Glucose-Induced O2 Consumption Activates Hypoxia Inducible Factors 1 and 2 in Rat Insulin-Secreting Pancreatic Beta-Cells
Identifieur interne : 005363 ( Main/Exploration ); précédent : 005362; suivant : 005364Glucose-Induced O2 Consumption Activates Hypoxia Inducible Factors 1 and 2 in Rat Insulin-Secreting Pancreatic Beta-Cells
Auteurs : Mohammed Bensellam [Belgique] ; Bertrand Duvillié [France] ; Galyna Rybachuk [Belgique] ; D. Ross Laybutt [Australie] ; Christophe Magnan [France] ; Yves Guiot [Belgique] ; Jacques Pouysségur [France] ; Jean-Christophe Jonas [Belgique]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
Glucose increases the expression of glycolytic enzymes and other hypoxia-response genes in pancreatic beta-cells. Here, we tested whether this effect results from the activation of Hypoxia-Inducible-factors (HIF) 1 and 2 in a hypoxia-dependent manner.
Isolated rat islets and insulin-secreting INS-1E cells were stimulated with nutrients at various pO2 values or treated with the HIF activator CoCl2. HIF-target gene mRNA levels and HIF subunit protein levels were measured by real-time RT-PCR, Western Blot and immunohistochemistry. The formation of pimonidazole-protein adducts was used as an indicator of hypoxia. In INS-1E and islet beta-cells, glucose concentration-dependently stimulated formation of pimonidazole-protein adducts, HIF1 and HIF2 nuclear expression and HIF-target gene mRNA levels to a lesser extent than CoCl2 or a four-fold reduction in pO2. Islets also showed signs of HIF activation in diabetic
Glucose-induced O2 consumption creates an intracellular hypoxia that activates HIF1 and HIF2 in rat beta-cells, and this glucose effect contributes, together with the activation of other transcription factors, to the glucose stimulation of expression of some glycolytic enzymes and other hypoxia response genes.
Url:
DOI: 10.1371/journal.pone.0029807
PubMed: 22235342
PubMed Central: 3250482
Affiliations:
- Australie, Belgique, France
- Nouvelle-Galles du Sud, Provence-Alpes-Côte d'Azur, Région de Bruxelles-Capitale, Île-de-France
- Bruxelles, Louvain-la-Neuve, Nice, Paris, Sydney
- Université Paris Diderot-Paris 7, Université Paris-Descartes, Université catholique de Louvain
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002C33
- to stream Pmc, to step Curation: 002A83
- to stream Pmc, to step Checkpoint: 001F18
- to stream Ncbi, to step Merge: 000C73
- to stream Ncbi, to step Curation: 000C73
- to stream Ncbi, to step Checkpoint: 000C73
- to stream Main, to step Merge: 005602
- to stream Main, to step Curation: 005363
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Glucose-Induced O<sub>2</sub>
Consumption Activates Hypoxia Inducible Factors 1 and 2 in Rat Insulin-Secreting Pancreatic Beta-Cells</title>
<author><name sortKey="Bensellam, Mohammed" sort="Bensellam, Mohammed" uniqKey="Bensellam M" first="Mohammed" last="Bensellam">Mohammed Bensellam</name>
<affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Pôle d′Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium</addr-line>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Pôle d′Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
<settlement type="city">Louvain-la-Neuve</settlement>
</placeName>
<orgName type="university">Université catholique de Louvain</orgName>
</affiliation>
</author>
<author><name sortKey="Duvillie, Bertrand" sort="Duvillie, Bertrand" uniqKey="Duvillie B" first="Bertrand" last="Duvillié">Bertrand Duvillié</name>
<affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>INSERM U845, Faculté de Médecine, Research Center Growth and Signalling, Université Paris Descartes, Hôpital Necker, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U845, Faculté de Médecine, Research Center Growth and Signalling, Université Paris Descartes, Hôpital Necker, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Paris-Descartes</orgName>
</affiliation>
</author>
<author><name sortKey="Rybachuk, Galyna" sort="Rybachuk, Galyna" uniqKey="Rybachuk G" first="Galyna" last="Rybachuk">Galyna Rybachuk</name>
<affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Pôle d′Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium</addr-line>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Pôle d′Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
<settlement type="city">Louvain-la-Neuve</settlement>
</placeName>
<orgName type="university">Université catholique de Louvain</orgName>
</affiliation>
</author>
<author><name sortKey="Laybutt, D Ross" sort="Laybutt, D Ross" uniqKey="Laybutt D" first="D. Ross" last="Laybutt">D. Ross Laybutt</name>
<affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St. Vincent's Hospital, Sydney, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St. Vincent's Hospital, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Magnan, Christophe" sort="Magnan, Christophe" uniqKey="Magnan C" first="Christophe" last="Magnan">Christophe Magnan</name>
<affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Unité de Biologie Fonctionnelle et Adaptative, CNRS-Université Paris Diderot-Paris 7, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité de Biologie Fonctionnelle et Adaptative, CNRS-Université Paris Diderot-Paris 7, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Paris Diderot-Paris 7</orgName>
</affiliation>
</author>
<author><name sortKey="Guiot, Yves" sort="Guiot, Yves" uniqKey="Guiot Y" first="Yves" last="Guiot">Yves Guiot</name>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Pôle de Morphologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium</addr-line>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Pôle de Morphologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
<settlement type="city">Louvain-la-Neuve</settlement>
</placeName>
<orgName type="university">Université catholique de Louvain</orgName>
</affiliation>
</author>
<author><name sortKey="Pouyssegur, Jacques" sort="Pouyssegur, Jacques" uniqKey="Pouyssegur J" first="Jacques" last="Pouysségur">Jacques Pouysségur</name>
<affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>Institute of Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Centre A. Lacassagne, Nice, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institute of Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Centre A. Lacassagne, Nice</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Nice</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jonas, Jean Christophe" sort="Jonas, Jean Christophe" uniqKey="Jonas J" first="Jean-Christophe" last="Jonas">Jean-Christophe Jonas</name>
<affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Pôle d′Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium</addr-line>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Pôle d′Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
<settlement type="city">Louvain-la-Neuve</settlement>
</placeName>
<orgName type="university">Université catholique de Louvain</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22235342</idno>
<idno type="pmc">3250482</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250482</idno>
<idno type="RBID">PMC:3250482</idno>
<idno type="doi">10.1371/journal.pone.0029807</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">002C33</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002C33</idno>
<idno type="wicri:Area/Pmc/Curation">002A83</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002A83</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001F18</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001F18</idno>
<idno type="wicri:Area/Ncbi/Merge">000C73</idno>
<idno type="wicri:Area/Ncbi/Curation">000C73</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000C73</idno>
<idno type="wicri:Area/Main/Merge">005602</idno>
<idno type="wicri:Area/Main/Curation">005363</idno>
<idno type="wicri:Area/Main/Exploration">005363</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Glucose-Induced O<sub>2</sub>
Consumption Activates Hypoxia Inducible Factors 1 and 2 in Rat Insulin-Secreting Pancreatic Beta-Cells</title>
<author><name sortKey="Bensellam, Mohammed" sort="Bensellam, Mohammed" uniqKey="Bensellam M" first="Mohammed" last="Bensellam">Mohammed Bensellam</name>
<affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Pôle d′Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium</addr-line>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Pôle d′Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
<settlement type="city">Louvain-la-Neuve</settlement>
</placeName>
<orgName type="university">Université catholique de Louvain</orgName>
</affiliation>
</author>
<author><name sortKey="Duvillie, Bertrand" sort="Duvillie, Bertrand" uniqKey="Duvillie B" first="Bertrand" last="Duvillié">Bertrand Duvillié</name>
<affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>INSERM U845, Faculté de Médecine, Research Center Growth and Signalling, Université Paris Descartes, Hôpital Necker, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U845, Faculté de Médecine, Research Center Growth and Signalling, Université Paris Descartes, Hôpital Necker, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Paris-Descartes</orgName>
</affiliation>
</author>
<author><name sortKey="Rybachuk, Galyna" sort="Rybachuk, Galyna" uniqKey="Rybachuk G" first="Galyna" last="Rybachuk">Galyna Rybachuk</name>
<affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Pôle d′Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium</addr-line>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Pôle d′Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
<settlement type="city">Louvain-la-Neuve</settlement>
</placeName>
<orgName type="university">Université catholique de Louvain</orgName>
</affiliation>
</author>
<author><name sortKey="Laybutt, D Ross" sort="Laybutt, D Ross" uniqKey="Laybutt D" first="D. Ross" last="Laybutt">D. Ross Laybutt</name>
<affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St. Vincent's Hospital, Sydney, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St. Vincent's Hospital, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Magnan, Christophe" sort="Magnan, Christophe" uniqKey="Magnan C" first="Christophe" last="Magnan">Christophe Magnan</name>
<affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Unité de Biologie Fonctionnelle et Adaptative, CNRS-Université Paris Diderot-Paris 7, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité de Biologie Fonctionnelle et Adaptative, CNRS-Université Paris Diderot-Paris 7, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Paris Diderot-Paris 7</orgName>
</affiliation>
</author>
<author><name sortKey="Guiot, Yves" sort="Guiot, Yves" uniqKey="Guiot Y" first="Yves" last="Guiot">Yves Guiot</name>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Pôle de Morphologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium</addr-line>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Pôle de Morphologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
<settlement type="city">Louvain-la-Neuve</settlement>
</placeName>
<orgName type="university">Université catholique de Louvain</orgName>
</affiliation>
</author>
<author><name sortKey="Pouyssegur, Jacques" sort="Pouyssegur, Jacques" uniqKey="Pouyssegur J" first="Jacques" last="Pouysségur">Jacques Pouysségur</name>
<affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>Institute of Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Centre A. Lacassagne, Nice, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institute of Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Centre A. Lacassagne, Nice</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Nice</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jonas, Jean Christophe" sort="Jonas, Jean Christophe" uniqKey="Jonas J" first="Jean-Christophe" last="Jonas">Jean-Christophe Jonas</name>
<affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Pôle d′Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium</addr-line>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Pôle d′Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
<settlement type="city">Louvain-la-Neuve</settlement>
</placeName>
<orgName type="university">Université catholique de Louvain</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Glucose increases the expression of glycolytic enzymes and other hypoxia-response genes in pancreatic beta-cells. Here, we tested whether this effect results from the activation of Hypoxia-Inducible-factors (HIF) 1 and 2 in a hypoxia-dependent manner.</p>
