AustralieFrV1, Main, Exploration, bibRecord, 002629

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

Identifieur interne : 002629 ( Main/Exploration ); précédent : 002628; suivant : 002630

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

Auteurs : Steven Goossens [Belgique, Australie] ; Enrico Radaelli [Italie, Belgique] ; Odile Blanchet [France] ; Kaat Durinck [Belgique] ; Joni Van Der Meulen [Belgique] ; Sofie Peirs [Belgique] ; Tom Taghon [Belgique] ; Cedric S. Tremblay [Australie] ; Magdaline Costa [Australie] ; Morvarid Farhang Ghahremani [Belgique] ; Jelle De Medts [Belgique] ; Sonia Bartunkova [Belgique] ; Katharina Haigh [Belgique, Australie] ; Claire Schwab [Royaume-Uni] ; Natalie Farla [Belgique] ; Tim Pieters [Belgique] ; Filip Matthijssens [Belgique] ; Nadine Van Roy [Belgique] ; J. Adam Best [États-Unis] ; Kim Deswarte [Belgique] ; Pieter Bogaert [Belgique] ; Catherine Carmichael [Australie] ; Adam Rickard [Australie] ; Santi Suryani [Australie] ; Lauryn S. Bracken [Australie] ; Raed Alserihi [Australie] ; Kirsten Canté-Barrett [Pays-Bas] ; Lieven Haenebalcke [Belgique] ; Emmanuelle Clappier [France] ; Pieter Rondou [Belgique] ; Karolina Slowicka [Belgique] ; Danny Huylebroeck [Belgique, Pays-Bas] ; Ananda W. Goldrath [États-Unis] ; Viktor Janzen [Allemagne] ; Matthew P. Mccormack [Australie] ; Richard B. Lock [Australie] ; David J. Curtis [Australie] ; Christine Harrison [Royaume-Uni] ; Geert Berx [Belgique] ; Frank Speleman [France] ; Jules P. P. Meijerink [Pays-Bas] ; Jean Soulier [France] ; Pieter Van Vlierberghe [Belgique] ; Jody J. Haigh [Belgique, Australie]

Source :

Nature Communications [ 2041-1723 ] ; 2015.

RBID : PMC:4354161

Descripteurs français

English descriptors

KwdEn :
- Animals, Blotting, Western, Chromatin Immunoprecipitation, Flow Cytometry, Gene Expression Profiling, Gene Expression Regulation, Neoplastic (genetics), Gene Expression Regulation, Neoplastic (physiology), Histological Techniques, Homeodomain Proteins (genetics), Homeodomain Proteins (immunology), Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence, Janus Kinases (metabolism), Kaplan-Meier Estimate, Karyotyping, Leukemia, T-Cell (physiopathology), Luciferases, Mice, Real-Time Polymerase Chain Reaction, Receptors, Interleukin-7 (metabolism), Repressor Proteins (genetics), Repressor Proteins (immunology), STAT Transcription Factors (metabolism), Signal Transduction (genetics), Signal Transduction (physiology).
MESH :
- chemical , genetics : Homeodomain Proteins, Repressor Proteins.
- genetics : Gene Expression Regulation, Neoplastic, Signal Transduction.
- chemical , immunology : Homeodomain Proteins, Repressor Proteins.
- chemical , metabolism : Janus Kinases, Receptors, Interleukin-7, STAT Transcription Factors.
- physiology : Gene Expression Regulation, Neoplastic, Signal Transduction.
- physiopathology : Leukemia, T-Cell.
- Animals, Blotting, Western, Chromatin Immunoprecipitation, Flow Cytometry, Gene Expression Profiling, Histological Techniques, Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence, Kaplan-Meier Estimate, Karyotyping, Luciferases, Mice, Real-Time Polymerase Chain Reaction.

Abstract

Early T-cell precursor leukaemia (ETP-ALL) is a high-risk subtype of human leukaemia that is poorly understood at the molecular level. Here we report translocations targeting the zinc finger E-box-binding transcription factor ZEB2 as a recurrent genetic lesion in immature/ETP-ALL. Using a conditional gain-of-function mouse model, we demonstrate that sustained Zeb2 expression initiates T-cell leukaemia. Moreover, Zeb2-driven mouse leukaemia exhibit some features of the human immature/ETP-ALL gene expression signature, as well as an enhanced leukaemia-initiation potential and activated Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signalling through transcriptional activation of IL7R. This study reveals ZEB2 as an oncogene in the biology of immature/ETP-ALL and paves the way towards pre-clinical studies of novel compounds for the treatment of this aggressive subtype of human T-ALL using our Zeb2-driven mouse model.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354161

DOI: 10.1038/ncomms6794
PubMed: 25565005
PubMed Central: 4354161

Affiliations:

Allemagne, Australie, Belgique, France, Italie, Pays-Bas, Royaume-Uni, États-Unis

