Patterns of Cell Activity in the Subthalamic Region Associated with the Neuroprotective Action of Near-Infrared Light Treatment in MPTP-Treated Mice
Identifieur interne : 005293 ( Main/Exploration ); précédent : 005292; suivant : 005294Patterns of Cell Activity in the Subthalamic Region Associated with the Neuroprotective Action of Near-Infrared Light Treatment in MPTP-Treated Mice
Auteurs : Victoria E. Shaw [Australie] ; Cassandra Peoples [Australie] ; Sharon Spana [Australie] ; Keyoumars Ashkan [Royaume-Uni] ; Alim-Louis Benabid [France] ; Jonathan Stone [Australie] ; Gary E. Baker [Royaume-Uni] ; John Mitrofanis [Australie]Source :
- Parkinson's Disease [ 2090-8083 ] ; 2012.
Abstract
We have shown previously that near-infrared light (NIr) treatment or photobiomodulation neuroprotects dopaminergic cells in substantia nigra pars compacta (SNc) from degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice. The present study explores whether NIr treatment changes the patterns of Fos expression in the subthalamic region, namely, the subthalamic nucleus (STN) and zona incerta (ZI); both cell groups have abnormally overactive cells in parkinsonian cases. BALB/c mice were treated with MPTP (100–250 mg/kg) or saline either over 30 hours followed by either a two-hour or six-day survival period (acute model) or over five weeks followed by a three-week survival period (chronic model). NIr and MPTP were applied simultaneously. Brains were processed for Fos immunochemistry, and cell number was estimated using stereology. Our major finding was that NIr treatment reduced (30–45%) the increase in Fos+ cell number evident in the STN and ZI after MPTP insult. This reduction was concurrent with the neuroprotection of dopaminergic SNc cells shown previously and was evident in both MPTP models (except for the 2 hours survival period which showed no changes in cell number). In summary, our results indicated that NIr had long lasting effects on the activity of cells located deep in the brain and had repaired partially the abnormal activity generated by the parkinsonian toxin.
Url:
DOI: 10.1155/2012/296875
PubMed: 22666627
PubMed Central: 3361324
Affiliations:
- Australie, France, Royaume-Uni
- Auvergne-Rhône-Alpes, Nouvelle-Galles du Sud, Rhône-Alpes
- Grenoble, Sydney
- Université de Sydney
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Baker</name><affiliation wicri:level="1"><nlm:aff id="I5">Deptartment of Optometry and Visual Science, City University London, London EC1VOHB, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Deptartment of Optometry and Visual Science, City University London, London EC1VOHB</wicri:regionArea><wicri:noRegion>London EC1VOHB</wicri:noRegion></affiliation></author><author><name sortKey="Mitrofanis, John" sort="Mitrofanis, John" uniqKey="Mitrofanis J" first="John" last="Mitrofanis">John Mitrofanis</name><affiliation wicri:level="4"><nlm:aff id="I1">Discipline of Anatomy and Histology, The University of Sydney, Sydney, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Discipline of Anatomy and Histology, The University of Sydney, Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author></analytic><series><title level="j">Parkinson's Disease</title><idno type="ISSN">2090-8083</idno><idno type="eISSN">2042-0080</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We have shown previously that near-infrared light (NIr) treatment or photobiomodulation neuroprotects dopaminergic cells in substantia nigra pars compacta (SNc) from degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice. The present study explores whether NIr treatment changes the patterns of Fos expression in the subthalamic region, namely, the subthalamic nucleus (STN) and zona incerta (ZI); both cell groups have abnormally overactive cells in parkinsonian cases. BALB/c mice were treated with MPTP (100–250 mg/kg) or saline either over 30 hours followed by either a two-hour or six-day survival period (acute model) or over five weeks followed by a three-week survival period (chronic model). NIr and MPTP were applied simultaneously. Brains were processed for Fos immunochemistry, and cell number was estimated using stereology. Our major finding was that NIr treatment reduced (30–45%) the increase in Fos<sup>+</sup> cell number evident in the STN and ZI after MPTP insult. This reduction was concurrent with the neuroprotection of dopaminergic SNc cells shown previously and was evident in both MPTP models (except for the 2 hours survival period which showed no changes in cell number). In summary, our results indicated that NIr had long lasting effects on the activity of cells located deep in the brain and had repaired partially the abnormal activity generated by the parkinsonian toxin.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Paxinos, G" uniqKey="Paxinos G">G Paxinos</name></author><author><name sortKey="Franklin, Kbj" uniqKey="Franklin K">KBJ Franklin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liang, Hl" uniqKey="Liang H">HL Liang</name></author><author><name sortKey="Whelan, Ht" uniqKey="Whelan H">HT Whelan</name></author><author><name sortKey="Eells, Jt" uniqKey="Eells J">JT Eells</name></author><author><name sortKey="Wong Riley, Mtt" uniqKey="Wong Riley M">MTT Wong-Riley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ying, R" uniqKey="Ying R">R Ying</name></author><author><name sortKey="Liang, Hl" uniqKey="Liang H">HL 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Sydney</li></orgName></list><tree><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Shaw, Victoria E" sort="Shaw, Victoria E" uniqKey="Shaw V" first="Victoria E." last="Shaw">Victoria E. Shaw</name></region><name sortKey="Mitrofanis, John" sort="Mitrofanis, John" uniqKey="Mitrofanis J" first="John" last="Mitrofanis">John Mitrofanis</name><name sortKey="Peoples, Cassandra" sort="Peoples, Cassandra" uniqKey="Peoples C" first="Cassandra" last="Peoples">Cassandra Peoples</name><name sortKey="Spana, Sharon" sort="Spana, Sharon" uniqKey="Spana S" first="Sharon" last="Spana">Sharon Spana</name><name sortKey="Stone, Jonathan" sort="Stone, Jonathan" uniqKey="Stone J" first="Jonathan" last="Stone">Jonathan Stone</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Ashkan, Keyoumars" sort="Ashkan, Keyoumars" uniqKey="Ashkan K" first="Keyoumars" last="Ashkan">Keyoumars Ashkan</name></noRegion><name sortKey="Baker, Gary E" sort="Baker, Gary E" uniqKey="Baker G" first="Gary E." last="Baker">Gary E. Baker</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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