Medical physics aspects of the synchrotron radiation therapies: Microbeam radiation therapy (MRT) and synchrotron stereotactic radiotherapy (SSRT).
Identifieur interne : 002B51 ( Main/Exploration ); précédent : 002B50; suivant : 002B52Medical physics aspects of the synchrotron radiation therapies: Microbeam radiation therapy (MRT) and synchrotron stereotactic radiotherapy (SSRT).
Auteurs : Elke Br Uer-Krisch [France] ; Jean-Francois Adam [France] ; Enver Alagoz [Norvège] ; Stefan Bartzsch [Royaume-Uni] ; Jeff Crosbie [Australie] ; Carlos Dewagter [Belgique] ; Andrew Dipuglia [Australie] ; Mattia Donzelli [France] ; Simon Doran [Royaume-Uni] ; Pauline Fournier [Australie] ; John Kalef-Ezra [Grèce] ; Angela Kock [Norvège] ; Michael Lerch [Australie] ; Ciara Mcerlean [Royaume-Uni] ; Uwe Oelfke [Royaume-Uni] ; Pawel Olko [Pologne] ; Marco Petasecca [Australie] ; Marco Povoli [Norvège] ; Anatoly Rosenfeld [Australie] ; Erik A. Siegbahn [Suède] ; Dan Sporea [Roumanie] ; Bjarne Stugu [Norvège]Source :
- Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) [ 1724-191X ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Conception d'appareillage, Fractionnement de la dose d'irradiation, Humains, Médecine factuelle, Planification de radiothérapie assistée par ordinateur (), Planification de radiothérapie assistée par ordinateur (instrumentation), Radiochirurgie (), Radiochirurgie (instrumentation), Radiométrie (), Radiométrie (instrumentation), Radiothérapie de haute énergie (), Radiothérapie de haute énergie (instrumentation), Résultat thérapeutique, Suidae, Synchrotrons (instrumentation), Tumeurs (), Tumeurs du cerveau (radiothérapie), Évaluation de la technologie biomédicale.
- MESH :
- radiothérapie : Tumeurs du cerveau.
- instrumentation : Animaux, Conception d'appareillage, Fractionnement de la dose d'irradiation, Humains, Médecine factuelle, Planification de radiothérapie assistée par ordinateur, Radiochirurgie, Radiométrie, Radiothérapie de haute énergie, Résultat thérapeutique, Suidae, Synchrotrons, Tumeurs, Évaluation de la technologie biomédicale.
English descriptors
- KwdEn :
- Animals, Brain Neoplasms (radiotherapy), Dose Fractionation, Equipment Design, Evidence-Based Medicine, Humans, Neoplasms (surgery), Radiometry (instrumentation), Radiometry (methods), Radiosurgery (instrumentation), Radiosurgery (methods), Radiotherapy Planning, Computer-Assisted (instrumentation), Radiotherapy Planning, Computer-Assisted (methods), Radiotherapy, High-Energy (instrumentation), Radiotherapy, High-Energy (methods), Swine, Synchrotrons (instrumentation), Technology Assessment, Biomedical, Treatment Outcome.
- MESH :
- instrumentation : Radiometry, Radiosurgery, Radiotherapy Planning, Computer-Assisted, Radiotherapy, High-Energy, Synchrotrons.
- methods : Radiometry, Radiosurgery, Radiotherapy Planning, Computer-Assisted, Radiotherapy, High-Energy.
- radiotherapy : Brain Neoplasms.
- surgery : Neoplasms.
- Animals, Dose Fractionation, Equipment Design, Evidence-Based Medicine, Humans, Swine, Technology Assessment, Biomedical, Treatment Outcome.
Abstract
Stereotactic Synchrotron Radiotherapy (SSRT) and Microbeam Radiation Therapy (MRT) are both novel approaches to treat brain tumor and potentially other tumors using synchrotron radiation. Although the techniques differ by their principles, SSRT and MRT share certain common aspects with the possibility of combining their advantages in the future. For MRT, the technique uses highly collimated, quasi-parallel arrays of X-ray microbeams between 50 and 600 keV. Important features of highly brilliant Synchrotron sources are a very small beam divergence and an extremely high dose rate. The minimal beam divergence allows the insertion of so called Multi Slit Collimators (MSC) to produce spatially fractionated beams of typically ∼25-75 micron-wide microplanar beams separated by wider (100-400 microns center-to-center(ctc)) spaces with a very sharp penumbra. Peak entrance doses of several hundreds of Gy are extremely well tolerated by normal tissues and at the same time provide a higher therapeutic index for various tumor models in rodents. The hypothesis of a selective radio-vulnerability of the tumor vasculature versus normal blood vessels by MRT was recently more solidified. SSRT (Synchrotron Stereotactic Radiotherapy) is based on a local drug uptake of high-Z elements in tumors followed by stereotactic irradiation with 80 keV photons to enhance the dose deposition only within the tumor. With SSRT already in its clinical trial stage at the ESRF, most medical physics problems are already solved and the implemented solutions are briefly described, while the medical physics aspects in MRT will be discussed in more detail in this paper.
DOI: 10.1016/j.ejmp.2015.04.016
PubMed: 26043881
Affiliations:
- Australie, Belgique, France, Grèce, Norvège, Pologne, Roumanie, Royaume-Uni, Suède
- Auvergne-Rhône-Alpes, Province de Flandre-Orientale, Rhône-Alpes, Svealand, Østlandet
- Gand, Grenoble, Oslo, Stockholm
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Le document en format XML
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<author><name sortKey="Fournier, Pauline" sort="Fournier, Pauline" uniqKey="Fournier P" first="Pauline" last="Fournier">Pauline Fournier</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>ESRF-The European Synchrotron, 71, Avenue des Martyrs, Grenoble, France; Centre for Medical Radiation Physics, University of Wollongong, Northfields Ave, NSW</wicri:regionArea>
<wicri:noRegion>NSW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kalef Ezra, John" sort="Kalef Ezra, John" uniqKey="Kalef Ezra J" first="John" last="Kalef-Ezra">John Kalef-Ezra</name>
<affiliation wicri:level="1"><nlm:affiliation>Medical Physics Laboratory, University of Ioannina, 451.10, Ioannina, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Medical Physics Laboratory, University of Ioannina, 451.10, Ioannina</wicri:regionArea>
<wicri:noRegion>Ioannina</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kock, Angela" sort="Kock, Angela" uniqKey="Kock A" first="Angela" last="Kock">Angela Kock</name>
<affiliation wicri:level="3"><nlm:affiliation>Sintef Minalab, Gaustadalléen 23C, 0373, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Sintef Minalab, Gaustadalléen 23C, 0373, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lerch, Michael" sort="Lerch, Michael" uniqKey="Lerch M" first="Michael" last="Lerch">Michael Lerch</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics, University of Wollongong, Northfields Ave, NSW, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Medical Radiation Physics, University of Wollongong, Northfields Ave, NSW</wicri:regionArea>
<wicri:noRegion>NSW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcerlean, Ciara" sort="Mcerlean, Ciara" uniqKey="Mcerlean C" first="Ciara" last="Mcerlean">Ciara Mcerlean</name>
