie, B K" uniqKey="Beattie B">B.K. Beattie</name>
</author>
<author><name sortKey="Barber, D L" uniqKey="Barber D">D.L. Barber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oltersdorf, T" uniqKey="Oltersdorf T">T. Oltersdorf</name>
</author>
<author><name sortKey="Elmore, S W" uniqKey="Elmore S">S.W. Elmore</name>
</author>
<author><name sortKey="Shoemaker, A R" uniqKey="Shoemaker A">A.R. Shoemaker</name>
</author>
<author><name sortKey="Armstrong, R C" uniqKey="Armstrong R">R.C. Armstrong</name>
</author>
<author><name sortKey="Augeri, D J" uniqKey="Augeri D">D.J. Augeri</name>
</author>
<author><name sortKey="Belli, B A" uniqKey="Belli B">B.A. Belli</name>
</author>
<author><name sortKey="Bruncko, M" uniqKey="Bruncko M">M. Bruncko</name>
</author>
<author><name sortKey="Deckwerth, T L" uniqKey="Deckwerth T">T.L. Deckwerth</name>
</author>
<author><name sortKey="Dinges, J" uniqKey="Dinges J">J. Dinges</name>
</author>
<author><name sortKey="Hajduk, P J" uniqKey="Hajduk P">P.J. Hajduk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pardanani, A" uniqKey="Pardanani A">A. Pardanani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pardanani, A" uniqKey="Pardanani A">A. Pardanani</name>
</author>
<author><name sortKey="Hood, J" uniqKey="Hood J">J. Hood</name>
</author>
<author><name sortKey="Lasho, T" uniqKey="Lasho T">T. Lasho</name>
</author>
<author><name sortKey="Levine, R L" uniqKey="Levine R">R.L. Levine</name>
</author>
<author><name sortKey="Martin, M B" uniqKey="Martin M">M.B. Martin</name>
</author>
<author><name sortKey="Noronha, G" uniqKey="Noronha G">G. Noronha</name>
</author>
<author><name sortKey="Finke, C" uniqKey="Finke C">C. Finke</name>
</author>
<author><name sortKey="Mak, C C" uniqKey="Mak C">C.C. Mak</name>
</author>
<author><name sortKey="Mesa, R" uniqKey="Mesa R">R. Mesa</name>
</author>
<author><name sortKey="Zhu, H" uniqKey="Zhu H">H. Zhu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roberts, K G" uniqKey="Roberts K">K.G. Roberts</name>
</author>
<author><name sortKey="Morin, R D" uniqKey="Morin R">R.D. Morin</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name>
</author>
<author><name sortKey="Hirst, M" uniqKey="Hirst M">M. Hirst</name>
</author>
<author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y. Zhao</name>
</author>
<author><name sortKey="Su, X" uniqKey="Su X">X. Su</name>
</author>
<author><name sortKey="Chen, S C" uniqKey="Chen S">S.C. Chen</name>
</author>
<author><name sortKey="Payne Turner, D" uniqKey="Payne Turner D">D. Payne-Turner</name>
</author>
<author><name sortKey="Churchman, M L" uniqKey="Churchman M">M.L. Churchman</name>
</author>
<author><name sortKey="Harvey, R C" uniqKey="Harvey R">R.C. Harvey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roder, S" uniqKey="Roder S">S. Röder</name>
</author>
<author><name sortKey="Steimle, C" uniqKey="Steimle C">C. Steimle</name>
</author>
<author><name sortKey="Meinhardt, G" uniqKey="Meinhardt G">G. Meinhardt</name>
</author>
<author><name sortKey="Pahl, H L" uniqKey="Pahl H">H.L. Pahl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Santos, F P" uniqKey="Santos F">F.P. Santos</name>
</author>
<author><name sortKey="Verstovsek, S" uniqKey="Verstovsek S">S. Verstovsek</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sayyah, J" uniqKey="Sayyah J">J. Sayyah</name>
</author>
<author><name sortKey="Sayeski, P P" uniqKey="Sayeski P">P.P. Sayeski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schwaller, J" uniqKey="Schwaller J">J. Schwaller</name>
</author>
<author><name sortKey="Frantsve, J" uniqKey="Frantsve J">J. Frantsve</name>
