AustralieFrV1, Main, Exploration, bibRecord, 005930

Segmental chromosomal alterations have prognostic impact in neuroblastoma: a report from the INRG project

Identifieur interne : 005930 ( Main/Exploration ); précédent : 005929; suivant : 005931

Segmental chromosomal alterations have prognostic impact in neuroblastoma: a report from the INRG project

Auteurs : G. Schleiermacher [France] ; V. Mosseri [France] ; W. B. London [États-Unis] ; J. M. Maris [États-Unis] ; G. M. Brodeur [États-Unis] ; E. Attiyeh [États-Unis] ; M. Haber [Australie] ; J. Khan [États-Unis] ; A. Nakagawara [Japon] ; F. Speleman [Belgique] ; R. Noguera [Espagne] ; G. P. Tonini [Italie] ; M. Fischer [Allemagne] ; I. Ambros [Autriche] ; T. Monclair [Norvège] ; K. K. Matthay [États-Unis] ; P. Ambros [Autriche] ; S. L. Cohn [États-Unis] ; Adj Pearson [Royaume-Uni]

Source :

British journal of cancer [ 0007-0920 ] ; 2012.

RBID : Pascal:12-0416784

Descripteurs français

Pascal (Inist)
- Neuroblastome, Segmentaire, Chromosome, Génétique, Pronostic, Génome, Cancérologie.
Wicri :
- topic : Génétique.

English descriptors

KwdEn :
- Cancerology, Chromosome, Genetics, Genome, Neuroblastoma, Prognosis, Segmental.

Abstract

BACKGROUND: In the INRG dataset, the hypothesis that any segmental chromosomal alteration might be of prognostic impact in neuroblastoma without MYCN amplification (MNA) was tested. METHODS: The presence of any segmental chromosomal alteration (chromosome I p deletion, I I q deletion and/or chromosome 17q gain) defined a segmental genomic profile. Only tumours with a confirmed unaltered status for all three chromosome arms were considered as having no segmental chromosomal alterations. RESULTS: Among the 8800 patients in the INRG database, a genomic type could be attributed for 505 patients without MNA: 397 cases had a segmental genomic type, whereas 108 cases had an absence of any segmental alteration. A segmental genomic type was more frequent in patients > 18 months and in stage 4 disease (P<0.0001). In univariate analysis, I I q deletion, 17q gain and a segmental genomic type were associated with a poorer event-free survival (EFS) (P<0.0001, P = 0.0002 and P < 0.0001, respectively). In multivariate analysis modelling EFS, the parameters age, stage and a segmental genomic type were retained in the model, whereas the individual genetic markers were not (P<0.0001 and RR = 2.56; P = 0.0002 and RR= 1.8; P = 0.01 and RR = 1.7, respectively). CONCLUSION: A segmental genomic profile, rather than the single genetic markers, adds prognostic information to the clinical markers age and stage in neuroblastoma patients without MNA, underlining the importance of pangenomic studies.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494425

Affiliations:

Allemagne, Australie, Autriche, Belgique, Espagne, France, Italie, Japon, Norvège, Royaume-Uni, États-Unis
Vienne (Autriche), Île-de-France, Østlandet
Oslo, Paris, Vienne (Autriche)

