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Clinical and intravascular imaging outcomes at 1 and 2 years after implantation of absorb everolimus eluting bioresorbable vascular scaffolds in small vessels. Late lumen enlargement: does bioresorption matter with small vessel size? Insight from the ABSORB cohort B trial

Identifieur interne : 004903 ( Main/Exploration ); précédent : 004902; suivant : 004904

Clinical and intravascular imaging outcomes at 1 and 2 years after implantation of absorb everolimus eluting bioresorbable vascular scaffolds in small vessels. Late lumen enlargement: does bioresorption matter with small vessel size? Insight from the ABSORB cohort B trial

Auteurs : Roberto Diletti [Pays-Bas] ; Vasim Farooq [Pays-Bas] ; Chrysafios Girasis [Pays-Bas] ; Christos Bourantas [Pays-Bas] ; Yoshinobu Onuma [Pays-Bas] ; Jung Ho Heo [Pays-Bas] ; Bill D. Gogas [Pays-Bas] ; Robert-Jan Van Geuns [Pays-Bas] ; Evelyn Regar [Pays-Bas] ; Bernard De Bruyne [Belgique] ; Dariusz Dudek [Pologne] ; Leif Thuesen [Danemark] ; Bernard Chevalier [France] ; Dougal Mcclean [Nouvelle-Zélande] ; Stephan Windecker [Suisse] ; Robert J. Whitbourn [Australie] ; Pieter Smits [Pays-Bas] ; Jacques Koolen [Pays-Bas] ; Ian Meredith [Australie] ; Xiaolin Li [États-Unis] ; Karine Miquel-Hebert [Belgique] ; Susan Veldhof [Belgique] ; Hector M. Garcia-Garcia [Pays-Bas] ; John A. Ormiston [Nouvelle-Zélande] ; Patrick W. Serruys [Pays-Bas]

Source :

RBID : ISTEX:392C4466844B3D18377BC59B41E0EF3F500048BD

Descripteurs français

English descriptors

Abstract

Background The long-term results after second generation everolimus eluting bioresorbable vascular scaffold (Absorb BVS) placement in small vessels are unknown. Therefore, we investigated the impact of vessel size on long-term outcomes, after Absorb BVS implantation. Methods In ABSORB Cohort B Trial, out of the total study population (101 patients), 45 patients were assigned to undergo 6-month and 2-year angiographic follow-up (Cohort B1) and 56 patients to have angiographic follow-up at 1-year (Cohort B2). The pre-reference vessel diameter (RVD) was <2.5 mm (small-vessel group) in 41 patients (41 lesions) and ≥2.5 mm (large-vessel group) in 60 patients (61 lesions). Outcomes were compared according to pre-RVD. Results At 2-year angiographic follow-up no differences in late lumen loss (0.29±0.16 mm vs 0.25±0.22 mm, p=0.4391), and in-segment binary restenosis (5.3% vs 5.3% p=1.0000) were demonstrated between groups. In the small-vessel group, intravascular ultrasound analysis showed a significant increase in vessel area (12.25±3.47 mm2 vs 13.09±3.38 mm2 p=0.0015), scaffold area (5.76±0.96 mm2 vs 6.41±1.30 mm2 p=0.0008) and lumen area (5.71±0.98 mm2 vs 6.20±1.27 mm2 p=0.0155) between 6-months and 2-year follow-up. No differences in plaque composition were reported between groups at either time point. At 2-year clinical follow-up, no differences in ischaemia-driven major adverse cardiac events (7.3% vs 10.2%, p=0.7335), myocardial infarction (4.9% vs 1.7%, p=0.5662) or ischaemia-driven target lesion revascularisation (2.4% vs 8.5%, p=0.3962) were reported between small and large vessels. No deaths or scaffold thrombosis were observed. Conclusions Similar clinical and angiographic outcomes at 2-year follow-up were reported in small and large vessel groups. A significant late lumen enlargement and positive vessel remodelling were observed in small vessels.

