AustralieFrV1, Main, Exploration, bibRecord, 00AF89

Viliuisk encephalomyelitis: intrathecal synthesis of oligoclonal IgG

Identifieur interne : 00AF89 ( Main/Exploration ); précédent : 00AF88; suivant : 00AF90

Viliuisk encephalomyelitis: intrathecal synthesis of oligoclonal IgG

Auteurs : Alison J. E. Green [Royaume-Uni] ; Tatiana M. Sivtseva [Russie] ; Al'Bina P. Danilova [Russie] ; Vladimir L. Osakovsky [Russie] ; Vsevolod A. Vladimirtsev [Russie] ; Martin Zeidler [Royaume-Uni] ; Richard S. Knight [Royaume-Uni] ; Feodor A. Platonov [Russie] ; Alexey Shatunov [États-Unis] ; Vasiliy P. Alekseev [Russie] ; Vadim G. Krivoshapkin [Russie] ; Colin L. Masters [Australie] ; D. Carleton Gajdusek [France] ; Lev G. Goldfarb [États-Unis]

Source :

Journal of the neurological sciences [ 0022-510X ] ; 2003.

RBID : Pascal:03-0400717

Descripteurs français

Pascal (Inist)
- Encéphalomyélite, Virus Vilyuisk, IgG, Immunoglobuline oligoclonale, Liquide céphalorachidien, Diagnostic, Marqueur biologique, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Biological marker, Cerebrospinal fluid, Diagnosis, Encephalomyelitis, Human, IgG, Oligoclonal immunoglobulin, Vilyuisk virus.

Abstract

Viliuisk encephalomyelitis (VE) is a neurodegenerative disorder expressed as subacute meningo-encephalitis progressing to a more prolonged pan-encephalitic syndrome with a fatal outcome within I to 10 years. Some patients survive to a steady state of global dementia and severe spasticity that may last for over 20 years, Multiple micronecrotic foci surrounded by inflammatory infiltrates are observed throughout the cerebral cortex and other gray matter areas. Infectious etiology of VE is strongly suspected, but the causative agent has not been identified. We conducted a search for assays that might be helpful for VE diagnosis and established for the first time that the majority of patients with definite VE show evidence for intrathecal IgG synthesis correlating with the clinical manifestations of the disease. This indicates that the detection of oligoclonal IgG banding in the cerebrospinal fluid is a valuable diagnostic assay for VE. Implications of these findings for a possible etiology of VE are discussed.

