Adiposity as a cause of cardiovascular disease: a Mendelian randomization study
Identifieur interne : 003205 ( Main/Exploration ); précédent : 003204; suivant : 003206Adiposity as a cause of cardiovascular disease: a Mendelian randomization study
Auteurs : Sara H Gg [Suède] ; Tove Fall [Suède] ; Alexander Ploner [Suède] ; Reedik M Gi [Estonie] ; Krista Fischer [Estonie] ; Harmen Hm Draisma [Pays-Bas] ; Mart Kals [Estonie] ; Paul S. De Vries [Pays-Bas] ; Abbas Dehghan [Pays-Bas] ; Sara M. Willems [Pays-Bas] ; Antti-Pekka Sarin [Finlande] ; Kati Kristiansson [Finlande] ; Marja-Liisa Nuotio [Finlande] ; Aki S. Havulinna [Finlande] ; Renée Fag De Bruijn [Pays-Bas] ; M Arfan Ikram [Pays-Bas] ; Maris Kuningas [Pays-Bas] ; Bruno H. Stricker [Pays-Bas] ; Oscar H. Franco [Pays-Bas] ; Beben Benyamin [Australie] ; Christian Gieger [Allemagne] ; Alistair S. Hall [Royaume-Uni] ; Ville Huikari [Finlande] ; Antti Jula [Finlande] ; Marjo-Riitta J Rvelin [Finlande, Royaume-Uni] ; Marika Kaakinen [Finlande] ; Jaakko Kaprio [Finlande] ; Michael Kobl [Allemagne] ; Massimo Mangino [Royaume-Uni] ; Christopher P. Nelson [Royaume-Uni] ; Aarno Palotie [Finlande, États-Unis] ; Nilesh J. Samani [Royaume-Uni] ; Tim D. Spector [Royaume-Uni] ; David P. Strachan [Royaume-Uni] ; Martin D. Tobin [Royaume-Uni] ; John B. Whitfield [Australie] ; André G. Uitterlinden [Pays-Bas] ; Veikko Salomaa [Finlande] ; Ann-Christine Syv Nen [Suède] ; Kari Kuulasmaa [Finlande] ; Patrik K. Magnusson [Suède] ; T Nu Esko [Estonie, États-Unis] ; Albert Hofman [Pays-Bas] ; Eco Jc De Geus [Pays-Bas] ; Lars Lind [Suède] ; Vilmantas Giedraitis [Suède] ; Markus Perola [Estonie, Finlande] ; Alun Evans [Royaume-Uni] ; Jean Ferrières [France] ; Jarmo Virtamo [Finlande] ; Frank Kee [Royaume-Uni] ; David-Alexandre Tregouet [France] ; Dominique Arveiler [France] ; Philippe Amouyel [France] ; Francesco Gianfagna [Italie] ; Paolo Brambilla [Italie] ; Samuli Ripatti [Finlande, Royaume-Uni] ; Cornelia M. Van Duijn [Pays-Bas] ; Andres Metspalu [Estonie] ; Inga Prokopenko [Royaume-Uni] ; Mark I. Mccarthy [Royaume-Uni] ; Nancy L. Pedersen [Suède] ; Erik Ingelsson [Suède, Royaume-Uni]Source :
- International Journal of Epidemiology [ 0300-5771 ] ; 2015.
Abstract
Url:
DOI: 10.1093/ije/dyv094
PubMed: 26016847
PubMed Central: 4553708
Affiliations:
- Allemagne, Australie, Estonie, Finlande, France, Italie, Pays-Bas, Royaume-Uni, Suède, États-Unis
- Alsace (région administrative), Angleterre, East Middle Sweden, Finlande occidentale, Grand Est, Grand Londres, Hauts-de-France, Hollande-Méridionale, Hollande-Septentrionale, Massachusetts, Midi-Pyrénées, Nord-Pas-de-Calais, Occitanie (région administrative), Oxfordshire, Svealand, Uusimaa, Yorkshire-et-Humber, Île-de-France
- Amsterdam, Helsinki, Leeds, Leyde, Lille, Londres, Oxford, Paris, Rotterdam, Stockholm, Strasbourg, Toulouse, Turku, Uppsala
- Université d'Helsinki, Université d'Oxford, Université d'Uppsala, Université de Leeds, Université de Londres
Links toward previous steps (curation, corpus...)
