AustralieFrV1, Main, Exploration, bibRecord, 005592

Tertiary prophylaxis in adults: is there a rationale?

Identifieur interne : 005592 ( Main/Exploration ); précédent : 005591; suivant : 005593

Tertiary prophylaxis in adults: is there a rationale?

Auteurs : A. Gringeri [Italie] ; T. Lambert [France] ; A. Street [Australie] ; L. Aledort [États-Unis]

Source :

Haemophilia [ 1351-8216 ] ; 2012-09.

RBID : ISTEX:DCCF75B35BA2C60CE99BE2DCA109489F82262339

Descripteurs français

Wicri :
- topic : Participation sociale.

English descriptors

Abstract

There is lack of evidence‐based recommendations or clear‐cut consensus regarding the clinical and economic utility of regular prophylaxis started in adulthood, with the aim of keeping the clinical situation from getting worse by prevention of further bleeds contributing to increasing musculo‐skeletal or other morbidity in haemophilia. Such a prophylaxis program has been shown in relatively small cohorts to be effective in reducing bleeding occurrence, with a variable effect on the joint status, but with significantly higher factor consumption and consequently higher costs than on‐demand therapy. There has been no attempt to identify subsets of patients who may benefit from “tertiary” prophylaxis more than others, for example, due to their bleeding phenotype and/or requirements for product issued on‐demand or to identify the dosage that provides the optimal balance of clinical benefit and cost effectiveness. This article reviews the published literature on prophylaxis started beyond the age of 18 years, the barriers to the uptake of prophylaxis programs particularly in adults and highlights areas in need of further research.

Url:

https://api.istex.fr/document/DCCF75B35BA2C60CE99BE2DCA109489F82262339/fulltext/pdf

DOI: 10.1111/j.1365-2516.2012.02843.x

Affiliations:

Australie, France, Italie, États-Unis
Lombardie, Victoria (État), État de New York
Melbourne, Milan

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 002924
to stream Istex, to step Curation: 002924
to stream Istex, to step Checkpoint: 000517
to stream Main, to step Merge: 005859
to stream Main, to step Curation: 005592

Le document en format XML

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<term>Secondary prophylaxis</term>
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<term>Orthopaedic scores</term>
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<front><div type="abstract">There is lack of evidence‐based recommendations or clear‐cut consensus regarding the clinical and economic utility of regular prophylaxis started in adulthood, with the aim of keeping the clinical situation from getting worse by prevention of further bleeds contributing to increasing musculo‐skeletal or other morbidity in haemophilia. Such a prophylaxis program has been shown in relatively small cohorts to be effective in reducing bleeding occurrence, with a variable effect on the joint status, but with significantly higher factor consumption and consequently higher costs than on‐demand therapy. There has been no attempt to identify subsets of patients who may benefit from “tertiary” prophylaxis more than others, for example, due to their bleeding phenotype and/or requirements for product issued on‐demand or to identify the dosage that provides the optimal balance of clinical benefit and cost effectiveness. This article reviews the published literature on prophylaxis started beyond the age of 18 years, the barriers to the uptake of prophylaxis programs particularly in adults and highlights areas in need of further research.</div>
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Tertiary prophylaxis in adults: is there a rationale?

Tertiary prophylaxis in adults: is there a rationale?

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri