AustralieFrV1, Main, Exploration, bibRecordById, PMC:3406313

Growth hormone effects on cortical bone dimensions in young adults with childhood-onset growth hormone deficiency

Identifieur interne : 006132 ( Main/Exploration ); précédent : 006131; suivant : 006133

Growth hormone effects on cortical bone dimensions in young adults with childhood-onset growth hormone deficiency

Auteurs : L. Hyldstrup [Danemark] ; G. S. Conway [Royaume-Uni] ; K. Racz [Hongrie] ; A. Keller [Allemagne] ; P. Chanson [France] ; M. Zacharin ; A. L. Lysgaard [Danemark] ; A. H. Andreasen [Danemark] ; A.-M. Kappelgaard [Danemark]

Source :

Osteoporosis International [ 0937-941X ] ; 2011.

RBID : PMC:3406313

Abstract

Summary

Growth hormone (GH) treatment in young adults with childhood-onset GH deficiency has beneficial effects on bone mass. The present study shows that cortical bone dimensions also benefit from GH treatment, with endosteal expansion and increased cortical thickness leading to improved bone strength.

Introduction

In young adults with childhood-onset growth hormone deficiency (CO GHD), GH treatment after final height is reached has been shown to have beneficial effects on spine and hip bone mineral density. The objective of the study was to evaluate the influence of GH on cortical bone dimensions.

Methods

Patients (n = 160; mean age, 21.2 years; 63% males) with CO GHD were randomised 2:1 to GH or no treatment for 24 months. Cortical bone dimensions were evaluated by digital x-ray radiogrammetry of the metacarpal bones every 6 months.

Results

After 24 months, cortical thickness was increased compared with the controls (6.43%, CI 3.34 to 9.61%; p = 0.0001) and metacarpal index (MCI) (6.14%, CI 3.95 to 8.38%; p < 0.0001), while the endosteal diameter decreased (−4.64%, CI −7.15 to −2.05; p < 0.001). Total bone width did not change significantly (0.68%, CI −1.17 to 2.57%; not significant (NS)). A gender effect was seen on bone width (p < 0.0001), endosteal diameter (p < 0.01) and cortical thickness (p < 0.01), but not with MCI (NS).

Conclusions

Cortical bone reacts promptly to reinstitution of GH beyond the attainment of final height by increasing the cortical thickness through endosteal bone growth. This leads to a higher peak bone mass and may reduce the risk of cortical bone fragility later in life.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406313

DOI: 10.1007/s00198-011-1854-0
PubMed: 22124576
PubMed Central: 3406313

Affiliations:

Allemagne, Danemark, France, Hongrie, Royaume-Uni
Angleterre, District de Leipzig, Grand Londres, Hongrie centrale, Saxe (Land)
Budapest, Leipzig, Londres