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Le document en format XML
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<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Department of Children, Young People and Families, National Institute for Health and Welfare, Oulu, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Children, Young People and Families, National Institute for Health and Welfare, Oulu</wicri:regionArea>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">MRC Health Protection Agency (HPE) Centre for Environment and Health, Imperial College London, London, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Health Protection Agency (HPE) Centre for Environment and Health, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Unit of Primary Care, Oulu University Hospital, Oulu, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Unit of Primary Care, Oulu University Hospital, Oulu</wicri:regionArea>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Center for Life Course and Systems Epidemiology, University of Oulu, Oulu, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Center for Life Course and Systems Epidemiology, University of Oulu, Oulu</wicri:regionArea>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">National Institute for Health and Welfare, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Hjelt Institute, University of Helsinki, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Hjelt Institute, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kobl, Michael" sort="Kobl, Michael" uniqKey="Kobl M" first="Michael" last="Kobl">Michael Kobl</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
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</author>
<author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Twin Research and Genetic Epidemiology, King's College London, London, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nelson, Christopher P" sort="Nelson, Christopher P" uniqKey="Nelson C" first="Christopher P" last="Nelson">Christopher P. Nelson</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Department of Cardiovascular Sciences, University of Leicester, Leicester, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Leicester</wicri:regionArea>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">National Institute for Health Research, Glenfield Hospital, Leicester, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>National Institute for Health Research, Glenfield Hospital, Leicester</wicri:regionArea>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">National Institute for Health and Welfare, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="dyv094-AFF1">Broad Institute, Cambridge, MA, USA,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Broad Institute, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J" last="Samani">Nilesh J. Samani</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Department of Cardiovascular Sciences, University of Leicester, Leicester, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Leicester</wicri:regionArea>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">National Institute for Health Research, Glenfield Hospital, Leicester, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>National Institute for Health Research, Glenfield Hospital, Leicester</wicri:regionArea>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D" last="Spector">Tim D. Spector</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Twin Research and Genetic Epidemiology, King's College London, London, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P" last="Strachan">David P. Strachan</name>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">St George's, University of London, London, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>St George's, University of London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">Université de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Tobin, Martin D" sort="Tobin, Martin D" uniqKey="Tobin M" first="Martin D" last="Tobin">Martin D. Tobin</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Department of Health Sciences, University of Leicester, Leicester, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Health Sciences, University of Leicester, Leicester</wicri:regionArea>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B" last="Whitfield">John B. Whitfield</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>QIMR Berghofer Medical Research Institute, Brisbane, QLD</wicri:regionArea>
<wicri:noRegion>QLD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G" last="Uitterlinden">André G. Uitterlinden</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">National Institute for Health and Welfare, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Syv Nen, Ann Christine" sort="Syv Nen, Ann Christine" uniqKey="Syv Nen A" first="Ann-Christine" last="Syv Nen">Ann-Christine Syv Nen</name>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala</wicri:regionArea>
<orgName type="university">Université d'Uppsala</orgName>
<placeName><settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kuulasmaa, Kari" sort="Kuulasmaa, Kari" uniqKey="Kuulasmaa K" first="Kari" last="Kuulasmaa">Kari Kuulasmaa</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">National Institute for Health and Welfare, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Magnusson, Patrik K" sort="Magnusson, Patrik K" uniqKey="Magnusson P" first="Patrik K" last="Magnusson">Patrik K. Magnusson</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Estonian Genome Center, University of Tartu, Tartu, Estonia,</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea>
<wicri:noRegion>Tartu</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="dyv094-AFF1">Broad Institute, Cambridge, MA, USA,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Broad Institute, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="dyv094-AFF1">Department of Genetics, Harvard Medical School, Boston, MA, USA,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Harvard Medical School, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="dyv094-AFF1">Division of Endocrinology, Children's Hospital Boston, Boston, MA, USA,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Endocrinology, Children's Hospital Boston, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Geus, Eco Jc" sort="De Geus, Eco Jc" uniqKey="De Geus E" first="Eco Jc" last="De Geus">Eco Jc De Geus</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">EMGO Institute for Health and Care Research, Amsterdam, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>EMGO Institute for Health and Care Research, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Department of Medical Sciences, Uppsala University, Uppsala, Sweden,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea>