</sec>
<sec><title>Methodology/Principal Findings</title>
<p>Isolated rat islets and insulin-secreting INS-1E cells were stimulated with nutrients at various pO<sub>2</sub>
values or treated with the HIF activator CoCl<sub>2</sub>
. HIF-target gene mRNA levels and HIF subunit protein levels were measured by real-time RT-PCR, Western Blot and immunohistochemistry. The formation of pimonidazole-protein adducts was used as an indicator of hypoxia. In INS-1E and islet beta-cells, glucose concentration-dependently stimulated formation of pimonidazole-protein adducts, HIF1 and HIF2 nuclear expression and HIF-target gene mRNA levels to a lesser extent than CoCl<sub>2</sub>
or a four-fold reduction in pO<sub>2</sub>
. Islets also showed signs of HIF activation in diabetic <italic>Lepr<sup>db/db</sup>
</italic>
but not non-diabetic <italic>Lepr<sup>db/+</sup>
</italic>
mice. <italic>In vitro</italic>
, these glucose effects were reproduced by nutrient secretagogues that bypass glycolysis, and were inhibited by a three-fold increase in pO<sub>2</sub>
or by inhibitors of Ca<sup>2+</sup>
influx and insulin secretion. In INS-1E cells, small interfering RNA-mediated knockdown of <italic>Hif1α</italic>
and <italic>Hif2α</italic>
, alone or in combination, indicated that the stimulation of glycolytic enzyme mRNA levels depended on both HIF isoforms while the vasodilating peptide adrenomedullin was a HIF2-specific target gene.</p>
</sec>
<sec><title>Conclusions/Significance</title>
<p>Glucose-induced O<sub>2</sub>
consumption creates an intracellular hypoxia that activates HIF1 and HIF2 in rat beta-cells, and this glucose effect contributes, together with the activation of other transcription factors, to the glucose stimulation of expression of some glycolytic enzymes and other hypoxia response genes.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Semenza, Gl" uniqKey="Semenza G">GL Semenza</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Taylor, Ct" uniqKey="Taylor C">CT Taylor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brahimi Horn, Mc" uniqKey="Brahimi Horn M">MC Brahimi-Horn</name>
</author>
<author><name sortKey="Chiche, J" uniqKey="Chiche J">J Chiche</name>
</author>
<author><name sortKey="Pouyssegur, J" uniqKey="Pouyssegur J">J Pouyssegur</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jitrapakdee, S" uniqKey="Jitrapakdee S">S Jitrapakdee</name>
</author>
<author><name sortKey="Wutthisathapornchai, A" uniqKey="Wutthisathapornchai A">A Wutthisathapornchai</name>
</author>
<author><name sortKey="Wallace, Jc" uniqKey="Wallace J">JC Wallace</name>
</author>
<author><name sortKey="Macdonald, Mj" uniqKey="Macdonald M">MJ MacDonald</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Henquin, Jc" uniqKey="Henquin J">JC Henquin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hinke, Sa" uniqKey="Hinke S">SA Hinke</name>
</author>
<author><name sortKey="Hellemans, K" uniqKey="Hellemans K">K Hellemans</name>
</author>
<author><name sortKey="Schuit, Fc" uniqKey="Schuit F">FC Schuit</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hutton, Jc" uniqKey="Hutton J">JC Hutton</name>
</author>
<author><name sortKey="Malaisse, Wj" uniqKey="Malaisse W">WJ Malaisse</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Longo, Ea" uniqKey="Longo E">EA Longo</name>
</author>
<author><name sortKey="Tornheim, K" uniqKey="Tornheim K">K Tornheim</name>
</author>
<author><name sortKey="Deeney, Jt" uniqKey="Deeney J">JT Deeney</name>
</author>
<author><name sortKey="Varnum, Ba" uniqKey="Varnum B">BA Varnum</name>
</author>
<author><name sortKey="Tillotson, D" uniqKey="Tillotson D">D Tillotson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name>
</author>
<author><name sortKey="Upshaw, L" uniqKey="Upshaw L">L Upshaw</name>
</author>
<author><name sortKey="Strong, Dm" uniqKey="Strong D">DM Strong</name>
</author>
<author><name sortKey="Robertson, Rp" uniqKey="Robertson R">RP Robertson</name>
</author>
<author><name sortKey="Reems, J" uniqKey="Reems J">J Reems</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carlsson, Po" uniqKey="Carlsson P">PO Carlsson</name>