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling</title>
<author><name sortKey="Goossens, Steven" sort="Goossens, Steven" uniqKey="Goossens S" first="Steven" last="Goossens">Steven Goossens</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Vascular Cell Biology Unit, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department for Biomedical Molecular Biology, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a3"><institution>Unit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a4"><institution>Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Department of Clinical Haematology, Monash University and Alfred Health Alfred Centre</institution>
, 99 Commercial Road, Melbourne, Victoria 3004,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Radaelli, Enrico" sort="Radaelli, Enrico" uniqKey="Radaelli E" first="Enrico" last="Radaelli">Enrico Radaelli</name>
<affiliation wicri:level="1"><nlm:aff id="a5"><institution>Mouse and Animal Pathology Laboratory, Department of Veterinary Medicine, Università degli Studi di Milano</institution>
, Milan 20122,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a6"><institution>VIB11 Center for the Biology of Disease, KU Leuven Center for Human Genetics</institution>
, KU Leuven, Leuven B-3000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blanchet, Odile" sort="Blanchet, Odile" uniqKey="Blanchet O" first="Odile" last="Blanchet">Odile Blanchet</name>
<affiliation wicri:level="1"><nlm:aff id="a7"><institution>Institut Universitaire d’Hématologie and U944 INSERM, Hopital Saint-Louis</institution>
, Paris 75010,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Hematology and Immunology, CHU</institution>
, Angers 49100,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Durinck, Kaat" sort="Durinck, Kaat" uniqKey="Durinck K" first="Kaat" last="Durinck">Kaat Durinck</name>
<affiliation wicri:level="1"><nlm:aff id="a9"><institution>Center for Medical Genetics, Ghent University Hospital</institution>
, Ghent B-9000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Der Meulen, Joni" sort="Van Der Meulen, Joni" uniqKey="Van Der Meulen J" first="Joni" last="Van Der Meulen">Joni Van Der Meulen</name>
<affiliation wicri:level="1"><nlm:aff id="a9"><institution>Center for Medical Genetics, Ghent University Hospital</institution>
, Ghent B-9000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peirs, Sofie" sort="Peirs, Sofie" uniqKey="Peirs S" first="Sofie" last="Peirs">Sofie Peirs</name>
<affiliation wicri:level="1"><nlm:aff id="a9"><institution>Center for Medical Genetics, Ghent University Hospital</institution>
, Ghent B-9000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Taghon, Tom" sort="Taghon, Tom" uniqKey="Taghon T" first="Tom" last="Taghon">Tom Taghon</name>
<affiliation wicri:level="1"><nlm:aff id="a10"><institution>Department of Clinical Chemistry, Microbiology and Immunology, Ghent University</institution>
, Ghent B-9000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tremblay, Cedric S" sort="Tremblay, Cedric S" uniqKey="Tremblay C" first="Cedric S." last="Tremblay">Cedric S. Tremblay</name>
<affiliation wicri:level="1"><nlm:aff id="a11"><institution>Stem Cell Research Group, Division of Blood Cancers, Australian Centre for Blood Diseases, Monash University</institution>
, Melbourne, Victoria 3004,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Costa, Magdaline" sort="Costa, Magdaline" uniqKey="Costa M" first="Magdaline" last="Costa">Magdaline Costa</name>
<affiliation wicri:level="1"><nlm:aff id="a4"><institution>Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Department of Clinical Haematology, Monash University and Alfred Health Alfred Centre</institution>
, 99 Commercial Road, Melbourne, Victoria 3004,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ghahremani, Morvarid Farhang" sort="Ghahremani, Morvarid Farhang" uniqKey="Ghahremani M" first="Morvarid Farhang" last="Ghahremani">Morvarid Farhang Ghahremani</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Vascular Cell Biology Unit, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department for Biomedical Molecular Biology, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Medts, Jelle" sort="De Medts, Jelle" uniqKey="De Medts J" first="Jelle" last="De Medts">Jelle De Medts</name>
<affiliation wicri:level="1"><nlm:aff id="a10"><institution>Department of Clinical Chemistry, Microbiology and Immunology, Ghent University</institution>
, Ghent B-9000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bartunkova, Sonia" sort="Bartunkova, Sonia" uniqKey="Bartunkova S" first="Sonia" last="Bartunkova">Sonia Bartunkova</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Vascular Cell Biology Unit, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haigh, Katharina" sort="Haigh, Katharina" uniqKey="Haigh K" first="Katharina" last="Haigh">Katharina Haigh</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Vascular Cell Biology Unit, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department for Biomedical Molecular Biology, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a4"><institution>Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Department of Clinical Haematology, Monash University and Alfred Health Alfred Centre</institution>
, 99 Commercial Road, Melbourne, Victoria 3004,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schwab, Claire" sort="Schwab, Claire" uniqKey="Schwab C" first="Claire" last="Schwab">Claire Schwab</name>
<affiliation wicri:level="1"><nlm:aff id="a12"><institution>Northern Institute for Cancer Research, Newcastle University</institution>