<orgName type="university">Université d'Uppsala</orgName>
<placeName><settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Giedraitis, Vilmantas" sort="Giedraitis, Vilmantas" uniqKey="Giedraitis V" first="Vilmantas" last="Giedraitis">Vilmantas Giedraitis</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Department of Public Health and Caring Sciences, Rudbeck Laboratory, Uppsala, Sweden,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Public Health and Caring Sciences, Rudbeck Laboratory, Uppsala</wicri:regionArea>
<wicri:noRegion>Uppsala</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Estonian Genome Center, University of Tartu, Tartu, Estonia,</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea>
<wicri:noRegion>Tartu</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">National Institute for Health and Welfare, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Evans, Alun" sort="Evans, Alun" uniqKey="Evans A" first="Alun" last="Evans">Alun Evans</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Centre for Public Health, Queen's University of Belfast, Belfast, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Public Health, Queen's University of Belfast, Belfast</wicri:regionArea>
<wicri:noRegion>Belfast</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrières">Jean Ferrières</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France,</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Midi-Pyrénées</region>
<settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">National Institute for Health and Welfare, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kee, Frank" sort="Kee, Frank" uniqKey="Kee F" first="Frank" last="Kee">Frank Kee</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">UKCRC Centre of Excellence for Public Health Northern Ireland, Queen's University of Belfast, Belfast, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UKCRC Centre of Excellence for Public Health Northern Ireland, Queen's University of Belfast, Belfast</wicri:regionArea>
<wicri:noRegion>Belfast</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Tregouet">David-Alexandre Tregouet</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Team Genomics & Pathophysiology of Cardiovascular Diseases, Sorbonne Universités, UPMC Univ Paris 06, Paris, France,</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Team Genomics & Pathophysiology of Cardiovascular Diseases, Sorbonne Universités, UPMC Univ Paris 06, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Team Genomics & Pathophysiology of Cardiovascular Diseases, INSERM, UMR_S 1166, Paris, France,</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Team Genomics & Pathophysiology of Cardiovascular Diseases, INSERM, UMR_S 1166, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">ICAN Institute for Cardiometabolism and Nutrition, Paris, France,</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>ICAN Institute for Cardiometabolism and Nutrition, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
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</affiliation>
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<author><name sortKey="Arveiler, Dominique" sort="Arveiler, Dominique" uniqKey="Arveiler D" first="Dominique" last="Arveiler">Dominique Arveiler</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Epidemiology and Public Health, University Hospital of Strasbourg, Strasbourg, France,</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Epidemiology and Public Health, University Hospital of Strasbourg, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
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<settlement type="city">Strasbourg</settlement>
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</affiliation>
</author>
<author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Institut Pasteur de Lille, Université Lille Nord de France, Lille, France,</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Université Lille Nord de France, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gianfagna, Francesco" sort="Gianfagna, Francesco" uniqKey="Gianfagna F" first="Francesco" last="Gianfagna">Francesco Gianfagna</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Research Centre for Epidemiology and Preventive Medicine (EPIMED), Department of Clinical and Experimental Medicine, University of Insubria at Varese, Italy,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Research Centre for Epidemiology and Preventive Medicine (EPIMED), Department of Clinical and Experimental Medicine, University of Insubria at Varese</wicri:regionArea>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Brambilla, Paolo" sort="Brambilla, Paolo" uniqKey="Brambilla P" first="Paolo" last="Brambilla">Paolo Brambilla</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Department of Experimental Medicine, University of Milano-Bicocca, Monza, Italy,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Milano-Bicocca, Monza</wicri:regionArea>
<wicri:noRegion>Monza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">National Institute for Health and Welfare, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Hjelt Institute, University of Helsinki, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Hjelt Institute, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK,</nlm:aff>
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<wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
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<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
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</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden, The Netherlands,</nlm:aff>
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<wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
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</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Netherlands Genomics Initiative, Leiden University Medical Center, Leiden, The Netherlands,</nlm:aff>
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<wicri:regionArea>Netherlands Genomics Initiative, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
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<author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Estonian Genome Center, University of Tartu, Tartu, Estonia,</nlm:aff>
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<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia,</nlm:aff>
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<wicri:regionArea>Institute of Molecular and Cell Biology, University of Tartu, Tartu</wicri:regionArea>
<wicri:noRegion>Tartu</wicri:noRegion>
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</author>
<author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
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<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
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<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK,</nlm:aff>
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<wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford</wicri:regionArea>
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<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
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<affiliation wicri:level="3"><nlm:aff wicri:cut=" and" id="dyv094-AFF1">Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK</nlm:aff>
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<placeName><settlement type="city">Londres</settlement>
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<author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I" last="Mccarthy">Mark I. Mccarthy</name>
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<settlement type="city">Oxford</settlement>
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<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK,</nlm:aff>
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<placeName><settlement type="city">Oxford</settlement>
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<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
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<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK</nlm:aff>
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<placeName><settlement type="city">Oxford</settlement>
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<author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L" last="Pedersen">Nancy L. Pedersen</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,</nlm:aff>
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<author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name>
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<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK,</nlm:aff>
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<settlement type="city">Oxford</settlement>
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<orgName type="university">Université d'Oxford</orgName>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Adiposity as a cause of cardiovascular disease: a Mendelian randomization study</title>
<author><name sortKey="H Gg, Sara" sort="H Gg, Sara" uniqKey="H Gg S" first="Sara" last="H Gg">Sara H Gg</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,</nlm:aff>
<country xml:lang="fr">Suède</country>
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</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden,</nlm:aff>
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<author><name sortKey="Fall, Tove" sort="Fall, Tove" uniqKey="Fall T" first="Tove" last="Fall">Tove Fall</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
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<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden,</nlm:aff>
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</affiliation>
</author>
<author><name sortKey="Ploner, Alexander" sort="Ploner, Alexander" uniqKey="Ploner A" first="Alexander" last="Ploner">Alexander Ploner</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Estonian Genome Center, University of Tartu, Tartu, Estonia,</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea>
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</author>
<author><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Estonian Genome Center, University of Tartu, Tartu, Estonia,</nlm:aff>
<country xml:lang="fr">Estonie</country>
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</author>
<author><name sortKey="Draisma, Harmen Hm" sort="Draisma, Harmen Hm" uniqKey="Draisma H" first="Harmen Hm" last="Draisma">Harmen Hm Draisma</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
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</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">EMGO Institute for Health and Care Research, Amsterdam, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>EMGO Institute for Health and Care Research, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Kals, Mart" sort="Kals, Mart" uniqKey="Kals M" first="Mart" last="Kals">Mart Kals</name>
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<country xml:lang="fr">Estonie</country>
<wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Institute of Mathematical Statistics, University of Tartu, Tartu, Estonia,</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea>Institute of Mathematical Statistics, University of Tartu, Tartu</wicri:regionArea>
<wicri:noRegion>Tartu</wicri:noRegion>
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</author>
<author><name sortKey="De Vries, Paul S" sort="De Vries, Paul S" uniqKey="De Vries P" first="Paul S" last="De Vries">Paul S. De Vries</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Willems, Sara M" sort="Willems, Sara M" uniqKey="Willems S" first="Sara M" last="Willems">Sara M. Willems</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Genetic Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sarin, Antti Pekka" sort="Sarin, Antti Pekka" uniqKey="Sarin A" first="Antti-Pekka" last="Sarin">Antti-Pekka Sarin</name>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">National Institute for Health and Welfare, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kristiansson, Kati" sort="Kristiansson, Kati" uniqKey="Kristiansson K" first="Kati" last="Kristiansson">Kati Kristiansson</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">National Institute for Health and Welfare, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nuotio, Marja Liisa" sort="Nuotio, Marja Liisa" uniqKey="Nuotio M" first="Marja-Liisa" last="Nuotio">Marja-Liisa Nuotio</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">National Institute for Health and Welfare, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Havulinna, Aki S" sort="Havulinna, Aki S" uniqKey="Havulinna A" first="Aki S" last="Havulinna">Aki S. Havulinna</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">National Institute for Health and Welfare, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Bruijn, Renee Fag" sort="De Bruijn, Renee Fag" uniqKey="De Bruijn R" first="Renée Fag" last="De Bruijn">Renée Fag De Bruijn</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation><nlm:aff wicri:cut=", and" id="dyv094-AFF1">Department of Neurology</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation><nlm:aff wicri:cut=", and" id="dyv094-AFF1">Department of Neurology</nlm:aff>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kuningas, Maris" sort="Kuningas, Maris" uniqKey="Kuningas M" first="Maris" last="Kuningas">Maris Kuningas</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Inspectorate for Health Care, The Hague, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Inspectorate for Health Care, The Hague</wicri:regionArea>