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<author><name sortKey="Alekseev, Vasiliy P" sort="Alekseev, Vasiliy P" uniqKey="Alekseev V" first="Vasiliy P." last="Alekseev">Vasiliy P. Alekseev</name>
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<s2>Victoria 3050, Parkville</s2>
<s3>AUS</s3>
<sZ>12 aut.</sZ>
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<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
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<author><name sortKey="Gajdusek, D Carleton" sort="Gajdusek, D Carleton" uniqKey="Gajdusek D" first="D. Carleton" last="Gajdusek">D. Carleton Gajdusek</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Centre National de la Rechaiche Scientifique, Institut Alfred Fessard</s1>
<s2>Gif-sur-Yvette</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Gif-sur-Yvette</settlement>
</placeName>
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</author>
<author><name sortKey="Goldfarb, Lev G" sort="Goldfarb, Lev G" uniqKey="Goldfarb L" first="Lev G." last="Goldfarb">Lev G. Goldfarb</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute of Neurological Disorders and Stroke, NIH</s1>
<s2>Bethesda, MD 20892</s2>
<s3>USA</s3>
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</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of the neurological sciences</title>
<title level="j" type="abbreviated">J. neurol. sci.</title>
<idno type="ISSN">0022-510X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological marker</term>
<term>Cerebrospinal fluid</term>
<term>Diagnosis</term>
<term>Encephalomyelitis</term>
<term>Human</term>
<term>IgG</term>
<term>Oligoclonal immunoglobulin</term>
<term>Vilyuisk virus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Encéphalomyélite</term>
<term>Virus Vilyuisk</term>
<term>IgG</term>
<term>Immunoglobuline oligoclonale</term>
<term>Liquide céphalorachidien</term>
<term>Diagnostic</term>
<term>Marqueur biologique</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Viliuisk encephalomyelitis (VE) is a neurodegenerative disorder expressed as subacute meningo-encephalitis progressing to a more prolonged pan-encephalitic syndrome with a fatal outcome within I to 10 years. Some patients survive to a steady state of global dementia and severe spasticity that may last for over 20 years, Multiple micronecrotic foci surrounded by inflammatory infiltrates are observed throughout the cerebral cortex and other gray matter areas. Infectious etiology of VE is strongly suspected, but the causative agent has not been identified. We conducted a search for assays that might be helpful for VE diagnosis and established for the first time that the majority of patients with definite VE show evidence for intrathecal IgG synthesis correlating with the clinical manifestations of the disease. This indicates that the detection of oligoclonal IgG banding in the cerebrospinal fluid is a valuable diagnostic assay for VE. Implications of these findings for a possible etiology of VE are discussed.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Royaume-Uni</li>
<li>Russie</li>
<li>États-Unis</li>
</country>
<region><li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Gif-sur-Yvette</li>
<li>Melbourne</li>
</settlement>
<orgName><li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><noRegion><name sortKey="Green, Alison J E" sort="Green, Alison J E" uniqKey="Green A" first="Alison J. E." last="Green">Alison J. E. Green</name>
</noRegion>
<name sortKey="Knight, Richard S" sort="Knight, Richard S" uniqKey="Knight R" first="Richard S." last="Knight">Richard S. Knight</name>
<name sortKey="Zeidler, Martin" sort="Zeidler, Martin" uniqKey="Zeidler M" first="Martin" last="Zeidler">Martin Zeidler</name>
</country>
<country name="Russie"><noRegion><name sortKey="Sivtseva, Tatiana M" sort="Sivtseva, Tatiana M" uniqKey="Sivtseva T" first="Tatiana M." last="Sivtseva">Tatiana M. Sivtseva</name>
</noRegion>
<name sortKey="Alekseev, Vasiliy P" sort="Alekseev, Vasiliy P" uniqKey="Alekseev V" first="Vasiliy P." last="Alekseev">Vasiliy P. Alekseev</name>
<name sortKey="Danilova, Al Bina P" sort="Danilova, Al Bina P" uniqKey="Danilova A" first="Al'Bina P." last="Danilova">Al'Bina P. Danilova</name>
<name sortKey="Krivoshapkin, Vadim G" sort="Krivoshapkin, Vadim G" uniqKey="Krivoshapkin V" first="Vadim G." last="Krivoshapkin">Vadim G. Krivoshapkin</name>
<name sortKey="Osakovsky, Vladimir L" sort="Osakovsky, Vladimir L" uniqKey="Osakovsky V" first="Vladimir L." last="Osakovsky">Vladimir L. Osakovsky</name>
<name sortKey="Platonov, Feodor A" sort="Platonov, Feodor A" uniqKey="Platonov F" first="Feodor A." last="Platonov">Feodor A. Platonov</name>
<name sortKey="Vladimirtsev, Vsevolod A" sort="Vladimirtsev, Vsevolod A" uniqKey="Vladimirtsev V" first="Vsevolod A." last="Vladimirtsev">Vsevolod A. Vladimirtsev</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Shatunov, Alexey" sort="Shatunov, Alexey" uniqKey="Shatunov A" first="Alexey" last="Shatunov">Alexey Shatunov</name>
</noRegion>
<name sortKey="Goldfarb, Lev G" sort="Goldfarb, Lev G" uniqKey="Goldfarb L" first="Lev G." last="Goldfarb">Lev G. Goldfarb</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Masters, Colin L" sort="Masters, Colin L" uniqKey="Masters C" first="Colin L." last="Masters">Colin L. Masters</name>
</region>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Gajdusek, D Carleton" sort="Gajdusek, D Carleton" uniqKey="Gajdusek D" first="D. Carleton" last="Gajdusek">D. Carleton Gajdusek</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Viliuisk encephalomyelitis: intrathecal synthesis of oligoclonal IgG

Viliuisk encephalomyelitis: intrathecal synthesis of oligoclonal IgG

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