<affiliation wicri:level="1"><nlm:affiliation>CRUK Cancer Imaging Centre, Institute of Cancer Research, 15 Cotswold Rd, Sutton Surrey, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>CRUK Cancer Imaging Centre, Institute of Cancer Research, 15 Cotswold Rd, Sutton Surrey</wicri:regionArea>
<wicri:noRegion>Sutton Surrey</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oelfke, Uwe" sort="Oelfke, Uwe" uniqKey="Oelfke U" first="Uwe" last="Oelfke">Uwe Oelfke</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute of Cancer Research, 15 Cotswold Rd, Sutton SM2 5NG, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Institute of Cancer Research, 15 Cotswold Rd, Sutton SM2 5NG</wicri:regionArea>
<wicri:noRegion>Sutton SM2 5NG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Olko, Pawel" sort="Olko, Pawel" uniqKey="Olko P" first="Pawel" last="Olko">Pawel Olko</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Nuclear Physics PAN, Radzikowskiego 152, 31-342, Krawkow, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Institute of Nuclear Physics PAN, Radzikowskiego 152, 31-342, Krawkow</wicri:regionArea>
<wicri:noRegion>Krawkow</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Petasecca, Marco" sort="Petasecca, Marco" uniqKey="Petasecca M" first="Marco" last="Petasecca">Marco Petasecca</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics, University of Wollongong, Northfields Ave, NSW, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Medical Radiation Physics, University of Wollongong, Northfields Ave, NSW</wicri:regionArea>
<wicri:noRegion>NSW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Povoli, Marco" sort="Povoli, Marco" uniqKey="Povoli M" first="Marco" last="Povoli">Marco Povoli</name>
<affiliation wicri:level="3"><nlm:affiliation>University of Oslo, Department of Physics, 0316, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>University of Oslo, Department of Physics, 0316, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rosenfeld, Anatoly" sort="Rosenfeld, Anatoly" uniqKey="Rosenfeld A" first="Anatoly" last="Rosenfeld">Anatoly Rosenfeld</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics, University of Wollongong, Northfields Ave, NSW, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Medical Radiation Physics, University of Wollongong, Northfields Ave, NSW</wicri:regionArea>
<wicri:noRegion>NSW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Siegbahn, Erik A" sort="Siegbahn, Erik A" uniqKey="Siegbahn E" first="Erik A" last="Siegbahn">Erik A. Siegbahn</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Oncolgy-Pathology, Karolinska Institutet, S-177176, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Oncolgy-Pathology, Karolinska Institutet, S-177176, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sporea, Dan" sort="Sporea, Dan" uniqKey="Sporea D" first="Dan" last="Sporea">Dan Sporea</name>
<affiliation wicri:level="1"><nlm:affiliation>National Institute for Laser, Plasma and Radiation Physics, Magurele, RO-077125, Romania.</nlm:affiliation>
<country xml:lang="fr">Roumanie</country>
<wicri:regionArea>National Institute for Laser, Plasma and Radiation Physics, Magurele, RO-077125</wicri:regionArea>
<wicri:noRegion>RO-077125</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stugu, Bjarne" sort="Stugu, Bjarne" uniqKey="Stugu B" first="Bjarne" last="Stugu">Bjarne Stugu</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Bergen, Department of Physics and Technology, PB 7803, 5020, Bergen, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>University of Bergen, Department of Physics and Technology, PB 7803, 5020, Bergen</wicri:regionArea>
<wicri:noRegion>Bergen</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)</title>
<idno type="eISSN">1724-191X</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Brain Neoplasms (radiotherapy)</term>
<term>Dose Fractionation</term>
<term>Equipment Design</term>
<term>Evidence-Based Medicine</term>
<term>Humans</term>
<term>Neoplasms (surgery)</term>
<term>Radiometry (instrumentation)</term>
<term>Radiometry (methods)</term>