Le document en format XML

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<wicri:noRegion>Valencia</wicri:noRegion>
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</author>
<author><name sortKey="Tonini, G P" sort="Tonini, G P" uniqKey="Tonini G" first="G. P." last="Tonini">G. P. Tonini</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Translational Oncopathology, National Cancer Research Institute</s1>
<s2>Genova</s2>
<s3>ITA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Genova</wicri:noRegion>
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</author>
<author><name sortKey="Fischer, M" sort="Fischer, M" uniqKey="Fischer M" first="M." last="Fischer">M. Fischer</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Children's Hospital, Department of Pediatric Oncology and Hematology and Center for Molecular Medicine Cologne, University of Cologne</s1>
<s2>Cologne</s2>
<s3>DEU</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>University of Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ambros, I" sort="Ambros, I" uniqKey="Ambros I" first="I." last="Ambros">I. Ambros</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>CCRI, Children's Cancer Research Institute, St. Anno Kinderkrebsforschung</s1>
<s2>Vienna</s2>
<s3>AUT</s3>
<sZ>14 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Monclair, T" sort="Monclair, T" uniqKey="Monclair T" first="T." last="Monclair">T. Monclair</name>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Section for Paediatric Surgery, Division of Surgery, Rikshospitatet University Hospital</s1>
<s2>Oslo</s2>
<s3>NOR</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Norvège</country>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Matthay, K K" sort="Matthay, K K" uniqKey="Matthay K" first="K. K." last="Matthay">K. K. Matthay</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>UCSF School of Medicine and Benioff Children's Hospital</s1>
<s2>San Francisco, CA</s2>
<s3>USA</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>UCSF School of Medicine and Benioff Children's Hospital</wicri:noRegion>
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</author>
<author><name sortKey="Ambros, P" sort="Ambros, P" uniqKey="Ambros P" first="P." last="Ambros">P. Ambros</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>CCRI, Children's Cancer Research Institute, St. Anno Kinderkrebsforschung</s1>
<s2>Vienna</s2>
<s3>AUT</s3>
<sZ>14 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cohn, S L" sort="Cohn, S L" uniqKey="Cohn S" first="S. L." last="Cohn">S. L. Cohn</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Section of Pediatric Hematology/ Oncology, Comer Children's Hospital, The University of Chicago</s1>
<s2>Chicago, IL</s2>
<s3>USA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Chicago, IL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pearson, Adj" sort="Pearson, Adj" uniqKey="Pearson A" first="Adj" last="Pearson">Adj Pearson</name>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Children's Department, Institute of Cancer Research, Royal Marsden Hospital</s1>
<s2>Sutton</s2>
<s3>GBR</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Sutton</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">British journal of cancer</title>
<title level="j" type="abbreviated">Br. j. cancer</title>
<idno type="ISSN">0007-0920</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">British journal of cancer</title>
<title level="j" type="abbreviated">Br. j. cancer</title>
<idno type="ISSN">0007-0920</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cancerology</term>
<term>Chromosome</term>
<term>Genetics</term>
<term>Genome</term>
<term>Neuroblastoma</term>
<term>Prognosis</term>
<term>Segmental</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Neuroblastome</term>
<term>Segmentaire</term>
<term>Chromosome</term>
<term>Génétique</term>
<term>Pronostic</term>
<term>Génome</term>
<term>Cancérologie</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">BACKGROUND: In the INRG dataset, the hypothesis that any segmental chromosomal alteration might be of prognostic impact in neuroblastoma without MYCN amplification (MNA) was tested. METHODS: The presence of any segmental chromosomal alteration (chromosome I p deletion, I I q deletion and/or chromosome 17q gain) defined a segmental genomic profile. Only tumours with a confirmed unaltered status for all three chromosome arms were considered as having no segmental chromosomal alterations. RESULTS: Among the 8800 patients in the INRG database, a genomic type could be attributed for 505 patients without MNA: 397 cases had a segmental genomic type, whereas 108 cases had an absence of any segmental alteration. A segmental genomic type was more frequent in patients > 18 months and in stage 4 disease (P<0.0001). In univariate analysis, I I q deletion, 17q gain and a segmental genomic type were associated with a poorer event-free survival (EFS) (P<0.0001, P = 0.0002 and P < 0.0001, respectively). In multivariate analysis modelling EFS, the parameters age, stage and a segmental genomic type were retained in the model, whereas the individual genetic markers were not (P<0.0001 and RR = 2.56; P = 0.0002 and RR= 1.8; P = 0.01 and RR = 1.7, respectively). CONCLUSION: A segmental genomic profile, rather than the single genetic markers, adds prognostic information to the clinical markers age and stage in neuroblastoma patients without MNA, underlining the importance of pangenomic studies.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Autriche</li>
<li>Belgique</li>
<li>Espagne</li>
<li>France</li>
<li>Italie</li>
<li>Japon</li>
<li>Norvège</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Vienne (Autriche)</li>
<li>Île-de-France</li>
<li>Østlandet</li>
</region>
<settlement><li>Oslo</li>
<li>Paris</li>
<li>Vienne (Autriche)</li>
</settlement>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Schleiermacher, G" sort="Schleiermacher, G" uniqKey="Schleiermacher G" first="G." last="Schleiermacher">G. Schleiermacher</name>
</region>
<name sortKey="Mosseri, V" sort="Mosseri, V" uniqKey="Mosseri V" first="V." last="Mosseri">V. Mosseri</name>
<name sortKey="Schleiermacher, G" sort="Schleiermacher, G" uniqKey="Schleiermacher G" first="G." last="Schleiermacher">G. Schleiermacher</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="London, W B" sort="London, W B" uniqKey="London W" first="W. B." last="London">W. B. London</name>
</noRegion>
<name sortKey="Attiyeh, E" sort="Attiyeh, E" uniqKey="Attiyeh E" first="E." last="Attiyeh">E. Attiyeh</name>
<name sortKey="Brodeur, G M" sort="Brodeur, G M" uniqKey="Brodeur G" first="G. M." last="Brodeur">G. M. Brodeur</name>
<name sortKey="Cohn, S L" sort="Cohn, S L" uniqKey="Cohn S" first="S. L." last="Cohn">S. L. Cohn</name>
<name sortKey="Khan, J" sort="Khan, J" uniqKey="Khan J" first="J." last="Khan">J. Khan</name>
<name sortKey="Maris, J M" sort="Maris, J M" uniqKey="Maris J" first="J. M." last="Maris">J. M. Maris</name>
<name sortKey="Matthay, K K" sort="Matthay, K K" uniqKey="Matthay K" first="K. K." last="Matthay">K. K. Matthay</name>
</country>
<country name="Australie"><noRegion><name sortKey="Haber, M" sort="Haber, M" uniqKey="Haber M" first="M." last="Haber">M. Haber</name>
</noRegion>
</country>
<country name="Japon"><noRegion><name sortKey="Nakagawara, A" sort="Nakagawara, A" uniqKey="Nakagawara A" first="A." last="Nakagawara">A. Nakagawara</name>
</noRegion>
</country>
<country name="Belgique"><noRegion><name sortKey="Speleman, F" sort="Speleman, F" uniqKey="Speleman F" first="F." last="Speleman">F. Speleman</name>
</noRegion>
</country>
<country name="Espagne"><noRegion><name sortKey="Noguera, R" sort="Noguera, R" uniqKey="Noguera R" first="R." last="Noguera">R. Noguera</name>
</noRegion>
</country>
<country name="Italie"><noRegion><name sortKey="Tonini, G P" sort="Tonini, G P" uniqKey="Tonini G" first="G. P." last="Tonini">G. P. Tonini</name>
</noRegion>
</country>
<country name="Allemagne"><noRegion><name sortKey="Fischer, M" sort="Fischer, M" uniqKey="Fischer M" first="M." last="Fischer">M. Fischer</name>
</noRegion>
</country>
<country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Ambros, I" sort="Ambros, I" uniqKey="Ambros I" first="I." last="Ambros">I. Ambros</name>
</region>
<name sortKey="Ambros, P" sort="Ambros, P" uniqKey="Ambros P" first="P." last="Ambros">P. Ambros</name>
</country>
<country name="Norvège"><region name="Østlandet"><name sortKey="Monclair, T" sort="Monclair, T" uniqKey="Monclair T" first="T." last="Monclair">T. Monclair</name>
</region>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Pearson, Adj" sort="Pearson, Adj" uniqKey="Pearson A" first="Adj" last="Pearson">Adj Pearson</name>
</noRegion>
</country>
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</record>

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Segmental chromosomal alterations have prognostic impact in neuroblastoma: a report from the INRG project

Segmental chromosomal alterations have prognostic impact in neuroblastoma: a report from the INRG project

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