AustralieFrV1, Main, Exploration, bibRecord, 006166

Effects of Translocator Protein (18 kDa) Ligands on Microglial Activation and Neuronal Death in the Quinolinic-Acid-Injected Rat Striatum

Identifieur interne : 006166 ( Main/Exploration ); précédent : 006165; suivant : 006167

Effects of Translocator Protein (18 kDa) Ligands on Microglial Activation and Neuronal Death in the Quinolinic-Acid-Injected Rat Striatum

Auteurs : Katherine X0a R. Leaver [Australie, France] ; Aaron Reynolds [Australie] ; Sylvie Bodard [France] ; Denis Guilloteau [France] ; Sylvie Chalon [France] ; Michael Kassiou [Australie]

Source :

ACS Chemical Neuroscience [ 1948-7193 ] ; 2011.

RBID : PMC:3369788

Abstract

There is evidence that excitotoxicity and prolonged microglial activation are involved in neuronal death in neurodegenerative disorders. Activated microglia express various molecules, including the translocator protein 18 kDa (TSPO; formerly known as the peripheral benzodiazepine receptor) on the outer mitochondrial membrane. The TSPO is a novel target for neuroprotective treatments which aim to reduce microglial activation. The effect of PK 11195 and three other TSPO ligands on the level of microglial activation and neuronal survival was evaluated in a quinolinic acid (QUIN) rat model of excitotoxic neurodegeneration. All three ligands were neuroprotective at a level comparable to PK 11195. All of the ligands decreased microglial activation following the injection of QUIN but had no effect on astrogliosis. Interestingly, we also observed neuroprotective effects from the vehicle, dimethyl sulfoxide (DMSO).

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369788

DOI: 10.1021/cn200099e
PubMed: 22860181
PubMed Central: 3369788

Affiliations:

Le document en format XML

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<p>There is evidence that excitotoxicity and prolonged microglial
activation are involved in neuronal death in neurodegenerative disorders.
Activated microglia express various molecules, including the translocator
protein 18 kDa (TSPO; formerly known as the peripheral benzodiazepine
receptor) on the outer mitochondrial membrane. The TSPO is a novel
target for neuroprotective treatments which aim to reduce microglial
activation. The effect of PK 11195 and three other TSPO ligands on
the level of microglial activation and neuronal survival was evaluated
in a quinolinic acid (QUIN) rat model of excitotoxic neurodegeneration.
All three ligands were neuroprotective at a level comparable to PK
11195. All of the ligands decreased microglial activation following
the injection of QUIN but had no effect on astrogliosis. Interestingly,
we also observed neuroprotective effects from the vehicle, dimethyl
sulfoxide (DMSO).</p>
</div>
</front>
</TEI>
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Effects of Translocator Protein (18 kDa) Ligands on Microglial Activation and Neuronal Death in the Quinolinic-Acid-Injected Rat Striatum

Effects of Translocator Protein (18 kDa) Ligands on Microglial Activation and Neuronal Death in the Quinolinic-Acid-Injected Rat Striatum

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