Url:
DOI: 10.1136/heartjnl-2012-302598


Affiliations:


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<name sortKey="Dudek, Dariusz" sort="Dudek, Dariusz" uniqKey="Dudek D" first="Dariusz" last="Dudek">Dariusz Dudek</name>
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<name sortKey="Li, Xiaolin" sort="Li, Xiaolin" uniqKey="Li X" first="Xiaolin" last="Li">Xiaolin Li</name>
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<term>Acute gain</term>
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<term>Angiographic outcomes</term>
<term>Angiography</term>
<term>Baseline</term>
<term>Binary restenosis</term>
<term>Bioresorbable</term>
<term>Blood vessel</term>
<term>Brous tissue</term>
<term>Cardiac</term>
<term>Cardiac death</term>
<term>Cardiac events</term>
<term>Cardiol</term>
<term>Cardiology</term>
<term>Circulatory system</term>
<term>Clinical outcomes</term>
<term>Cohort</term>
<term>Coronary angioplasty</term>
<term>Dense calcium content</term>
<term>Diletti</term>
<term>Everolimus</term>
<term>Everolimus eluting bioresorbable</term>
<term>Gain index</term>
<term>Imaging</term>
<term>Immunosuppressive agent</term>
<term>Implantation</term>
<term>Infarction</term>
<term>Interventional</term>
<term>Interventional cardiology</term>
<term>Intravascular</term>
<term>Ivus</term>
<term>Large vessel group</term>
<term>Large vessels</term>
<term>Late</term>
<term>Late loss</term>
<term>Late lumen enlargement</term>
<term>Lesion</term>
<term>Loss index</term>
<term>Lumen</term>
<term>Lumen area</term>
<term>Luminal</term>
<term>Medical imagery</term>
<term>Minimal lumen area</term>
<term>Minimal luminal diameter</term>
<term>Minimal scaffold area</term>
<term>Myocardial infarction</term>
<term>Neointimal</term>
<term>Neointimal hyperplasia area</term>
<term>Online</term>
<term>Onuma</term>
<term>Optical coherence tomography</term>
<term>Percentage diameter stenosis</term>
<term>Percentage lumen area stenosis</term>
<term>Plaque</term>
<term>Plaque area</term>
<term>Plaque composition</term>
<term>Present study</term>
<term>Prognosis</term>
<term>Relative gain</term>
<term>Restenosis</term>
<term>Santa clara</term>
<term>Scaffold</term>
<term>Scaffold area</term>
<term>Second generation</term>
<term>Serruys</term>
<term>Size</term>
<term>Small vessel</term>
<term>Small vessel group</term>
<term>Small vessels</term>
<term>Stenosis</term>
<term>Stent</term>
<term>Target lesion</term>
<term>Target lesion revascularisation</term>
<term>Time point</term>
<term>Vessel</term>
<term>Vessel area</term>
<term>Vessel injury</term>
<term>Vessel size</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr">
<term>Appareil circulatoire</term>
<term>Cardiologie</term>
<term>Evérolimus</term>
<term>Imagerie médicale</term>
<term>Immunodépresseur</term>
<term>Implantation</term>
<term>Pronostic</term>
<term>Taille</term>
<term>Tardif</term>
<term>Vaisseau sanguin</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en">
<term>Acute gain</term>
<term>Angiographic</term>
<term>Angiographic outcomes</term>
<term>Angiography</term>
<term>Baseline</term>
<term>Binary restenosis</term>
<term>Bioresorbable</term>
<term>Brous tissue</term>
<term>Cardiac</term>
<term>Cardiac death</term>
<term>Cardiac events</term>
<term>Cardiol</term>
<term>Cardiology</term>
<term>Clinical outcomes</term>
<term>Cohort</term>
<term>Coronary angioplasty</term>
<term>Dense calcium content</term>
<term>Diletti</term>
<term>Everolimus eluting bioresorbable</term>
<term>Gain index</term>
<term>Imaging</term>
<term>Implantation</term>
<term>Infarction</term>
<term>Interventional</term>
<term>Interventional cardiology</term>
<term>Intravascular</term>
<term>Ivus</term>
<term>Large vessel group</term>
<term>Large vessels</term>
<term>Late loss</term>
<term>Late lumen enlargement</term>
<term>Lesion</term>
<term>Loss index</term>
<term>Lumen</term>
<term>Lumen area</term>