</author>
<author><name sortKey="Aster, J" uniqKey="Aster J">J. Aster</name>
</author>
<author><name sortKey="Williams, I R" uniqKey="Williams I">I.R. Williams</name>
</author>
<author><name sortKey="Tomasson, M H" uniqKey="Tomasson M">M.H. Tomasson</name>
</author>
<author><name sortKey="Ross, T S" uniqKey="Ross T">T.S. Ross</name>
</author>
<author><name sortKey="Peeters, P" uniqKey="Peeters P">P. Peeters</name>
</author>
<author><name sortKey="Van Rompaey, L" uniqKey="Van Rompaey L">L. Van Rompaey</name>
</author>
<author><name sortKey="Van Etten, R A" uniqKey="Van Etten R">R.A. Van Etten</name>
</author>
<author><name sortKey="Ilaria, R" uniqKey="Ilaria R">R. Ilaria</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Silva, M" uniqKey="Silva M">M. Silva</name>
</author>
<author><name sortKey="Richard, C" uniqKey="Richard C">C. Richard</name>
</author>
<author><name sortKey="Benito, A" uniqKey="Benito A">A. Benito</name>
</author>
<author><name sortKey="Sanz, C" uniqKey="Sanz C">C. Sanz</name>
</author>
<author><name sortKey="Olalla, I" uniqKey="Olalla I">I. Olalla</name>
</author>
<author><name sortKey="Fernandez Luna, J L" uniqKey="Fernandez Luna J">J.L. Fernández-Luna</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Souers, A J" uniqKey="Souers A">A.J. Souers</name>
</author>
<author><name sortKey="Leverson, J D" uniqKey="Leverson J">J.D. Leverson</name>
</author>
<author><name sortKey="Boghaert, E R" uniqKey="Boghaert E">E.R. Boghaert</name>
</author>
<author><name sortKey="Ackler, S L" uniqKey="Ackler S">S.L. Ackler</name>
</author>
<author><name sortKey="Catron, N D" uniqKey="Catron N">N.D. Catron</name>
</author>
<author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name>
</author>
<author><name sortKey="Dayton, B D" uniqKey="Dayton B">B.D. Dayton</name>
</author>
<author><name sortKey="Ding, H" uniqKey="Ding H">H. Ding</name>
</author>
<author><name sortKey="Enschede, S H" uniqKey="Enschede S">S.H. Enschede</name>
</author>
<author><name sortKey="Fairbrother, W J" uniqKey="Fairbrother W">W.J. Fairbrother</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stein, B L" uniqKey="Stein B">B.L. Stein</name>
</author>
<author><name sortKey="Crispino, J D" uniqKey="Crispino J">J.D. Crispino</name>
</author>
<author><name sortKey="Moliterno, A R" uniqKey="Moliterno A">A.R. Moliterno</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Roosbroeck, K" uniqKey="Van Roosbroeck K">K. Van Roosbroeck</name>
</author>
<author><name sortKey="Cox, L" uniqKey="Cox L">L. Cox</name>
</author>
<author><name sortKey="Tousseyn, T" uniqKey="Tousseyn T">T. Tousseyn</name>
</author>
<author><name sortKey="Lahortiga, I" uniqKey="Lahortiga I">I. Lahortiga</name>
</author>
<author><name sortKey="Gielen, O" uniqKey="Gielen O">O. Gielen</name>
</author>
<author><name sortKey="Cauwelier, B" uniqKey="Cauwelier B">B. Cauwelier</name>
</author>
<author><name sortKey="De Paepe, P" uniqKey="De Paepe P">P. De Paepe</name>
</author>
<author><name sortKey="Verhoef, G" uniqKey="Verhoef G">G. Verhoef</name>
</author>
<author><name sortKey="Marynen, P" uniqKey="Marynen P">P. Marynen</name>
</author>
<author><name sortKey="Vandenberghe, P" uniqKey="Vandenberghe P">P. Vandenberghe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weigert, O" uniqKey="Weigert O">O. Weigert</name>
</author>
<author><name sortKey="Lane, A A" uniqKey="Lane A">A.A. Lane</name>
</author>
<author><name sortKey="Bird, L" uniqKey="Bird L">L. Bird</name>
</author>
<author><name sortKey="Kopp, N" uniqKey="Kopp N">N. Kopp</name>
</author>
