The conserved metalloprotease invadolysin localizes to the surface of lipid droplets
Identifieur interne : 007B47 ( Main/Exploration ); précédent : 007B46; suivant : 007B48The conserved metalloprotease invadolysin localizes to the surface of lipid droplets
Auteurs : Neville Cobbe [Royaume-Uni] ; Kathryn M. Marshall [Australie] ; Shubha Gururaja Rao [États-Unis] ; Ching-Wen Chang [Royaume-Uni] ; Francesca Di Cara [Royaume-Uni] ; Edward Duca [Royaume-Uni] ; Sharron Vass [Royaume-Uni] ; Adam Kassan [Espagne] ; Margarete M. S. Heck [Royaume-Uni]Source :
- Journal of Cell Science [ 0021-9533 ] ; 2009.
Abstract
Invadolysin is a metalloprotease conserved in many different organisms,
previously shown to be essential in
Url:
DOI: 10.1242/jcs.044610
PubMed: 19706689
PubMed Central: 2736869
Affiliations:
- Australie, Espagne, Royaume-Uni, États-Unis
- Californie, Catalogne, Victoria (État), Écosse
- Barcelone, Melbourne, Édimbourg
- Université d'Édimbourg, Université de Barcelone, Université de Melbourne
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S." last="Heck">Margarete M. S. Heck</name><affiliation wicri:level="4"><nlm:aff id="aff1"> University of Edinburgh, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> University of Edinburgh, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19706689</idno><idno type="pmc">2736869</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736869</idno><idno type="RBID">PMC:2736869</idno><idno type="doi">10.1242/jcs.044610</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">001008</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001008</idno><idno type="wicri:Area/Pmc/Curation">000E69</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000E69</idno><idno type="wicri:Area/Pmc/Checkpoint">002708</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002708</idno><idno type="wicri:Area/Ncbi/Merge">000633</idno><idno type="wicri:Area/Ncbi/Curation">000633</idno><idno type="wicri:Area/Ncbi/Checkpoint">000633</idno><idno type="wicri:doubleKey">0021-9533:2009:Cobbe N:the:conserved:metalloprotease</idno><idno type="wicri:Area/Main/Merge">008198</idno><idno type="wicri:Area/Main/Curation">007B47</idno><idno type="wicri:Area/Main/Exploration">007B47</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The conserved metalloprotease invadolysin localizes to the surface of
lipid droplets</title><author><name sortKey="Cobbe, Neville" sort="Cobbe, Neville" uniqKey="Cobbe N" first="Neville" last="Cobbe">Neville Cobbe</name><affiliation wicri:level="4"><nlm:aff id="aff1"> University of Edinburgh, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> University of Edinburgh, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Marshall, Kathryn M" sort="Marshall, Kathryn M" uniqKey="Marshall K" first="Kathryn M." last="Marshall">Kathryn M. Marshall</name><affiliation wicri:level="4"><nlm:aff id="aff2"> Department of Surgery, University of Melbourne, Austin Health, Studley Road, Heidelberg, Melbourne, Victoria 3084, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Department of Surgery, University of Melbourne, Austin Health, Studley Road, Heidelberg, Melbourne, Victoria 3084</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Rao, Shubha Gururaja" sort="Rao, Shubha Gururaja" uniqKey="Rao S" first="Shubha Gururaja" last="Rao">Shubha Gururaja Rao</name><affiliation wicri:level="2"><nlm:aff id="aff3"> Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Chang, Ching Wen" sort="Chang, Ching Wen" uniqKey="Chang C" first="Ching-Wen" last="Chang">Ching-Wen Chang</name><affiliation wicri:level="4"><nlm:aff id="aff1"> University of Edinburgh, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> University of Edinburgh, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Di Cara, Francesca" sort="Di Cara, Francesca" uniqKey="Di Cara F" first="Francesca" last="Di Cara">Francesca Di Cara</name><affiliation wicri:level="4"><nlm:aff id="aff1"> University of Edinburgh, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> University of Edinburgh, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Duca, Edward" sort="Duca, Edward" uniqKey="Duca E" first="Edward" last="Duca">Edward Duca</name><affiliation wicri:level="4"><nlm:aff id="aff1"> University of