Plexiform Spitz nevus : An intradermal Spitz nevus with plexiform growth pattern
Identifieur interne : 00C662 ( Main/Exploration ); précédent : 00C661; suivant : 00C663Plexiform Spitz nevus : An intradermal Spitz nevus with plexiform growth pattern
Auteurs : A. Spatz [France] ; S. Peterse [Australie] ; C. D. M. Fletcher [États-Unis] ; R. L. Barnhill [États-Unis]Source :
- The American journal of dermatopathology [ 0193-1091 ] ; 1999.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Two cases of a distinctive variant of Spitz (spindle and epithelioid cell) nevus are described. One lesion developed on the lower leg of a 17-year-old boy and the other lesion on the back of a 52-year-old man. The microscopic appearance was characterized by a plexiform arrangement of bundles and lobules of enlarged spindle to epithelioid melanocytes throughout the superficial and deep dermis. Intraepidermal melanocytic proliferation was unappreciated. Some lobules were circumscribed by a thin rim of compressed fibrous tissue. In both cases a myxoid stroma was present. The cells had abundant eosinophilic cytoplasm with well-defined borders. The nuclei were enlarged, consistently ovoid and vesicular, with small nucleoli. Both cases contained scattered multinucleate giant cells similar to those observed in classical form of Spitz nevi. No melanin pigment was detectable by light microscopy. No mitoses were observed in one case and a rare mitosis was present in the other. Tumor cells were strongly immunoreactive for S-100, but not for HMB-45, desmin, and actin. The differential diagnosis of this distinctive tumor includes desmoplastic/neurotropic melanoma, plexiform spindle cell nevus, cellular blue nevus, plexiform neurofibroma, and cellular neurothekeoma. The designation of "plexiform Spitz nevus' is chosen to emphasize its distinctive plexiform growth pattern.
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Barnhill</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Division of Dermatopathology and Oral Pathology, The Johns Hopkins Medical Institutions</s1><s2>Baltimore, Maryland</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">00-0061287</idno><date when="1999">1999</date><idno type="stanalyst">PASCAL 00-0061287 INIST</idno><idno type="RBID">Pascal:00-0061287</idno><idno type="wicri:Area/PascalFrancis/Corpus">006078</idno><idno type="wicri:Area/PascalFrancis/Curation">000092</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">005F39</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">005F39</idno><idno type="wicri:doubleKey">0193-1091:1999:Spatz A:plexiform:spitz:nevus</idno><idno type="wicri:Area/Main/Merge">00D652</idno><idno type="wicri:Area/Main/Curation">00C662</idno><idno type="wicri:Area/Main/Exploration">00C662</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Plexiform Spitz nevus : An intradermal Spitz nevus with plexiform growth pattern</title><author><name sortKey="Spatz, A" sort="Spatz, A" uniqKey="Spatz A" first="A." last="Spatz">A. Spatz</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pathology, Institut Gustave-Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave-Roussy</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Peterse, S" sort="Peterse, S" uniqKey="Peterse S" first="S." last="Peterse">S. Peterse</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>ClinPath Laboratories</s1><s2>Ken Town</s2><s3>AUS</s3><sZ>2 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>ClinPath Laboratories</wicri:noRegion></affiliation></author><author><name sortKey="Fletcher, C D M" sort="Fletcher, C D M" uniqKey="Fletcher C" first="C. D. M." last="Fletcher">C. D. M. Fletcher</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Pathology, Brigham and Women's Hospital</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Barnhill, R L" sort="Barnhill, R L" uniqKey="Barnhill R" first="R. L." last="Barnhill">R. L. Barnhill</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Division of Dermatopathology and Oral Pathology, The Johns Hopkins Medical Institutions</s1><s2>Baltimore, Maryland</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><series><title level="j" type="main">The American journal of dermatopathology</title><title level="j" type="abbreviated">Am. j. dermatopathol.</title><idno type="ISSN">0193-1091</idno><imprint><date when="1999">1999</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The American journal of dermatopathology</title><title level="j" type="abbreviated">Am. j. dermatopathol.</title><idno type="ISSN">0193-1091</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Human</term><term>Pathology</term><term>Spitz nevus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Naevus Spitz</term><term>Anatomopathologie</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Two cases of a distinctive variant of Spitz (spindle and epithelioid cell) nevus are described. One lesion developed on the lower leg of a 17-year-old boy and the other lesion on the back of a 52-year-old man. The microscopic appearance was characterized by a plexiform arrangement of bundles and lobules of enlarged spindle to epithelioid melanocytes throughout the superficial and deep dermis. Intraepidermal melanocytic proliferation was unappreciated. Some lobules were circumscribed by a thin rim of compressed fibrous tissue. In both cases a myxoid stroma was present. The cells had abundant eosinophilic cytoplasm with well-defined borders. The nuclei were enlarged, consistently ovoid and vesicular, with small nucleoli. Both cases contained scattered multinucleate giant cells similar to those observed in classical form of Spitz nevi. No melanin pigment was detectable by light microscopy. No mitoses were observed in one case and a rare mitosis was present in the other. Tumor cells were strongly immunoreactive for S-100, but not for HMB-45, desmin, and actin. The differential diagnosis of this distinctive tumor includes desmoplastic/neurotropic melanoma, plexiform spindle cell nevus, cellular blue nevus, plexiform neurofibroma, and cellular neurothekeoma. The designation of "plexiform Spitz nevus' is chosen to emphasize its distinctive plexiform growth pattern.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="France"><noRegion><name sortKey="Spatz, A" sort="Spatz, A" uniqKey="Spatz A" first="A." last="Spatz">A. Spatz</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Peterse, S" sort="Peterse, S" uniqKey="Peterse S" first="S." last="Peterse">S. Peterse</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Fletcher, C D M" sort="Fletcher, C D M" uniqKey="Fletcher C" first="C. D. M." last="Fletcher">C. D. M. Fletcher</name></noRegion><name sortKey="Barnhill, R L" sort="Barnhill, R L" uniqKey="Barnhill R" first="R. L." last="Barnhill">R. L. Barnhill</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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