<author><name sortKey="Chapuy, B" uniqKey="Chapuy B">B. Chapuy</name>
</author>
<author><name sortKey="Van Bodegom, D" uniqKey="Van Bodegom D">D. van Bodegom</name>
</author>
<author><name sortKey="Toms, A V" uniqKey="Toms A">A.V. Toms</name>
</author>
<author><name sortKey="Marubayashi, S" uniqKey="Marubayashi S">S. Marubayashi</name>
</author>
<author><name sortKey="Christie, A L" uniqKey="Christie A">A.L. Christie</name>
</author>
<author><name sortKey="Mckeown, M" uniqKey="Mckeown M">M. McKeown</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Whitecross, K F" uniqKey="Whitecross K">K.F. Whitecross</name>
</author>
<author><name sortKey="Alsop, A E" uniqKey="Alsop A">A.E. Alsop</name>
</author>
<author><name sortKey="Cluse, L A" uniqKey="Cluse L">L.A. Cluse</name>
</author>
<author><name sortKey="Wiegmans, A" uniqKey="Wiegmans A">A. Wiegmans</name>
</author>
<author><name sortKey="Banks, K M" uniqKey="Banks K">K.M. Banks</name>
</author>
<author><name sortKey="Coomans, C" uniqKey="Coomans C">C. Coomans</name>
</author>
<author><name sortKey="Peart, M J" uniqKey="Peart M">M.J. Peart</name>
</author>
<author><name sortKey="Newbold, A" uniqKey="Newbold A">A. Newbold</name>
</author>
<author><name sortKey="Lindemann, R K" uniqKey="Lindemann R">R.K. Lindemann</name>
</author>
<author><name sortKey="Johnstone, R W" uniqKey="Johnstone R">R.W. Johnstone</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Will, B" uniqKey="Will B">B. Will</name>
</author>
<author><name sortKey="Siddiqi, T" uniqKey="Siddiqi T">T. Siddiqi</name>
</author>
<author><name sortKey="Jorda, M A" uniqKey="Jorda M">M.A. Jordà</name>
</author>
<author><name sortKey="Shimamura, T" uniqKey="Shimamura T">T. Shimamura</name>
</author>
<author><name sortKey="Luptakova, K" uniqKey="Luptakova K">K. Luptakova</name>
</author>
<author><name sortKey="Staber, P B" uniqKey="Staber P">P.B. Staber</name>
</author>
<author><name sortKey="Costa, D B" uniqKey="Costa D">D.B. Costa</name>
</author>
<author><name sortKey="Steidl, U" uniqKey="Steidl U">U. Steidl</name>
</author>
<author><name sortKey="Tenen, D G" uniqKey="Tenen D">D.G. Tenen</name>
</author>
<author><name sortKey="Kobayashi, S" uniqKey="Kobayashi S">S. Kobayashi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zeuner, A" uniqKey="Zeuner A">A. Zeuner</name>
</author>
<author><name sortKey="Pedini, F" uniqKey="Pedini F">F. Pedini</name>
</author>
<author><name sortKey="Francescangeli, F" uniqKey="Francescangeli F">F. Francescangeli</name>
</author>
<author><name sortKey="Signore, M" uniqKey="Signore M">M. Signore</name>
</author>
<author><name sortKey="Girelli, G" uniqKey="Girelli G">G. Girelli</name>
</author>
<author><name sortKey="Tafuri, A" uniqKey="Tafuri A">A. Tafuri</name>
</author>
<author><name sortKey="De Maria, R" uniqKey="De Maria R">R. De Maria</name>
</author>
</analytic>
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<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Angleterre de l'Est</li>
<li>Tennessee</li>
<li>Victoria (État)</li>
<li>État de New York</li>
<li>Île-de-France</li>
</region>
<settlement><li>Cambridge</li>
<li>Melbourne</li>
<li>Orsay</li>
</settlement>
<orgName><li>Université de Cambridge</li>
<li>Université de Melbourne</li>
</orgName>
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<name sortKey="Johnstone, Ricky W" sort="Johnstone, Ricky W" uniqKey="Johnstone R" first="Ricky W." last="Johnstone">Ricky W. Johnstone</name>
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<name sortKey="Kim, Sang Kyu" sort="Kim, Sang Kyu" uniqKey="Kim S" first="Sang-Kyu" last="Kim">Sang-Kyu Kim</name>
