International consensus for neuroblastoma molecular diagnostics: report from the International Neuroblastoma Risk Group (INRG) Biology Committee
Identifieur interne : 008258 ( Main/Exploration ); précédent : 008257; suivant : 008259International consensus for neuroblastoma molecular diagnostics: report from the International Neuroblastoma Risk Group (INRG) Biology Committee
Auteurs : P. F. Ambros [Autriche] ; M. Ambros [Autriche] ; G. M. Brodeur [États-Unis] ; M. Haber [Australie] ; J. Khan [États-Unis] ; A. Nakagawara [Japon] ; G. Schleiermacher [France] ; F. Speleman [Belgique] ; R. Spitz [Allemagne] ; W. B. London [États-Unis] ; S. L. Cohn [États-Unis] ; Adj Pearson [Royaume-Uni] ; J. M. Maris [États-Unis]Source :
- British journal of cancer [ 0007-0920 ] ; 2009.
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English descriptors
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Abstract
Neuroblastoma serves as a paradigm for utilising tumour genomic data for determining patient prognosis and treatment allocation. However, before the establishment of the International Neuroblastoma Risk Group (INRG) Task Force in 2004, international consensus on markers, methodology, and data interpretation did not exist, compromising the reliability of decisive genetic markers and inhibiting translational research efforts, The objectives of the INRG Biology Committee were to identify highly prognostic genetic aberrations to be included in the new INRG risk classification schema and to develop precise definitions, decisive biomarkers, and technique standardisation. The review of the INRG database (n = 8800 patients) by the INRG Task Force finally enabled the identifcation of the most significant neuroblastoma biomarkers. In addition, the Biology Committee compared the standard operating procedures of different cooperative groups to arrive at international consensus for methodology, nomenclature, and future directions. Consensus was reached to include MYCN status, 11 q23 allelic status, and ploidy in the INRG classification system on the basis of an evidence-based review of the INRG database. Standardised operating procedures for analysing these genetic factors were adopted, and criteria for proper nomenclature were developed. Neuroblastoma treatment planning is highly dependant on tumour cell genomic features, and it is likely that a comprehensive panel of DNA-based biomarkers will be used in future risk assignment algorithms applying genome-wide techniques. Consensus on methodology and interpretation is essential for uniform INRG classifcation and will greatly facilitate international and cooperative clinical and translational research studies.
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Affiliations:
- Allemagne, Australie, Autriche, Belgique, France, Japon, Royaume-Uni, États-Unis
- Nouvelle-Galles du Sud, Vienne (Autriche), Île-de-France
- Paris, Sydney, Vienne (Autriche)
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F." last="Ambros">P. F. Ambros</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>CCRI, Children's Cancer Research Institute</s1><s2>Vienna</s2><s3>AUT</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Ambros, M" sort="Ambros, M" uniqKey="Ambros M" first="M." last="Ambros">M. Ambros</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>CCRI, Children's Cancer Research Institute</s1><s2>Vienna</s2><s3>AUT</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Brodeur, G M" sort="Brodeur, G M" uniqKey="Brodeur G" first="G. M." last="Brodeur">G. M. Brodeur</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Center for Childhood Cancer Research, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine</s1><s2>PA</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>PA</wicri:noRegion></affiliation></author><author><name sortKey="Haber, M" sort="Haber, M" uniqKey="Haber M" first="M." last="Haber">M. Haber</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Children's Cancer Institute Australia</s1><s2>Sydney</s2><s3>AUS</s3><sZ>4 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Khan, J" sort="Khan, J" uniqKey="Khan J" first="J." last="Khan">J. Khan</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>National Cancer Institute</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>National Cancer Institute</wicri:noRegion></affiliation></author><author><name sortKey="Nakagawara, A" sort="Nakagawara, A" uniqKey="Nakagawara A" first="A." last="Nakagawara">A. Nakagawara</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Chiba Cancer Center Research Institute</s1><s3>JPN</s3><sZ>6 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Chiba Cancer Center Research Institute</wicri:noRegion></affiliation></author><author><name sortKey="Schleiermacher, G" sort="Schleiermacher, G" uniqKey="Schleiermacher G" first="G." last="Schleiermacher">G. Schleiermacher</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Institut Curie</s1><s2>Paris</s2><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Speleman, F" sort="Speleman, F" uniqKey="Speleman F" first="F." last="Speleman">F. Speleman</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Centre for Medical Genetics</s1><s2>Ghent</s2><s3>BEL</s3><sZ>8 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Centre for Medical Genetics</wicri:noRegion></affiliation></author><author><name sortKey="Spitz, R" sort="Spitz, R" uniqKey="Spitz R" first="R." last="Spitz">R. Spitz</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Universlty of Cologne</s1><s3>DEU</s3><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Universlty of Cologne</wicri:noRegion><wicri:noRegion>Universlty of Cologne</wicri:noRegion></affiliation></author><author><name sortKey="London, W B" sort="London, W B" uniqKey="London W" first="W. B." last="London">W. B. London</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Children's Oncology Group Statistics and Data Center, University of Florida</s1><s2>Gainesville, FL</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Gainesville, FL</wicri:noRegion></affiliation></author><author><name sortKey="Cohn, S L" sort="Cohn, S L" uniqKey="Cohn S" first="S. L." last="Cohn">S. L. Cohn</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>The University of Chicago</s1><s2>Chicago, IL</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>The University of Chicago</wicri:noRegion></affiliation></author><author><name sortKey="Pearson, Adj" sort="Pearson, Adj" uniqKey="Pearson A" first="Adj" last="Pearson">Adj Pearson</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Section of Paediatrics, Institute of Cancer Research and Royal Marsden Hospital</s1><s2>Surrey</s2><s3>GBR</s3><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Maris, J M" sort="Maris, J M" uniqKey="Maris J" first="J. M." last="Maris">J. M. Maris</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Center for Childhood Cancer Research, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine</s1><s2>PA</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>PA</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">British journal of cancer</title><title level="j" type="abbreviated">Br. J. cancer</title><idno type="ISSN">0007-0920</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">British journal of cancer</title><title level="j" type="abbreviated">Br. J. cancer</title><idno type="ISSN">0007-0920</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biology</term><term>Cancerology</term><term>Consensus</term><term>Epidemiology</term><term>Genetic translation</term><term>Genetics</term><term>Genome</term><term>International</term><term>Molecular diagnostic</term><term>Neuroblastoma</term><term>Risk factor</term><term>Treatment planning</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Neuroblastome</term><term>International</term><term>Consensus</term><term>Facteur risque</term><term>Biologie</term><term>Plan traitement</term><term>Génome</term><term>Traduction génétique</term><term>Génétique</term><term>Epidémiologie</term><term>Cancérologie</term><term>Diagnostic moléculaire</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Biologie</term><term>Génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Neuroblastoma serves as a paradigm for utilising tumour genomic data for determining patient prognosis and treatment allocation. However, before the establishment of the International Neuroblastoma Risk Group (INRG) Task Force in 2004, international consensus on markers, methodology, and data interpretation did not exist, compromising the reliability of decisive genetic markers and inhibiting translational research efforts, The objectives of the INRG Biology Committee were to identify highly prognostic genetic aberrations to be included in the new INRG risk classification schema and to develop precise definitions, decisive biomarkers, and technique standardisation. The review of the INRG database (n = 8800 patients) by the INRG Task Force finally enabled the identifcation of the most significant neuroblastoma biomarkers. In addition, the Biology Committee compared the standard operating procedures of different cooperative groups to arrive at international consensus for methodology, nomenclature, and future directions. Consensus was reached to include MYCN status, 11 q23 allelic status, and ploidy in the INRG classification system on the basis of an evidence-based review of the INRG database. Standardised operating procedures for analysing these genetic factors were adopted, and criteria for proper nomenclature were developed. Neuroblastoma treatment planning is highly dependant on tumour cell genomic features, and it is likely that a comprehensive panel of DNA-based biomarkers will be used in future risk assignment algorithms applying genome-wide techniques. Consensus on methodology and interpretation is essential for uniform INRG classifcation and will greatly facilitate international and cooperative clinical and translational research studies.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Belgique</li><li>France</li><li>Japon</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Nouvelle-Galles du Sud</li><li>Vienne (Autriche)</li><li>Île-de-France</li></region><settlement><li>Paris</li><li>Sydney</li><li>Vienne (Autriche)</li></settlement></list><tree><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Ambros, P F" sort="Ambros, P F" uniqKey="Ambros P" first="P. F." last="Ambros">P. F. Ambros</name></region><name sortKey="Ambros, M" sort="Ambros, M" uniqKey="Ambros M" first="M." last="Ambros">M. Ambros</name></country><country name="États-Unis"><noRegion><name sortKey="Brodeur, G M" sort="Brodeur, G M" uniqKey="Brodeur G" first="G. M." last="Brodeur">G. M. Brodeur</name></noRegion><name sortKey="Cohn, S L" sort="Cohn, S L" uniqKey="Cohn S" first="S. L." last="Cohn">S. L. Cohn</name><name sortKey="Khan, J" sort="Khan, J" uniqKey="Khan J" first="J." last="Khan">J. Khan</name><name sortKey="London, W B" sort="London, W B" uniqKey="London W" first="W. B." last="London">W. B. London</name><name sortKey="Maris, J M" sort="Maris, J M" uniqKey="Maris J" first="J. M." last="Maris">J. M. Maris</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Haber, M" sort="Haber, M" uniqKey="Haber M" first="M." last="Haber">M. Haber</name></region></country><country name="Japon"><noRegion><name sortKey="Nakagawara, A" sort="Nakagawara, A" uniqKey="Nakagawara A" first="A." last="Nakagawara">A. Nakagawara</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Schleiermacher, G" sort="Schleiermacher, G" uniqKey="Schleiermacher G" first="G." last="Schleiermacher">G. Schleiermacher</name></region></country><country name="Belgique"><noRegion><name sortKey="Speleman, F" sort="Speleman, F" uniqKey="Speleman F" first="F." last="Speleman">F. Speleman</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Spitz, R" sort="Spitz, R" uniqKey="Spitz R" first="R." last="Spitz">R. Spitz</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Pearson, Adj" sort="Pearson, Adj" uniqKey="Pearson A" first="Adj" last="Pearson">Adj Pearson</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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