, Newcastle-upon-Tyne NE2 4AD,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Farla, Natalie" sort="Farla, Natalie" uniqKey="Farla N" first="Natalie" last="Farla">Natalie Farla</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Vascular Cell Biology Unit, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department for Biomedical Molecular Biology, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a3"><institution>Unit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pieters, Tim" sort="Pieters, Tim" uniqKey="Pieters T" first="Tim" last="Pieters">Tim Pieters</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Vascular Cell Biology Unit, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department for Biomedical Molecular Biology, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a3"><institution>Unit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a9"><institution>Center for Medical Genetics, Ghent University Hospital</institution>
, Ghent B-9000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Matthijssens, Filip" sort="Matthijssens, Filip" uniqKey="Matthijssens F" first="Filip" last="Matthijssens">Filip Matthijssens</name>
<affiliation wicri:level="1"><nlm:aff id="a9"><institution>Center for Medical Genetics, Ghent University Hospital</institution>
, Ghent B-9000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Roy, Nadine" sort="Van Roy, Nadine" uniqKey="Van Roy N" first="Nadine" last="Van Roy">Nadine Van Roy</name>
<affiliation wicri:level="1"><nlm:aff id="a9"><institution>Center for Medical Genetics, Ghent University Hospital</institution>
, Ghent B-9000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Best, J Adam" sort="Best, J Adam" uniqKey="Best J" first="J. Adam" last="Best">J. Adam Best</name>
<affiliation wicri:level="1"><nlm:aff id="a13"><institution>Division of Biological Sciences, Section of Molecular Biology, University of California at San Diego</institution>
, La Jolla, California 92093,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Deswarte, Kim" sort="Deswarte, Kim" uniqKey="Deswarte K" first="Kim" last="Deswarte">Kim Deswarte</name>
<affiliation wicri:level="1"><nlm:aff id="a14"><institution>VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bogaert, Pieter" sort="Bogaert, Pieter" uniqKey="Bogaert P" first="Pieter" last="Bogaert">Pieter Bogaert</name>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department for Biomedical Molecular Biology, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Carmichael, Catherine" sort="Carmichael, Catherine" uniqKey="Carmichael C" first="Catherine" last="Carmichael">Catherine Carmichael</name>
<affiliation wicri:level="1"><nlm:aff id="a4"><institution>Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Department of Clinical Haematology, Monash University and Alfred Health Alfred Centre</institution>
, 99 Commercial Road, Melbourne, Victoria 3004,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rickard, Adam" sort="Rickard, Adam" uniqKey="Rickard A" first="Adam" last="Rickard">Adam Rickard</name>
<affiliation wicri:level="1"><nlm:aff id="a4"><institution>Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Department of Clinical Haematology, Monash University and Alfred Health Alfred Centre</institution>
, 99 Commercial Road, Melbourne, Victoria 3004,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Suryani, Santi" sort="Suryani, Santi" uniqKey="Suryani S" first="Santi" last="Suryani">Santi Suryani</name>
<affiliation wicri:level="1"><nlm:aff id="a15"><institution>Children’s Cancer Institute, Leukaemia Biology Program, Lowy Cancer Research Centre, University of New South Wales</institution>
, Sydney, New South Wales 2052,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bracken, Lauryn S" sort="Bracken, Lauryn S" uniqKey="Bracken L" first="Lauryn S." last="Bracken">Lauryn S. Bracken</name>
<affiliation wicri:level="1"><nlm:aff id="a15"><institution>Children’s Cancer Institute, Leukaemia Biology Program, Lowy Cancer Research Centre, University of New South Wales</institution>
, Sydney, New South Wales 2052,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alserihi, Raed" sort="Alserihi, Raed" uniqKey="Alserihi R" first="Raed" last="Alserihi">Raed Alserihi</name>
<affiliation wicri:level="1"><nlm:aff id="a16"><institution>Cancer and Haematology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne University</institution>
, Parkville, Victoria 3052,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cante Barrett, Kirsten" sort="Cante Barrett, Kirsten" uniqKey="Cante Barrett K" first="Kirsten" last="Canté-Barrett">Kirsten Canté-Barrett</name>
<affiliation wicri:level="1"><nlm:aff id="a17"><institution>Department of Pediatric Oncology/Hematology, Erasmus MC Rotterdam—Sophia Children’s Hospital</institution>
, Rotterdam 3015CE,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haenebalcke, Lieven" sort="Haenebalcke, Lieven" uniqKey="Haenebalcke L" first="Lieven" last="Haenebalcke">Lieven Haenebalcke</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Vascular Cell Biology Unit, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department for Biomedical Molecular Biology, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Clappier, Emmanuelle" sort="Clappier, Emmanuelle" uniqKey="Clappier E" first="Emmanuelle" last="Clappier">Emmanuelle Clappier</name>
<affiliation wicri:level="1"><nlm:aff id="a7"><institution>Institut Universitaire d’Hématologie and U944 INSERM, Hopital Saint-Louis</institution>
, Paris 75010,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Hematology and Immunology, CHU</institution>
, Angers 49100,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rondou, Pieter" sort="Rondou, Pieter" uniqKey="Rondou P" first="Pieter" last="Rondou">Pieter Rondou</name>
<affiliation wicri:level="1"><nlm:aff id="a9"><institution>Center for Medical Genetics, Ghent University Hospital</institution>
, Ghent B-9000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Slowicka, Karolina" sort="Slowicka, Karolina" uniqKey="Slowicka K" first="Karolina" last="Slowicka">Karolina Slowicka</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Vascular Cell Biology Unit, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department for Biomedical Molecular Biology, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huylebroeck, Danny" sort="Huylebroeck, Danny" uniqKey="Huylebroeck D" first="Danny" last="Huylebroeck">Danny Huylebroeck</name>
<affiliation wicri:level="1"><nlm:aff id="a18"><institution>Department of Development and Regeneration, KU Leuven</institution>
, Leuven B-3000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a19"><institution>Department of Cell Biology, Erasmus MC</institution>
, Rotterdam 3015CE,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Goldrath, Ananda W" sort="Goldrath, Ananda W" uniqKey="Goldrath A" first="Ananda W." last="Goldrath">Ananda W. Goldrath</name>
<affiliation wicri:level="1"><nlm:aff id="a13"><institution>Division of Biological Sciences, Section of Molecular Biology, University of California at San Diego</institution>
, La Jolla, California 92093,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Janzen, Viktor" sort="Janzen, Viktor" uniqKey="Janzen V" first="Viktor" last="Janzen">Viktor Janzen</name>
<affiliation wicri:level="1"><nlm:aff id="a20"><institution>Department of Internal Medicine III, Hematology and Oncology, University of Bonn</institution>
, D-53012 Bonn,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mccormack, Matthew P" sort="Mccormack, Matthew P" uniqKey="Mccormack M" first="Matthew P." last="Mccormack">Matthew P. Mccormack</name>
<affiliation wicri:level="1"><nlm:aff id="a16"><institution>Cancer and Haematology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne University</institution>
, Parkville, Victoria 3052,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lock, Richard B" sort="Lock, Richard B" uniqKey="Lock R" first="Richard B." last="Lock">Richard B. Lock</name>
<affiliation wicri:level="1"><nlm:aff id="a15"><institution>Children’s Cancer Institute, Leukaemia Biology Program, Lowy Cancer Research Centre, University of New South Wales</institution>
, Sydney, New South Wales 2052,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Curtis, David J" sort="Curtis, David J" uniqKey="Curtis D" first="David J." last="Curtis">David J. Curtis</name>
<affiliation wicri:level="1"><nlm:aff id="a11"><institution>Stem Cell Research Group, Division of Blood Cancers, Australian Centre for Blood Diseases, Monash University</institution>
, Melbourne, Victoria 3004,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Harrison, Christine" sort="Harrison, Christine" uniqKey="Harrison C" first="Christine" last="Harrison">Christine Harrison</name>
<affiliation wicri:level="1"><nlm:aff id="a12"><institution>Northern Institute for Cancer Research, Newcastle University</institution>
, Newcastle-upon-Tyne NE2 4AD,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Berx, Geert" sort="Berx, Geert" uniqKey="Berx G" first="Geert" last="Berx">Geert Berx</name>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department for Biomedical Molecular Biology, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a3"><institution>Unit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Speleman, Frank" sort="Speleman, Frank" uniqKey="Speleman F" first="Frank" last="Speleman">Frank Speleman</name>
<affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Hematology and Immunology, CHU</institution>
, Angers 49100,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meijerink, Jules P P" sort="Meijerink, Jules P P" uniqKey="Meijerink J" first="Jules P. P." last="Meijerink">Jules P. P. Meijerink</name>
<affiliation wicri:level="1"><nlm:aff id="a17"><institution>Department of Pediatric Oncology/Hematology, Erasmus MC Rotterdam—Sophia Children’s Hospital</institution>
, Rotterdam 3015CE,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Soulier, Jean" sort="Soulier, Jean" uniqKey="Soulier J" first="Jean" last="Soulier">Jean Soulier</name>
<affiliation wicri:level="1"><nlm:aff id="a7"><institution>Institut Universitaire d’Hématologie and U944 INSERM, Hopital Saint-Louis</institution>
, Paris 75010,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Hematology and Immunology, CHU</institution>
, Angers 49100,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Vlierberghe, Pieter" sort="Van Vlierberghe, Pieter" uniqKey="Van Vlierberghe P" first="Pieter" last="Van Vlierberghe">Pieter Van Vlierberghe</name>
<affiliation wicri:level="1"><nlm:aff id="a9"><institution>Center for Medical Genetics, Ghent University Hospital</institution>
, Ghent B-9000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haigh, Jody J" sort="Haigh, Jody J" uniqKey="Haigh J" first="Jody J." last="Haigh">Jody J. Haigh</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Vascular Cell Biology Unit, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department for Biomedical Molecular Biology, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a4"><institution>Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Department of Clinical Haematology, Monash University and Alfred Health Alfred Centre</institution>
, 99 Commercial Road, Melbourne, Victoria 3004,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25565005</idno>
<idno type="pmc">4354161</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354161</idno>