<name sortKey="Knight, Deborah A" sort="Knight, Deborah A" uniqKey="Knight D" first="Deborah A." last="Knight">Deborah A. Knight</name>
<name sortKey="Lock, Richard B" sort="Lock, Richard B" uniqKey="Lock R" first="Richard B." last="Lock">Richard B. Lock</name>
<name sortKey="Ralli, Rachael A" sort="Ralli, Rachael A" uniqKey="Ralli R" first="Rachael A." last="Ralli">Rachael A. Ralli</name>
<name sortKey="Sia, Keith C S" sort="Sia, Keith C S" uniqKey="Sia K" first="Keith C. S." last="Sia">Keith C. S. Sia</name>
<name sortKey="Solomon, Vanessa S" sort="Solomon, Vanessa S" uniqKey="Solomon V" first="Vanessa S." last="Solomon">Vanessa S. Solomon</name>
<name sortKey="Takiguchi, Megumi" sort="Takiguchi, Megumi" uniqKey="Takiguchi M" first="Megumi" last="Takiguchi">Megumi Takiguchi</name>
<name sortKey="Vidacs, Eva" sort="Vidacs, Eva" uniqKey="Vidacs E" first="Eva" last="Vidacs">Eva Vidacs</name>
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<country name="France"><noRegion><name sortKey="Virely, Clemence" sort="Virely, Clemence" uniqKey="Virely C" first="Clemence" last="Virely">Clemence Virely</name>
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<name sortKey="Ghysdael, Jacques" sort="Ghysdael, Jacques" uniqKey="Ghysdael J" first="Jacques" last="Ghysdael">Jacques Ghysdael</name>
<name sortKey="Ghysdael, Jacques" sort="Ghysdael, Jacques" uniqKey="Ghysdael J" first="Jacques" last="Ghysdael">Jacques Ghysdael</name>
<name sortKey="Ghysdael, Jacques" sort="Ghysdael, Jacques" uniqKey="Ghysdael J" first="Jacques" last="Ghysdael">Jacques Ghysdael</name>
<name sortKey="Virely, Clemence" sort="Virely, Clemence" uniqKey="Virely C" first="Clemence" last="Virely">Clemence Virely</name>
<name sortKey="Virely, Clemence" sort="Virely, Clemence" uniqKey="Virely C" first="Clemence" last="Virely">Clemence Virely</name>
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<country name="États-Unis"><region name="Tennessee"><name sortKey="Collins Underwood, Racquel" sort="Collins Underwood, Racquel" uniqKey="Collins Underwood R" first="Racquel" last="Collins-Underwood">Racquel Collins-Underwood</name>
</region>
<name sortKey="Drenberg, Christina" sort="Drenberg, Christina" uniqKey="Drenberg C" first="Christina" last="Drenberg">Christina Drenberg</name>
<name sortKey="Levine, Ross" sort="Levine, Ross" uniqKey="Levine R" first="Ross" last="Levine">Ross Levine</name>
<name sortKey="Meyer, Sara C" sort="Meyer, Sara C" uniqKey="Meyer S" first="Sara C." last="Meyer">Sara C. Meyer</name>
<name sortKey="Mullighan, Charles G" sort="Mullighan, Charles G" uniqKey="Mullighan C" first="Charles G." last="Mullighan">Charles G. Mullighan</name>
<name sortKey="Ramsey, Laura B" sort="Ramsey, Laura B" uniqKey="Ramsey L" first="Laura B." last="Ramsey">Laura B. Ramsey</name>
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<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Dawson, Mark A" sort="Dawson, Mark A" uniqKey="Dawson M" first="Mark A." last="Dawson">Mark A. Dawson</name>
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Serveur d'exploration sur les relations entre la France et l'Australie

Combined Targeting of JAK2 and Bcl-2/Bcl-xL to Cure Mutant JAK2-Driven Malignancies and Overcome Acquired Resistance to JAK2 Inhibitors

Combined Targeting of JAK2 and Bcl-2/Bcl-xL to Cure Mutant JAK2-Driven Malignancies and Overcome Acquired Resistance to JAK2 Inhibitors

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	Serveur d'exploration sur les relations entre la France et l'Australie
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