<term>Luminal</term>
<term>Minimal lumen area</term>
<term>Minimal luminal diameter</term>
<term>Minimal scaffold area</term>
<term>Myocardial infarction</term>
<term>Neointimal</term>
<term>Neointimal hyperplasia area</term>
<term>Online</term>
<term>Onuma</term>
<term>Optical coherence tomography</term>
<term>Percentage diameter stenosis</term>
<term>Percentage lumen area stenosis</term>
<term>Plaque</term>
<term>Plaque area</term>
<term>Plaque composition</term>
<term>Present study</term>
<term>Relative gain</term>
<term>Restenosis</term>
<term>Santa clara</term>
<term>Scaffold</term>
<term>Scaffold area</term>
<term>Second generation</term>
<term>Serruys</term>
<term>Small vessel</term>
<term>Small vessel group</term>
<term>Small vessels</term>
<term>Stenosis</term>
<term>Stent</term>
<term>Target lesion</term>
<term>Target lesion revascularisation</term>
<term>Time point</term>
<term>Vessel</term>
<term>Vessel area</term>
<term>Vessel injury</term>
<term>Vessel size</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr">
<term>Bateau</term>
</keywords>
</textClass>
<langUsage>
<language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front>
<div type="abstract">Background The long-term results after second generation everolimus eluting bioresorbable vascular scaffold (Absorb BVS) placement in small vessels are unknown. Therefore, we investigated the impact of vessel size on long-term outcomes, after Absorb BVS implantation. Methods In ABSORB Cohort B Trial, out of the total study population (101 patients), 45 patients were assigned to undergo 6-month and 2-year angiographic follow-up (Cohort B1) and 56 patients to have angiographic follow-up at 1-year (Cohort B2). The pre-reference vessel diameter (RVD) was <2.5 mm (small-vessel group) in 41 patients (41 lesions) and ≥2.5 mm (large-vessel group) in 60 patients (61 lesions). Outcomes were compared according to pre-RVD. Results At 2-year angiographic follow-up no differences in late lumen loss (0.29±0.16 mm vs 0.25±0.22 mm, p=0.4391), and in-segment binary restenosis (5.3% vs 5.3% p=1.0000) were demonstrated between groups. In the small-vessel group, intravascular ultrasound analysis showed a significant increase in vessel area (12.25±3.47 mm2 vs 13.09±3.38 mm2 p=0.0015), scaffold area (5.76±0.96 mm2 vs 6.41±1.30 mm2 p=0.0008) and lumen area (5.71±0.98 mm2 vs 6.20±1.27 mm2 p=0.0155) between 6-months and 2-year follow-up. No differences in plaque composition were reported between groups at either time point. At 2-year clinical follow-up, no differences in ischaemia-driven major adverse cardiac events (7.3% vs 10.2%, p=0.7335), myocardial infarction (4.9% vs 1.7%, p=0.5662) or ischaemia-driven target lesion revascularisation (2.4% vs 8.5%, p=0.3962) were reported between small and large vessels. No deaths or scaffold thrombosis were observed. Conclusions Similar clinical and angiographic outcomes at 2-year follow-up were reported in small and large vessel groups. A significant late lumen enlargement and positive vessel remodelling were observed in small vessels.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Australie</li>
<li>Belgique</li>
<li>Danemark</li>
<li>France</li>
<li>Nouvelle-Zélande</li>
<li>Pays-Bas</li>
<li>Pologne</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region>
<li>Californie</li>
<li>Canton de Berne</li>
<li>Hollande-Méridionale</li>
</region>
<settlement>
<li>Berne</li>
<li>Rotterdam</li>
</settlement>
</list>
<tree>
<country name="Pays-Bas">
<region name="Hollande-Méridionale">
<name sortKey="Diletti, Roberto" sort="Diletti, Roberto" uniqKey="Diletti R" first="Roberto" last="Diletti">Roberto Diletti</name>
</region>
<name sortKey="Bourantas, Christos" sort="Bourantas, Christos" uniqKey="Bourantas C" first="Christos" last="Bourantas">Christos Bourantas</name>
<name sortKey="Farooq, Vasim" sort="Farooq, Vasim" uniqKey="Farooq V" first="Vasim" last="Farooq">Vasim Farooq</name>