<idno type="RBID">PMC:4354161</idno>
<idno type="doi">10.1038/ncomms6794</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000734</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000734</idno>
<idno type="wicri:Area/Pmc/Curation">000733</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000733</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000C28</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C28</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">003117</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003117</idno>
<idno type="wicri:Area/PubMed/Curation">003021</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003021</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003021</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003021</idno>
<idno type="wicri:Area/Ncbi/Merge">002145</idno>
<idno type="wicri:Area/Ncbi/Curation">002145</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002145</idno>
<idno type="wicri:Area/Main/Merge">002628</idno>
<idno type="wicri:Area/Main/Curation">002629</idno>
<idno type="wicri:Area/Main/Exploration">002629</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling</title>
<author><name sortKey="Goossens, Steven" sort="Goossens, Steven" uniqKey="Goossens S" first="Steven" last="Goossens">Steven Goossens</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Vascular Cell Biology Unit, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department for Biomedical Molecular Biology, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a3"><institution>Unit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a4"><institution>Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Department of Clinical Haematology, Monash University and Alfred Health Alfred Centre</institution>
, 99 Commercial Road, Melbourne, Victoria 3004,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Radaelli, Enrico" sort="Radaelli, Enrico" uniqKey="Radaelli E" first="Enrico" last="Radaelli">Enrico Radaelli</name>
<affiliation wicri:level="1"><nlm:aff id="a5"><institution>Mouse and Animal Pathology Laboratory, Department of Veterinary Medicine, Università degli Studi di Milano</institution>
, Milan 20122,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a6"><institution>VIB11 Center for the Biology of Disease, KU Leuven Center for Human Genetics</institution>
, KU Leuven, Leuven B-3000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blanchet, Odile" sort="Blanchet, Odile" uniqKey="Blanchet O" first="Odile" last="Blanchet">Odile Blanchet</name>
<affiliation wicri:level="1"><nlm:aff id="a7"><institution>Institut Universitaire d’Hématologie and U944 INSERM, Hopital Saint-Louis</institution>
, Paris 75010,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Hematology and Immunology, CHU</institution>
, Angers 49100,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Durinck, Kaat" sort="Durinck, Kaat" uniqKey="Durinck K" first="Kaat" last="Durinck">Kaat Durinck</name>
<affiliation wicri:level="1"><nlm:aff id="a9"><institution>Center for Medical Genetics, Ghent University Hospital</institution>
, Ghent B-9000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Der Meulen, Joni" sort="Van Der Meulen, Joni" uniqKey="Van Der Meulen J" first="Joni" last="Van Der Meulen">Joni Van Der Meulen</name>
<affiliation wicri:level="1"><nlm:aff id="a9"><institution>Center for Medical Genetics, Ghent University Hospital</institution>
, Ghent B-9000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peirs, Sofie" sort="Peirs, Sofie" uniqKey="Peirs S" first="Sofie" last="Peirs">Sofie Peirs</name>
<affiliation wicri:level="1"><nlm:aff id="a9"><institution>Center for Medical Genetics, Ghent University Hospital</institution>
, Ghent B-9000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Taghon, Tom" sort="Taghon, Tom" uniqKey="Taghon T" first="Tom" last="Taghon">Tom Taghon</name>
<affiliation wicri:level="1"><nlm:aff id="a10"><institution>Department of Clinical Chemistry, Microbiology and Immunology, Ghent University</institution>
, Ghent B-9000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tremblay, Cedric S" sort="Tremblay, Cedric S" uniqKey="Tremblay C" first="Cedric S." last="Tremblay">Cedric S. Tremblay</name>
<affiliation wicri:level="1"><nlm:aff id="a11"><institution>Stem Cell Research Group, Division of Blood Cancers, Australian Centre for Blood Diseases, Monash University</institution>
, Melbourne, Victoria 3004,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Costa, Magdaline" sort="Costa, Magdaline" uniqKey="Costa M" first="Magdaline" last="Costa">Magdaline Costa</name>
<affiliation wicri:level="1"><nlm:aff id="a4"><institution>Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Department of Clinical Haematology, Monash University and Alfred Health Alfred Centre</institution>
, 99 Commercial Road, Melbourne, Victoria 3004,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ghahremani, Morvarid Farhang" sort="Ghahremani, Morvarid Farhang" uniqKey="Ghahremani M" first="Morvarid Farhang" last="Ghahremani">Morvarid Farhang Ghahremani</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Vascular Cell Biology Unit, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department for Biomedical Molecular Biology, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Medts, Jelle" sort="De Medts, Jelle" uniqKey="De Medts J" first="Jelle" last="De Medts">Jelle De Medts</name>
<affiliation wicri:level="1"><nlm:aff id="a10"><institution>Department of Clinical Chemistry, Microbiology and Immunology, Ghent University</institution>