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Growth hormone effects on cortical bone dimensions in young adults with childhood-onset growth hormone deficiency</title>
<author><name sortKey="Hyldstrup, L" sort="Hyldstrup, L" uniqKey="Hyldstrup L" first="L." last="Hyldstrup">L. Hyldstrup</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Endocrinology (541), Hvidovre University Hospital, DK-2650 Hvidovre, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Endocrinology (541), Hvidovre University Hospital, DK-2650 Hvidovre</wicri:regionArea>
<wicri:noRegion>DK-2650 Hvidovre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Conway, G S" sort="Conway, G S" uniqKey="Conway G" first="G. S." last="Conway">G. S. Conway</name>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Department of Endocrinology and Diabetes, University College London Hospitals, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Endocrinology and Diabetes, University College London Hospitals, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Racz, K" sort="Racz, K" uniqKey="Racz K" first="K." last="Racz">K. Racz</name>
<affiliation wicri:level="3"><nlm:aff id="Aff3">2nd Department of Medicine, Semmelweis University, Budapest, Hungary</nlm:aff>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea>2nd Department of Medicine, Semmelweis University, Budapest</wicri:regionArea>
<placeName><settlement type="city">Budapest</settlement>
<region nuts="2">Hongrie centrale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Keller, A" sort="Keller, A" uniqKey="Keller A" first="A." last="Keller">A. Keller</name>
<affiliation wicri:level="3"><nlm:aff id="Aff4">Children’s Hospital, University of Leipzig, Leipzig, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Children’s Hospital, University of Leipzig, Leipzig</wicri:regionArea>
<placeName><region type="land" nuts="1">Saxe (Land)</region>
<region type="district" nuts="2">District de Leipzig</region>
<settlement type="city">Leipzig</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chanson, P" sort="Chanson, P" uniqKey="Chanson P" first="P." last="Chanson">P. Chanson</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5">Service d’Endocrinologie et des Maladies de la Reproduction, and Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Assistance-Publique Hôpitaux de Paris, Hôpital de Bicêtre, University Paris-Sud, Le Kremlin-Bicêtre, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service d’Endocrinologie et des Maladies de la Reproduction, and Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Assistance-Publique Hôpitaux de Paris, Hôpital de Bicêtre, University Paris-Sud, Le Kremlin-Bicêtre</wicri:regionArea>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zacharin, M" sort="Zacharin, M" uniqKey="Zacharin M" first="M." last="Zacharin">M. Zacharin</name>
<affiliation><nlm:aff id="Aff6">Department of Endocrinology and Diabetes, Royal Children’s Hospital, Parkville, VIC Australia</nlm:aff>
<wicri:noCountry code="subfield">VIC Australia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lysgaard, A L" sort="Lysgaard, A L" uniqKey="Lysgaard A" first="A. L." last="Lysgaard">A. L. Lysgaard</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Endocrinology (541), Hvidovre University Hospital, DK-2650 Hvidovre, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Endocrinology (541), Hvidovre University Hospital, DK-2650 Hvidovre</wicri:regionArea>
<wicri:noRegion>DK-2650 Hvidovre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Andreasen, A H" sort="Andreasen, A H" uniqKey="Andreasen A" first="A. H." last="Andreasen">A. H. Andreasen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff7">GHT Medical Affairs, Global Marketing, Novo Nordisk, Bagsvaerd, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>GHT Medical Affairs, Global Marketing, Novo Nordisk, Bagsvaerd</wicri:regionArea>
<wicri:noRegion>Bagsvaerd</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kappelgaard, A M" sort="Kappelgaard, A M" uniqKey="Kappelgaard A" first="A.-M." last="Kappelgaard">A.-M. Kappelgaard</name>
<affiliation wicri:level="1"><nlm:aff id="Aff7">GHT Medical Affairs, Global Marketing, Novo Nordisk, Bagsvaerd, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>GHT Medical Affairs, Global Marketing, Novo Nordisk, Bagsvaerd</wicri:regionArea>
<wicri:noRegion>Bagsvaerd</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22124576</idno>
<idno type="pmc">3406313</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406313</idno>
<idno type="RBID">PMC:3406313</idno>
<idno type="doi">10.1007/s00198-011-1854-0</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">000E01</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E01</idno>
<idno type="wicri:Area/Pmc/Curation">000C62</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C62</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002292</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002292</idno>
<idno type="wicri:Area/Ncbi/Merge">000C43</idno>
<idno type="wicri:Area/Ncbi/Curation">000C43</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000C43</idno>
<idno type="wicri:doubleKey">0937-941X:2011:Hyldstrup L:growth:hormone:effects</idno>
<idno type="wicri:Area/Main/Merge">006488</idno>
<idno type="wicri:Area/Main/Curation">006132</idno>
<idno type="wicri:Area/Main/Exploration">006132</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Growth hormone effects on cortical bone dimensions in young adults with childhood-onset growth hormone deficiency</title>
<author><name sortKey="Hyldstrup, L" sort="Hyldstrup, L" uniqKey="Hyldstrup L" first="L." last="Hyldstrup">L. Hyldstrup</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Endocrinology (541), Hvidovre University Hospital, DK-2650 Hvidovre, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Endocrinology (541), Hvidovre University Hospital, DK-2650 Hvidovre</wicri:regionArea>
<wicri:noRegion>DK-2650 Hvidovre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Conway, G S" sort="Conway, G S" uniqKey="Conway G" first="G. S." last="Conway">G. S. Conway</name>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Department of Endocrinology and Diabetes, University College London Hospitals, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Endocrinology and Diabetes, University College London Hospitals, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Racz, K" sort="Racz, K" uniqKey="Racz K" first="K." last="Racz">K. Racz</name>
<affiliation wicri:level="3"><nlm:aff id="Aff3">2nd Department of Medicine, Semmelweis University, Budapest, Hungary</nlm:aff>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea>2nd Department of Medicine, Semmelweis University, Budapest</wicri:regionArea>
<placeName><settlement type="city">Budapest</settlement>
<region nuts="2">Hongrie centrale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Keller, A" sort="Keller, A" uniqKey="Keller A" first="A." last="Keller">A. Keller</name>
<affiliation wicri:level="3"><nlm:aff id="Aff4">Children’s Hospital, University of Leipzig, Leipzig, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Children’s Hospital, University of Leipzig, Leipzig</wicri:regionArea>
<placeName><region type="land" nuts="1">Saxe (Land)</region>
<region type="district" nuts="2">District de Leipzig</region>
<settlement type="city">Leipzig</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chanson, P" sort="Chanson, P" uniqKey="Chanson P" first="P." last="Chanson">P. Chanson</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5">Service d’Endocrinologie et des Maladies de la Reproduction, and Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Assistance-Publique Hôpitaux de Paris, Hôpital de Bicêtre, University Paris-Sud, Le Kremlin-Bicêtre, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service d’Endocrinologie et des Maladies de la Reproduction, and Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Assistance-Publique Hôpitaux de Paris, Hôpital de Bicêtre, University Paris-Sud, Le Kremlin-Bicêtre</wicri:regionArea>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zacharin, M" sort="Zacharin, M" uniqKey="Zacharin M" first="M." last="Zacharin">M. Zacharin</name>
<affiliation><nlm:aff id="Aff6">Department of Endocrinology and Diabetes, Royal Children’s Hospital, Parkville, VIC Australia</nlm:aff>
<wicri:noCountry code="subfield">VIC Australia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lysgaard, A L" sort="Lysgaard, A L" uniqKey="Lysgaard A" first="A. L." last="Lysgaard">A. L. Lysgaard</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Endocrinology (541), Hvidovre University Hospital, DK-2650 Hvidovre, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Endocrinology (541), Hvidovre University Hospital, DK-2650 Hvidovre</wicri:regionArea>