</author>
<author><name sortKey="Jansson, L" uniqKey="Jansson L">L Jansson</name>
</author>
<author><name sortKey="Ostenson, Cg" uniqKey="Ostenson C">CG Ostenson</name>
</author>
<author><name sortKey="Kallskog, O" uniqKey="Kallskog O">O Kallskog</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carlsson, Po" uniqKey="Carlsson P">PO Carlsson</name>
</author>
<author><name sortKey="Jansson, L" uniqKey="Jansson L">L Jansson</name>
</author>
<author><name sortKey="Palm, F" uniqKey="Palm F">F Palm</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jung, Sk" uniqKey="Jung S">SK Jung</name>
</author>
<author><name sortKey="Kauri, Lm" uniqKey="Kauri L">LM Kauri</name>
</author>
<author><name sortKey="Qian, Wj" uniqKey="Qian W">WJ Qian</name>
</author>
<author><name sortKey="Kennedy, Rt" uniqKey="Kennedy R">RT Kennedy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ortsater, H" uniqKey="Ortsater H">H Ortsater</name>
</author>
<author><name sortKey="Liss, P" uniqKey="Liss P">P Liss</name>
</author>
<author><name sortKey="Akerman, Ke" uniqKey="Akerman K">KE Akerman</name>
</author>
<author><name sortKey="Bergsten, P" uniqKey="Bergsten P">P Bergsten</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lau, J" uniqKey="Lau J">J Lau</name>
</author>
<author><name sortKey="Henriksnas, J" uniqKey="Henriksnas J">J Henriksnas</name>
</author>
<author><name sortKey="Svensson, J" uniqKey="Svensson J">J Svensson</name>
</author>
<author><name sortKey="Carlsson, Po" uniqKey="Carlsson P">PO Carlsson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sweet, Ir" uniqKey="Sweet I">IR Sweet</name>
</author>
<author><name sortKey="Gilbert, M" uniqKey="Gilbert M">M Gilbert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sato, Y" uniqKey="Sato Y">Y Sato</name>
</author>
<author><name sortKey="Endo, H" uniqKey="Endo H">H Endo</name>
</author>
<author><name sortKey="Okuyama, H" uniqKey="Okuyama H">H Okuyama</name>
</author>
<author><name sortKey="Takeda, T" uniqKey="Takeda T">T Takeda</name>
</author>
<author><name sortKey="Iwahashi, H" uniqKey="Iwahashi H">H Iwahashi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hosokawa, H" uniqKey="Hosokawa H">H Hosokawa</name>
</author>
<author><name sortKey="Hosokawa, Ya" uniqKey="Hosokawa Y">YA Hosokawa</name>
</author>
<author><name sortKey="Leahy, Jl" uniqKey="Leahy J">JL Leahy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jonas, Jc" uniqKey="Jonas J">JC Jonas</name>
</author>
<author><name sortKey="Sharma, A" uniqKey="Sharma A">A Sharma</name>
</author>
<author><name sortKey="Hasenkamp, W" uniqKey="Hasenkamp W">W Hasenkamp</name>
</author>
<author><name sortKey="Ilkova, H" uniqKey="Ilkova H">H Ilkova</name>
</author>
<author><name sortKey="Patane, G" uniqKey="Patane G">G Patane</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Laybutt, Dr" uniqKey="Laybutt D">DR Laybutt</name>
</author>
<author><name sortKey="Sharma, A" uniqKey="Sharma A">A Sharma</name>
</author>
<author><name sortKey="Sgroi, Dc" uniqKey="Sgroi D">DC Sgroi</name>
</author>
<author><name sortKey="Gaudet, J" uniqKey="Gaudet J">J Gaudet</name>
</author>
<author><name sortKey="Bonner Weir, S" uniqKey="Bonner Weir S">S Bonner-Weir</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
<author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name>
</author>
<author><name sortKey="Meshinchi, S" uniqKey="Meshinchi S">S Meshinchi</name>
</author>
<author><name sortKey="Dias Leme, C" uniqKey="Dias Leme C">C Dias-Leme</name>
</author>
<author><name sortKey="Raffin, D" uniqKey="Raffin D">D Raffin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bensellam, M" uniqKey="Bensellam M">M Bensellam</name>
</author>
<author><name sortKey="Van Lommel, L" uniqKey="Van Lommel L">L Van Lommel</name>
</author>
<author><name sortKey="Overbergh, L" uniqKey="Overbergh L">L Overbergh</name>
</author>
<author><name sortKey="Schuit, Fc" uniqKey="Schuit F">FC Schuit</name>
</author>
<author><name sortKey="Jonas, Jc" uniqKey="Jonas J">JC Jonas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zehetner, J" uniqKey="Zehetner J">J Zehetner</name>
</author>
<author><name sortKey="Danzer, C" uniqKey="Danzer C">C Danzer</name>