, Ghent B-9000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bartunkova, Sonia" sort="Bartunkova, Sonia" uniqKey="Bartunkova S" first="Sonia" last="Bartunkova">Sonia Bartunkova</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Vascular Cell Biology Unit, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haigh, Katharina" sort="Haigh, Katharina" uniqKey="Haigh K" first="Katharina" last="Haigh">Katharina Haigh</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Vascular Cell Biology Unit, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department for Biomedical Molecular Biology, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a4"><institution>Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Department of Clinical Haematology, Monash University and Alfred Health Alfred Centre</institution>
, 99 Commercial Road, Melbourne, Victoria 3004,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schwab, Claire" sort="Schwab, Claire" uniqKey="Schwab C" first="Claire" last="Schwab">Claire Schwab</name>
<affiliation wicri:level="1"><nlm:aff id="a12"><institution>Northern Institute for Cancer Research, Newcastle University</institution>
, Newcastle-upon-Tyne NE2 4AD,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Farla, Natalie" sort="Farla, Natalie" uniqKey="Farla N" first="Natalie" last="Farla">Natalie Farla</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Vascular Cell Biology Unit, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department for Biomedical Molecular Biology, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a3"><institution>Unit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pieters, Tim" sort="Pieters, Tim" uniqKey="Pieters T" first="Tim" last="Pieters">Tim Pieters</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Vascular Cell Biology Unit, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department for Biomedical Molecular Biology, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a3"><institution>Unit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a9"><institution>Center for Medical Genetics, Ghent University Hospital</institution>
, Ghent B-9000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Matthijssens, Filip" sort="Matthijssens, Filip" uniqKey="Matthijssens F" first="Filip" last="Matthijssens">Filip Matthijssens</name>
<affiliation wicri:level="1"><nlm:aff id="a9"><institution>Center for Medical Genetics, Ghent University Hospital</institution>
, Ghent B-9000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Roy, Nadine" sort="Van Roy, Nadine" uniqKey="Van Roy N" first="Nadine" last="Van Roy">Nadine Van Roy</name>
<affiliation wicri:level="1"><nlm:aff id="a9"><institution>Center for Medical Genetics, Ghent University Hospital</institution>
, Ghent B-9000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Best, J Adam" sort="Best, J Adam" uniqKey="Best J" first="J. Adam" last="Best">J. Adam Best</name>
<affiliation wicri:level="1"><nlm:aff id="a13"><institution>Division of Biological Sciences, Section of Molecular Biology, University of California at San Diego</institution>
, La Jolla, California 92093,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Deswarte, Kim" sort="Deswarte, Kim" uniqKey="Deswarte K" first="Kim" last="Deswarte">Kim Deswarte</name>
<affiliation wicri:level="1"><nlm:aff id="a14"><institution>VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bogaert, Pieter" sort="Bogaert, Pieter" uniqKey="Bogaert P" first="Pieter" last="Bogaert">Pieter Bogaert</name>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department for Biomedical Molecular Biology, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Carmichael, Catherine" sort="Carmichael, Catherine" uniqKey="Carmichael C" first="Catherine" last="Carmichael">Catherine Carmichael</name>
<affiliation wicri:level="1"><nlm:aff id="a4"><institution>Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Department of Clinical Haematology, Monash University and Alfred Health Alfred Centre</institution>
, 99 Commercial Road, Melbourne, Victoria 3004,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rickard, Adam" sort="Rickard, Adam" uniqKey="Rickard A" first="Adam" last="Rickard">Adam Rickard</name>
<affiliation wicri:level="1"><nlm:aff id="a4"><institution>Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Department of Clinical Haematology, Monash University and Alfred Health Alfred Centre</institution>
, 99 Commercial Road, Melbourne, Victoria 3004,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Suryani, Santi" sort="Suryani, Santi" uniqKey="Suryani S" first="Santi" last="Suryani">Santi Suryani</name>
<affiliation wicri:level="1"><nlm:aff id="a15"><institution>Children’s Cancer Institute, Leukaemia Biology Program, Lowy Cancer Research Centre, University of New South Wales</institution>
, Sydney, New South Wales 2052,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bracken, Lauryn S" sort="Bracken, Lauryn S" uniqKey="Bracken L" first="Lauryn S." last="Bracken">Lauryn S. Bracken</name>
<affiliation wicri:level="1"><nlm:aff id="a15"><institution>Children’s Cancer Institute, Leukaemia Biology Program, Lowy Cancer Research Centre, University of New South Wales</institution>
, Sydney, New South Wales 2052,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alserihi, Raed" sort="Alserihi, Raed" uniqKey="Alserihi R" first="Raed" last="Alserihi">Raed Alserihi</name>
<affiliation wicri:level="1"><nlm:aff id="a16"><institution>Cancer and Haematology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne University</institution>
, Parkville, Victoria 3052,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cante Barrett, Kirsten" sort="Cante Barrett, Kirsten" uniqKey="Cante Barrett K" first="Kirsten" last="Canté-Barrett">Kirsten Canté-Barrett</name>