<wicri:noRegion>DK-2650 Hvidovre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Andreasen, A H" sort="Andreasen, A H" uniqKey="Andreasen A" first="A. H." last="Andreasen">A. H. Andreasen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff7">GHT Medical Affairs, Global Marketing, Novo Nordisk, Bagsvaerd, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>GHT Medical Affairs, Global Marketing, Novo Nordisk, Bagsvaerd</wicri:regionArea>
<wicri:noRegion>Bagsvaerd</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kappelgaard, A M" sort="Kappelgaard, A M" uniqKey="Kappelgaard A" first="A.-M." last="Kappelgaard">A.-M. Kappelgaard</name>
<affiliation wicri:level="1"><nlm:aff id="Aff7">GHT Medical Affairs, Global Marketing, Novo Nordisk, Bagsvaerd, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>GHT Medical Affairs, Global Marketing, Novo Nordisk, Bagsvaerd</wicri:regionArea>
<wicri:noRegion>Bagsvaerd</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Osteoporosis International</title>
<idno type="ISSN">0937-941X</idno>
<idno type="eISSN">1433-2965</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Summary</title>
<p>Growth hormone (GH) treatment in young adults with childhood-onset GH deficiency has beneficial effects on bone mass. The present study shows that cortical bone dimensions also benefit from GH treatment, with endosteal expansion and increased cortical thickness leading to improved bone strength.</p>
</sec>
<sec><title>Introduction</title>
<p>In young adults with childhood-onset growth hormone deficiency (CO GHD), GH treatment after final height is reached has been shown to have beneficial effects on spine and hip bone mineral density. The objective of the study was to evaluate the influence of GH on cortical bone dimensions.</p>
</sec>
<sec><title>Methods</title>
<p>Patients (<italic>n</italic>
 = 160; mean age, 21.2 years; 63% males) with CO GHD were randomised 2:1 to GH or no treatment for 24 months. Cortical bone dimensions were evaluated by digital x-ray radiogrammetry of the metacarpal bones every 6 months.</p>
</sec>
<sec><title>Results</title>
<p>After 24 months, cortical thickness was increased compared with the controls (6.43%, CI 3.34 to 9.61%; <italic>p</italic>
 = 0.0001) and metacarpal index (MCI) (6.14%, CI 3.95 to 8.38%; <italic>p</italic>
 < 0.0001), while the endosteal diameter decreased (−4.64%, CI −7.15 to −2.05; <italic>p</italic>
 < 0.001). Total bone width did not change significantly (0.68%, CI −1.17 to 2.57%; not significant (NS)). A gender effect was seen on bone width (<italic>p</italic>
 < 0.0001), endosteal diameter (<italic>p</italic>
 < 0.01) and cortical thickness (<italic>p</italic>
 < 0.01), but not with MCI (NS).</p>
</sec>
<sec><title>Conclusions</title>
<p>Cortical bone reacts promptly to reinstitution of GH beyond the attainment of final height by increasing the cortical thickness through endosteal bone growth. This leads to a higher peak bone mass and may reduce the risk of cortical bone fragility later in life.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kaufman, Jm" uniqKey="Kaufman J">JM Kaufman</name>
</author>
<author><name sortKey="Taelman, P" uniqKey="Taelman P">P Taelman</name>
</author>
<author><name sortKey="Vermeulen, A" uniqKey="Vermeulen A">A Vermeulen</name>
</author>
<author><name sortKey="Vandeweghe, M" uniqKey="Vandeweghe M">M Vandeweghe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boot, Am" uniqKey="Boot A">AM Boot</name>
</author>
<author><name sortKey="Sluis, Im" uniqKey="Sluis I">IM Sluis</name>
</author>
<author><name sortKey="Krenning, Ep" uniqKey="Krenning E">EP Krenning</name>
</author>
<author><name sortKey="Muinck Keizer Schrama, Sm" uniqKey="Muinck Keizer Schrama S">SM Muinck Keizer-Schrama</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boer, H" uniqKey="Boer H">H Boer</name>
</author>
<author><name sortKey="Blok, Gj" uniqKey="Blok G">GJ Blok</name>
</author>
<author><name sortKey="Lingen, A" uniqKey="Lingen A">A Lingen</name>
</author>
<author><name sortKey="Teule, Gj" uniqKey="Teule G">GJ Teule</name>
</author>
<author><name sortKey="Lips, P" uniqKey="Lips P">P Lips</name>
</author>
<author><name sortKey="Veen, Ea" uniqKey="Veen E">EA Veen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Holmer, H" uniqKey="Holmer H">H Holmer</name>
</author>
<author><name sortKey="Svensson, J" uniqKey="Svensson J">J Svensson</name>
</author>
<author><name sortKey="Rylander, L" uniqKey="Rylander L">L Rylander</name>
</author>
<author><name sortKey="Johannsson, G" uniqKey="Johannsson G">G Johannsson</name>
</author>
<author><name sortKey="Rosen, T" uniqKey="Rosen T">T Rosen</name>
</author>
<author><name sortKey="Bengtsson, Ba" uniqKey="Bengtsson B">BA Bengtsson</name>
</author>
<author><name sortKey="Thoren, M" uniqKey="Thoren M">M Thoren</name>
</author>
<author><name sortKey="Hoybye, C" uniqKey="Hoybye C">C Hoybye</name>
</author>
<author><name sortKey="Degerblad, M" uniqKey="Degerblad M">M Degerblad</name>
</author>
<author><name sortKey="Bramnert, M" uniqKey="Bramnert M">M Bramnert</name>
</author>
<author><name sortKey="Hagg, E" uniqKey="Hagg E">E Hagg</name>
</author>
<author><name sortKey="Engstrom, Be" uniqKey="Engstrom B">BE Engstrom</name>
</author>
<author><name sortKey="Ekman, B" uniqKey="Ekman B">B Ekman</name>
</author>
<author><name sortKey="Thorngren, Kg" uniqKey="Thorngren K">KG Thorngren</name>
</author>
<author><name sortKey="Hagmar, L" uniqKey="Hagmar L">L Hagmar</name>
</author>
<author><name sortKey="Erfurth, Em" uniqKey="Erfurth E">EM Erfurth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bouillon, R" uniqKey="Bouillon R">R Bouillon</name>
</author>
<author><name sortKey="Koledova, E" uniqKey="Koledova E">E Koledova</name>
</author>
<author><name sortKey="Bezlepkina, O" uniqKey="Bezlepkina O">O Bezlepkina</name>
</author>
<author><name sortKey="Nijs, J" uniqKey="Nijs J">J Nijs</name>
</author>
<author><name sortKey="Shavrikhova, E" uniqKey="Shavrikhova E">E Shavrikhova</name>
</author>
<author><name sortKey="Nagaeva, E" uniqKey="Nagaeva E">E Nagaeva</name>
</author>
<author><name sortKey="Chikulaeva, O" uniqKey="Chikulaeva O">O Chikulaeva</name>
</author>
<author><name sortKey="Peterkova, V" uniqKey="Peterkova V">V Peterkova</name>
</author>
<author><name sortKey="Dedov, I" uniqKey="Dedov I">I Dedov</name>
</author>
<author><name sortKey="Bakulin, A" uniqKey="Bakulin A">A Bakulin</name>
</author>
<author><name sortKey="Oganov, V" uniqKey="Oganov V">V Oganov</name>
</author>
<author><name sortKey="Attanasio, Af" uniqKey="Attanasio A">AF Attanasio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baroncelli, Gi" uniqKey="Baroncelli G">GI Baroncelli</name>
</author>
<author><name sortKey="Bertelloni, S" uniqKey="Bertelloni S">S Bertelloni</name>
</author>
<author><name sortKey="Sodini, F" uniqKey="Sodini F">F Sodini</name>
</author>
<author><name sortKey="Saggese, G" uniqKey="Saggese G">G Saggese</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bonjour, Jp" uniqKey="Bonjour J">JP Bonjour</name>
</author>
<author><name sortKey="Theintz, G" uniqKey="Theintz G">G Theintz</name>
</author>
<author><name sortKey="Buchs, B" uniqKey="Buchs B">B Buchs</name>
</author>
<author><name sortKey="Slosman, D" uniqKey="Slosman D">D Slosman</name>
</author>
<author><name sortKey="Rizzoli, R" uniqKey="Rizzoli R">R Rizzoli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mauras, N" uniqKey="Mauras N">N Mauras</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Biller, Bm" uniqKey="Biller B">BM Biller</name>
</author>
<author><name sortKey="Sesmilo, G" uniqKey="Sesmilo G">G Sesmilo</name>
</author>
<author><name sortKey="Baum, Hb" uniqKey="Baum H">HB Baum</name>
</author>
<author><name sortKey="Hayden, D" uniqKey="Hayden D">D Hayden</name>
</author>
<author><name sortKey="Schoenfeld, D" uniqKey="Schoenfeld D">D Schoenfeld</name>
</author>
<author><name sortKey="Klibanski, A" uniqKey="Klibanski A">A Klibanski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Underwood, Le" uniqKey="Underwood L">LE Underwood</name>
</author>
<author><name sortKey="Attie, Km" uniqKey="Attie K">KM Attie</name>
</author>
<author><name sortKey="Baptista, J" uniqKey="Baptista J">J Baptista</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drake, Wm" uniqKey="Drake W">WM Drake</name>
</author>
<author><name sortKey="Carroll, Pv" uniqKey="Carroll P">PV Carroll</name>
