Microtubule-associated protein 6 mediates neuronal connectivity through Semaphorin 3E-dependent signalling for axonal growth
Identifieur interne : 002B33 ( Main/Exploration ); précédent : 002B32; suivant : 002B34Microtubule-associated protein 6 mediates neuronal connectivity through Semaphorin 3E-dependent signalling for axonal growth
Auteurs : Jean-Christophe Deloulme [France] ; Sylvie Gory-Fauré [France] ; Franck Mauconduit [France] ; Sophie Chauvet [France] ; Julie Jonckheere [France] ; Benoit Boulan [France] ; Erik Mire [France] ; Jing Xue [Australie] ; Marion Jany [France] ; Caroline Maucler [France] ; Agathe A. Deparis [France] ; Olivier Montigon [France] ; Alexia Daoust [France] ; Emmanuel L. Barbier [France] ; Christophe Bosc [France] ; Nicole Deglon [Suisse] ; Jacques Brocard [France] ; Eric Denarier [France] ; Isabelle Le Brun [France] ; Karin Pernet-Gallay [France] ; Isabelle Vilgrain [France] ; Phillip J. Robinson [Australie] ; Hana Lahrech [France] ; Fanny Mann [France] ; Annie Andrieux [France]Source :
- Nature Communications [ 2041-1723 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Axones (métabolisme), Cellules HEK293, Domaine d'homologie SRC, Encéphale (anatomopathologie), Encéphale (métabolisme), Fornix (encéphale) (anatomopathologie), Fornix (encéphale) (embryologie), Fornix (encéphale) (métabolisme), Glycoprotéines (métabolisme), Humains, Imagerie par résonance magnétique, Imagerie par tenseur de diffusion, Microscopie électronique, Neurites (métabolisme), Neurones (métabolisme), Protéines associées aux microtubules (génétique), Protéines membranaires (métabolisme), Souris, Souris de lignée C57BL, Souris knockout, Taille d'organe, Techniques de traçage neuroanatomique, Voies nerveuses (embryologie), Voies nerveuses (métabolisme).
- MESH :
- anatomopathologie : Encéphale, Fornix (encéphale).
- embryologie : Fornix (encéphale), Voies nerveuses.
- génétique : Protéines associées aux microtubules.
- métabolisme : Axones, Encéphale, Fornix (encéphale), Glycoprotéines, Neurites, Neurones, Protéines membranaires, Voies nerveuses.
- Animaux, Cellules HEK293, Domaine d'homologie SRC, Humains, Imagerie par résonance magnétique, Imagerie par tenseur de diffusion, Microscopie électronique, Souris, Souris de lignée C57BL, Souris knockout, Taille d'organe, Techniques de traçage neuroanatomique.
English descriptors
- KwdEn :
- Animals, Axons (metabolism), Brain (metabolism), Brain (pathology), Diffusion Tensor Imaging, Fornix, Brain (embryology), Fornix, Brain (metabolism), Fornix, Brain (pathology), Glycoproteins (metabolism), HEK293 Cells, Humans, Magnetic Resonance Imaging, Membrane Proteins (metabolism), Mice, Mice, Inbred C57BL, Mice, Knockout, Microscopy, Electron, Microtubule-Associated Proteins (genetics), Neural Pathways (embryology), Neural Pathways (metabolism), Neurites (metabolism), Neuroanatomical Tract-Tracing Techniques, Neurons (metabolism), Organ Size, src Homology Domains.
- MESH :
- chemical , genetics : Microtubule-Associated Proteins.
- chemical , metabolism : Glycoproteins, Membrane Proteins.
- embryology : Fornix, Brain, Neural Pathways.
- metabolism : Axons, Brain, Fornix, Brain, Neural Pathways, Neurites, Neurons.
- pathology : Brain, Fornix, Brain.
- Animals, Diffusion Tensor Imaging, HEK293 Cells, Humans, Magnetic Resonance Imaging, Mice, Mice, Inbred C57BL, Mice, Knockout, Microscopy, Electron, Neuroanatomical Tract-Tracing Techniques, Organ Size, src Homology Domains.
Abstract
Structural microtubule associated proteins (MAPs) stabilize microtubules, a property that was thought to be essential for development, maintenance and function of neuronal circuits. However, deletion of the structural MAPs in mice does not lead to major neurodevelopment defects. Here we demonstrate a role for MAP6 in brain wiring that is independent of microtubule binding. We find that MAP6 deletion disrupts brain connectivity and is associated with a lack of post-commissural fornix fibres. MAP6 contributes to fornix development by regulating axonal elongation induced by Semaphorin 3E. We show that MAP6 acts downstream of receptor activation through a mechanism that requires a proline-rich domain distinct from its microtubule-stabilizing domains. We also show that MAP6 directly binds to SH3 domain proteins known to be involved in neurite extension and semaphorin function. We conclude that MAP6 is critical to interface guidance molecules with intracellular signalling effectors during the development of cerebral axon tracts.
Url:
DOI: 10.1038/ncomms8246
PubMed: 26037503
PubMed Central: 4468860
Affiliations:
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Le document en format XML
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Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bosc, Christophe" sort="Bosc, Christophe" uniqKey="Bosc C" first="Christophe" last="Bosc">Christophe Bosc</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U836, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deglon, Nicole" sort="Deglon, Nicole" uniqKey="Deglon N" first="Nicole" last="Deglon">Nicole Deglon</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Lausanne University Hospital (CHUV), Department of Clinical Neurosciences (DNC), Laboratory of Cellular and Molecular Neurotherapies (LCMN)</institution>, 1011 Lausanne,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Lausanne University Hospital (CHUV), Neuroscience Research Center (CRN)</institution>, 1011 Lausanne,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brocard, Jacques" sort="Brocard, Jacques" uniqKey="Brocard J" first="Jacques" last="Brocard">Jacques Brocard</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U836, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Denarier, Eric" sort="Denarier, Eric" uniqKey="Denarier E" first="Eric" last="Denarier">Eric Denarier</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U836, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a10"><institution>CEA, iRTSV</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Le Brun, Isabelle" sort="Le Brun, Isabelle" uniqKey="Le Brun I" first="Isabelle" last="Le Brun">Isabelle Le Brun</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a9"><institution>INSERM</institution>, U1036, 38054 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a10"><institution>CEA, iRTSV</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pernet Gallay, Karin" sort="Pernet Gallay, Karin" uniqKey="Pernet Gallay K" first="Karin" last="Pernet-Gallay">Karin Pernet-Gallay</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U836, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vilgrain, Isabelle" sort="Vilgrain, Isabelle" uniqKey="Vilgrain I" first="Isabelle" last="Vilgrain">Isabelle Vilgrain</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a9"><institution>INSERM</institution>, U1036, 38054 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a9"><institution>INSERM</institution>, U1036, 38054 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Robinson, Phillip J" sort="Robinson, Phillip J" uniqKey="Robinson P" first="Phillip J." last="Robinson">Phillip J. Robinson</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Cell Signalling Unit, Children's Medical Research Institute, University of Sydney, Wentworthville</institution>, New South Wales 2145,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lahrech, Hana" sort="Lahrech, Hana" uniqKey="Lahrech H" first="Hana" last="Lahrech">Hana Lahrech</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U836, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a11"><institution>CEA, LETI, CLINATEC, MINATEC Campus</institution>, F-38054 