<affiliation wicri:level="1"><nlm:aff id="a17"><institution>Department of Pediatric Oncology/Hematology, Erasmus MC Rotterdam—Sophia Children’s Hospital</institution>
, Rotterdam 3015CE,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haenebalcke, Lieven" sort="Haenebalcke, Lieven" uniqKey="Haenebalcke L" first="Lieven" last="Haenebalcke">Lieven Haenebalcke</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Vascular Cell Biology Unit, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department for Biomedical Molecular Biology, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Clappier, Emmanuelle" sort="Clappier, Emmanuelle" uniqKey="Clappier E" first="Emmanuelle" last="Clappier">Emmanuelle Clappier</name>
<affiliation wicri:level="1"><nlm:aff id="a7"><institution>Institut Universitaire d’Hématologie and U944 INSERM, Hopital Saint-Louis</institution>
, Paris 75010,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Hematology and Immunology, CHU</institution>
, Angers 49100,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rondou, Pieter" sort="Rondou, Pieter" uniqKey="Rondou P" first="Pieter" last="Rondou">Pieter Rondou</name>
<affiliation wicri:level="1"><nlm:aff id="a9"><institution>Center for Medical Genetics, Ghent University Hospital</institution>
, Ghent B-9000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Slowicka, Karolina" sort="Slowicka, Karolina" uniqKey="Slowicka K" first="Karolina" last="Slowicka">Karolina Slowicka</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Vascular Cell Biology Unit, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department for Biomedical Molecular Biology, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huylebroeck, Danny" sort="Huylebroeck, Danny" uniqKey="Huylebroeck D" first="Danny" last="Huylebroeck">Danny Huylebroeck</name>
<affiliation wicri:level="1"><nlm:aff id="a18"><institution>Department of Development and Regeneration, KU Leuven</institution>
, Leuven B-3000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a19"><institution>Department of Cell Biology, Erasmus MC</institution>
, Rotterdam 3015CE,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Goldrath, Ananda W" sort="Goldrath, Ananda W" uniqKey="Goldrath A" first="Ananda W." last="Goldrath">Ananda W. Goldrath</name>
<affiliation wicri:level="1"><nlm:aff id="a13"><institution>Division of Biological Sciences, Section of Molecular Biology, University of California at San Diego</institution>
, La Jolla, California 92093,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Janzen, Viktor" sort="Janzen, Viktor" uniqKey="Janzen V" first="Viktor" last="Janzen">Viktor Janzen</name>
<affiliation wicri:level="1"><nlm:aff id="a20"><institution>Department of Internal Medicine III, Hematology and Oncology, University of Bonn</institution>
, D-53012 Bonn,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mccormack, Matthew P" sort="Mccormack, Matthew P" uniqKey="Mccormack M" first="Matthew P." last="Mccormack">Matthew P. Mccormack</name>
<affiliation wicri:level="1"><nlm:aff id="a16"><institution>Cancer and Haematology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne University</institution>
, Parkville, Victoria 3052,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lock, Richard B" sort="Lock, Richard B" uniqKey="Lock R" first="Richard B." last="Lock">Richard B. Lock</name>
<affiliation wicri:level="1"><nlm:aff id="a15"><institution>Children’s Cancer Institute, Leukaemia Biology Program, Lowy Cancer Research Centre, University of New South Wales</institution>
, Sydney, New South Wales 2052,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Curtis, David J" sort="Curtis, David J" uniqKey="Curtis D" first="David J." last="Curtis">David J. Curtis</name>
<affiliation wicri:level="1"><nlm:aff id="a11"><institution>Stem Cell Research Group, Division of Blood Cancers, Australian Centre for Blood Diseases, Monash University</institution>
, Melbourne, Victoria 3004,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Harrison, Christine" sort="Harrison, Christine" uniqKey="Harrison C" first="Christine" last="Harrison">Christine Harrison</name>
<affiliation wicri:level="1"><nlm:aff id="a12"><institution>Northern Institute for Cancer Research, Newcastle University</institution>
, Newcastle-upon-Tyne NE2 4AD,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Berx, Geert" sort="Berx, Geert" uniqKey="Berx G" first="Geert" last="Berx">Geert Berx</name>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department for Biomedical Molecular Biology, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a3"><institution>Unit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Speleman, Frank" sort="Speleman, Frank" uniqKey="Speleman F" first="Frank" last="Speleman">Frank Speleman</name>
<affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Hematology and Immunology, CHU</institution>
, Angers 49100,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meijerink, Jules P P" sort="Meijerink, Jules P P" uniqKey="Meijerink J" first="Jules P. P." last="Meijerink">Jules P. P. Meijerink</name>
<affiliation wicri:level="1"><nlm:aff id="a17"><institution>Department of Pediatric Oncology/Hematology, Erasmus MC Rotterdam—Sophia Children’s Hospital</institution>
, Rotterdam 3015CE,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Soulier, Jean" sort="Soulier, Jean" uniqKey="Soulier J" first="Jean" last="Soulier">Jean Soulier</name>
<affiliation wicri:level="1"><nlm:aff id="a7"><institution>Institut Universitaire d’Hématologie and U944 INSERM, Hopital Saint-Louis</institution>
, Paris 75010,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Hematology and Immunology, CHU</institution>
