AustralieFrV1, Main, Exploration, bibRecord, 00B482

Transient hematologic and clinical effect of E21R in a child with end-stage juvenile myelomonocytic leukemia

Identifieur interne : 00B482 ( Main/Exploration ); précédent : 00B481; suivant : 00B483

Transient hematologic and clinical effect of E21R in a child with end-stage juvenile myelomonocytic leukemia

Auteurs : Frédéric Bernard [France, Australie] ; Caroline Thomas ; Jean Francois Emile ; Timothy Hercus ; Bruno Cassinat ; Christine Chomienne ; Jean Donadieu

Source :

Blood [ 0006-4971 ] ; 2002.

RBID : Pascal:02-0277138

Descripteurs français

Pascal (Inist)
- Leucémie myélomonocytaire, Chronique, Enfant, Traitement, Antagoniste, Anticancéreux, Facteur stimulant colonie granulocyte macrophage, Facteur croissance, Etude cas, Récepteur E21R.
Wicri :
- topic : Enfant.

English descriptors

KwdEn :
- Antagonist, Antineoplastic agent, Case study, Child, Chronic, Granulocyte macrophage colony stimulating factor, Growth factor, Myelomonocytic leukemia, Treatment.

Abstract

E21R is a modified granulocyte macrophage-colony-stimulating factor (GM-CSF) protein which results in antagonism of GM-CSF function via selective binding to the GM-CSF receptor complex. Juvenile chronic myelomonocytic leukemia (JMML) is a rare leukemia where spontaneous proliferation of myeloid and monocytic precursors In patients' bone marrow cultures Is dependent on GM-CSF. For patients who progress after systemic chemotherapy, there are no effective therapies. In vitro and in vivo studies in an animal model demonstrating that E21R exerts an antileukemic action prompted us to consider its potential utility in a child with end-stage JMML. E21R was well-tolerated during the 3 courses of subcutaneous treatment. A clear in vivo efficacy was observed after 2 courses of E21R but the disease appeared completely refractory during the third course. This novel therapeutic approach clearly deserves further evaluation in JMML.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">E21R is a modified granulocyte macrophage-colony-stimulating factor (GM-CSF) protein which results in antagonism of GM-CSF function via selective binding to the GM-CSF receptor complex. Juvenile chronic myelomonocytic leukemia (JMML) is a rare leukemia where spontaneous proliferation of myeloid and monocytic precursors In patients' bone marrow cultures Is dependent on GM-CSF. For patients who progress after systemic chemotherapy, there are no effective therapies. In vitro and in vivo studies in an animal model demonstrating that E21R exerts an antileukemic action prompted us to consider its potential utility in a child with end-stage JMML. E21R was well-tolerated during the 3 courses of subcutaneous treatment. A clear in vivo efficacy was observed after 2 courses of E21R but the disease appeared completely refractory during the third course. This novel therapeutic approach clearly deserves further evaluation in JMML.</div>
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<name sortKey="Bernard, Frederic" sort="Bernard, Frederic" uniqKey="Bernard F" first="Frédéric" last="Bernard">Frédéric Bernard</name>
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Transient hematologic and clinical effect of E21R in a child with end-stage juvenile myelomonocytic leukemia

Transient hematologic and clinical effect of E21R in a child with end-stage juvenile myelomonocytic leukemia

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri