The 5A apolipoprotein A-I mimetic peptide displays anti-inflammatory and antioxidant properties in vivo and in vitro
Identifieur interne : 007B54 ( Main/Exploration ); précédent : 007B53; suivant : 007B55The 5A apolipoprotein A-I mimetic peptide displays anti-inflammatory and antioxidant properties in vivo and in vitro
Auteurs : Fatiha Tabet [Australie] ; Alan T. Remaley [États-Unis] ; Aude I. Segaliny [Australie] ; Jonathan Millet [Australie] ; Ling Yan [Australie] ; Shirley Nakhla [Australie] ; Philip J. Barter [Australie] ; Kerry-Anne Rye [Australie] ; Gilles Lambert [Australie, France]Source :
- Arteriosclerosis, thrombosis, and vascular biology [ 1079-5642 ] ; 2009.
Abstract
The apolipoprotein (apo) A-I mimetic peptide 5A is highly specific for ABCA1-transporter mediated cholesterol efflux. We investigated whether the 5A peptide shares other beneficial features of apoA-I, such as protection against inflammation and oxidation.
New-Zealand White rabbits received an infusion of apoA-I, reconstituted HDL containing apoA-I ((A-I)rHDL) or the 5A peptide complexed with phospholipids (PLPC), prior to inserting a collar around the carotid artery. Human coronary artery endothelial cells (HCAECs) were incubated with (A-I)rHDL or 5A/PLPC prior to TNFa stimulation.
ApoA-I, (A-I)rHDL and 5A/PLPC reduced the collar mediated increase in (i) endothelial expression of cell adhesion molecules VCAM-1 and ICAM-1, (ii) O2− production as well as the expression of the Nox4 catalytic subunits of the NADPH oxidase, and (iii) infiltration of circulating neutrophils into the carotid intima-media. In HCAECs, both 5A/PLPC and (A-I)rHDL inhibited TNFa induced ICAM-1 and VCAM-1 expression as well as the NF-κB signalling cascade and O2− production. The effects of the 5A/PLPC complex were no longer apparent in HCAECs knocked down for ABCA1.
Like apoA-I, the 5A peptide inhibits acute inflammation and oxidative stress in rabbit carotids and HCAECs. In vitro, the 5A peptide exerts these beneficial effects through interaction with ABCA1.
Url:
DOI: 10.1161/ATVBAHA.109.200196
PubMed: 19965776
PubMed Central: 2828392
Affiliations:
- Australie, France, États-Unis
- Maryland, Nouvelle-Galles du Sud, Pays de la Loire, Victoria (État)
- Melbourne, Nantes, Sydney
- Université de Melbourne, Université de Nantes, Université de Sydney
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Group, The Heart Research Institute, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Remaley, Alan T" sort="Remaley, Alan T" uniqKey="Remaley A" first="Alan T." last="Remaley">Alan T. Remaley</name><affiliation wicri:level="2"><nlm:aff id="A2">National Heart Lung and Blood Institute, Pulmonary and Vascular Medicine Branch, Lipoprotein Metabolism Section, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Heart Lung and Blood Institute, Pulmonary and Vascular Medicine Branch, Lipoprotein Metabolism Section, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Segaliny, Aude I" sort="Segaliny, Aude I" uniqKey="Segaliny A" first="Aude I." last="Segaliny">Aude I. Segaliny</name><affiliation wicri:level="1"><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Lipid Research Group, The Heart Research Institute, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Millet, Jonathan" sort="Millet, Jonathan" uniqKey="Millet J" first="Jonathan" last="Millet">Jonathan Millet</name><affiliation wicri:level="1"><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Lipid Research Group, The Heart Research Institute, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Yan, Ling" sort="Yan, Ling" uniqKey="Yan L" first="Ling" last="Yan">Ling Yan</name><affiliation wicri:level="1"><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Lipid Research Group, The Heart Research Institute, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Nakhla, Shirley" sort="Nakhla, Shirley" uniqKey="Nakhla S" first="Shirley" last="Nakhla">Shirley Nakhla</name><affiliation wicri:level="1"><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Lipid Research Group, The Heart Research Institute, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Barter, Philip J" sort="Barter, Philip J" uniqKey="Barter P" first="Philip J." last="Barter">Philip J. Barter</name><affiliation wicri:level="1"><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Lipid Research Group, The Heart Research Institute, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A4">Faculty of Medicine, University of Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Medicine, University of Sydney, New South Wales</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Rye, Kerry Anne" sort="Rye, Kerry Anne" uniqKey="Rye K" first="Kerry-Anne" last="Rye">Kerry-Anne Rye</name><affiliation wicri:level="1"><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Lipid Research Group, The Heart Research Institute, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A4">Faculty