AustralieFrV1, Main, Exploration, bibRecord, 00D699

Enhanced potency of intravenous, but not intrathecal, morphine and morphine-6-glucuronide after burn trauma

Identifieur interne : 00D699 ( Main/Exploration ); précédent : 00D698; suivant : 00D700

Enhanced potency of intravenous, but not intrathecal, morphine and morphine-6-glucuronide after burn trauma

Auteurs : Agnes Langlade [États-Unis, France] ; Daniel B. Carr [États-Unis] ; Alain Serrie [France] ; Brendan S. Silbert [États-Unis, Australie] ; Stanislaw K. Szyfelbein [États-Unis] ; Andrzej W. Lipkowski [États-Unis, Pologne]

Source :

Life Sciences [ 0024-3205 ] ; 1994.

RBID : ISTEX:32C13B7C090F4099606FD5776D06B95C56D20E58

Descripteurs français

Wicri :
- topic : Traumatisme.

English descriptors

Abstract

Abstract: We examined the analgesic effect of morphine (M) and its metabolite morphine-6-glucuronide (M6G) in a rat model of acute thermal trauma. M or M6G were given by intrathecal (IT) or intravenous (IV) routes after brief burn or sham burn delivered during inhalational anesthesia. In the sham group, M6G was significantly less potent than M when given IV, yet tended to be more potent than M when given IT. For both drugs, thermal injury increased IV potency, yet decreased (for M) or displayed a trend to decrease (for M6G) IT potency. The increased potency seen with IV but not IT opioid administration may reflect pharmacokinetic (e.g., diminished clearance) and/or pharmacodynamic responses (e.g., activation of peripheral opioid receptors) after thermal injury.

Url:

https://api.istex.fr/document/32C13B7C090F4099606FD5776D06B95C56D20E58/fulltext/pdf

DOI: 10.1016/0024-3205(94)00610-5

Affiliations:

Australie, France, Pologne, États-Unis
Massachusetts, Victoria (État), Île-de-France
Boston, Melbourne, Paris

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000966
to stream Istex, to step Curation: 000966
to stream Istex, to step Checkpoint: 002854
to stream Main, to step Merge: 00E912
to stream Main, to step Curation: 00D699

Le document en format XML

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<term>Analgesic peptide research unit</term>
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<front><div type="abstract" xml:lang="en">Abstract: We examined the analgesic effect of morphine (M) and its metabolite morphine-6-glucuronide (M6G) in a rat model of acute thermal trauma. M or M6G were given by intrathecal (IT) or intravenous (IV) routes after brief burn or sham burn delivered during inhalational anesthesia. In the sham group, M6G was significantly less potent than M when given IV, yet tended to be more potent than M when given IT. For both drugs, thermal injury increased IV potency, yet decreased (for M) or displayed a trend to decrease (for M6G) IT potency. The increased potency seen with IV but not IT opioid administration may reflect pharmacokinetic (e.g., diminished clearance) and/or pharmacodynamic responses (e.g., activation of peripheral opioid receptors) after thermal injury.</div>
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Enhanced potency of intravenous, but not intrathecal, morphine and morphine-6-glucuronide after burn trauma

Enhanced potency of intravenous, but not intrathecal, morphine and morphine-6-glucuronide after burn trauma

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri