Antigen-Independent Maturation of CD2, CD11a/CD18, CD44, and CD58 Expression on Thymic Emigrants in Fetal and Postnatal Sheep
Identifieur interne : 00D414 ( Main/Exploration ); précédent : 00D413; suivant : 00D415Antigen-Independent Maturation of CD2, CD11a/CD18, CD44, and CD58 Expression on Thymic Emigrants in Fetal and Postnatal Sheep
Auteurs : Deborah A. Witherden [Australie] ; Nevin J. Abernethy [France] ; Wayne G. Kimpton [Nouvelle-Zélande] ; Ross N. P. Cahill [Nouvelle-Zélande]Source :
- Developmental Immunology [ 1044-6672 ] ; 1995.
Abstract
We have compared the expression of CD2, CD11a/CD18, CD44, and CD58 on
Url:
DOI: 10.1155/1995/35075
PubMed: 8770559
PubMed Central: 2275959
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000716
- to stream Pmc, to step Curation: 000715
- to stream Pmc, to step Checkpoint: 002D93
- to stream Ncbi, to step Merge: 005241
- to stream Ncbi, to step Curation: 005241
- to stream Ncbi, to step Checkpoint: 005241
- to stream Main, to step Merge: 00E615
- to stream Main, to step Curation: 00D414
Le document en format XML
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<author><name sortKey="Abernethy, Nevin J" sort="Abernethy, Nevin J" uniqKey="Abernethy N" first="Nevin J." last="Abernethy">Nevin J. Abernethy</name>
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<author><name sortKey="Kimpton, Wayne G" sort="Kimpton, Wayne G" uniqKey="Kimpton W" first="Wayne G." last="Kimpton">Wayne G. Kimpton</name>
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<country xml:lang="fr">Nouvelle-Zélande</country>
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<author><name sortKey="Cahill, Ross N P" sort="Cahill, Ross N P" uniqKey="Cahill R" first="Ross N. P." last="Cahill">Ross N. P. Cahill</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antigen-Independent Maturation of CD2, CD11a/CD18, CD44, and CD58 Expression on Thymic Emigrants in Fetal and Postnatal Sheep</title>
<author><name sortKey="Witherden, Deborah A" sort="Witherden, Deborah A" uniqKey="Witherden D" first="Deborah A." last="Witherden">Deborah A. Witherden</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Laboratory for Foetal and Neonatal Immunology</addr-line>
<addr-line>The University of Melbourne</addr-line>
<addr-line>Cnr. Flemington Road and Park Drive</addr-line>
<addr-line>Parkville</addr-line>
<addr-line>Victoria</addr-line>
<addr-line>3052</addr-line>
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Abernethy, Nevin J" sort="Abernethy, Nevin J" uniqKey="Abernethy N" first="Nevin J." last="Abernethy">Nevin J. Abernethy</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>IGBMC</addr-line>
<addr-line>BP163</addr-line>
<addr-line>Illkirch Cedex</addr-line>
<addr-line>C.U. de Strasbourg</addr-line>
<addr-line>67404</addr-line>
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Kimpton, Wayne G" sort="Kimpton, Wayne G" uniqKey="Kimpton W" first="Wayne G." last="Kimpton">Wayne G. Kimpton</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Molecular Medicine</addr-line>
<addr-line>University of Auckland</addr-line>
<country>New Zealand</country>
</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cahill, Ross N P" sort="Cahill, Ross N P" uniqKey="Cahill R" first="Ross N. P." last="Cahill">Ross N. P. Cahill</name>
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<addr-line>University of Auckland</addr-line>
<country>New Zealand</country>
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<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<series><title level="j">Developmental Immunology</title>
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<front><div type="abstract" xml:lang="en"><p>We have compared the expression of CD2, CD11a/CD18, CD44, and CD58 on <italic>αβ</italic>
and <italic>γδ</italic>
T cells emigrating from the fetal and postnatal thymus. We report that both <italic>γδ</italic>
and the
CD4<sup>+</sup>
CD8<sup>-</sup>
and CD4<sup>-</sup>
CD8<sup>+</sup>
subsets of <italic>αβ</italic>
T cells express mature levels of the adhesion
molecules CD11a/CD18, CD44, and CD58 upon emigration from the thymus. Whereas
CD44 is up-regulated on <italic>γδ</italic>
<sup>+</sup>
thymocytes prior to export, down-regulation of both
CD11a/CD18 and CD58 occurs prior to emigration from the thymus, suggesting that
down-regulation of these molecules may be a final maturational step taken by developing
<italic>γδ</italic>
T cells before their export from the thymus. In contrast, there is continued up-regulation
of CD2 on <italic>αβ</italic>
and <italic>γδ</italic>
T cells upon emigration from the thymus and as they move into the
mature peripheral T-cell pool. There was also a marked reduction in the number of CD2<sup>+</sup>
<italic>γδ</italic>
T cells exported during fetal development that was associated with a marked reduction
in the percentage of CD2<sup>2+</sup>
<italic>γδ</italic>
thymocytes exported. The postthymic maturation of CD2 and
the other changes in adhesion-molecule expression appear to be independent of extrinsic
antigen, as the same changes were observed in the antigen-free environment of the fetus
as in the postnatal lamb, which has been exposed to extrinsic antigen. It thus appears that
these changes in adhesion-molecule expression are as a result of the normal maturation
pathway from a developing thymocyte to a mature peripheral T cell.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Nouvelle-Zélande</li>
</country>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Witherden, Deborah A" sort="Witherden, Deborah A" uniqKey="Witherden D" first="Deborah A." last="Witherden">Deborah A. Witherden</name>
</noRegion>
</country>
<country name="France"><noRegion><name sortKey="Abernethy, Nevin J" sort="Abernethy, Nevin J" uniqKey="Abernethy N" first="Nevin J." last="Abernethy">Nevin J. Abernethy</name>
</noRegion>
</country>
<country name="Nouvelle-Zélande"><noRegion><name sortKey="Kimpton, Wayne G" sort="Kimpton, Wayne G" uniqKey="Kimpton W" first="Wayne G." last="Kimpton">Wayne G. Kimpton</name>
</noRegion>
<name sortKey="Cahill, Ross N P" sort="Cahill, Ross N P" uniqKey="Cahill R" first="Ross N. P." last="Cahill">Ross N. P. Cahill</name>
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