Interaction between asthma and smoking increases the risk of adult airway obstruction.
Identifieur interne : 002C36 ( Main/Exploration ); précédent : 002C35; suivant : 002C37Interaction between asthma and smoking increases the risk of adult airway obstruction.
Auteurs : Marianne Aanerud [Norvège] ; Anne-Elie Carsin [Espagne] ; Jordi Sunyer [Espagne] ; Julia Dratva [Suisse] ; Thorarinn Gislason [Islande] ; Deborah Jarvis [Royaume-Uni] ; Roberto Demarco [Italie] ; Chantal Raherison [France] ; Matthias Wjst [Allemagne] ; Shyamali C. Dharmage [Australie] ; Cecilie Svanes [Norvège]Source :
- The European respiratory journal [ 1399-3003 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Asthme (), Asthme (psychologie), Asthme (épidémiologie), Enquêtes de santé, Europe (épidémiologie), Facteurs de l'âge, Facteurs de risque, Facteurs sexuels, Femelle, Humains, Modèles linéaires, Mâle, Obstruction des voies aériennes (diagnostic), Obstruction des voies aériennes (épidémiologie), Obstruction des voies aériennes (étiologie), Pronostic, Reproductibilité des résultats, Tabagisme (effets indésirables), Tabagisme (physiopathologie), Tabagisme (épidémiologie), Tests de la fonction respiratoire (), Âge de début, Évaluation des risques.
- MESH :
- diagnostic : Obstruction des voies aériennes.
- effets indésirables : Tabagisme.
- physiopathologie : Tabagisme.
- psychologie : Asthme.
- épidémiologie : Asthme, Europe, Obstruction des voies aériennes, Tabagisme.
- étiologie : Obstruction des voies aériennes.
- Adulte, Adulte d'âge moyen, Asthme, Enquêtes de santé, Facteurs de l'âge, Facteurs de risque, Facteurs sexuels, Femelle, Humains, Modèles linéaires, Mâle, Pronostic, Reproductibilité des résultats, Tests de la fonction respiratoire, Âge de début, Évaluation des risques.
English descriptors
- KwdEn :
- Adult, Age Factors, Age of Onset, Airway Obstruction (diagnosis), Airway Obstruction (epidemiology), Airway Obstruction (etiology), Asthma (complications), Asthma (epidemiology), Asthma (psychology), Europe (epidemiology), Female, Health Surveys, Humans, Linear Models, Male, Middle Aged, Prognosis, Reproducibility of Results, Respiratory Function Tests (methods), Respiratory Function Tests (statistics & numerical data), Risk Assessment, Risk Factors, Sex Factors, Smoking (adverse effects), Smoking (epidemiology), Smoking (physiopathology).
- MESH :
- geographic , epidemiology : Europe.
- adverse effects : Smoking.
- complications : Asthma.
- diagnosis : Airway Obstruction.
- epidemiology : Airway Obstruction, Asthma, Smoking.
- etiology : Airway Obstruction.
- methods : Respiratory Function Tests.
- physiopathology : Smoking.
- psychology : Asthma.
- statistics & numerical data : Respiratory Function Tests.
- Adult, Age Factors, Age of Onset, Female, Health Surveys, Humans, Linear Models, Male, Middle Aged, Prognosis, Reproducibility of Results, Risk Assessment, Risk Factors, Sex Factors.
Abstract
The aim of the present study was to analyse the interaction between asthma and smoking in the risk of adult airway obstruction, accounting for atopy. In the European Community Respiratory Health Survey, 15 668 persons aged 20-56 years underwent spirometry in 1991-1993 and 9 years later (n=8916). Risk of airway obstruction and lung function decline associated with smoking and early-onset (<10 years of age) and late-onset (>10 years of age) asthma were analysed with generalised estimating equation models and random-effect linear models, adjusting for covariates. Interaction of asthma with smoking was expressed as relative excess risk due to interaction (RERI). A 20-fold increase in adult airway obstruction was found among those with early-onset asthma independently of smoking status (never-smokers: OR 21.0, 95% CI 12.7-35; current smokers: OR 23.7, 95% CI 13.9-40.6). Late-onset asthma was associated with airway obstruction, with a stronger association among current smokers (OR 25.6, 95% CI 15.6-41.9) than among never-smokers (OR 11.2, 95% CI 6.8-18.6) (RERI 12.02, 95% CI 1.96-22.07). Stratifying by atopy, the association between smoking and asthma was most pronounced among nonatopics. Early- and late-onset asthma were associated with 10-20-fold increased risk of adult airway obstruction. Smoking increased the risk of adult airway obstruction in subjects with asthma onset after age 10 years. Investigation of measures potentially preventive of chronic obstructive pulmonary disease development following asthma is urgently needed.