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mann, Fanny" sort="Mann, Fanny" uniqKey="Mann F" first="Fanny" last="Mann">Fanny Mann</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Aix-Marseille Université, CNRS</institution>, IBDM UMR 7288, 13288 Marseille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Andrieux, Annie" sort="Andrieux, Annie" uniqKey="Andrieux A" first="Annie" last="Andrieux">Annie Andrieux</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U836, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a10"><institution>CEA, iRTSV</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26037503</idno><idno type="pmc">4468860</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468860</idno><idno type="RBID">PMC:4468860</idno><idno type="doi">10.1038/ncomms8246</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000741</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000741</idno><idno type="wicri:Area/Pmc/Curation">000740</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000740</idno><idno type="wicri:Area/Pmc/Checkpoint">000E60</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000E60</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002D13</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002D13</idno><idno type="wicri:Area/PubMed/Curation">002C38</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002C38</idno><idno type="wicri:Area/PubMed/Checkpoint">002C38</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002C38</idno><idno type="wicri:Area/Ncbi/Merge">002660</idno><idno type="wicri:Area/Ncbi/Curation">002660</idno><idno type="wicri:Area/Ncbi/Checkpoint">002660</idno><idno type="wicri:Area/Main/Merge">002B33</idno><idno type="wicri:Area/Main/Curation">002B33</idno><idno type="wicri:Area/Main/Exploration">002B33</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Microtubule-associated protein 6 mediates neuronal connectivity through Semaphorin 3E-dependent signalling for axonal growth</title><author><name sortKey="Deloulme, Jean Christophe" sort="Deloulme, Jean Christophe" uniqKey="Deloulme J" first="Jean-Christophe" last="Deloulme">Jean-Christophe Deloulme</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U836, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gory Faure, Sylvie" sort="Gory Faure, Sylvie" uniqKey="Gory Faure S" first="Sylvie" last="Gory-Fauré">Sylvie Gory-Fauré</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U836, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mauconduit, Franck" sort="Mauconduit, Franck" uniqKey="Mauconduit F" first="Franck" last="Mauconduit">Franck Mauconduit</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U836, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chauvet, Sophie" sort="Chauvet, Sophie" uniqKey="Chauvet S" first="Sophie" last="Chauvet">Sophie Chauvet</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Aix-Marseille Université, CNRS</institution>, IBDM UMR 7288, 13288 Marseille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jonckheere, Julie" sort="Jonckheere, Julie" uniqKey="Jonckheere J" first="Julie" last="Jonckheere">Julie Jonckheere</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U836, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boulan, Benoit" sort="Boulan, Benoit" uniqKey="Boulan B" first="Benoit" last="Boulan">Benoit Boulan</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U836, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mire, Erik" sort="Mire, Erik" uniqKey="Mire E" first="Erik" last="Mire">Erik Mire</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Aix-Marseille Université, CNRS</institution>, IBDM UMR 7288, 13288 Marseille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xue, Jing" sort="Xue, Jing" uniqKey="Xue J" first="Jing" last="Xue">Jing Xue</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Cell Signalling Unit, Children's Medical Research Institute, University of Sydney, Wentworthville</institution>, New South Wales 2145,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jany, Marion" sort="Jany, Marion" uniqKey="Jany M" first="Marion" last="Jany">Marion Jany</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U836, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Maucler, Caroline" sort="Maucler, Caroline" uniqKey="Maucler C" first="Caroline" last="Maucler">Caroline Maucler</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U836, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deparis, Agathe A" sort="Deparis, Agathe A" uniqKey="Deparis A" first="Agathe A." last="Deparis">Agathe A. Deparis</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U836, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Montigon, Olivier" sort="Montigon, Olivier" uniqKey="Montigon O" first="Olivier" last="Montigon">Olivier Montigon</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U836, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Centre Hospitalier Universitaire de Grenoble, IRMaGe</institution>, 38043 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a6"><institution>CNRS</institution>, UMS 3552, 38042 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Daoust, Alexia" sort="Daoust, Alexia" uniqKey="Daoust A" first="Alexia" last="Daoust">Alexia Daoust</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U836, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barbier, Emmanuel L" sort="Barbier, Emmanuel L" uniqKey="Barbier E" first="Emmanuel L." last="Barbier">Emmanuel L. Barbier</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U836, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bosc, Christophe" sort="Bosc, Christophe" uniqKey="Bosc C" first="Christophe" last="Bosc">Christophe Bosc</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U836, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deglon, Nicole" sort="Deglon, Nicole" uniqKey="Deglon N" first="Nicole" last="Deglon">Nicole Deglon</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Lausanne University Hospital (CHUV), Department of Clinical Neurosciences (DNC), Laboratory of Cellular and Molecular Neurotherapies (LCMN)</institution>, 1011 Lausanne,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Lausanne University Hospital (CHUV), Neuroscience Research Center (CRN)</institution>, 1011 Lausanne,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brocard, Jacques" sort="Brocard, Jacques" uniqKey="Brocard J" first="Jacques" last="Brocard">Jacques Brocard</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U836, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Denarier, Eric" sort="Denarier, Eric" uniqKey="Denarier E" first="Eric" last="Denarier">Eric Denarier</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U836, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a10"><institution>CEA, iRTSV</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Le Brun, Isabelle" sort="Le Brun, Isabelle" uniqKey="Le Brun I" first="Isabelle" last="Le Brun">Isabelle Le Brun</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a9"><institution>INSERM</institution>, U1036, 38054 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a10"><institution>CEA, iRTSV</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pernet Gallay, Karin" sort="Pernet Gallay, Karin" uniqKey="Pernet Gallay K" first="Karin" last="Pernet-Gallay">Karin Pernet-Gallay</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U836, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vilgrain, Isabelle" sort="Vilgrain, Isabelle" uniqKey="Vilgrain I" first="Isabelle" last="Vilgrain">Isabelle Vilgrain</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a9"><institution>INSERM</institution>, U1036, 38054 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a9"><institution>INSERM</institution>, U1036, 38054 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Robinson, Phillip J" sort="Robinson, Phillip J" uniqKey="Robinson P" first="Phillip J." last="Robinson">Phillip J. Robinson</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Cell Signalling Unit, Children's Medical Research Institute, University of Sydney, Wentworthville</institution>, New South Wales 2145,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lahrech, Hana" sort="Lahrech, Hana" uniqKey="Lahrech H" first="Hana" last="Lahrech">Hana Lahrech</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U836, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a11"><institution>CEA, LETI, CLINATEC, MINATEC Campus</institution>, F-38054 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mann, Fanny" sort="Mann, Fanny" uniqKey="Mann F" first="Fanny" last="Mann">Fanny Mann</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Aix-Marseille Université, CNRS</institution>, IBDM UMR 7288, 13288 Marseille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Andrieux, Annie" sort="Andrieux, Annie" uniqKey="Andrieux A" first="Annie" last="Andrieux">Annie Andrieux</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U836, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ. Grenoble Alpes, Grenoble Institut Neurosciences</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a10"><institution>CEA, iRTSV</institution>, F-38000 Grenoble,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Axons (metabolism)</term><term>Brain (metabolism)</term><term>Brain (pathology)</term><term>Diffusion Tensor Imaging</term><term>Fornix, Brain (embryology)</term><term>Fornix, Brain (metabolism)</term><term>Fornix, Brain (pathology)</term><term>Glycoproteins (metabolism)</term><term>HEK293 Cells</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Membrane Proteins (metabolism)</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Microscopy, Electron</term><term>Microtubule-Associated Proteins (genetics)</term><term>Neural Pathways (embryology)</term><term>Neural Pathways (metabolism)</term><term>Neurites (metabolism)</term><term>Neuroanatomical Tract-Tracing Techniques</term><term>Neurons (metabolism)</term><term>Organ Size</term><term>src Homology Domains</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Axones (métabolisme)</term><term>Cellules HEK293</term><term>Domaine d'homologie SRC</term><term>Encéphale (anatomopathologie)</term><term>Encéphale (métabolisme)</term><term>Fornix (encéphale) (anatomopathologie)</term><term>Fornix (encéphale) (embryologie)</term><term>Fornix (encéphale) (métabolisme)</term><term>Glycoprotéines (métabolisme)</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Imagerie par tenseur de diffusion</term><term>Microscopie électronique</term><term>Neurites (métabolisme)</term><term>Neurones (métabolisme)</term><term>Protéines associées aux microtubules (génétique)</term><term>Protéines membranaires (métabolisme)</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Souris knockout</term><term>Taille d'organe</term><term>Techniques de traçage neuroanatomique</term><term>Voies nerveuses (embryologie)</term><term>Voies nerveuses (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Microtubule-Associated Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glycoproteins</term><term>Membrane Proteins</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphale</term><term>Fornix (encéphale)</term></keywords><keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Fornix (encéphale)</term><term>Voies nerveuses</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Fornix, Brain</term><term>Neural Pathways</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines associées aux microtubules</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Axons</term><term>Brain</term><term>Fornix, Brain</term><term>Neural Pathways</term><term>Neurites</term><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Axones</term><term>Encéphale</term><term>Fornix (encéphale)</term><term>Glycoprotéines</term><term>Neurites</term><term>Neurones</term><term>Protéines membranaires</term><term>Voies nerveuses</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Fornix, Brain</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Diffusion Tensor Imaging</term><term>HEK293 Cells</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Microscopy, Electron</term><term>Neuroanatomical Tract-Tracing Techniques</term><term>Organ Size</term><term>src Homology Domains</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules HEK293</term><term>Domaine d'homologie SRC</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Imagerie par tenseur de diffusion</term><term>Microscopie électronique</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Souris knockout</term><term>Taille d'organe</term><term>Techniques