<term>Radiosurgery (instrumentation)</term>
<term>Radiosurgery (methods)</term>
<term>Radiotherapy Planning, Computer-Assisted (instrumentation)</term>
<term>Radiotherapy Planning, Computer-Assisted (methods)</term>
<term>Radiotherapy, High-Energy (instrumentation)</term>
<term>Radiotherapy, High-Energy (methods)</term>
<term>Swine</term>
<term>Synchrotrons (instrumentation)</term>
<term>Technology Assessment, Biomedical</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Conception d'appareillage</term>
<term>Fractionnement de la dose d'irradiation</term>
<term>Humains</term>
<term>Médecine factuelle</term>
<term>Planification de radiothérapie assistée par ordinateur ()</term>
<term>Planification de radiothérapie assistée par ordinateur (instrumentation)</term>
<term>Radiochirurgie ()</term>
<term>Radiochirurgie (instrumentation)</term>
<term>Radiométrie ()</term>
<term>Radiométrie (instrumentation)</term>
<term>Radiothérapie de haute énergie ()</term>
<term>Radiothérapie de haute énergie (instrumentation)</term>
<term>Résultat thérapeutique</term>
<term>Suidae</term>
<term>Synchrotrons (instrumentation)</term>
<term>Tumeurs ()</term>
<term>Tumeurs du cerveau (radiothérapie)</term>
<term>Évaluation de la technologie biomédicale</term>
</keywords>
<keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Radiometry</term>
<term>Radiosurgery</term>
<term>Radiotherapy Planning, Computer-Assisted</term>
<term>Radiotherapy, High-Energy</term>
<term>Synchrotrons</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Radiometry</term>
<term>Radiosurgery</term>
<term>Radiotherapy Planning, Computer-Assisted</term>
<term>Radiotherapy, High-Energy</term>
</keywords>
<keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Brain Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Tumeurs du cerveau</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Neoplasms</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Dose Fractionation</term>
<term>Equipment Design</term>
<term>Evidence-Based Medicine</term>
<term>Humans</term>
<term>Swine</term>
<term>Technology Assessment, Biomedical</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" qualifier="instrumentation" xml:lang="fr"><term>Animaux</term>
<term>Conception d'appareillage</term>
<term>Fractionnement de la dose d'irradiation</term>
<term>Humains</term>
<term>Médecine factuelle</term>
<term>Planification de radiothérapie assistée par ordinateur</term>
<term>Radiochirurgie</term>
<term>Radiométrie</term>
<term>Radiothérapie de haute énergie</term>
<term>Résultat thérapeutique</term>
<term>Suidae</term>
<term>Synchrotrons</term>
<term>Tumeurs</term>
<term>Évaluation de la technologie biomédicale</term>
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<front><div type="abstract" xml:lang="en">Stereotactic Synchrotron Radiotherapy (SSRT) and Microbeam Radiation Therapy (MRT) are both novel approaches to treat brain tumor and potentially other tumors using synchrotron radiation. Although the techniques differ by their principles, SSRT and MRT share certain common aspects with the possibility of combining their advantages in the future. For MRT, the technique uses highly collimated, quasi-parallel arrays of X-ray microbeams between 50 and 600 keV. Important features of highly brilliant Synchrotron sources are a very small beam divergence and an extremely high dose rate. The minimal beam divergence allows the insertion of so called Multi Slit Collimators (MSC) to produce spatially fractionated beams of typically ∼25-75 micron-wide microplanar beams separated by wider (100-400 microns center-to-center(ctc)) spaces with a very sharp penumbra. Peak entrance doses of several hundreds of Gy are extremely well tolerated by normal tissues and at the same time provide a higher therapeutic index for various tumor models in rodents. The hypothesis of a selective radio-vulnerability of the tumor vasculature versus normal blood vessels by MRT was recently more solidified. SSRT (Synchrotron Stereotactic Radiotherapy) is based on a local drug uptake of high-Z elements in tumors followed by stereotactic irradiation with 80 keV photons to enhance the dose deposition only within the tumor. With SSRT already in its clinical trial stage at the ESRF, most medical physics problems are already solved and the implemented solutions are briefly described, while the medical physics aspects in MRT will be discussed in more detail in this paper.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Belgique</li>
<li>France</li>
<li>Grèce</li>
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<tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Br Uer Krisch, Elke" sort="Br Uer Krisch, Elke" uniqKey="Br Uer Krisch E" first="Elke" last="Br Uer-Krisch">Elke Br Uer-Krisch</name>
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<name sortKey="Adam, Jean Francois" sort="Adam, Jean Francois" uniqKey="Adam J" first="Jean-Francois" last="Adam">Jean-Francois Adam</name>
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<country name="Norvège"><noRegion><name sortKey="Alagoz, Enver" sort="Alagoz, Enver" uniqKey="Alagoz E" first="Enver" last="Alagoz">Enver Alagoz</name>
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<name sortKey="Povoli, Marco" sort="Povoli, Marco" uniqKey="Povoli M" first="Marco" last="Povoli">Marco Povoli</name>
<name sortKey="Stugu, Bjarne" sort="Stugu, Bjarne" uniqKey="Stugu B" first="Bjarne" last="Stugu">Bjarne Stugu</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Bartzsch, Stefan" sort="Bartzsch, Stefan" uniqKey="Bartzsch S" first="Stefan" last="Bartzsch">Stefan Bartzsch</name>
</noRegion>
<name sortKey="Doran, Simon" sort="Doran, Simon" uniqKey="Doran S" first="Simon" last="Doran">Simon Doran</name>
<name sortKey="Mcerlean, Ciara" sort="Mcerlean, Ciara" uniqKey="Mcerlean C" first="Ciara" last="Mcerlean">Ciara Mcerlean</name>
<name sortKey="Oelfke, Uwe" sort="Oelfke, Uwe" uniqKey="Oelfke U" first="Uwe" last="Oelfke">Uwe Oelfke</name>
</country>
<country name="Australie"><noRegion><name sortKey="Crosbie, Jeff" sort="Crosbie, Jeff" uniqKey="Crosbie J" first="Jeff" last="Crosbie">Jeff Crosbie</name>
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<name sortKey="Dipuglia, Andrew" sort="Dipuglia, Andrew" uniqKey="Dipuglia A" first="Andrew" last="Dipuglia">Andrew Dipuglia</name>
<name sortKey="Fournier, Pauline" sort="Fournier, Pauline" uniqKey="Fournier P" first="Pauline" last="Fournier">Pauline Fournier</name>
<name sortKey="Lerch, Michael" sort="Lerch, Michael" uniqKey="Lerch M" first="Michael" last="Lerch">Michael Lerch</name>
<name sortKey="Petasecca, Marco" sort="Petasecca, Marco" uniqKey="Petasecca M" first="Marco" last="Petasecca">Marco Petasecca</name>
<name sortKey="Rosenfeld, Anatoly" sort="Rosenfeld, Anatoly" uniqKey="Rosenfeld A" first="Anatoly" last="Rosenfeld">Anatoly Rosenfeld</name>
</country>
<country name="Belgique"><region name="Province de Flandre-Orientale"><name sortKey="Dewagter, Carlos" sort="Dewagter, Carlos" uniqKey="Dewagter C" first="Carlos" last="Dewagter">Carlos Dewagter</name>
</region>
</country>
<country name="Grèce"><noRegion><name sortKey="Kalef Ezra, John" sort="Kalef Ezra, John" uniqKey="Kalef Ezra J" first="John" last="Kalef-Ezra">John Kalef-Ezra</name>
</noRegion>
</country>
<country name="Pologne"><noRegion><name sortKey="Olko, Pawel" sort="Olko, Pawel" uniqKey="Olko P" first="Pawel" last="Olko">Pawel Olko</name>
</noRegion>
</country>
<country name="Suède"><region name="Svealand"><name sortKey="Siegbahn, Erik A" sort="Siegbahn, Erik A" uniqKey="Siegbahn E" first="Erik A" last="Siegbahn">Erik A. Siegbahn</name>
</region>
</country>
<country name="Roumanie"><noRegion><name sortKey="Sporea, Dan" sort="Sporea, Dan" uniqKey="Sporea D" first="Dan" last="Sporea">Dan Sporea</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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