Measuring Serum Amyloid A for Infection Prediction in Aneurysmal Subarachnoid Hemorrhage.
Identifieur interne : 002B54 ( Main/Exploration ); précédent : 002B53; suivant : 002B55Measuring Serum Amyloid A for Infection Prediction in Aneurysmal Subarachnoid Hemorrhage.
Auteurs : Leire Azurmendi [Suisse] ; Vincent Degos [France] ; Natalia Tiberti [Australie] ; Natacha Kapandji [France] ; Paola Sanchez [France] ; Asita Sarrafzadeh [Allemagne] ; Louis Puybasset [France] ; Natacha Turck [Suisse] ; Jean-Charles Sanchez [Suisse]Source :
- Journal of proteome research [ 1535-3907 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Anévrysme intracrânien (), Anévrysme intracrânien (sang), Femelle, Hospitalisation, Humains, Hémorragie meningée (), Hémorragie meningée (sang), Infection croisée (), Infection croisée (sang), Mâle, Protéine amyloïde A sérique (analyse), Protéome (analyse), Protéomique, Reproductibilité des résultats, Sujet âgé, Valeur prédictive des tests.
- MESH :
- analyse : Protéine amyloïde A sérique, Protéome.
- sang : Anévrysme intracrânien, Hémorragie meningée, Infection croisée.
- Adulte, Adulte d'âge moyen, Anévrysme intracrânien, Femelle, Hospitalisation, Humains, Hémorragie meningée, Infection croisée, Mâle, Protéomique, Reproductibilité des résultats, Sujet âgé, Valeur prédictive des tests.
English descriptors
- KwdEn :
- Adult, Aged, Cross Infection (blood), Cross Infection (complications), Female, Hospitalization, Humans, Intracranial Aneurysm (blood), Intracranial Aneurysm (complications), Male, Middle Aged, Predictive Value of Tests, Proteome (analysis), Proteomics, Reproducibility of Results, Serum Amyloid A Protein (analysis), Subarachnoid Hemorrhage (blood), Subarachnoid Hemorrhage (complications).
- MESH :
- chemical , analysis : Proteome, Serum Amyloid A Protein.
- blood : Cross Infection, Intracranial Aneurysm, Subarachnoid Hemorrhage.
- complications : Cross Infection, Intracranial Aneurysm, Subarachnoid Hemorrhage.
- Adult, Aged, Female, Hospitalization, Humans, Male, Middle Aged, Predictive Value of Tests, Proteomics, Reproducibility of Results.
Abstract
Aneurysmal subarachnoid hemorrhage (aSAH) is associated with high rates of mortality and morbidity. Nosocomial infections, such as pneumonia or urinary tract infections, are among the main causes of worsening outcomes and death. The aim of this study was to discover a biomarker to predict infection in aSAH patients. For this purpose, the plasma of infected and noninfected patients was compared using quantitative mass spectrometry. The most interesting differentially expressed proteins were selected for validation by immunoassays on plasma samples taken from patients (n = 81) over 10 days of hospitalization. Predictive performances were established using Mann-Whitney U tests and receiver operating characteristic curves. Quantitative proteomics identified 17 significantly regulated proteins. Of these, levels of serum amyloid A (SAA) were significantly higher in infected patients (p < 0.007). ELISA confirmed that the concentrations were significantly higher (p < 0.002) already at hospital admission in patients who subsequently developed an infection during their hospitalization, (AUC of 76%) for a cutoff value of 90.9 μg/mL. Our data suggested that measuring SAA could be an efficient means of detecting patients susceptible of developing an infection during hospitalization after an aSAH. Its predictive capacity could lead to earlier antibiotherapy, improved patient management, and potentially better long-term outcomes.