<wicri:noRegion>The Hague</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stricker, Bruno H" sort="Stricker, Bruno H" uniqKey="Stricker B" first="Bruno H" last="Stricker">Bruno H. Stricker</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Inspectorate for Health Care, The Hague, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Inspectorate for Health Care, The Hague</wicri:regionArea>
<wicri:noRegion>The Hague</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H" last="Franco">Oscar H. Franco</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Benyamin, Beben" sort="Benyamin, Beben" uniqKey="Benyamin B" first="Beben" last="Benyamin">Beben Benyamin</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Brain Institute, University of Queensland, Brisbane, QLD</wicri:regionArea>
<wicri:noRegion>QLD</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>QIMR Berghofer Medical Research Institute, Brisbane, QLD</wicri:regionArea>
<wicri:noRegion>QLD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hall, Alistair S" sort="Hall, Alistair S" uniqKey="Hall A" first="Alistair S" last="Hall">Alistair S. Hall</name>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Division of Epidemiology, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Epidemiology, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds</wicri:regionArea>
<orgName type="university">Université de Leeds</orgName>
<placeName><settlement type="city">Leeds</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Yorkshire-et-Humber</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huikari, Ville" sort="Huikari, Ville" uniqKey="Huikari V" first="Ville" last="Huikari">Ville Huikari</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Center for Life Course and Systems Epidemiology, University of Oulu, Oulu, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Center for Life Course and Systems Epidemiology, University of Oulu, Oulu</wicri:regionArea>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jula, Antti" sort="Jula, Antti" uniqKey="Jula A" first="Antti" last="Jula">Antti Jula</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku</wicri:regionArea>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="J Rvelin, Marjo Riitta" sort="J Rvelin, Marjo Riitta" uniqKey="J Rvelin M" first="Marjo-Riitta" last="J Rvelin">Marjo-Riitta J Rvelin</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Center for Life Course and Systems Epidemiology, University of Oulu, Oulu, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Center for Life Course and Systems Epidemiology, University of Oulu, Oulu</wicri:regionArea>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Department of Children, Young People and Families, National Institute for Health and Welfare, Oulu, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Children, Young People and Families, National Institute for Health and Welfare, Oulu</wicri:regionArea>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">MRC Health Protection Agency (HPE) Centre for Environment and Health, Imperial College London, London, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Health Protection Agency (HPE) Centre for Environment and Health, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Unit of Primary Care, Oulu University Hospital, Oulu, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Unit of Primary Care, Oulu University Hospital, Oulu</wicri:regionArea>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Center for Life Course and Systems Epidemiology, University of Oulu, Oulu, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Center for Life Course and Systems Epidemiology, University of Oulu, Oulu</wicri:regionArea>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">National Institute for Health and Welfare, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Hjelt Institute, University of Helsinki, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Hjelt Institute, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kobl, Michael" sort="Kobl, Michael" uniqKey="Kobl M" first="Michael" last="Kobl">Michael Kobl</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Twin Research and Genetic Epidemiology, King's College London, London, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nelson, Christopher P" sort="Nelson, Christopher P" uniqKey="Nelson C" first="Christopher P" last="Nelson">Christopher P. Nelson</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Department of Cardiovascular Sciences, University of Leicester, Leicester, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Leicester</wicri:regionArea>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">National Institute for Health Research, Glenfield Hospital, Leicester, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>National Institute for Health Research, Glenfield Hospital, Leicester</wicri:regionArea>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">National Institute for Health and Welfare, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="dyv094-AFF1">Broad Institute, Cambridge, MA, USA,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Broad Institute, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J" last="Samani">Nilesh J. Samani</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Department of Cardiovascular Sciences, University of Leicester, Leicester, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Leicester</wicri:regionArea>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">National Institute for Health Research, Glenfield Hospital, Leicester, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>National Institute for Health Research, Glenfield Hospital, Leicester</wicri:regionArea>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D" last="Spector">Tim D. Spector</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Twin Research and Genetic Epidemiology, King's College London, London, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P" last="Strachan">David P. Strachan</name>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">St George's, University of London, London, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>St George's, University of London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">Université de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Tobin, Martin D" sort="Tobin, Martin D" uniqKey="Tobin M" first="Martin D" last="Tobin">Martin D. Tobin</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Department of Health Sciences, University of Leicester, Leicester, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Health Sciences, University of Leicester, Leicester</wicri:regionArea>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B" last="Whitfield">John B. Whitfield</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>QIMR Berghofer Medical Research Institute, Brisbane, QLD</wicri:regionArea>
