AustralieFrV1, Main, Exploration, bibRecord, 006D51

Altered Medial Temporal Activation Related to Local Glutamate Levels in Subjects with Prodromal Signs of Psychosis

Identifieur interne : 006D51 ( Main/Exploration ); précédent : 006D50; suivant : 006D52

Altered Medial Temporal Activation Related to Local Glutamate Levels in Subjects with Prodromal Signs of Psychosis

Auteurs : Isabel Valli [Royaume-Uni] ; James Stone [Royaume-Uni] ; Andrea Mechelli [Royaume-Uni] ; Sagnik Bhattacharyya [Royaume-Uni] ; Marie Raffin [Royaume-Uni, France] ; Paul Allen [Royaume-Uni] ; Paolo Fusar-Poli [Royaume-Uni, Italie, Australie] ; David Lythgoe [Royaume-Uni] ; Ruth O'Gorman [Royaume-Uni] ; Marc Seal [Royaume-Uni] ; Philip Mcguire [Royaume-Uni]

Source :

Biological psychiatry : (1969) [ 0006-3223 ] ; 2011.

RBID : Pascal:12-0059089

Descripteurs français

Pascal (Inist)
- Activation, Glutamate, Etat prépsychotique, Mémoire épisodique, Cortex temporal, Psychose, Schizophrénie, Homme, Imagerie par résonance magnétique fonctionnelle.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Activation, Episodic memory, Functional magnetic resonance imaging, Glutamate, Human, Prepsychotic state, Psychosis, Schizophrenia, Temporal cortex.

Abstract

Background: Both medial temporal cortical dysfunction and perturbed glutamatergic neurotransmission are regarded as fundamental pathophysiological features of psychosis. However, although animal models of psychosis suggest that these two abnormalities are interrelated, their relationship in humans has yet to be investigated. Methods: We used a combination of functional magnetic resonance imaging and magnetic resonance spectroscopy to investigate the relationship between medial temporal activation during an episodic memory task and local glutamate levels in 22 individuals with an at-risk mental state for psychosis and 14 healthy volunteers. Results: We observed a significant between-group difference in the coupling of medial temporal activation with local glutamate levels. In control subjects, medial temporal activation during episodic encoding was positively associated with medial temporal glutamate. However, in the clinical population, medial temporal activation was reduced, and the relationship with glutamate was absent. Conclusions: In individuals at high risk of psychosis, medial temporal dysfunction seemed related to a loss of the normal relationship with local glutamate levels. This study provides the first evidence that links medial temporal dysfunction with the central glutamate system in humans and is consistent with evidence that drugs that modulate glutamatergic transmission might be useful in the treatment of psychosis.

Affiliations:

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<series><title level="j" type="main">Biological psychiatry : (1969)</title>
<title level="j" type="abbreviated">Biol. psychiatry : (1969)</title>
<idno type="ISSN">0006-3223</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Biological psychiatry : (1969)</title>
<title level="j" type="abbreviated">Biol. psychiatry : (1969)</title>
<idno type="ISSN">0006-3223</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activation</term>
<term>Episodic memory</term>
<term>Functional magnetic resonance imaging</term>
<term>Glutamate</term>
<term>Human</term>
<term>Prepsychotic state</term>
<term>Psychosis</term>
<term>Schizophrenia</term>
<term>Temporal cortex</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Activation</term>
<term>Glutamate</term>
<term>Etat prépsychotique</term>
<term>Mémoire épisodique</term>
<term>Cortex temporal</term>
<term>Psychose</term>
<term>Schizophrénie</term>
<term>Homme</term>
<term>Imagerie par résonance magnétique fonctionnelle</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: Both medial temporal cortical dysfunction and perturbed glutamatergic neurotransmission are regarded as fundamental pathophysiological features of psychosis. However, although animal models of psychosis suggest that these two abnormalities are interrelated, their relationship in humans has yet to be investigated. Methods: We used a combination of functional magnetic resonance imaging and magnetic resonance spectroscopy to investigate the relationship between medial temporal activation during an episodic memory task and local glutamate levels in 22 individuals with an at-risk mental state for psychosis and 14 healthy volunteers. Results: We observed a significant between-group difference in the coupling of medial temporal activation with local glutamate levels. In control subjects, medial temporal activation during episodic encoding was positively associated with medial temporal glutamate. However, in the clinical population, medial temporal activation was reduced, and the relationship with glutamate was absent. Conclusions: In individuals at high risk of psychosis, medial temporal dysfunction seemed related to a loss of the normal relationship with local glutamate levels. This study provides the first evidence that links medial temporal dysfunction with the central glutamate system in humans and is consistent with evidence that drugs that modulate glutamatergic transmission might be useful in the treatment of psychosis.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Italie</li>
<li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
<li>Île-de-France</li>
</region>
<settlement><li>Londres</li>
<li>Paris</li>
</settlement>
<orgName><li>Université Pierre-et-Marie-Curie</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><noRegion><name sortKey="Valli, Isabel" sort="Valli, Isabel" uniqKey="Valli I" first="Isabel" last="Valli">Isabel Valli</name>
</noRegion>
<name sortKey="Allen, Paul" sort="Allen, Paul" uniqKey="Allen P" first="Paul" last="Allen">Paul Allen</name>
<name sortKey="Bhattacharyya, Sagnik" sort="Bhattacharyya, Sagnik" uniqKey="Bhattacharyya S" first="Sagnik" last="Bhattacharyya">Sagnik Bhattacharyya</name>
<name sortKey="Fusar Poli, Paolo" sort="Fusar Poli, Paolo" uniqKey="Fusar Poli P" first="Paolo" last="Fusar-Poli">Paolo Fusar-Poli</name>
<name sortKey="Lythgoe, David" sort="Lythgoe, David" uniqKey="Lythgoe D" first="David" last="Lythgoe">David Lythgoe</name>
<name sortKey="Mcguire, Philip" sort="Mcguire, Philip" uniqKey="Mcguire P" first="Philip" last="Mcguire">Philip Mcguire</name>
<name sortKey="Mechelli, Andrea" sort="Mechelli, Andrea" uniqKey="Mechelli A" first="Andrea" last="Mechelli">Andrea Mechelli</name>
<name sortKey="O Gorman, Ruth" sort="O Gorman, Ruth" uniqKey="O Gorman R" first="Ruth" last="O'Gorman">Ruth O'Gorman</name>
<name sortKey="Raffin, Marie" sort="Raffin, Marie" uniqKey="Raffin M" first="Marie" last="Raffin">Marie Raffin</name>
<name sortKey="Seal, Marc" sort="Seal, Marc" uniqKey="Seal M" first="Marc" last="Seal">Marc Seal</name>
<name sortKey="Stone, James" sort="Stone, James" uniqKey="Stone J" first="James" last="Stone">James Stone</name>
<name sortKey="Stone, James" sort="Stone, James" uniqKey="Stone J" first="James" last="Stone">James Stone</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Raffin, Marie" sort="Raffin, Marie" uniqKey="Raffin M" first="Marie" last="Raffin">Marie Raffin</name>
</region>
</country>
<country name="Italie"><noRegion><name sortKey="Fusar Poli, Paolo" sort="Fusar Poli, Paolo" uniqKey="Fusar Poli P" first="Paolo" last="Fusar-Poli">Paolo Fusar-Poli</name>
</noRegion>
</country>
<country name="Australie"><noRegion><name sortKey="Fusar Poli, Paolo" sort="Fusar Poli, Paolo" uniqKey="Fusar Poli P" first="Paolo" last="Fusar-Poli">Paolo Fusar-Poli</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Altered Medial Temporal Activation Related to Local Glutamate Levels in Subjects with Prodromal Signs of Psychosis

Altered Medial Temporal Activation Related to Local Glutamate Levels in Subjects with Prodromal Signs of Psychosis

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