AustralieFrV1, Main, Exploration, bibRecord, 006C90

CONFIRMATION OF A LOW α/β RATIO FOR PROSTATE CANCER TREATED BY EXTERNAL BEAM RADIATION THERAPY ALONE USING A POST-TREATMENT REPEATED-MEASURES MODEL FOR PSA DYNAMICS

Identifieur interne : 006C90 ( Main/Exploration ); précédent : 006C89; suivant : 006C91

CONFIRMATION OF A LOW α/β RATIO FOR PROSTATE CANCER TREATED BY EXTERNAL BEAM RADIATION THERAPY ALONE USING A POST-TREATMENT REPEATED-MEASURES MODEL FOR PSA DYNAMICS

Auteurs : Cecile Proust-Lima [France] ; Jeremy M. G. Taylor [États-Unis] ; Solène Secher [France] ; Howard Sandler [États-Unis] ; Larry Kestin [États-Unis] ; Tom Pickles [Canada] ; Kyoungwha Bae [États-Unis] ; Roger Allison [Australie] ; Scott Williams [Australie]

Source :

International journal of radiation oncology, biology, physics [ 0360-3016 ] ; 2011.

RBID : Pascal:11-0170080

Descripteurs français

Pascal (Inist)
- Cancer de la prostate, Radiothérapie, Traitement, Prostate, Radiosensibilité.

English descriptors

KwdEn :
- Prostate, Prostate cancer, Radiosensitivity, Radiotherapy, Treatment.

Abstract

Purpose: To estimate the α/β ratio of prostate cancer treated with external beam radiation only by use of a model of long-term prostate-specific antigen (PSA) dynamics. Methods and Materials: Repeated measures of PSA from 5,093 patients from 6 institutions treated for localized prostate cancer by external beam radiation therapy (EBRT) without planned androgen deprivation were analyzed. A biphasic linear mixed model described the post-treatment evolution of PSA, rather than a conventional model of time to biochemical recurrence. The model was adjusted for standard prognostic factors (T stage, initial PSA level, and Gleason score) and cohort-specific effects. The radiation dose fractionation effect was estimated from the long-term rate of rise of PSA level. Results: Adjusted for other factors, total dose of EBRT and sum of squared doses per fraction were associated with long-term rate of change of PSA level (p = 0.0017 and p = 0.0003, respectively), an increase of each being associated with a lower rate of rise. The α/β ratio was estimated at 1.55 Gy (95% confidence band, 0.46-4.52 Gy). This estimate was robust to adjustment of the linear mixed model. Conclusions: By analysis of a large EBRT-only cohort along with a method that uses all the repeated measures of PSA after the end of treatment, a low and precise α/β was estimated. These data support the use of hypofractionation at fractional doses up to 2.8 Gy but cannot presently be assumed to accurately represent higher doses per fraction.

Affiliations:

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Le document en format XML

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<author><name sortKey="Bae, Kyoungwha" sort="Bae, Kyoungwha" uniqKey="Bae K" first="Kyoungwha" last="Bae">Kyoungwha Bae</name>
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<wicri:noRegion>Brisbane</wicri:noRegion>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">CONFIRMATION OF A LOW α/β RATIO FOR PROSTATE CANCER TREATED BY EXTERNAL BEAM RADIATION THERAPY ALONE USING A POST-TREATMENT REPEATED-MEASURES MODEL FOR PSA DYNAMICS</title>
<author><name sortKey="Proust Lima, Cecile" sort="Proust Lima, Cecile" uniqKey="Proust Lima C" first="Cecile" last="Proust-Lima">Cecile Proust-Lima</name>
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<author><name sortKey="Taylor, Jeremy M G" sort="Taylor, Jeremy M G" uniqKey="Taylor J" first="Jeremy M. G." last="Taylor">Jeremy M. G. Taylor</name>
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<author><name sortKey="Secher, Solene" sort="Secher, Solene" uniqKey="Secher S" first="Solène" last="Secher">Solène Secher</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U897, Epidemiology and Biostatistics Research Center</s1>
<s2>Bordeaux</s2>
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<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
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<author><name sortKey="Sandler, Howard" sort="Sandler, Howard" uniqKey="Sandler H" first="Howard" last="Sandler">Howard Sandler</name>
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<author><name sortKey="Kestin, Larry" sort="Kestin, Larry" uniqKey="Kestin L" first="Larry" last="Kestin">Larry Kestin</name>
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<author><name sortKey="Pickles, Tom" sort="Pickles, Tom" uniqKey="Pickles T" first="Tom" last="Pickles">Tom Pickles</name>
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<s3>CAN</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>British Columbia Cancer Agency</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bae, Kyoungwha" sort="Bae, Kyoungwha" uniqKey="Bae K" first="Kyoungwha" last="Bae">Kyoungwha Bae</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Radiation Therapy Oncology Group</s1>
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<sZ>7 aut.</sZ>
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<country>États-Unis</country>
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</affiliation>
</author>
<author><name sortKey="Allison, Roger" sort="Allison, Roger" uniqKey="Allison R" first="Roger" last="Allison">Roger Allison</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Division of Oncology, Royal Brisbane and Women's Hospital</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Williams, Scott" sort="Williams, Scott" uniqKey="Williams S" first="Scott" last="Williams">Scott Williams</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Division of Radiation Oncology, Peter MacCallum Cancer Centre</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">International journal of radiation oncology, biology, physics</title>
<title level="j" type="abbreviated">Int. j. radiat. oncol. biol. phys.</title>
<idno type="ISSN">0360-3016</idno>
<imprint><date when="2011">2011</date>
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<seriesStmt><title level="j" type="main">International journal of radiation oncology, biology, physics</title>
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<idno type="ISSN">0360-3016</idno>
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</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Prostate</term>
<term>Prostate cancer</term>
<term>Radiosensitivity</term>
<term>Radiotherapy</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Cancer de la prostate</term>
<term>Radiothérapie</term>
<term>Traitement</term>
<term>Prostate</term>
<term>Radiosensibilité</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Purpose: To estimate the α/β ratio of prostate cancer treated with external beam radiation only by use of a model of long-term prostate-specific antigen (PSA) dynamics. Methods and Materials: Repeated measures of PSA from 5,093 patients from 6 institutions treated for localized prostate cancer by external beam radiation therapy (EBRT) without planned androgen deprivation were analyzed. A biphasic linear mixed model described the post-treatment evolution of PSA, rather than a conventional model of time to biochemical recurrence. The model was adjusted for standard prognostic factors (T stage, initial PSA level, and Gleason score) and cohort-specific effects. The radiation dose fractionation effect was estimated from the long-term rate of rise of PSA level. Results: Adjusted for other factors, total dose of EBRT and sum of squared doses per fraction were associated with long-term rate of change of PSA level (p = 0.0017 and p = 0.0003, respectively), an increase of each being associated with a lower rate of rise. The α/β ratio was estimated at 1.55 Gy (95% confidence band, 0.46-4.52 Gy). This estimate was robust to adjustment of the linear mixed model. Conclusions: By analysis of a large EBRT-only cohort along with a method that uses all the repeated measures of PSA after the end of treatment, a low and precise α/β was estimated. These data support the use of hypofractionation at fractional doses up to 2.8 Gy but cannot presently be assumed to accurately represent higher doses per fraction.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
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<li>France</li>
<li>États-Unis</li>
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<tree><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Proust Lima, Cecile" sort="Proust Lima, Cecile" uniqKey="Proust Lima C" first="Cecile" last="Proust-Lima">Cecile Proust-Lima</name>
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<name sortKey="Proust Lima, Cecile" sort="Proust Lima, Cecile" uniqKey="Proust Lima C" first="Cecile" last="Proust-Lima">Cecile Proust-Lima</name>
<name sortKey="Secher, Solene" sort="Secher, Solene" uniqKey="Secher S" first="Solène" last="Secher">Solène Secher</name>
<name sortKey="Secher, Solene" sort="Secher, Solene" uniqKey="Secher S" first="Solène" last="Secher">Solène Secher</name>
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<country name="États-Unis"><noRegion><name sortKey="Taylor, Jeremy M G" sort="Taylor, Jeremy M G" uniqKey="Taylor J" first="Jeremy M. G." last="Taylor">Jeremy M. G. Taylor</name>
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<name sortKey="Bae, Kyoungwha" sort="Bae, Kyoungwha" uniqKey="Bae K" first="Kyoungwha" last="Bae">Kyoungwha Bae</name>
<name sortKey="Kestin, Larry" sort="Kestin, Larry" uniqKey="Kestin L" first="Larry" last="Kestin">Larry Kestin</name>
<name sortKey="Sandler, Howard" sort="Sandler, Howard" uniqKey="Sandler H" first="Howard" last="Sandler">Howard Sandler</name>
<name sortKey="Taylor, Jeremy M G" sort="Taylor, Jeremy M G" uniqKey="Taylor J" first="Jeremy M. G." last="Taylor">Jeremy M. G. Taylor</name>
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<country name="Canada"><noRegion><name sortKey="Pickles, Tom" sort="Pickles, Tom" uniqKey="Pickles T" first="Tom" last="Pickles">Tom Pickles</name>
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<country name="Australie"><noRegion><name sortKey="Allison, Roger" sort="Allison, Roger" uniqKey="Allison R" first="Roger" last="Allison">Roger Allison</name>
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<name sortKey="Williams, Scott" sort="Williams, Scott" uniqKey="Williams S" first="Scott" last="Williams">Scott Williams</name>
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CONFIRMATION OF A LOW α/β RATIO FOR PROSTATE CANCER TREATED BY EXTERNAL BEAM RADIATION THERAPY ALONE USING A POST-TREATMENT REPEATED-MEASURES MODEL FOR PSA DYNAMICS

CONFIRMATION OF A LOW α/β RATIO FOR PROSTATE CANCER TREATED BY EXTERNAL BEAM RADIATION THERAPY ALONE USING A POST-TREATMENT REPEATED-MEASURES MODEL FOR PSA DYNAMICS

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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