<wicri:noRegion>QLD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G" last="Uitterlinden">André G. Uitterlinden</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">National Institute for Health and Welfare, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Syv Nen, Ann Christine" sort="Syv Nen, Ann Christine" uniqKey="Syv Nen A" first="Ann-Christine" last="Syv Nen">Ann-Christine Syv Nen</name>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala</wicri:regionArea>
<orgName type="university">Université d'Uppsala</orgName>
<placeName><settlement type="city">Uppsala</settlement>
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<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kuulasmaa, Kari" sort="Kuulasmaa, Kari" uniqKey="Kuulasmaa K" first="Kari" last="Kuulasmaa">Kari Kuulasmaa</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">National Institute for Health and Welfare, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Magnusson, Patrik K" sort="Magnusson, Patrik K" uniqKey="Magnusson P" first="Patrik K" last="Magnusson">Patrik K. Magnusson</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Estonian Genome Center, University of Tartu, Tartu, Estonia,</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea>
<wicri:noRegion>Tartu</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="dyv094-AFF1">Broad Institute, Cambridge, MA, USA,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Broad Institute, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="dyv094-AFF1">Department of Genetics, Harvard Medical School, Boston, MA, USA,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Harvard Medical School, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="dyv094-AFF1">Division of Endocrinology, Children's Hospital Boston, Boston, MA, USA,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Endocrinology, Children's Hospital Boston, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Geus, Eco Jc" sort="De Geus, Eco Jc" uniqKey="De Geus E" first="Eco Jc" last="De Geus">Eco Jc De Geus</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Biological Psychology, VU University Amsterdam, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">EMGO Institute for Health and Care Research, Amsterdam, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>EMGO Institute for Health and Care Research, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Department of Medical Sciences, Uppsala University, Uppsala, Sweden,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea>
<orgName type="university">Université d'Uppsala</orgName>
<placeName><settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Giedraitis, Vilmantas" sort="Giedraitis, Vilmantas" uniqKey="Giedraitis V" first="Vilmantas" last="Giedraitis">Vilmantas Giedraitis</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Department of Public Health and Caring Sciences, Rudbeck Laboratory, Uppsala, Sweden,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Public Health and Caring Sciences, Rudbeck Laboratory, Uppsala</wicri:regionArea>
<wicri:noRegion>Uppsala</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Estonian Genome Center, University of Tartu, Tartu, Estonia,</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea>
<wicri:noRegion>Tartu</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">National Institute for Health and Welfare, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Evans, Alun" sort="Evans, Alun" uniqKey="Evans A" first="Alun" last="Evans">Alun Evans</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Centre for Public Health, Queen's University of Belfast, Belfast, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Public Health, Queen's University of Belfast, Belfast</wicri:regionArea>
<wicri:noRegion>Belfast</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrières">Jean Ferrières</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France,</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Midi-Pyrénées</region>
<settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">National Institute for Health and Welfare, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kee, Frank" sort="Kee, Frank" uniqKey="Kee F" first="Frank" last="Kee">Frank Kee</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">UKCRC Centre of Excellence for Public Health Northern Ireland, Queen's University of Belfast, Belfast, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UKCRC Centre of Excellence for Public Health Northern Ireland, Queen's University of Belfast, Belfast</wicri:regionArea>
<wicri:noRegion>Belfast</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Tregouet">David-Alexandre Tregouet</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Team Genomics & Pathophysiology of Cardiovascular Diseases, Sorbonne Universités, UPMC Univ Paris 06, Paris, France,</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Team Genomics & Pathophysiology of Cardiovascular Diseases, Sorbonne Universités, UPMC Univ Paris 06, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Team Genomics & Pathophysiology of Cardiovascular Diseases, INSERM, UMR_S 1166, Paris, France,</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Team Genomics & Pathophysiology of Cardiovascular Diseases, INSERM, UMR_S 1166, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">ICAN Institute for Cardiometabolism and Nutrition, Paris, France,</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>ICAN Institute for Cardiometabolism and Nutrition, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Arveiler, Dominique" sort="Arveiler, Dominique" uniqKey="Arveiler D" first="Dominique" last="Arveiler">Dominique Arveiler</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Epidemiology and Public Health, University Hospital of Strasbourg, Strasbourg, France,</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Epidemiology and Public Health, University Hospital of Strasbourg, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Institut Pasteur de Lille, Université Lille Nord de France, Lille, France,</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Université Lille Nord de France, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gianfagna, Francesco" sort="Gianfagna, Francesco" uniqKey="Gianfagna F" first="Francesco" last="Gianfagna">Francesco Gianfagna</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Research Centre for Epidemiology and Preventive Medicine (EPIMED), Department of Clinical and Experimental Medicine, University of Insubria at Varese, Italy,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Research Centre for Epidemiology and Preventive Medicine (EPIMED), Department of Clinical and Experimental Medicine, University of Insubria at Varese</wicri:regionArea>