</author>
<author><name sortKey="Collins, S" uniqKey="Collins S">S Collins</name>
</author>
<author><name sortKey="Eckhardt, K" uniqKey="Eckhardt K">K Eckhardt</name>
</author>
<author><name sortKey="Gerber, Pa" uniqKey="Gerber P">PA Gerber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Buchwald, P" uniqKey="Buchwald P">P Buchwald</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arteel, Ge" uniqKey="Arteel G">GE Arteel</name>
</author>
<author><name sortKey="Thurman, Rg" uniqKey="Thurman R">RG Thurman</name>
</author>
<author><name sortKey="Raleigh, Ja" uniqKey="Raleigh J">JA Raleigh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Trube, G" uniqKey="Trube G">G Trube</name>
</author>
<author><name sortKey="Rorsman, P" uniqKey="Rorsman P">P Rorsman</name>
</author>
<author><name sortKey="Ohno Shosaku, T" uniqKey="Ohno Shosaku T">T Ohno-Shosaku</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kjorholt, C" uniqKey="Kjorholt C">C Kjorholt</name>
</author>
<author><name sortKey="Akerfeldt, Mc" uniqKey="Akerfeldt M">MC Akerfeldt</name>
</author>
<author><name sortKey="Biden, Tj" uniqKey="Biden T">TJ Biden</name>
</author>
<author><name sortKey="Laybutt, Dr" uniqKey="Laybutt D">DR Laybutt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jung, Sr" uniqKey="Jung S">SR Jung</name>
</author>
<author><name sortKey="Reed, Bj" uniqKey="Reed B">BJ Reed</name>
</author>
<author><name sortKey="Sweet, Ir" uniqKey="Sweet I">IR Sweet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pipeleers, D" uniqKey="Pipeleers D">D Pipeleers</name>
</author>
<author><name sortKey="Kiekens, R" uniqKey="Kiekens R">R Kiekens</name>
</author>
<author><name sortKey="Ling, Z" uniqKey="Ling Z">Z Ling</name>
</author>
<author><name sortKey="Wilikens, A" uniqKey="Wilikens A">A Wilikens</name>
</author>
<author><name sortKey="Schuit, F" uniqKey="Schuit F">F Schuit</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moritz, W" uniqKey="Moritz W">W Moritz</name>
</author>
<author><name sortKey="Meier, F" uniqKey="Meier F">F Meier</name>
</author>
<author><name sortKey="Stroka, Dm" uniqKey="Stroka D">DM Stroka</name>
</author>
<author><name sortKey="Giuliani, M" uniqKey="Giuliani M">M Giuliani</name>
</author>
<author><name sortKey="Kugelmeier, P" uniqKey="Kugelmeier P">P Kugelmeier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cantley, J" uniqKey="Cantley J">J Cantley</name>
</author>
<author><name sortKey="Selman, C" uniqKey="Selman C">C Selman</name>
</author>
<author><name sortKey="Shukla, D" uniqKey="Shukla D">D Shukla</name>
</author>
<author><name sortKey="Abramov, Ay" uniqKey="Abramov A">AY Abramov</name>
</author>
<author><name sortKey="Forstreuter, F" uniqKey="Forstreuter F">F Forstreuter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Heinis, M" uniqKey="Heinis M">M Heinis</name>
</author>
<author><name sortKey="Simon, Mt" uniqKey="Simon M">MT Simon</name>
</author>
<author><name sortKey="Ilc, K" uniqKey="Ilc K">K Ilc</name>
</author>
<author><name sortKey="Mazure, Nm" uniqKey="Mazure N">NM Mazure</name>
</author>
<author><name sortKey="Pouyssegur, J" uniqKey="Pouyssegur J">J Pouyssegur</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roche, E" uniqKey="Roche E">E Roche</name>
</author>
<author><name sortKey="Assimacopoulos Jeannet, F" uniqKey="Assimacopoulos Jeannet F">F Assimacopoulos-Jeannet</name>
</author>
<author><name sortKey="Witters, La" uniqKey="Witters L">LA Witters</name>
</author>
<author><name sortKey="Perruchoud, B" uniqKey="Perruchoud B">B Perruchoud</name>
</author>
<author><name sortKey="Yaney, G" uniqKey="Yaney G">G Yaney</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ma, Z" uniqKey="Ma Z">Z Ma</name>
</author>
<author><name sortKey="Portwood, N" uniqKey="Portwood N">N Portwood</name>
</author>
<author><name sortKey="Brodin, D" uniqKey="Brodin D">D Brodin</name>
</author>
<author><name sortKey="Grill, V" uniqKey="Grill V">V Grill</name>
</author>
<author><name sortKey="Bjorklund, A" uniqKey="Bjorklund A">A Bjorklund</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Da Silva Xavier, G" uniqKey="Da Silva Xavier G">G da Silva Xavier</name>
</author>
