AustralieFrV1, Main, Exploration, bibRecordById, PMC:375196

Dendritic cell populations in Leishmania major-infected skin and draining lymph nodes

Identifieur interne : 00AD20 ( Main/Exploration ); précédent : 00AD19; suivant : 00AD21

Dendritic cell populations in Leishmania major-infected skin and draining lymph nodes

Auteurs : Tracey Baldwin [Australie] ; Sandrine Henri [France] ; Joan Curtis [Australie] ; Meredith O'Keeffe [Australie] ; David Vremec [Australie] ; Ken Shortman [Australie] ; Emanuela Handman [Australie]

Source :

Infection and immunity [ 0019-9567 ] ; 2004.

RBID : Pascal:04-0216456

Descripteurs français

Pascal (Inist)
- Leishmania major, Cellule dendritique, Population cellulaire, Cellule infectée, Peau, Ganglion lymphatique, Immunologie, Immunopathologie, Infection, Microbiologie, Immunité.
Wicri :
- topic : Immunologie.

English descriptors

KwdEn :
- Cell population, Dendritic cell, Immunity, Immunology, Immunopathology, Infected cell, Infection, Leishmania major, Lymph node, Microbiology, Skin.

Abstract

Using a metacyclic promastigote ear infection model of cutaneous leishmaniasis, we examined the phenotype, parasite load, and cytokine production of dendritic cells in the skin and draining lymph nodes of resistant C57BL/6J and susceptible BALB/c mice. Five dendritic cell populations were isolated from the skin and lymph nodes, and the main difference between the groups of mice was an increased number of plasmacytoid dendritic cells in the lymph nodes of the susceptible mice. Although similar cell types were present in the skin emigrants of both strains, there was a 10-fold larger number of cells in BALB/c mouse skin early in infection than in C57BL/6J mouse skin. None of the dendritic cells in the lymph nodes harbored parasites until 3 weeks after infection, with the Langerhans cells having the largest load and the plasmacytoid dendritic cells having the smallest load but the longest lasting infection. Although parasites could be detected in the lymph nodes a few hours after infection, none of the skin emigrants harbored parasites, indicating that they are not the vehicle that ferries the parasites from the skin to the lymph nodes. The presence of larger numbers of plasmacytoid cells in infected BALB/c mice, the more protracted infection of these cells, and their production of alpha interferon point to a complex and important role for the plasmacytoid cells in leishmaniasis.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC375196

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Using a metacyclic promastigote ear infection model of cutaneous leishmaniasis, we examined the phenotype, parasite load, and cytokine production of dendritic cells in the skin and draining lymph nodes of resistant C57BL/6J and susceptible BALB/c mice. Five dendritic cell populations were isolated from the skin and lymph nodes, and the main difference between the groups of mice was an increased number of plasmacytoid dendritic cells in the lymph nodes of the susceptible mice. Although similar cell types were present in the skin emigrants of both strains, there was a 10-fold larger number of cells in BALB/c mouse skin early in infection than in C57BL/6J mouse skin. None of the dendritic cells in the lymph nodes harbored parasites until 3 weeks after infection, with the Langerhans cells having the largest load and the plasmacytoid dendritic cells having the smallest load but the longest lasting infection. Although parasites could be detected in the lymph nodes a few hours after infection, none of the skin emigrants harbored parasites, indicating that they are not the vehicle that ferries the parasites from the skin to the lymph nodes. The presence of larger numbers of plasmacytoid cells in infected BALB/c mice, the more protracted infection of these cells, and their production of alpha interferon point to a complex and important role for the plasmacytoid cells in leishmaniasis.</div>
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Dendritic cell populations in Leishmania major-infected skin and draining lymph nodes

Dendritic cell populations in Leishmania major-infected skin and draining lymph nodes

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration sur les relations entre la France et l'Australie
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