DOI: 10.1183/09031936.00055514
PubMed: 25431272
Affiliations:
- Allemagne, Australie, Espagne, France, Islande, Italie, Norvège, Royaume-Uni, Suisse
- Angleterre, Aquitaine, Bavière, Catalogne, District de Haute-Bavière, Grand Londres, Nouvelle-Aquitaine, Victoria (État)
- Barcelone, Bordeaux, Londres, Melbourne, Munich
- Université Pompeu Fabra, Université de Melbourne
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Le document en format XML
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uniqKey="Gislason T" first="Thorarinn" last="Gislason">Thorarinn Gislason</name><affiliation wicri:level="1"><nlm:affiliation>Dept of Respiratory Medicine and Sleep, Landspitali University Hospital (E7) and Faculty of Medicine, University of Iceland, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Dept of Respiratory Medicine and Sleep, Landspitali University Hospital (E7) and Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Jarvis, Deborah" sort="Jarvis, Deborah" uniqKey="Jarvis D" first="Deborah" last="Jarvis">Deborah Jarvis</name><affiliation wicri:level="3"><nlm:affiliation>Dept of Public Health Sciences, Imperial College, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Dept of Public Health Sciences, Imperial College, London</wicri:regionArea><placeName><settlement 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xml:lang="fr">France</country><wicri:regionArea>INSERM, ISPED, Centre INSEM U897, CHU Bordeaux, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Wjst, Matthias" sort="Wjst, Matthias" uniqKey="Wjst M" first="Matthias" last="Wjst">Matthias Wjst</name><affiliation wicri:level="3"><nlm:affiliation>Helmholtz Center Munich, National Research Centre for Environmental Health, Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Helmholtz Center Munich, National Research Centre for Environmental Health, Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Dharmage, Shyamali C" sort="Dharmage, Shyamali C" uniqKey="Dharmage S" first="Shyamali C" last="Dharmage">Shyamali C. Dharmage</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Svanes, Cecilie" sort="Svanes, Cecilie" uniqKey="Svanes C" first="Cecilie" last="Svanes">Cecilie Svanes</name><affiliation wicri:level="1"><nlm:affiliation>Dept of Occupational Medicine, Haukeland University Hospital, Bergen, Norway Centre for International Health, University of Bergen, Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Dept of Occupational Medicine, Haukeland University Hospital, Bergen, Norway Centre for International Health, University of Bergen, Bergen</wicri:regionArea><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author></analytic><series><title level="j">The European respiratory journal</title><idno type="eISSN">1399-3003</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Age of Onset</term><term>Airway Obstruction (diagnosis)</term><term>Airway Obstruction (epidemiology)</term><term>Airway Obstruction (etiology)</term><term>Asthma (complications)</term><term>Asthma (epidemiology)</term><term>Asthma (psychology)</term><term>Europe (epidemiology)</term><term>Female</term><term>Health Surveys</term><term>Humans</term><term>Linear Models</term><term>Male</term><term>Middle Aged</term><term>Prognosis</term><term>Reproducibility of Results</term><term>Respiratory Function Tests (methods)</term><term>Respiratory Function Tests (statistics & numerical data)</term><term>Risk Assessment</term><term>Risk Factors</term><term>Sex Factors</term><term>Smoking (adverse effects)</term><term>Smoking (epidemiology)</term><term>Smoking (physiopathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Asthme ()</term><term>Asthme (psychologie)</term><term>Asthme (épidémiologie)</term><term>Enquêtes de santé</term><term>Europe (épidémiologie)</term><term>Facteurs de l'âge</term><term>Facteurs de risque</term><term>Facteurs sexuels</term><term>Femelle</term><term>Humains</term><term>Modèles linéaires</term><term>Mâle</term><term>Obstruction des voies aériennes (diagnostic)</term><term>Obstruction des voies aériennes (épidémiologie)</term><term>Obstruction des voies aériennes (étiologie)</term><term>Pronostic</term><term>Reproductibilité des résultats</term><term>Tabagisme (effets indésirables)</term><term>Tabagisme (physiopathologie)</term><term>Tabagisme (épidémiologie)</term><term>Tests de la fonction respiratoire ()</term><term>Âge de début</term><term>Évaluation des risques</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Europe</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Smoking</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Asthma</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Airway Obstruction</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Obstruction des voies aériennes</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Tabagisme</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Airway Obstruction</term><term>Asthma</term><term>Smoking</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Airway Obstruction</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Respiratory Function Tests</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Tabagisme</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Smoking</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Asthme</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Asthma</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Respiratory