de traçage neuroanatomique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Structural microtubule associated proteins (MAPs) stabilize microtubules, a property that was thought to be essential for development, maintenance and function of neuronal circuits. However, deletion of the structural MAPs in mice does not lead to major neurodevelopment defects. Here we demonstrate a role for MAP6 in brain wiring that is independent of microtubule binding. We find that MAP6 deletion disrupts brain connectivity and is associated with a lack of post-commissural fornix fibres. MAP6 contributes to fornix development by regulating axonal elongation induced by Semaphorin 3E. We show that MAP6 acts downstream of receptor activation through a mechanism that requires a proline-rich domain distinct from its microtubule-stabilizing domains. We also show that MAP6 directly binds to SH3 domain proteins known to be involved in neurite extension and semaphorin function. We conclude that MAP6 is critical to interface guidance molecules with intracellular signalling effectors during the development of cerebral axon tracts.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="De Peri, L" uniqKey="De Peri L">L. 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Galiano</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Suisse</li></country></list><tree><country name="France"><noRegion><name sortKey="Deloulme, Jean Christophe" sort="Deloulme, Jean Christophe" uniqKey="Deloulme J" first="Jean-Christophe" last="Deloulme">Jean-Christophe Deloulme</name></noRegion><name sortKey="Andrieux, Annie" sort="Andrieux, Annie" uniqKey="Andrieux A" first="Annie" last="Andrieux">Annie Andrieux</name><name sortKey="Andrieux, Annie" sort="Andrieux, Annie" uniqKey="Andrieux A" first="Annie" last="Andrieux">Annie Andrieux</name><name sortKey="Andrieux, Annie" sort="Andrieux, Annie" uniqKey="Andrieux A" first="Annie" last="Andrieux">Annie Andrieux</name><name sortKey="Barbier, Emmanuel L" sort="Barbier, Emmanuel L" uniqKey="Barbier E" first="Emmanuel L." last="Barbier">Emmanuel L. Barbier</name><name sortKey="Barbier, Emmanuel L" sort="Barbier, Emmanuel L" uniqKey="Barbier E" first="Emmanuel L." last="Barbier">Emmanuel L. Barbier</name><name sortKey="Bosc, Christophe" sort="Bosc, Christophe" uniqKey="Bosc C" first="Christophe" last="Bosc">Christophe Bosc</name><name sortKey="Bosc, Christophe" sort="Bosc, Christophe" uniqKey="Bosc C" first="Christophe" last="Bosc">Christophe Bosc</name><name sortKey="Boulan, Benoit" sort="Boulan, Benoit" uniqKey="Boulan B" first="Benoit" last="Boulan">Benoit Boulan</name><name sortKey="Boulan, Benoit" sort="Boulan, Benoit" uniqKey="Boulan B" first="Benoit" last="Boulan">Benoit Boulan</name><name sortKey="Brocard, Jacques" sort="Brocard, Jacques" uniqKey="Brocard J" first="Jacques" last="Brocard">Jacques Brocard</name><name sortKey="Brocard, Jacques" sort="Brocard, Jacques" uniqKey="Brocard J" first="Jacques" last="Brocard">Jacques Brocard</name><name sortKey="Chauvet, Sophie" sort="Chauvet, Sophie" uniqKey="Chauvet S" first="Sophie" last="Chauvet">Sophie Chauvet</name><name sortKey="Daoust, Alexia" sort="Daoust, Alexia" uniqKey="Daoust A" first="Alexia" last="Daoust">Alexia Daoust</name><name sortKey="Daoust, Alexia" sort="Daoust, Alexia" uniqKey="Daoust A" first="Alexia" last="Daoust">Alexia Daoust</name><name sortKey="Deloulme, Jean Christophe" sort="Deloulme, Jean Christophe" uniqKey="Deloulme J" first="Jean-Christophe" last="Deloulme">Jean-Christophe Deloulme</name><name sortKey="Denarier, Eric" sort="Denarier, Eric" uniqKey="Denarier E" first="Eric" last="Denarier">Eric Denarier</name><name sortKey="Denarier, Eric" sort="Denarier, Eric" uniqKey="Denarier E" first="Eric" last="Denarier">Eric Denarier</name><name sortKey="Denarier, Eric" sort="Denarier, Eric" uniqKey="Denarier E" first="Eric" last="Denarier">Eric Denarier</name><name sortKey="Deparis, Agathe A" sort="Deparis, Agathe A" uniqKey="Deparis A" first="Agathe A." last="Deparis">Agathe A. Deparis</name><name sortKey="Deparis, Agathe A" sort="Deparis, Agathe A" uniqKey="Deparis A" first="Agathe A." last="Deparis">Agathe A. Deparis</name><name sortKey="Gory Faure, Sylvie" sort="Gory Faure, Sylvie" uniqKey="Gory Faure S" first="Sylvie" last="Gory-Fauré">Sylvie Gory-Fauré</name><name sortKey="Gory Faure, Sylvie" sort="Gory Faure, Sylvie" uniqKey="Gory Faure S" first="Sylvie" last="Gory-Fauré">Sylvie Gory-Fauré</name><name sortKey="Jany, Marion" sort="Jany, Marion" uniqKey="Jany M" first="Marion" last="Jany">Marion Jany</name><name sortKey="Jany, Marion" sort="Jany, Marion" uniqKey="Jany M" first="Marion" last="Jany">Marion Jany</name><name sortKey="Jonckheere, Julie" sort="Jonckheere, Julie" uniqKey="Jonckheere J" first="Julie" last="Jonckheere">Julie Jonckheere</name><name sortKey="Jonckheere, Julie" sort="Jonckheere, Julie" uniqKey="Jonckheere J" first="Julie" last="Jonckheere">Julie Jonckheere</name><name sortKey="Lahrech, Hana" sort="Lahrech, Hana" uniqKey="Lahrech H" first="Hana" last="Lahrech">Hana Lahrech</name><name sortKey="Lahrech, Hana" sort="Lahrech, Hana" uniqKey="Lahrech H" first="Hana" last="Lahrech">Hana Lahrech</name><name sortKey="Lahrech, Hana" sort="Lahrech, Hana" uniqKey="Lahrech H" first="Hana" last="Lahrech">Hana Lahrech</name><name sortKey="Le Brun, Isabelle" sort="Le Brun, Isabelle" uniqKey="Le Brun I" first="Isabelle" last="Le Brun">Isabelle Le Brun</name><name sortKey="Le Brun, Isabelle" sort="Le Brun, Isabelle" uniqKey="Le Brun I" first="Isabelle" last="Le Brun">Isabelle Le Brun</name><name sortKey="Le Brun, Isabelle" sort="Le Brun, Isabelle" uniqKey="Le Brun I" first="Isabelle" last="Le Brun">Isabelle Le Brun</name><name sortKey="Mann, Fanny" sort="Mann, Fanny" uniqKey="Mann F" first="Fanny" last="Mann">Fanny Mann</name><name sortKey="Maucler, Caroline" sort="Maucler, Caroline" uniqKey="Maucler C" first="Caroline" last="Maucler">Caroline Maucler</name><name sortKey="Maucler, Caroline" sort="Maucler, Caroline" uniqKey="Maucler C" first="Caroline" last="Maucler">Caroline Maucler</name><name sortKey="Mauconduit, Franck" sort="Mauconduit, Franck" uniqKey="Mauconduit F" first="Franck" last="Mauconduit">Franck Mauconduit</name><name sortKey="Mauconduit, Franck" sort="Mauconduit, Franck" uniqKey="Mauconduit F" first="Franck" last="Mauconduit">Franck Mauconduit</name><name sortKey="Mire, Erik" sort="Mire, Erik" uniqKey="Mire E" first="Erik" last="Mire">Erik Mire</name><name sortKey="Montigon, Olivier" sort="Montigon, Olivier" uniqKey="Montigon O" first="Olivier" last="Montigon">Olivier Montigon</name><name sortKey="Montigon, Olivier" sort="Montigon, Olivier" uniqKey="Montigon O" first="Olivier" last="Montigon">Olivier Montigon</name><name sortKey="Montigon, Olivier" sort="Montigon, Olivier" uniqKey="Montigon O" first="Olivier" last="Montigon">Olivier Montigon</name><name sortKey="Montigon, Olivier" sort="Montigon, Olivier" uniqKey="Montigon O" first="Olivier" last="Montigon">Olivier Montigon</name><name sortKey="Pernet Gallay, Karin" sort="Pernet Gallay, Karin" uniqKey="Pernet Gallay K" first="Karin" last="Pernet-Gallay">Karin Pernet-Gallay</name><name sortKey="Pernet Gallay, Karin" sort="Pernet Gallay, Karin" uniqKey="Pernet Gallay K" first="Karin" last="Pernet-Gallay">Karin Pernet-Gallay</name><name sortKey="Vilgrain, Isabelle" sort="Vilgrain, Isabelle" uniqKey="Vilgrain I" first="Isabelle" last="Vilgrain">Isabelle Vilgrain</name><name sortKey="Vilgrain, Isabelle" sort="Vilgrain, Isabelle" uniqKey="Vilgrain I" first="Isabelle" last="Vilgrain">Isabelle Vilgrain</name><name sortKey="Vilgrain, Isabelle" sort="Vilgrain, Isabelle" uniqKey="Vilgrain I" first="Isabelle" last="Vilgrain">Isabelle Vilgrain</name></country><country name="Australie"><noRegion><name sortKey="Xue, Jing" sort="Xue, Jing" uniqKey="Xue J" first="Jing" last="Xue">Jing Xue</name></noRegion><name sortKey="Robinson, Phillip J" sort="Robinson, Phillip J" uniqKey="Robinson P" first="Phillip J." last="Robinson">Phillip J. Robinson</name></country><country name="Suisse"><noRegion><name sortKey="Deglon, Nicole" sort="Deglon, Nicole" uniqKey="Deglon N" first="Nicole" last="Deglon">Nicole Deglon</name></noRegion><name sortKey="Deglon, Nicole" sort="Deglon, Nicole" uniqKey="Deglon N" first="Nicole" last="Deglon">Nicole Deglon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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