Proteases: common culprits in human skin disorders.
Identifieur interne : 003594 ( Main/Exploration ); précédent : 003593; suivant : 003595Proteases: common culprits in human skin disorders.
Auteurs : Simon J. De Veer [Australie] ; Laetitia Furio [France] ; Jonathan M. Harris [Australie] ; Alain Hovnanian [France]Source :
- Trends in molecular medicine [ 1471-499X ] ; 2014.
Descripteurs français
- KwdFr :
- Différenciation cellulaire, Homéostasie, Humains, Inhibiteurs de protéases (métabolisme), Kératinocytes (métabolisme), Maladies de la peau (anatomopathologie), Maladies de la peau (enzymologie), Peau (anatomopathologie), Peau (enzymologie), Peptide hydrolases (métabolisme), Protéolyse, Épiderme (enzymologie).
- MESH :
- anatomopathologie : Maladies de la peau, Peau.
- enzymologie : Maladies de la peau, Peau, Épiderme.
- métabolisme : Inhibiteurs de protéases, Kératinocytes, Peptide hydrolases.
- Différenciation cellulaire, Homéostasie, Humains, Protéolyse.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Peptide Hydrolases, Protease Inhibitors.
- enzymology : Epidermis, Skin, Skin Diseases.
- metabolism : Keratinocytes.
- pathology : Skin, Skin Diseases.
- Cell Differentiation, Homeostasis, Humans, Proteolysis.
Abstract
Recent findings from the clinic and the laboratory have transformed the way proteases and their inhibitors are perceived in the outermost layer of the skin, the epidermis. It now appears that an integrated proteolytic network operates within the epidermis, comprising more than 30 enzymes that carry out a growing list of essential functions. Equally, defective regulation or execution of protease-mediated processes is emerging as a key contributor to diverse human skin pathologies, and in recent years the number of diseases attributable to aberrant proteolytic activity has more than doubled. Here, we survey the different roles of proteases in epidermal homeostasis (from processing enzymes to signalling molecules) and explore the spectrum of rare and common human skin disorders where proteolytic pathways are dysregulated.
DOI: 10.1016/j.molmed.2013.11.005
PubMed: 24380647
Affiliations:
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Le document en format XML
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De Veer</name><affiliation wicri:level="1"><nlm:affiliation>INSERM, U781, 75743 Cedex 15, Paris, France; Université Paris Descartes and Institute Imagine, 75743 Cedex 15, Paris, France; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>INSERM, U781, 75743 Cedex 15, Paris, France; Université Paris Descartes and Institute Imagine, 75743 Cedex 15, Paris, France; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059</wicri:regionArea><wicri:noRegion>QLD 4059</wicri:noRegion></affiliation></author><author><name sortKey="Furio, Laetitia" sort="Furio, Laetitia" uniqKey="Furio L" first="Laetitia" last="Furio">Laetitia Furio</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, U781, 75743 Cedex 15, Paris, France; Université Paris Descartes and Institute Imagine, 75743 Cedex 15, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U781, 75743 Cedex 15, Paris, France; Université Paris Descartes and Institute Imagine, 75743 Cedex 15, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Harris, Jonathan M" sort="Harris, Jonathan M" uniqKey="Harris J" first="Jonathan M" last="Harris">Jonathan M. 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Electronic address: alain.hovnanian@inserm.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U781, 75743 Cedex 15, Paris, France; Université Paris Descartes and Institute Imagine, 75743 Cedex 15, Paris, France; Department of Genetics, CHU Necker-Enfants Malades, 75743 Cedex 15, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Trends in molecular medicine</title><idno type="eISSN">1471-499X</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Differentiation</term><term>Epidermis (enzymology)</term><term>Homeostasis</term><term>Humans</term><term>Keratinocytes (metabolism)</term><term>Peptide Hydrolases (metabolism)</term><term>Protease Inhibitors (metabolism)</term><term>Proteolysis</term><term>Skin (enzymology)</term><term>Skin (pathology)</term><term>Skin Diseases (enzymology)</term><term>Skin Diseases (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Différenciation cellulaire</term><term>Homéostasie</term><term>Humains</term><term>Inhibiteurs de protéases (métabolisme)</term><term>Kératinocytes (métabolisme)</term><term>Maladies de la peau (anatomopathologie)</term><term>Maladies de la peau (enzymologie)</term><term>Peau (anatomopathologie)</term><term>Peau (enzymologie)</term><term>Peptide hydrolases (métabolisme)</term><term>Protéolyse</term><term>Épiderme (enzymologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Peptide Hydrolases</term><term>Protease Inhibitors</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Maladies de la peau</term><term>Peau</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Maladies de la peau</term><term>Peau</term><term>Épiderme</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Epidermis</term><term>Skin</term><term>Skin Diseases</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Keratinocytes</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Inhibiteurs de protéases</term><term>Kératinocytes</term><term>Peptide hydrolases</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Skin</term><term>Skin Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Differentiation</term><term>Homeostasis</term><term>Humans</term><term>Proteolysis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Différenciation cellulaire</term><term>Homéostasie</term><term>Humains</term><term>Protéolyse</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent findings from the clinic and the laboratory have transformed the way proteases and their inhibitors are perceived in the outermost layer of the skin, the epidermis. It now appears that an integrated proteolytic network operates within the epidermis, comprising more than 30 enzymes that carry out a growing list of essential functions. Equally, defective regulation or execution of protease-mediated processes is emerging as a key contributor to diverse human skin pathologies, and in recent years the number of diseases attributable to aberrant proteolytic activity has more than doubled. Here, we survey the different roles of proteases in epidermal homeostasis (from processing enzymes to signalling molecules) and explore the spectrum of rare and common human skin disorders where proteolytic pathways are dysregulated.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="Australie"><noRegion><name sortKey="De Veer, Simon J" sort="De Veer, Simon J" uniqKey="De Veer S" first="Simon J" last="De Veer">Simon J. De Veer</name></noRegion><name sortKey="Harris, Jonathan M" sort="Harris, Jonathan M" uniqKey="Harris J" first="Jonathan M" last="Harris">Jonathan M. Harris</name></country><country name="France"><region name="Île-de-France"><name sortKey="Furio, Laetitia" sort="Furio, Laetitia" uniqKey="Furio L" first="Laetitia" last="Furio">Laetitia Furio</name></region><name sortKey="Hovnanian, Alain" sort="Hovnanian, Alain" uniqKey="Hovnanian A" first="Alain" last="Hovnanian">Alain Hovnanian</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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