<author><name sortKey="Leclerc, I" uniqKey="Leclerc I">I Leclerc</name>
</author>
<author><name sortKey="Salt, Ip" uniqKey="Salt I">IP Salt</name>
</author>
<author><name sortKey="Doiron, B" uniqKey="Doiron B">B Doiron</name>
</author>
<author><name sortKey="Hardie, Dg" uniqKey="Hardie D">DG Hardie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
<author><name sortKey="Wollheim, Cb" uniqKey="Wollheim C">CB Wollheim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Collier, Jj" uniqKey="Collier J">JJ Collier</name>
</author>
<author><name sortKey="Zhang, Pl" uniqKey="Zhang P">PL Zhang</name>
</author>
<author><name sortKey="Pedersen, Kb" uniqKey="Pedersen K">KB Pedersen</name>
</author>
<author><name sortKey="Burke, Sj" uniqKey="Burke S">SJ Burke</name>
</author>
<author><name sortKey="Haycock, Jw" uniqKey="Haycock J">JW Haycock</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Diraison, F" uniqKey="Diraison F">F Diraison</name>
</author>
<author><name sortKey="Ravier, Ma" uniqKey="Ravier M">MA Ravier</name>
</author>
<author><name sortKey="Richards, Sk" uniqKey="Richards S">SK Richards</name>
</author>
<author><name sortKey="Smith, Rm" uniqKey="Smith R">RM Smith</name>
</author>
<author><name sortKey="Shimano, H" uniqKey="Shimano H">H Shimano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hu, Cj" uniqKey="Hu C">CJ Hu</name>
</author>
<author><name sortKey="Wang, Ly" uniqKey="Wang L">LY Wang</name>
</author>
<author><name sortKey="Chodosh, La" uniqKey="Chodosh L">LA Chodosh</name>
</author>
<author><name sortKey="Keith, B" uniqKey="Keith B">B Keith</name>
</author>
<author><name sortKey="Simon, Mc" uniqKey="Simon M">MC Simon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Collier, Jj" uniqKey="Collier J">JJ Collier</name>
</author>
<author><name sortKey="Doan, Tt" uniqKey="Doan T">TT Doan</name>
</author>
<author><name sortKey="Daniels, Mc" uniqKey="Daniels M">MC Daniels</name>
</author>
<author><name sortKey="Schurr, Jr" uniqKey="Schurr J">JR Schurr</name>
</author>
<author><name sortKey="Kolls, Jk" uniqKey="Kolls J">JK Kolls</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matschinsky, Fm" uniqKey="Matschinsky F">FM Matschinsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Quintens, R" uniqKey="Quintens R">R Quintens</name>
</author>
<author><name sortKey="Hendrickx, N" uniqKey="Hendrickx N">N Hendrickx</name>
</author>
<author><name sortKey="Lemaire, K" uniqKey="Lemaire K">K Lemaire</name>
</author>
<author><name sortKey="Schuit, F" uniqKey="Schuit F">F Schuit</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gunton, Je" uniqKey="Gunton J">JE Gunton</name>
</author>
<author><name sortKey="Kulkarni, Rn" uniqKey="Kulkarni R">RN Kulkarni</name>
</author>
<author><name sortKey="Yim, S" uniqKey="Yim S">S Yim</name>
</author>
<author><name sortKey="Okada, T" uniqKey="Okada T">T Okada</name>
</author>
<author><name sortKey="Hawthorne, Wj" uniqKey="Hawthorne W">WJ Hawthorne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cheng, K" uniqKey="Cheng K">K Cheng</name>
</author>
<author><name sortKey="Ho, K" uniqKey="Ho K">K Ho</name>
</author>
<author><name sortKey="Stokes, R" uniqKey="Stokes R">R Stokes</name>
</author>
<author><name sortKey="Scott, C" uniqKey="Scott C">C Scott</name>
</author>
<author><name sortKey="Lau, Sm" uniqKey="Lau S">SM Lau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khaldi, Mz" uniqKey="Khaldi M">MZ Khaldi</name>
</author>
<author><name sortKey="Guiot, Y" uniqKey="Guiot Y">Y Guiot</name>
</author>
<author><name sortKey="Gilon, P" uniqKey="Gilon P">P Gilon</name>
</author>
<author><name sortKey="Henquin, Jc" uniqKey="Henquin J">JC Henquin</name>
</author>
<author><name sortKey="Jonas, Jc" uniqKey="Jonas J">JC Jonas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Olsson, R" uniqKey="Olsson R">R Olsson</name>
</author>
<author><name sortKey="Carlsson, Po" uniqKey="Carlsson P">PO Carlsson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ishihara, H" uniqKey="Ishihara H">H Ishihara</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
<author><name sortKey="Drewes, Lr" uniqKey="Drewes L">LR Drewes</name>
</author>