of Medicine, University of Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Medicine, University of Sydney, New South Wales</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Lambert, Gilles" sort="Lambert, Gilles" uniqKey="Lambert G" first="Gilles" last="Lambert">Gilles Lambert</name><affiliation wicri:level="1"><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Lipid Research Group, The Heart Research Institute, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A5">Université de Nantes, Faculté de Médecine, Nantes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université de Nantes, Faculté de Médecine, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement><settlement type="city">Nantes</settlement></placeName><orgName type="university">Université de Nantes</orgName></affiliation></author></analytic><series><title level="j">Arteriosclerosis, thrombosis, and vascular biology</title><idno type="ISSN">1079-5642</idno><idno type="eISSN">1524-4636</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objectives</title><p id="P1">The apolipoprotein (apo) A-I mimetic peptide 5A is highly specific for ABCA1-transporter mediated cholesterol efflux. We investigated whether the 5A peptide shares other beneficial features of apoA-I, such as protection against inflammation and oxidation.</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P2">New-Zealand White rabbits received an infusion of apoA-I, reconstituted HDL containing apoA-I ((A-I)rHDL) or the 5A peptide complexed with phospholipids (PLPC), prior to inserting a collar around the carotid artery. Human coronary artery endothelial cells (HCAECs) were incubated with (A-I)rHDL or 5A/PLPC prior to TNFa stimulation.</p></sec><sec id="S3"><title>Results</title><p id="P3">ApoA-I, (A-I)rHDL and 5A/PLPC reduced the collar mediated increase in (i) endothelial expression of cell adhesion molecules VCAM-1 and ICAM-1, (ii) O<sub>2</sub><sup>−</sup> production as well as the expression of the Nox4 catalytic subunits of the NADPH oxidase, and (iii) infiltration of circulating neutrophils into the carotid intima-media. In HCAECs, both 5A/PLPC and (A-I)rHDL inhibited TNFa induced ICAM-1 and VCAM-1 expression as well as the NF-κB signalling cascade and O<sub>2</sub><sup>−</sup> production. The effects of the 5A/PLPC complex were no longer apparent in HCAECs knocked down for ABCA1.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Like apoA-I, the 5A peptide inhibits acute inflammation and oxidative stress in rabbit carotids and HCAECs. In vitro, the 5A peptide exerts these beneficial effects through interaction with ABCA1.</p></sec></div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>États-Unis</li></country><region><li>Maryland</li><li>Nouvelle-Galles du Sud</li><li>Pays de la Loire</li><li>Victoria (État)</li></region><settlement><li>Melbourne</li><li>Nantes</li><li>Sydney</li></settlement><orgName><li>Université de Melbourne</li><li>Université de Nantes</li><li>Université de Sydney</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="Tabet, Fatiha" sort="Tabet, Fatiha" uniqKey="Tabet F" first="Fatiha" last="Tabet">Fatiha Tabet</name></noRegion><name sortKey="Barter, Philip J" sort="Barter, Philip J" uniqKey="Barter P" first="Philip J." last="Barter">Philip J. Barter</name><name sortKey="Barter, Philip J" sort="Barter, Philip J" uniqKey="Barter P" first="Philip J." last="Barter">Philip J. Barter</name><name sortKey="Lambert, Gilles" sort="Lambert, Gilles" uniqKey="Lambert G" first="Gilles" last="Lambert">Gilles Lambert</name><name sortKey="Millet, Jonathan" sort="Millet, Jonathan" uniqKey="Millet J" first="Jonathan" last="Millet">Jonathan Millet</name><name sortKey="Nakhla, Shirley" sort="Nakhla, Shirley" uniqKey="Nakhla S" first="Shirley" last="Nakhla">Shirley Nakhla</name><name sortKey="Rye, Kerry Anne" sort="Rye, Kerry Anne" uniqKey="Rye K" first="Kerry-Anne" last="Rye">Kerry-Anne Rye</name><name sortKey="Rye, Kerry Anne" sort="Rye, Kerry Anne" uniqKey="Rye K" first="Kerry-Anne" last="Rye">Kerry-Anne Rye</name><name sortKey="Rye, Kerry Anne" sort="Rye, Kerry Anne" uniqKey="Rye K" first="Kerry-Anne" last="Rye">Kerry-Anne Rye</name><name sortKey="Segaliny, Aude I" sort="Segaliny, Aude I" uniqKey="Segaliny A" first="Aude I." last="Segaliny">Aude I. Segaliny</name><name sortKey="Yan, Ling" sort="Yan, Ling" uniqKey="Yan L" first="Ling" last="Yan">Ling Yan</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Remaley, Alan T" sort="Remaley, Alan T" uniqKey="Remaley A" first="Alan T." last="Remaley">Alan T. Remaley</name></region></country><country name="France"><region name="Pays de la Loire"><name sortKey="Lambert, Gilles" sort="Lambert, Gilles" uniqKey="Lambert G" first="Gilles" last="Lambert">Gilles Lambert</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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