AustralieFrV1, Main, Exploration, bibRecordById, PMC:2903286

Type I Interferons Mediate the Innate Cytokine Response to Recombinant Fowlpox Virus but Not the Induction of Plasmacytoid Dendritic Cell-Dependent Adaptive Immunity

Identifieur interne : 007431 ( Main/Exploration ); précédent : 007430; suivant : 007432

Type I Interferons Mediate the Innate Cytokine Response to Recombinant Fowlpox Virus but Not the Induction of Plasmacytoid Dendritic Cell-Dependent Adaptive Immunity

Auteurs : Erin L. Lousberg [Australie] ; Cara K. Fraser [Australie] ; Michael G. Tovey [France] ; Kerrilyn R. Diener [Australie] ; John D. Hayball [Australie]

Source :

Journal of virology [ 0022-538X ] ; 2010.

RBID : Pascal:10-0420858

Descripteurs français

Pascal (Inist)
- Avipoxvirus, Interféron, Immunité naturelle, Cytokine, Virus recombinant, Cellule dendritique.

English descriptors

KwdEn :
- Avipoxvirus, Cytokine, Dendritic cell, Interferon, Natural immunity, Recombinant virus.

Abstract

Type I interferons (IFNs) are considered to be important mediators of innate immunity due to their inherent antiviral activity, ability to drive the transcription of a number of genes involved in viral clearance, and their role in the initiation of innate and adaptive immune responses. Due to the central role of type I IFNs, we sought to determine their importance in the generation of immunity to a recombinant vaccine vector fowlpox virus (FPV). In analyzing the role of type I IFNs in immunity to FPV, we show that they are critical to the secretion of a number of innate and proinflammatory cytokines, including type I IFNs themselves as well as interleukin-12 (IL-12), tumor necrosis factor-alpha (TNF-α), IL-6, and IL-1β, and that deficiency leads to enhanced virus-mediated antigen expression. Interestingly, however, type I IFNs were not required for adaptive immune responses to recombinant FPV even though plasmacytoid dendritic cells (pDCs), the primary producers of type I IFNs, have been shown to be requisite for this to occur. Furthermore, we provide evidence that the importance of pDCs may lie in their ability to capture and present virally derived antigen to T cells rather than in their capacity as professional type I IFN-producing cells.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903286

Affiliations:

Australie, France

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Type I Interferons Mediate the Innate Cytokine Response to Recombinant Fowlpox Virus but Not the Induction of Plasmacytoid Dendritic Cell-Dependent Adaptive Immunity</title>
<author><name sortKey="Lousberg, Erin L" sort="Lousberg, Erin L" uniqKey="Lousberg E" first="Erin L." last="Lousberg">Erin L. Lousberg</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hanson Institute, SA Pathology</s1>
<s2>Adelaide, South Australia</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Adelaide, South Australia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Sansom Institute, School of Pharmacy and Medical Science, University of South Australia</s1>
<s2>Adelaide, South Australia</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Adelaide, South Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fraser, Cara K" sort="Fraser, Cara K" uniqKey="Fraser C" first="Cara K." last="Fraser">Cara K. Fraser</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hanson Institute, SA Pathology</s1>
<s2>Adelaide, South Australia</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Adelaide, South Australia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Sansom Institute, School of Pharmacy and Medical Science, University of South Australia</s1>
<s2>Adelaide, South Australia</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Adelaide, South Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tovey, Michael G" sort="Tovey, Michael G" uniqKey="Tovey M" first="Michael G." last="Tovey">Michael G. Tovey</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratory of Viral Oncology, Institute Andre Lwoff</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institute Andre Lwoff</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Diener, Kerrilyn R" sort="Diener, Kerrilyn R" uniqKey="Diener K" first="Kerrilyn R." last="Diener">Kerrilyn R. Diener</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hanson Institute, SA Pathology</s1>
<s2>Adelaide, South Australia</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Adelaide, South Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hayball, John D" sort="Hayball, John D" uniqKey="Hayball J" first="John D." last="Hayball">John D. Hayball</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hanson Institute, SA Pathology</s1>
<s2>Adelaide, South Australia</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Adelaide, South Australia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>School of Medicine, University of Adelaide</s1>
<s2>Adelaide, South Australia</s2>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Adelaide, South Australia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Sansom Institute, School of Pharmacy and Medical Science, University of South Australia</s1>
<s2>Adelaide, South Australia</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Adelaide, South Australia</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">10-0420858</idno>
<date when="2010">2010</date>
<idno type="stanalyst">PASCAL 10-0420858 INIST</idno>
<idno type="RBID">Pascal:10-0420858</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">002401</idno>
<idno type="wicri:Area/PascalFrancis/Curation">003B92</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001F03</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001F03</idno>
<idno type="wicri:doubleKey">0022-538X:2010:Lousberg E:type:i:interferons</idno>
<idno type="wicri:Area/Main/Merge">007971</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903286</idno>
<idno type="RBID">PMC:2903286</idno>
<idno type="wicri:Area/Pmc/Corpus">001A17</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001A17</idno>
<idno type="wicri:Area/Pmc/Curation">001875</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001875</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002446</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002446</idno>
<idno type="wicri:Area/Ncbi/Merge">000768</idno>
<idno type="wicri:Area/Ncbi/Curation">000768</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000768</idno>
<idno type="wicri:doubleKey">0022-538X:2010:Lousberg E:type:i:interferons</idno>
<idno type="wicri:Area/Main/Merge">007346</idno>
<idno type="wicri:Area/Main/Curation">007431</idno>
<idno type="wicri:Area/Main/Exploration">007431</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Type I Interferons Mediate the Innate Cytokine Response to Recombinant Fowlpox Virus but Not the Induction of Plasmacytoid Dendritic Cell-Dependent Adaptive Immunity</title>
<author><name sortKey="Lousberg, Erin L" sort="Lousberg, Erin L" uniqKey="Lousberg E" first="Erin L." last="Lousberg">Erin L. Lousberg</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hanson Institute, SA Pathology</s1>
<s2>Adelaide, South Australia</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Adelaide, South Australia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Sansom Institute, School of Pharmacy and Medical Science, University of South Australia</s1>
<s2>Adelaide, South Australia</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Adelaide, South Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fraser, Cara K" sort="Fraser, Cara K" uniqKey="Fraser C" first="Cara K." last="Fraser">Cara K. Fraser</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hanson Institute, SA Pathology</s1>
<s2>Adelaide, South Australia</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Adelaide, South Australia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Sansom Institute, School of Pharmacy and Medical Science, University of South Australia</s1>
<s2>Adelaide, South Australia</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Adelaide, South Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tovey, Michael G" sort="Tovey, Michael G" uniqKey="Tovey M" first="Michael G." last="Tovey">Michael G. Tovey</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratory of Viral Oncology, Institute Andre Lwoff</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institute Andre Lwoff</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Diener, Kerrilyn R" sort="Diener, Kerrilyn R" uniqKey="Diener K" first="Kerrilyn R." last="Diener">Kerrilyn R. Diener</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hanson Institute, SA Pathology</s1>
<s2>Adelaide, South Australia</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Adelaide, South Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hayball, John D" sort="Hayball, John D" uniqKey="Hayball J" first="John D." last="Hayball">John D. Hayball</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hanson Institute, SA Pathology</s1>
<s2>Adelaide, South Australia</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Adelaide, South Australia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>School of Medicine, University of Adelaide</s1>
<s2>Adelaide, South Australia</s2>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Adelaide, South Australia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Sansom Institute, School of Pharmacy and Medical Science, University of South Australia</s1>
<s2>Adelaide, South Australia</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Adelaide, South Australia</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Avipoxvirus</term>
<term>Cytokine</term>
<term>Dendritic cell</term>
<term>Interferon</term>
<term>Natural immunity</term>
<term>Recombinant virus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Avipoxvirus</term>
<term>Interféron</term>
<term>Immunité naturelle</term>
<term>Cytokine</term>
<term>Virus recombinant</term>
<term>Cellule dendritique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Type I interferons (IFNs) are considered to be important mediators of innate immunity due to their inherent antiviral activity, ability to drive the transcription of a number of genes involved in viral clearance, and their role in the initiation of innate and adaptive immune responses. Due to the central role of type I IFNs, we sought to determine their importance in the generation of immunity to a recombinant vaccine vector fowlpox virus (FPV). In analyzing the role of type I IFNs in immunity to FPV, we show that they are critical to the secretion of a number of innate and proinflammatory cytokines, including type I IFNs themselves as well as interleukin-12 (IL-12), tumor necrosis factor-alpha (TNF-α), IL-6, and IL-1β, and that deficiency leads to enhanced virus-mediated antigen expression. Interestingly, however, type I IFNs were not required for adaptive immune responses to recombinant FPV even though plasmacytoid dendritic cells (pDCs), the primary producers of type I IFNs, have been shown to be requisite for this to occur. Furthermore, we provide evidence that the importance of pDCs may lie in their ability to capture and present virally derived antigen to T cells rather than in their capacity as professional type I IFN-producing cells.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Lousberg, Erin L" sort="Lousberg, Erin L" uniqKey="Lousberg E" first="Erin L." last="Lousberg">Erin L. Lousberg</name>
</noRegion>
<name sortKey="Diener, Kerrilyn R" sort="Diener, Kerrilyn R" uniqKey="Diener K" first="Kerrilyn R." last="Diener">Kerrilyn R. Diener</name>
<name sortKey="Fraser, Cara K" sort="Fraser, Cara K" uniqKey="Fraser C" first="Cara K." last="Fraser">Cara K. Fraser</name>
<name sortKey="Fraser, Cara K" sort="Fraser, Cara K" uniqKey="Fraser C" first="Cara K." last="Fraser">Cara K. Fraser</name>
<name sortKey="Hayball, John D" sort="Hayball, John D" uniqKey="Hayball J" first="John D." last="Hayball">John D. Hayball</name>
<name sortKey="Hayball, John D" sort="Hayball, John D" uniqKey="Hayball J" first="John D." last="Hayball">John D. Hayball</name>
<name sortKey="Hayball, John D" sort="Hayball, John D" uniqKey="Hayball J" first="John D." last="Hayball">John D. Hayball</name>
<name sortKey="Lousberg, Erin L" sort="Lousberg, Erin L" uniqKey="Lousberg E" first="Erin L." last="Lousberg">Erin L. Lousberg</name>
</country>
<country name="France"><noRegion><name sortKey="Tovey, Michael G" sort="Tovey, Michael G" uniqKey="Tovey M" first="Michael G." last="Tovey">Michael G. Tovey</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007431 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 007431 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:10-0420858
   |texte=   Type I Interferons Mediate the Innate Cytokine Response to Recombinant Fowlpox Virus but Not the Induction of Plasmacytoid Dendritic Cell-Dependent Adaptive Immunity
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Type I Interferons Mediate the Innate Cytokine Response to Recombinant Fowlpox Virus but Not the Induction of Plasmacytoid Dendritic Cell-Dependent Adaptive Immunity

Type I Interferons Mediate the Innate Cytokine Response to Recombinant Fowlpox Virus but Not the Induction of Plasmacytoid Dendritic Cell-Dependent Adaptive Immunity

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.