</author>
<author><name sortKey="Maher, Kt" uniqKey="Maher K">KT Maher</name>
</author>
<author><name sortKey="Metcalfe, Ka" uniqKey="Metcalfe K">KA Metcalfe</name>
</author>
<author><name sortKey="Camacho Hubner, C" uniqKey="Camacho Hubner C">C Camacho-Hubner</name>
</author>
<author><name sortKey="Shaw, Nj" uniqKey="Shaw N">NJ Shaw</name>
</author>
<author><name sortKey="Dunger, Db" uniqKey="Dunger D">DB Dunger</name>
</author>
<author><name sortKey="Cheetham, Td" uniqKey="Cheetham T">TD Cheetham</name>
</author>
<author><name sortKey="Savage, Mo" uniqKey="Savage M">MO Savage</name>
</author>
<author><name sortKey="Monson, Jp" uniqKey="Monson J">JP Monson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bravenboer, N" uniqKey="Bravenboer N">N Bravenboer</name>
</author>
<author><name sortKey="Holzmann, P" uniqKey="Holzmann P">P Holzmann</name>
</author>
<author><name sortKey="Boer, H" uniqKey="Boer H">H Boer</name>
</author>
<author><name sortKey="Roos, Jc" uniqKey="Roos J">JC Roos</name>
</author>
<author><name sortKey="Veen, Ea" uniqKey="Veen E">EA Veen</name>
</author>
<author><name sortKey="Lips, P" uniqKey="Lips P">P Lips</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Conway, Gs" uniqKey="Conway G">GS Conway</name>
</author>
<author><name sortKey="Szarras Czapnik, M" uniqKey="Szarras Czapnik M">M Szarras-Czapnik</name>
</author>
<author><name sortKey="Racz, K" uniqKey="Racz K">K Racz</name>
</author>
<author><name sortKey="Keller, A" uniqKey="Keller A">A Keller</name>
</author>
<author><name sortKey="Chanson, P" uniqKey="Chanson P">P Chanson</name>
</author>
<author><name sortKey="Tauber, M" uniqKey="Tauber M">M Tauber</name>
</author>
<author><name sortKey="Zacharin, M" uniqKey="Zacharin M">M Zacharin</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Bengtsson, Ba" uniqKey="Bengtsson B">BA Bengtsson</name>
</author>
<author><name sortKey="Abs, R" uniqKey="Abs R">R Abs</name>
</author>
<author><name sortKey="Bennmarker, H" uniqKey="Bennmarker H">H Bennmarker</name>
</author>
<author><name sortKey="Monson, Jp" uniqKey="Monson J">JP Monson</name>
</author>
<author><name sortKey="Feldt Rasmussen, U" uniqKey="Feldt Rasmussen U">U Feldt-Rasmussen</name>
</author>
<author><name sortKey="Hernberg Stahl, E" uniqKey="Hernberg Stahl E">E Hernberg-Stahl</name>
</author>
<author><name sortKey="Westberg, B" uniqKey="Westberg B">B Westberg</name>
</author>
<author><name sortKey="Wilton, P" uniqKey="Wilton P">P Wilton</name>
</author>
<author><name sortKey="Wuster, C" uniqKey="Wuster C">C Wüster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="J Rgensen, Jt" uniqKey="J Rgensen J">JT Jørgensen</name>
</author>
<author><name sortKey="Andersen, Pb" uniqKey="Andersen P">PB Andersen</name>
</author>
<author><name sortKey="Rosholm, A" uniqKey="Rosholm A">A Rosholm</name>
</author>
<author><name sortKey="Bjarnason, Nh" uniqKey="Bjarnason N">NH Bjarnason</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Black, Dm" uniqKey="Black D">DM Black</name>
</author>
<author><name sortKey="Palermo, L" uniqKey="Palermo L">L Palermo</name>
</author>
<author><name sortKey="Sorensen, T" uniqKey="Sorensen T">T Sorensen</name>
</author>
<author><name sortKey="J Rgensen, Jt" uniqKey="J Rgensen J">JT Jørgensen</name>
</author>
<author><name sortKey="Lewis, C" uniqKey="Lewis C">C Lewis</name>
</author>
<author><name sortKey="Tylavsky, F" uniqKey="Tylavsky F">F Tylavsky</name>
</author>
<author><name sortKey="Wallace, R" uniqKey="Wallace R">R Wallace</name>
</author>
<author><name sortKey="Harris, E" uniqKey="Harris E">E Harris</name>
</author>
<author><name sortKey="Cummings, Sr" uniqKey="Cummings S">SR Cummings</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seeman, E" uniqKey="Seeman E">E Seeman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ammann, P" uniqKey="Ammann P">P Ammann</name>
</author>
<author><name sortKey="Rizzoli, R" uniqKey="Rizzoli R">R Rizzoli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name>
</author>
<author><name sortKey="Seeman, E" uniqKey="Seeman E">E Seeman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name>
</author>
<author><name sortKey="Ghasem Zadeh, A" uniqKey="Ghasem Zadeh A">A Ghasem-Zadeh</name>
</author>
<author><name sortKey="Wang, Xf" uniqKey="Wang X">XF Wang</name>