DOI: 10.1021/acs.jproteome.5b00391
PubMed: 26198378
Affiliations:
- Allemagne, Australie, France, Suisse
- Bade-Wurtemberg, District de Karlsruhe, Île-de-France
- Heidelberg, Paris
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Aneurysmal Subarachnoid Hemorrhage.</title><author><name sortKey="Azurmendi, Leire" sort="Azurmendi, Leire" uniqKey="Azurmendi L" first="Leire" last="Azurmendi">Leire Azurmendi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Human Protein Sciences, University of Geneva , Rue Michel Servet 1, CH-1211 Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Human Protein Sciences, University of Geneva , Rue Michel Servet 1, CH-1211 Geneva</wicri:regionArea><wicri:noRegion>CH-1211 Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Degos, Vincent" sort="Degos, Vincent" uniqKey="Degos V" first="Vincent" last="Degos">Vincent Degos</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesiology, Pitié-Salpêtrière University Hospital , 47-83 Boulevard de l'Hôpital, 75013 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Anesthesiology, 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of Human Protein Sciences, University of Geneva , Rue Michel Servet 1, CH-1211 Geneva</wicri:regionArea><wicri:noRegion>CH-1211 Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Sanchez, Jean Charles" sort="Sanchez, Jean Charles" uniqKey="Sanchez J" first="Jean-Charles" last="Sanchez">Jean-Charles Sanchez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Human Protein Sciences, University of Geneva , Rue Michel Servet 1, CH-1211 Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Human Protein Sciences, University of Geneva , Rue Michel Servet 1, CH-1211 Geneva</wicri:regionArea><wicri:noRegion>CH-1211 Geneva</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of proteome research</title><idno type="eISSN">1535-3907</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Cross Infection (blood)</term><term>Cross Infection (complications)</term><term>Female</term><term>Hospitalization</term><term>Humans</term><term>Intracranial Aneurysm (blood)</term><term>Intracranial Aneurysm (complications)</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Proteome (analysis)</term><term>Proteomics</term><term>Reproducibility of Results</term><term>Serum Amyloid A Protein (analysis)</term><term>Subarachnoid Hemorrhage (blood)</term><term>Subarachnoid Hemorrhage (complications)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anévrysme intracrânien ()</term><term>Anévrysme intracrânien (sang)</term><term>Femelle</term><term>Hospitalisation</term><term>Humains</term><term>Hémorragie meningée ()</term><term>Hémorragie meningée (sang)</term><term>Infection croisée ()</term><term>Infection croisée (sang)</term><term>Mâle</term><term>Protéine amyloïde A sérique (analyse)</term><term>Protéome (analyse)</term><term>Protéomique</term><term>Reproductibilité des résultats</term><term>Sujet âgé</term><term>Valeur prédictive des tests</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Proteome</term><term>Serum Amyloid A Protein</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Protéine amyloïde A sérique</term><term>Protéome</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Cross Infection</term><term>Intracranial Aneurysm</term><term>Subarachnoid Hemorrhage</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Cross Infection</term><term>Intracranial Aneurysm</term><term>Subarachnoid Hemorrhage</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anévrysme intracrânien</term><term>Hémorragie meningée</term><term>Infection croisée</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Hospitalization</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Proteomics</term><term>Reproducibility of Results</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anévrysme intracrânien</term><term>Femelle</term><term>Hospitalisation</term><term>Humains</term><term>Hémorragie meningée</term><term>Infection croisée</term><term>Mâle</term><term>Protéomique</term><term>Reproductibilité des résultats</term><term>Sujet âgé</term><term>Valeur prédictive des tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aneurysmal subarachnoid hemorrhage (aSAH) is associated with high rates of mortality and morbidity. Nosocomial infections, such as pneumonia or urinary tract infections, are among the main causes of worsening outcomes and death. The aim of this study was to discover a biomarker to predict infection in aSAH patients. For this purpose, the plasma of infected and noninfected patients was compared using quantitative mass spectrometry. The most interesting differentially expressed proteins were selected for validation by immunoassays on plasma samples taken from patients (n = 81) over 10 days of hospitalization. Predictive performances were established using Mann-Whitney U tests and receiver operating characteristic curves. Quantitative proteomics identified 17 significantly regulated proteins. Of these, levels of serum amyloid A (SAA) were significantly higher in infected patients (p < 0.007). ELISA confirmed that the concentrations were significantly higher (p < 0.002) already at hospital admission in patients who subsequently developed an infection during their hospitalization, (AUC of 76%) for a cutoff value of 90.9 μg/mL. Our data suggested that measuring SAA could be an efficient means of detecting patients susceptible of developing an infection during hospitalization after an aSAH. Its predictive capacity could lead to earlier antibiotherapy, improved patient management, and potentially better long-term outcomes.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Suisse</li></country><region><li>Bade-Wurtemberg</li><li>District de Karlsruhe</li><li>Île-de-France</li></region><settlement><li>Heidelberg</li><li>Paris</li></settlement></list><tree><country name="Suisse"><noRegion><name sortKey="Azurmendi, Leire" sort="Azurmendi, Leire" uniqKey="Azurmendi L" first="Leire" last="Azurmendi">Leire Azurmendi</name></noRegion><name sortKey="Sanchez, Jean Charles" sort="Sanchez, Jean Charles" uniqKey="Sanchez J" first="Jean-Charles" last="Sanchez">Jean-Charles Sanchez</name><name sortKey="Turck, Natacha" sort="Turck, Natacha" uniqKey="Turck N" first="Natacha" last="Turck">Natacha Turck</name></country><country name="France"><region name="Île-de-France"><name sortKey="Degos, Vincent" sort="Degos, Vincent" uniqKey="Degos V" first="Vincent" last="Degos">Vincent Degos</name></region><name sortKey="Kapandji, Natacha" sort="Kapandji, Natacha" uniqKey="Kapandji N" first="Natacha" last="Kapandji">Natacha Kapandji</name><name sortKey="Puybasset, Louis" sort="Puybasset, Louis" uniqKey="Puybasset L" first="Louis" last="Puybasset">Louis Puybasset</name><name sortKey="Sanchez, Paola" sort="Sanchez, Paola" uniqKey="Sanchez P" first="Paola" last="Sanchez">Paola Sanchez</name></country><country name="Australie"><noRegion><name sortKey="Tiberti, Natalia" sort="Tiberti, Natalia" uniqKey="Tiberti N" first="Natalia" last="Tiberti">Natalia Tiberti</name></noRegion></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Sarrafzadeh, Asita" sort="Sarrafzadeh, Asita" uniqKey="Sarrafzadeh A" first="Asita" last="Sarrafzadeh">Asita Sarrafzadeh</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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