<author><name sortKey="Wollheim, Cb" uniqKey="Wollheim C">CB Wollheim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sekine, N" uniqKey="Sekine N">N Sekine</name>
</author>
<author><name sortKey="Cirulli, V" uniqKey="Cirulli V">V Cirulli</name>
</author>
<author><name sortKey="Regazzi, R" uniqKey="Regazzi R">R Regazzi</name>
</author>
<author><name sortKey="Brown, Lj" uniqKey="Brown L">LJ Brown</name>
</author>
<author><name sortKey="Gine, E" uniqKey="Gine E">E Gine</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Puri, S" uniqKey="Puri S">S Puri</name>
</author>
<author><name sortKey="Cano, Da" uniqKey="Cano D">DA Cano</name>
</author>
<author><name sortKey="Hebrok, M" uniqKey="Hebrok M">M Hebrok</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Richard, De" uniqKey="Richard D">DE Richard</name>
</author>
<author><name sortKey="Berra, E" uniqKey="Berra E">E Berra</name>
</author>
<author><name sortKey="Gothie, E" uniqKey="Gothie E">E Gothie</name>
</author>
<author><name sortKey="Roux, D" uniqKey="Roux D">D Roux</name>
</author>
<author><name sortKey="Pouyssegur, J" uniqKey="Pouyssegur J">J Pouyssegur</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Elouil, H" uniqKey="Elouil H">H Elouil</name>
</author>
<author><name sortKey="Bensellam, M" uniqKey="Bensellam M">M Bensellam</name>
</author>
<author><name sortKey="Guiot, Y" uniqKey="Guiot Y">Y Guiot</name>
</author>
<author><name sortKey="Vander Mierde, D" uniqKey="Vander Mierde D">D Vander Mierde</name>
</author>
<author><name sortKey="Pascal, Sm" uniqKey="Pascal S">SM Pascal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Benita, Y" uniqKey="Benita Y">Y Benita</name>
</author>
<author><name sortKey="Kikuchi, H" uniqKey="Kikuchi H">H Kikuchi</name>
</author>
<author><name sortKey="Smith, Ad" uniqKey="Smith A">AD Smith</name>
</author>
<author><name sortKey="Zhang, Mq" uniqKey="Zhang M">MQ Zhang</name>
</author>
<author><name sortKey="Chung, Dc" uniqKey="Chung D">DC Chung</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Belgique</li>
<li>France</li>
</country>
<region><li>Nouvelle-Galles du Sud</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Région de Bruxelles-Capitale</li>
<li>Île-de-France</li>
</region>
<settlement><li>Bruxelles</li>
<li>Louvain-la-Neuve</li>
<li>Nice</li>
<li>Paris</li>
<li>Sydney</li>
</settlement>
<orgName><li>Université Paris Diderot-Paris 7</li>
<li>Université Paris-Descartes</li>
<li>Université catholique de Louvain</li>
</orgName>
</list>
<tree><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Bensellam, Mohammed" sort="Bensellam, Mohammed" uniqKey="Bensellam M" first="Mohammed" last="Bensellam">Mohammed Bensellam</name>
</region>
<name sortKey="Guiot, Yves" sort="Guiot, Yves" uniqKey="Guiot Y" first="Yves" last="Guiot">Yves Guiot</name>
<name sortKey="Jonas, Jean Christophe" sort="Jonas, Jean Christophe" uniqKey="Jonas J" first="Jean-Christophe" last="Jonas">Jean-Christophe Jonas</name>
<name sortKey="Rybachuk, Galyna" sort="Rybachuk, Galyna" uniqKey="Rybachuk G" first="Galyna" last="Rybachuk">Galyna Rybachuk</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Duvillie, Bertrand" sort="Duvillie, Bertrand" uniqKey="Duvillie B" first="Bertrand" last="Duvillié">Bertrand Duvillié</name>
</region>
<name sortKey="Magnan, Christophe" sort="Magnan, Christophe" uniqKey="Magnan C" first="Christophe" last="Magnan">Christophe Magnan</name>
<name sortKey="Pouyssegur, Jacques" sort="Pouyssegur, Jacques" uniqKey="Pouyssegur J" first="Jacques" last="Pouysségur">Jacques Pouysségur</name>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Laybutt, D Ross" sort="Laybutt, D Ross" uniqKey="Laybutt D" first="D. Ross" last="Laybutt">D. Ross Laybutt</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005363 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 005363 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:3250482 |texte= Glucose-Induced O2 Consumption Activates Hypoxia Inducible Factors 1 and 2 in Rat Insulin-Secreting Pancreatic Beta-Cells }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:22235342" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
This area was generated with Dilib version V0.6.33. |