<wicri:noRegion>University of Insubria at Varese</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli</wicri:regionArea>
<wicri:noRegion>Pozzilli</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brambilla, Paolo" sort="Brambilla, Paolo" uniqKey="Brambilla P" first="Paolo" last="Brambilla">Paolo Brambilla</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Department of Experimental Medicine, University of Milano-Bicocca, Monza, Italy,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Milano-Bicocca, Monza</wicri:regionArea>
<wicri:noRegion>Monza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">National Institute for Health and Welfare, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Hjelt Institute, University of Helsinki, Helsinki, Finland,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Hjelt Institute, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Netherlands Genomics Initiative, Leiden University Medical Center, Leiden, The Netherlands,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Genomics Initiative, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Estonian Genome Center, University of Tartu, Tartu, Estonia,</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea>
<wicri:noRegion>Tartu</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="dyv094-AFF1">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia,</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea>Institute of Molecular and Cell Biology, University of Tartu, Tartu</wicri:regionArea>
<wicri:noRegion>Tartu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff wicri:cut=" and" id="dyv094-AFF1">Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Genomics of Common Disease, School of Public Health, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I" last="Mccarthy">Mark I. Mccarthy</name>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L" last="Pedersen">Nancy L. Pedersen</name>
<affiliation wicri:level="3"><nlm:aff id="dyv094-AFF1">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea>
<orgName type="university">Université d'Uppsala</orgName>
<placeName><settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="dyv094-AFF1">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">International Journal of Epidemiology</title>
<idno type="ISSN">0300-5771</idno>
<idno type="eISSN">1464-3685</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
Adiposity, as indicated by body mass index (BMI), has been associated with risk of cardiovascular diseases in epidemiological studies. We aimed to investigate if these associations are causal, using Mendelian randomization (MR) methods.</p>
<p><bold>Methods:</bold>
The associations of BMI with cardiovascular outcomes [coronary heart disease (CHD), heart failure and ischaemic stroke], and associations of a genetic score (32 BMI single nucleotide polymorphisms) with BMI and cardiovascular outcomes were examined in up to 22 193 individuals with 3062 incident cardiovascular events from nine prospective follow-up studies within the ENGAGE consortium. We used random-effects meta-analysis in an MR framework to provide causal estimates of the effect of adiposity on cardiovascular outcomes.</p>
<p><bold>Results:</bold>
There was a strong association between BMI and incident CHD (HR = 1.20 per SD-increase of BMI, 95% CI, 1.12–1.28, P = 1.9·10<sup>−7</sup>
), heart failure (HR = 1.47, 95% CI, 1.35–1.60, P = 9·10<sup>−19</sup>
) and ischaemic stroke (HR = 1.15, 95% CI, 1.06–1.24, P = 0.0008) in observational analyses. The genetic score was robustly associated with BMI (β = 0.030 SD-increase of BMI per additional allele, 95% CI, 0.028–0.033, P = 3·10<sup>−107</sup>
). Analyses indicated a causal effect of adiposity on development of heart failure (HR = 1.93 per SD-increase of BMI, 95% CI, 1.12–3.30, P = 0.017) and ischaemic stroke (HR = 1.83, 95% CI, 1.05–3.20, P = 0.034). Additional cross-sectional analyses using both ENGAGE and CARDIoGRAMplusC4D data showed a causal effect of adiposity on CHD.</p>
<p><bold>Conclusions:</bold>
Using MR methods, we provide support for the hypothesis that adiposity causes CHD, heart failure and, previously not demonstrated, ischaemic stroke.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Estonie</li>
<li>Finlande</li>
<li>France</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Alsace (région administrative)</li>
<li>Angleterre</li>
<li>East Middle Sweden</li>
<li>Finlande occidentale</li>
<li>Grand Est</li>
<li>Grand Londres</li>
<li>Hauts-de-France</li>
<li>Hollande-Méridionale</li>
<li>Hollande-Septentrionale</li>
<li>Massachusetts</li>
<li>Midi-Pyrénées</li>
<li>Nord-Pas-de-Calais</li>
<li>Occitanie (région administrative)</li>
<li>Oxfordshire</li>
<li>Svealand</li>
<li>Uusimaa</li>
<li>Yorkshire-et-Humber</li>
<li>Île-de-France</li>
</region>
<settlement><li>Amsterdam</li>
<li>Helsinki</li>
<li>Leeds</li>
<li>Leyde</li>
<li>Lille</li>
<li>Londres</li>
<li>Oxford</li>
<li>Paris</li>
<li>Rotterdam</li>
<li>Stockholm</li>
<li>Strasbourg</li>
<li>Toulouse</li>
<li>Turku</li>
<li>Uppsala</li>
</settlement>
<orgName><li>Université d'Helsinki</li>
<li>Université d'Oxford</li>
<li>Université d'Uppsala</li>
<li>Université de Leeds</li>
<li>Université de Londres</li>
</orgName>
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<name sortKey="Fall, Tove" sort="Fall, Tove" uniqKey="Fall T" first="Tove" last="Fall">Tove Fall</name>
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<name sortKey="H Gg, Sara" sort="H Gg, Sara" uniqKey="H Gg S" first="Sara" last="H Gg">Sara H Gg</name>
<name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name>
<name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name>
<name sortKey="Magnusson, Patrik K" sort="Magnusson, Patrik K" uniqKey="Magnusson P" first="Patrik K" last="Magnusson">Patrik K. Magnusson</name>
<name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L" last="Pedersen">Nancy L. Pedersen</name>
<name sortKey="Ploner, Alexander" sort="Ploner, Alexander" uniqKey="Ploner A" first="Alexander" last="Ploner">Alexander Ploner</name>
<name sortKey="Syv Nen, Ann Christine" sort="Syv Nen, Ann Christine" uniqKey="Syv Nen A" first="Ann-Christine" last="Syv Nen">Ann-Christine Syv Nen</name>
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<name sortKey="Kals, Mart" sort="Kals, Mart" uniqKey="Kals M" first="Mart" last="Kals">Mart Kals</name>
<name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name>
<name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name>
<name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Draisma, Harmen Hm" sort="Draisma, Harmen Hm" uniqKey="Draisma H" first="Harmen Hm" last="Draisma">Harmen Hm Draisma</name>
</region>
<name sortKey="De Bruijn, Renee Fag" sort="De Bruijn, Renee Fag" uniqKey="De Bruijn R" first="Renée Fag" last="De Bruijn">Renée Fag De Bruijn</name>
<name sortKey="De Geus, Eco Jc" sort="De Geus, Eco Jc" uniqKey="De Geus E" first="Eco Jc" last="De Geus">Eco Jc De Geus</name>
<name sortKey="De Geus, Eco Jc" sort="De Geus, Eco Jc" uniqKey="De Geus E" first="Eco Jc" last="De Geus">Eco Jc De Geus</name>
<name sortKey="De Vries, Paul S" sort="De Vries, Paul S" uniqKey="De Vries P" first="Paul S" last="De Vries">Paul S. De Vries</name>
<name sortKey="De Vries, Paul S" sort="De Vries, Paul S" uniqKey="De Vries P" first="Paul S" last="De Vries">Paul S. De Vries</name>
<name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name>
<name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name>
<name sortKey="Draisma, Harmen Hm" sort="Draisma, Harmen Hm" uniqKey="Draisma H" first="Harmen Hm" last="Draisma">Harmen Hm Draisma</name>
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<name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name>
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<name sortKey="Kuningas, Maris" sort="Kuningas, Maris" uniqKey="Kuningas M" first="Maris" last="Kuningas">Maris Kuningas</name>
<name sortKey="Stricker, Bruno H" sort="Stricker, Bruno H" uniqKey="Stricker B" first="Bruno H" last="Stricker">Bruno H. Stricker</name>
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<name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G" last="Uitterlinden">André G. Uitterlinden</name>
<name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G" last="Uitterlinden">André G. Uitterlinden</name>
<name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G" last="Uitterlinden">André G. Uitterlinden</name>
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</region>
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<name sortKey="J Rvelin, Marjo Riitta" sort="J Rvelin, Marjo Riitta" uniqKey="J Rvelin M" first="Marjo-Riitta" last="J Rvelin">Marjo-Riitta J Rvelin</name>
<name sortKey="J Rvelin, Marjo Riitta" sort="J Rvelin, Marjo Riitta" uniqKey="J Rvelin M" first="Marjo-Riitta" last="J Rvelin">Marjo-Riitta J Rvelin</name>
<name sortKey="Jula, Antti" sort="Jula, Antti" uniqKey="Jula A" first="Antti" last="Jula">Antti Jula</name>
<name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name>
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<name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name>
<name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name>
<name sortKey="Kristiansson, Kati" sort="Kristiansson, Kati" uniqKey="Kristiansson K" first="Kati" last="Kristiansson">Kati Kristiansson</name>
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<name sortKey="Nuotio, Marja Liisa" sort="Nuotio, Marja Liisa" uniqKey="Nuotio M" first="Marja-Liisa" last="Nuotio">Marja-Liisa Nuotio</name>
<name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
<name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
<name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
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<name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name>
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<name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name>
<name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name>
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<country name="Australie"><noRegion><name sortKey="Benyamin, Beben" sort="Benyamin, Beben" uniqKey="Benyamin B" first="Beben" last="Benyamin">Beben Benyamin</name>
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</country>
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<name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I" last="Mccarthy">Mark I. Mccarthy</name>
<name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I" last="Mccarthy">Mark I. Mccarthy</name>
<name sortKey="Nelson, Christopher P" sort="Nelson, Christopher P" uniqKey="Nelson C" first="Christopher P" last="Nelson">Christopher P. Nelson</name>
<name sortKey="Nelson, Christopher P" sort="Nelson, Christopher P" uniqKey="Nelson C" first="Christopher P" last="Nelson">Christopher P. Nelson</name>
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<name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name>
<name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name>
<name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name>
<name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J" last="Samani">Nilesh J. Samani</name>
<name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J" last="Samani">Nilesh J. Samani</name>
<name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D" last="Spector">Tim D. Spector</name>
<name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P" last="Strachan">David P. Strachan</name>
<name sortKey="Tobin, Martin D" sort="Tobin, Martin D" uniqKey="Tobin M" first="Martin D" last="Tobin">Martin D. Tobin</name>
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<country name="États-Unis"><region name="Massachusetts"><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
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<name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name>
<name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name>
<name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name>
</country>
<country name="France"><region name="Occitanie (région administrative)"><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrières">Jean Ferrières</name>
</region>
<name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
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<name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Tregouet">David-Alexandre Tregouet</name>
<name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Tregouet">David-Alexandre Tregouet</name>
<name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Tregouet">David-Alexandre Tregouet</name>
</country>
<country name="Italie"><noRegion><name sortKey="Gianfagna, Francesco" sort="Gianfagna, Francesco" uniqKey="Gianfagna F" first="Francesco" last="Gianfagna">Francesco Gianfagna</name>
</noRegion>
<name sortKey="Brambilla, Paolo" sort="Brambilla, Paolo" uniqKey="Brambilla P" first="Paolo" last="Brambilla">Paolo Brambilla</name>
<name sortKey="Gianfagna, Francesco" sort="Gianfagna, Francesco" uniqKey="Gianfagna F" first="Francesco" last="Gianfagna">Francesco Gianfagna</name>
</country>
</tree>
</affiliations>
</record>
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