</author>
<author><name sortKey="Iuliano Burns, S" uniqKey="Iuliano Burns S">S Iuliano-Burns</name>
</author>
<author><name sortKey="Seeman, E" uniqKey="Seeman E">E Seeman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schweizer, R" uniqKey="Schweizer R">R Schweizer</name>
</author>
<author><name sortKey="Martin, Dd" uniqKey="Martin D">DD Martin</name>
</author>
<author><name sortKey="Schwarze, Cp" uniqKey="Schwarze C">CP Schwarze</name>
</author>
<author><name sortKey="Binder, G" uniqKey="Binder G">G Binder</name>
</author>
<author><name sortKey="Georgiadou, A" uniqKey="Georgiadou A">A Georgiadou</name>
</author>
<author><name sortKey="Ihle, J" uniqKey="Ihle J">J Ihle</name>
</author>
<author><name sortKey="Ranke, Mb" uniqKey="Ranke M">MB Ranke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bex, M" uniqKey="Bex M">M Bex</name>
</author>
<author><name sortKey="Bouillon, R" uniqKey="Bouillon R">R Bouillon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hogler, W" uniqKey="Hogler W">W Högler</name>
</author>
<author><name sortKey="Briody, J" uniqKey="Briody J">J Briody</name>
</author>
<author><name sortKey="Moore, B" uniqKey="Moore B">B Moore</name>
</author>
<author><name sortKey="Lu, Pw" uniqKey="Lu P">PW Lu</name>
</author>
<author><name sortKey="Cowell, Ct" uniqKey="Cowell C">CT Cowell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brixen, K" uniqKey="Brixen K">K Brixen</name>
</author>
<author><name sortKey="Hansen, Tb" uniqKey="Hansen T">TB Hansen</name>
</author>
<author><name sortKey="Hauge, E" uniqKey="Hauge E">E Hauge</name>
</author>
<author><name sortKey="Vahl, N" uniqKey="Vahl N">N Vahl</name>
</author>
<author><name sortKey="J Rgensen, Jo" uniqKey="J Rgensen J">JO Jørgensen</name>
</author>
<author><name sortKey="Christiansen, Js" uniqKey="Christiansen J">JS Christiansen</name>
</author>
<author><name sortKey="Mosekilde, L" uniqKey="Mosekilde L">L Mosekilde</name>
</author>
<author><name sortKey="Hagen, C" uniqKey="Hagen C">C Hagen</name>
</author>
<author><name sortKey="Melsen, F" uniqKey="Melsen F">F Melsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Giustina, A" uniqKey="Giustina A">A Giustina</name>
</author>
<author><name sortKey="Mazziotti, G" uniqKey="Mazziotti G">G Mazziotti</name>
</author>
<author><name sortKey="Canalis, E" uniqKey="Canalis E">E Canalis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Canalis, E" uniqKey="Canalis E">E Canalis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vestergaard, P" uniqKey="Vestergaard P">P Vestergaard</name>
</author>
<author><name sortKey="J Rgensen, Jo" uniqKey="J Rgensen J">JO Jørgensen</name>
</author>
<author><name sortKey="Hagen, C" uniqKey="Hagen C">C Hagen</name>
</author>
<author><name sortKey="Hoeck, Hc" uniqKey="Hoeck H">HC Hoeck</name>
</author>
<author><name sortKey="Laurberg, P" uniqKey="Laurberg P">P Laurberg</name>
</author>
<author><name sortKey="Rejnmark, L" uniqKey="Rejnmark L">L Rejnmark</name>
</author>
<author><name sortKey="Brixen, K" uniqKey="Brixen K">K Brixen</name>
</author>
<author><name sortKey="Weeke, J" uniqKey="Weeke J">J Weeke</name>
</author>
<author><name sortKey="Andersen, M" uniqKey="Andersen M">M Andersen</name>
</author>
<author><name sortKey="Conceicao, Fl" uniqKey="Conceicao F">FL Conceicao</name>
</author>
<author><name sortKey="Nielsen, Tl" uniqKey="Nielsen T">TL Nielsen</name>
</author>
<author><name sortKey="Mosekilde, L" uniqKey="Mosekilde L">L Mosekilde</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Holmer, H" uniqKey="Holmer H">H Holmer</name>
</author>
<author><name sortKey="Svensson, J" uniqKey="Svensson J">J Svensson</name>
</author>
<author><name sortKey="Rylander, L" uniqKey="Rylander L">L Rylander</name>
</author>
<author><name sortKey="Johannsson, G" uniqKey="Johannsson G">G Johannsson</name>
</author>
<author><name sortKey="Rosen, T" uniqKey="Rosen T">T Rosén</name>
</author>
<author><name sortKey="Bengtsson, Ba" uniqKey="Bengtsson B">BA Bengtsson</name>
</author>
<author><name sortKey="Thoren, M" uniqKey="Thoren M">M Thorén</name>
</author>
<author><name sortKey="Hoybye, C" uniqKey="Hoybye C">C Höybye</name>
</author>
<author><name sortKey="Degerblad, M" uniqKey="Degerblad M">M Degerblad</name>
</author>
<author><name sortKey="Bramnert, M" uniqKey="Bramnert M">M Bramnert</name>
</author>
<author><name sortKey="H Gg, E" uniqKey="H Gg E">E Hägg</name>
</author>
<author><name sortKey="Engstrom, Be" uniqKey="Engstrom B">BE Engström</name>
</author>
<author><name sortKey="Ekman, B" uniqKey="Ekman B">B Ekman</name>
</author>
<author><name sortKey="Thorngren, Kg" uniqKey="Thorngren K">KG Thorngren</name>
</author>
<author><name sortKey="Hagmar, L" uniqKey="Hagmar L">L Hagmar</name>
</author>
<author><name sortKey="Erfurth, Em" uniqKey="Erfurth E">EM Erfurth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baroncelli, Gi" uniqKey="Baroncelli G">GI Baroncelli</name>
</author>
<author><name sortKey="Bertelloni, S" uniqKey="Bertelloni S">S Bertelloni</name>
</author>
<author><name sortKey="Sodini, F" uniqKey="Sodini F">F Sodini</name>
</author>
<author><name sortKey="Saggese, G" uniqKey="Saggese G">G Saggese</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name>
</author>
<author><name sortKey="Zhou, X" uniqKey="Zhou X">X Zhou</name>
</author>
<author><name sortKey="Shoumura, S" uniqKey="Shoumura S">S Shoumura</name>
</author>
<author><name sortKey="Emura, S" uniqKey="Emura S">S Emura</name>
</author>
<author><name sortKey="Bunai, Y" uniqKey="Bunai Y">Y Bunai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hogler, W" uniqKey="Hogler W">W Högler</name>
</author>
<author><name sortKey="Shaw, N" uniqKey="Shaw N">N Shaw</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Toledo, Va" uniqKey="Toledo V">VA Toledo</name>
</author>
<author><name sortKey="Jergas, M" uniqKey="Jergas M">M Jergas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bouxsein, Ml" uniqKey="Bouxsein M">ML Bouxsein</name>
</author>
<author><name sortKey="Palermo, L" uniqKey="Palermo L">L Palermo</name>
</author>
<author><name sortKey="Yeung, C" uniqKey="Yeung C">C Yeung</name>
</author>
<author><name sortKey="Black, Dm" uniqKey="Black D">DM Black</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Danemark</li>
<li>France</li>
<li>Hongrie</li>
<li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>District de Leipzig</li>
<li>Grand Londres</li>
<li>Hongrie centrale</li>
<li>Saxe (Land)</li>
</region>
<settlement><li>Budapest</li>
<li>Leipzig</li>
<li>Londres</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Zacharin, M" sort="Zacharin, M" uniqKey="Zacharin M" first="M." last="Zacharin">M. Zacharin</name>
</noCountry>
<country name="Danemark"><noRegion><name sortKey="Hyldstrup, L" sort="Hyldstrup, L" uniqKey="Hyldstrup L" first="L." last="Hyldstrup">L. Hyldstrup</name>
</noRegion>
<name sortKey="Andreasen, A H" sort="Andreasen, A H" uniqKey="Andreasen A" first="A. H." last="Andreasen">A. H. Andreasen</name>
<name sortKey="Kappelgaard, A M" sort="Kappelgaard, A M" uniqKey="Kappelgaard A" first="A.-M." last="Kappelgaard">A.-M. Kappelgaard</name>
<name sortKey="Lysgaard, A L" sort="Lysgaard, A L" uniqKey="Lysgaard A" first="A. L." last="Lysgaard">A. L. Lysgaard</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Conway, G S" sort="Conway, G S" uniqKey="Conway G" first="G. S." last="Conway">G. S. Conway</name>
</region>
</country>
<country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Racz, K" sort="Racz, K" uniqKey="Racz K" first="K." last="Racz">K. Racz</name>
</region>
</country>
<country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Keller, A" sort="Keller, A" uniqKey="Keller A" first="A." last="Keller">A. Keller</name>
</region>
</country>
<country name="France"><noRegion><name sortKey="Chanson, P" sort="Chanson, P" uniqKey="Chanson P" first="P." last="Chanson">P. Chanson</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006132 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 006132 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:3406313
   |texte=   Growth hormone effects on cortical bone dimensions in young adults with childhood-onset growth hormone deficiency
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:22124576" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Growth hormone effects on cortical bone dimensions in young adults with childhood-onset growth hormone deficiency

Growth hormone effects on cortical bone dimensions in young adults with childhood-onset growth hormone deficiency

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.