Function Tests</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Asthme</term><term>Europe</term><term>Obstruction des voies aériennes</term><term>Tabagisme</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Obstruction des voies aériennes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Age of Onset</term><term>Female</term><term>Health Surveys</term><term>Humans</term><term>Linear Models</term><term>Male</term><term>Middle Aged</term><term>Prognosis</term><term>Reproducibility of Results</term><term>Risk Assessment</term><term>Risk Factors</term><term>Sex Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Asthme</term><term>Enquêtes de santé</term><term>Facteurs de l'âge</term><term>Facteurs de risque</term><term>Facteurs sexuels</term><term>Femelle</term><term>Humains</term><term>Modèles linéaires</term><term>Mâle</term><term>Pronostic</term><term>Reproductibilité des résultats</term><term>Tests de la fonction respiratoire</term><term>Âge de début</term><term>Évaluation des risques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of the present study was to analyse the interaction between asthma and smoking in the risk of adult airway obstruction, accounting for atopy. In the European Community Respiratory Health Survey, 15 668 persons aged 20-56 years underwent spirometry in 1991-1993 and 9 years later (n=8916). Risk of airway obstruction and lung function decline associated with smoking and early-onset (<10 years of age) and late-onset (>10 years of age) asthma were analysed with generalised estimating equation models and random-effect linear models, adjusting for covariates. Interaction of asthma with smoking was expressed as relative excess risk due to interaction (RERI). A 20-fold increase in adult airway obstruction was found among those with early-onset asthma independently of smoking status (never-smokers: OR 21.0, 95% CI 12.7-35; current smokers: OR 23.7, 95% CI 13.9-40.6). Late-onset asthma was associated with airway obstruction, with a stronger association among current smokers (OR 25.6, 95% CI 15.6-41.9) than among never-smokers (OR 11.2, 95% CI 6.8-18.6) (RERI 12.02, 95% CI 1.96-22.07). Stratifying by atopy, the association between smoking and asthma was most pronounced among nonatopics. Early- and late-onset asthma were associated with 10-20-fold increased risk of adult airway obstruction. Smoking increased the risk of adult airway obstruction in subjects with asthma onset after age 10 years. Investigation of measures potentially preventive of chronic obstructive pulmonary disease development following asthma is urgently needed.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Espagne</li><li>France</li><li>Islande</li><li>Italie</li><li>Norvège</li><li>Royaume-Uni</li><li>Suisse</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Bavière</li><li>Catalogne</li><li>District de Haute-Bavière</li><li>Grand Londres</li><li>Nouvelle-Aquitaine</li><li>Victoria (État)</li></region><settlement><li>Barcelone</li><li>Bordeaux</li><li>Londres</li><li>Melbourne</li><li>Munich</li></settlement><orgName><li>Université Pompeu Fabra</li><li>Université de Melbourne</li></orgName></list><tree><country name="Norvège"><noRegion><name sortKey="Aanerud, Marianne" sort="Aanerud, Marianne" uniqKey="Aanerud M" first="Marianne" last="Aanerud">Marianne Aanerud</name></noRegion><name sortKey="Svanes, Cecilie" sort="Svanes, Cecilie" uniqKey="Svanes C" first="Cecilie" last="Svanes">Cecilie Svanes</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Carsin, Anne Elie" sort="Carsin, Anne Elie" uniqKey="Carsin A" first="Anne-Elie" last="Carsin">Anne-Elie Carsin</name></region><name sortKey="Sunyer, Jordi" sort="Sunyer, Jordi" uniqKey="Sunyer J" first="Jordi" last="Sunyer">Jordi Sunyer</name></country><country name="Suisse"><noRegion><name sortKey="Dratva, Julia" sort="Dratva, Julia" uniqKey="Dratva J" first="Julia" last="Dratva">Julia Dratva</name></noRegion></country><country name="Islande"><noRegion><name sortKey="Gislason, Thorarinn" sort="Gislason, Thorarinn" uniqKey="Gislason T" first="Thorarinn" last="Gislason">Thorarinn Gislason</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Jarvis, Deborah" sort="Jarvis, Deborah" uniqKey="Jarvis D" first="Deborah" last="Jarvis">Deborah Jarvis</name></region></country><country name="Italie"><noRegion><name sortKey="Demarco, Roberto" sort="Demarco, Roberto" uniqKey="Demarco R" first="Roberto" last="Demarco">Roberto Demarco</name></noRegion></country><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Raherison, Chantal" sort="Raherison, Chantal" uniqKey="Raherison C" first="Chantal" last="Raherison">Chantal Raherison</name></region></country><country name="Allemagne"><region name="Bavière"><name sortKey="Wjst, Matthias" sort="Wjst, Matthias" uniqKey="Wjst M" first="Matthias" last="Wjst">Matthias Wjst</name></region></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Dharmage, Shyamali C" sort="Dharmage, Shyamali C" uniqKey="Dharmage S" first="Shyamali C" last="Dharmage">Shyamali C. 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