Edinburgh, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> University of Edinburgh, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Vass, Sharron" sort="Vass, Sharron" uniqKey="Vass S" first="Sharron" last="Vass">Sharron Vass</name><affiliation wicri:level="4"><nlm:aff id="aff1"> University of Edinburgh, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> University of Edinburgh, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Kassan, Adam" sort="Kassan, Adam" uniqKey="Kassan A" first="Adam" last="Kassan">Adam Kassan</name><affiliation wicri:level="4"><nlm:aff id="aff4"> Departament de Biologia Cellular, Facultat de Medicina, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Casanova 143, 08036 Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Departament de Biologia Cellular, Facultat de Medicina, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Casanova 143, 08036 Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université de Barcelone</orgName></affiliation></author><author><name sortKey="Heck, Margarete M S" sort="Heck, Margarete M S" uniqKey="Heck M" first="Margarete M. S." last="Heck">Margarete M. S. Heck</name><affiliation wicri:level="4"><nlm:aff id="aff1"> University of Edinburgh, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> University of Edinburgh, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Cell Science</title><idno type="ISSN">0021-9533</idno><idno type="eISSN">1477-9137</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>Invadolysin is a metalloprotease conserved in many different organisms,
previously shown to be essential in <italic>Drosophila</italic> with roles in cell
division and cell migration. The gene seems to be ubiquitously expressed and
four distinct splice variants have been identified in human cells but not in
most other species examined. Immunofluorescent detection of human invadolysin
in cultured cells reveals the protein to be associated with the surface of
lipid droplets. By means of subcellular fractionation, we have independently
confirmed the association of invadolysin with lipid droplets. We thus identify
invadolysin as the first metalloprotease located on these dynamic organelles.
In addition, analysis of larval fat-body morphological appearance and
triglyceride levels in the <italic>Drosophila</italic> invadolysin mutant suggests
that invadolysin plays a role in lipid storage or metabolism.</p></div></front></TEI><affiliations><list><country><li>Australie</li><li>Espagne</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Californie</li><li>Catalogne</li><li>Victoria (État)</li><li>Écosse</li></region><settlement><li>Barcelone</li><li>Melbourne</li><li>Édimbourg</li></settlement><orgName><li>Université d'Édimbourg</li><li>Université de Barcelone</li><li>Université de Melbourne</li></orgName></list><tree><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Cobbe, Neville" sort="Cobbe, Neville" uniqKey="Cobbe N" first="Neville" last="Cobbe">Neville Cobbe</name></region><name sortKey="Chang, Ching Wen" sort="Chang, Ching Wen" uniqKey="Chang C" first="Ching-Wen" last="Chang">Ching-Wen Chang</name><name sortKey="Di Cara, Francesca" sort="Di Cara, Francesca" uniqKey="Di Cara F" first="Francesca" last="Di Cara">Francesca Di Cara</name><name sortKey="Duca, Edward" sort="Duca, Edward" uniqKey="Duca E" first="Edward" last="Duca">Edward Duca</name><name sortKey="Heck, Margarete M S" sort="Heck, Margarete M S" uniqKey="Heck M" first="Margarete M. S." last="Heck">Margarete M. S. Heck</name><name sortKey="Vass, Sharron" sort="Vass, Sharron" uniqKey="Vass S" first="Sharron" last="Vass">Sharron Vass</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Marshall, Kathryn M" sort="Marshall, Kathryn M" uniqKey="Marshall K" first="Kathryn M." last="Marshall">Kathryn M. Marshall</name></region></country><country name="États-Unis"><region name="Californie"><name sortKey="Rao, Shubha Gururaja" sort="Rao, Shubha Gururaja" uniqKey="Rao S" first="Shubha Gururaja" last="Rao">Shubha Gururaja Rao</name></region></country><country name="Espagne"><region name="Catalogne"><name sortKey="Kassan, Adam" sort="Kassan, Adam" uniqKey="Kassan A" first="Adam" last="Kassan">Adam Kassan</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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