Fibroblast growth factor receptor expression in outer hair cells of rat cochlea
Identifieur interne : 00CC19 ( Main/Exploration ); précédent : 00CC18; suivant : 00CC20Fibroblast growth factor receptor expression in outer hair cells of rat cochlea
Auteurs : J. O. Pickles [Australie] ; C. Harter [France] ; G. Rebillard [France]Source :
- Neuroreport : (Oxford) [ 0959-4965 ] ; 1998.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
FIBROBLAST growth factors (FGFs) are critical for normal development of the organ of Corti, and may also protect hair cells from ototoxic damage. Four different fibroblast growth factors are known, three of which have different splice variants in the extracellular immunoglobin-like (Ig) III FGF-binding domain, giving different patterns of sensitivity to the different FGFs. Analysis of a cDNA library of rat outer hair cells by the polymerase chain reaction, using isoform specific primers, showed expression only of FGF receptor 3, splice variant IIIc. This allows us to predict the pattern of sensitivity to applied FGFs, which may be useful in targeting outer hair cells selectively during an FGF-based strategy for cochlear therapy.
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Harter</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM U254, CHU Hopital St-Charles</s1><s2>34205 Montpellier</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>34205 Montpellier</wicri:noRegion><placeName><settlement type="city">Montpellier</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region></placeName></affiliation></author><author><name sortKey="Rebillard, G" sort="Rebillard, G" uniqKey="Rebillard G" first="G." last="Rebillard">G. 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O." last="Pickles">J. O. Pickles</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vision, Touch and Hearing Research Centre, University of Queensland</s1><s2>4072 Qld</s2><s3>AUS</s3><sZ>1 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>4072 Qld</wicri:noRegion></affiliation></author><author><name sortKey="Harter, C" sort="Harter, C" uniqKey="Harter C" first="C." last="Harter">C. Harter</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM U254, CHU Hopital St-Charles</s1><s2>34205 Montpellier</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>34205 Montpellier</wicri:noRegion><placeName><settlement type="city">Montpellier</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region></placeName></affiliation></author><author><name sortKey="Rebillard, G" sort="Rebillard, G" uniqKey="Rebillard G" first="G." last="Rebillard">G. Rebillard</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM U254, CHU Hopital St-Charles</s1><s2>34205 Montpellier</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>34205 Montpellier</wicri:noRegion><placeName><settlement type="city">Montpellier</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Neuroreport : (Oxford)</title><title level="j" type="abbreviated">Neuroreport : (Oxf.)</title><idno type="ISSN">0959-4965</idno><imprint><date when="1998">1998</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neuroreport : (Oxford)</title><title level="j" type="abbreviated">Neuroreport : (Oxf.)</title><idno type="ISSN">0959-4965</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological receptor</term><term>Cochlea</term><term>Fibroblast growth factor</term><term>Gene expression</term><term>Outer hair cell</term><term>Rat</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cellule ciliée externe</term><term>Cochlée</term><term>Facteur croissance fibroblaste</term><term>Récepteur biologique</term><term>Expression génique</term><term>Rat</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">FIBROBLAST growth factors (FGFs) are critical for normal development of the organ of Corti, and may also protect hair cells from ototoxic damage. Four different fibroblast growth factors are known, three of which have different splice variants in the extracellular immunoglobin-like (Ig) III FGF-binding domain, giving different patterns of sensitivity to the different FGFs. Analysis of a cDNA library of rat outer hair cells by the polymerase chain reaction, using isoform specific primers, showed expression only of FGF receptor 3, splice variant IIIc. This allows us to predict the pattern of sensitivity to applied FGFs, which may be useful in targeting outer hair cells selectively during an FGF-based strategy for cochlear therapy.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Languedoc-Roussillon</li><li>Occitanie (région administrative)</li></region><settlement><li>Montpellier</li></settlement></list><tree><country name="Australie"><noRegion><name sortKey="Pickles, J O" sort="Pickles, J O" uniqKey="Pickles J" first="J. O." last="Pickles">J. O. Pickles</name></noRegion></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Harter, C" sort="Harter, C" uniqKey="Harter C" first="C." last="Harter">C. Harter</name></region><name sortKey="Rebillard, G" sort="Rebillard, G" uniqKey="Rebillard G" first="G." last="Rebillard">G. Rebillard</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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