<name sortKey="Garcia Garcia, Hector M" sort="Garcia Garcia, Hector M" uniqKey="Garcia Garcia H" first="Hector M" last="Garcia-Garcia">Hector M. Garcia-Garcia</name>
<name sortKey="Girasis, Chrysafios" sort="Girasis, Chrysafios" uniqKey="Girasis C" first="Chrysafios" last="Girasis">Chrysafios Girasis</name>
<name sortKey="Gogas, Bill D" sort="Gogas, Bill D" uniqKey="Gogas B" first="Bill D" last="Gogas">Bill D. Gogas</name>
<name sortKey="Heo, Jung Ho" sort="Heo, Jung Ho" uniqKey="Heo J" first="Jung Ho" last="Heo">Jung Ho Heo</name>
<name sortKey="Koolen, Jacques" sort="Koolen, Jacques" uniqKey="Koolen J" first="Jacques" last="Koolen">Jacques Koolen</name>
<name sortKey="Onuma, Yoshinobu" sort="Onuma, Yoshinobu" uniqKey="Onuma Y" first="Yoshinobu" last="Onuma">Yoshinobu Onuma</name>
<name sortKey="Regar, Evelyn" sort="Regar, Evelyn" uniqKey="Regar E" first="Evelyn" last="Regar">Evelyn Regar</name>
<name sortKey="Serruys, Patrick W" sort="Serruys, Patrick W" uniqKey="Serruys P" first="Patrick W" last="Serruys">Patrick W. Serruys</name>
<name sortKey="Smits, Pieter" sort="Smits, Pieter" uniqKey="Smits P" first="Pieter" last="Smits">Pieter Smits</name>
<name sortKey="Van Geuns, Robert Jan" sort="Van Geuns, Robert Jan" uniqKey="Van Geuns R" first="Robert-Jan" last="Van Geuns">Robert-Jan Van Geuns</name>
</country>
<country name="Belgique">
<noRegion>
<name sortKey="De Bruyne, Bernard" sort="De Bruyne, Bernard" uniqKey="De Bruyne B" first="Bernard" last="De Bruyne">Bernard De Bruyne</name>
</noRegion>
<name sortKey="Miquel Hebert, Karine" sort="Miquel Hebert, Karine" uniqKey="Miquel Hebert K" first="Karine" last="Miquel-Hebert">Karine Miquel-Hebert</name>
<name sortKey="Veldhof, Susan" sort="Veldhof, Susan" uniqKey="Veldhof S" first="Susan" last="Veldhof">Susan Veldhof</name>
</country>
<country name="Pologne">
<noRegion>
<name sortKey="Dudek, Dariusz" sort="Dudek, Dariusz" uniqKey="Dudek D" first="Dariusz" last="Dudek">Dariusz Dudek</name>
</noRegion>
</country>
<country name="Danemark">
<noRegion>
<name sortKey="Thuesen, Leif" sort="Thuesen, Leif" uniqKey="Thuesen L" first="Leif" last="Thuesen">Leif Thuesen</name>
</noRegion>
</country>
<country name="France">
<noRegion>
<name sortKey="Chevalier, Bernard" sort="Chevalier, Bernard" uniqKey="Chevalier B" first="Bernard" last="Chevalier">Bernard Chevalier</name>
</noRegion>
</country>
<country name="Nouvelle-Zélande">
<noRegion>
<name sortKey="Mcclean, Dougal" sort="Mcclean, Dougal" uniqKey="Mcclean D" first="Dougal" last="Mcclean">Dougal Mcclean</name>
</noRegion>
<name sortKey="Ormiston, John A" sort="Ormiston, John A" uniqKey="Ormiston J" first="John A" last="Ormiston">John A. Ormiston</name>
</country>
<country name="Suisse">
<region name="Canton de Berne">
<name sortKey="Windecker, Stephan" sort="Windecker, Stephan" uniqKey="Windecker S" first="Stephan" last="Windecker">Stephan Windecker</name>
</region>
</country>
<country name="Australie">
<noRegion>
<name sortKey="Whitbourn, Robert J" sort="Whitbourn, Robert J" uniqKey="Whitbourn R" first="Robert J" last="Whitbourn">Robert J. Whitbourn</name>
</noRegion>
<name sortKey="Meredith, Ian" sort="Meredith, Ian" uniqKey="Meredith I" first="Ian" last="Meredith">Ian Meredith</name>
</country>
<country name="États-Unis">
<region name="Californie">
<name sortKey="Li, Xiaolin" sort="Li, Xiaolin" uniqKey="Li X" first="Xiaolin" last="Li">Xiaolin Li</name>
</region>
</country>
</tree>
</affiliations>
</record>

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   |texte=   Clinical and intravascular imaging outcomes at 1 and 2 years after implantation of absorb everolimus eluting bioresorbable vascular scaffolds in small vessels. Late lumen enlargement: does bioresorption matter with small vessel size? Insight from the ABSORB cohort B trial
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