, Angers 49100,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Vlierberghe, Pieter" sort="Van Vlierberghe, Pieter" uniqKey="Van Vlierberghe P" first="Pieter" last="Van Vlierberghe">Pieter Van Vlierberghe</name>
<affiliation wicri:level="1"><nlm:aff id="a9"><institution>Center for Medical Genetics, Ghent University Hospital</institution>
, Ghent B-9000,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haigh, Jody J" sort="Haigh, Jody J" uniqKey="Haigh J" first="Jody J." last="Haigh">Jody J. Haigh</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Vascular Cell Biology Unit, VIB Inflammation Research Center, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department for Biomedical Molecular Biology, Ghent University</institution>
, Ghent B-9052,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a4"><institution>Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Department of Clinical Haematology, Monash University and Alfred Health Alfred Centre</institution>
, 99 Commercial Road, Melbourne, Victoria 3004,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature Communications</title>
<idno type="eISSN">2041-1723</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Blotting, Western</term>
<term>Chromatin Immunoprecipitation</term>
<term>Flow Cytometry</term>
<term>Gene Expression Profiling</term>
<term>Gene Expression Regulation, Neoplastic (genetics)</term>
<term>Gene Expression Regulation, Neoplastic (physiology)</term>
<term>Histological Techniques</term>
<term>Homeodomain Proteins (genetics)</term>
<term>Homeodomain Proteins (immunology)</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>In Situ Hybridization, Fluorescence</term>
<term>Janus Kinases (metabolism)</term>
<term>Kaplan-Meier Estimate</term>
<term>Karyotyping</term>
<term>Leukemia, T-Cell (physiopathology)</term>
<term>Luciferases</term>
<term>Mice</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>Receptors, Interleukin-7 (metabolism)</term>
<term>Repressor Proteins (genetics)</term>
<term>Repressor Proteins (immunology)</term>
<term>STAT Transcription Factors (metabolism)</term>
<term>Signal Transduction (genetics)</term>
<term>Signal Transduction (physiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term>
<term>Animaux</term>
<term>Caryotypage</term>
<term>Cytométrie en flux</term>
<term>Estimation de Kaplan-Meier</term>
<term>Facteurs de transcription STAT (métabolisme)</term>
<term>Humains</term>
<term>Immunohistochimie</term>
<term>Immunoprécipitation de la chromatine</term>
<term>Janus kinases (métabolisme)</term>
<term>Leucémie à cellules T (physiopathologie)</term>
<term>Luciferases</term>
<term>Protéines de répression (génétique)</term>
<term>Protéines de répression (immunologie)</term>
<term>Protéines à homéodomaine (génétique)</term>
<term>Protéines à homéodomaine (immunologie)</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
<term>Récepteurs à l'interleukine-7 (métabolisme)</term>
<term>Régulation de l'expression des gènes tumoraux (génétique)</term>
<term>Régulation de l'expression des gènes tumoraux (physiologie)</term>
<term>Souris</term>
<term>Technique FISH</term>
<term>Technique de Western</term>
<term>Techniques histologiques</term>
<term>Transduction du signal (génétique)</term>
<term>Transduction du signal (physiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Homeodomain Proteins</term>
<term>Repressor Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Gene Expression Regulation, Neoplastic</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines de répression</term>
<term>Protéines à homéodomaine</term>
<term>Régulation de l'expression des gènes tumoraux</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Protéines de répression</term>
<term>Protéines à homéodomaine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Homeodomain Proteins</term>
<term>Repressor Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Janus Kinases</term>
<term>Receptors, Interleukin-7</term>
<term>STAT Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de transcription STAT</term>
<term>Janus kinases</term>
<term>Récepteurs à l'interleukine-7</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Régulation de l'expression des gènes tumoraux</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gene Expression Regulation, Neoplastic</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Leucémie à cellules T</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Leukemia, T-Cell</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Blotting, Western</term>
<term>Chromatin Immunoprecipitation</term>
<term>Flow Cytometry</term>
<term>Gene Expression Profiling</term>
<term>Histological Techniques</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>In Situ Hybridization, Fluorescence</term>
<term>Kaplan-Meier Estimate</term>
<term>Karyotyping</term>
<term>Luciferases</term>
<term>Mice</term>
<term>Real-Time Polymerase Chain Reaction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term>
<term>Animaux</term>
<term>Caryotypage</term>
<term>Cytométrie en flux</term>
<term>Estimation de Kaplan-Meier</term>
<term>Humains</term>
<term>Immunohistochimie</term>
<term>Immunoprécipitation de la chromatine</term>
<term>Luciferases</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
<term>Souris</term>
<term>Technique FISH</term>
<term>Technique de Western</term>
<term>Techniques histologiques</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Early T-cell precursor leukaemia (ETP-ALL) is a high-risk subtype of human leukaemia that is poorly understood at the molecular level. Here we report translocations targeting the zinc finger E-box-binding transcription factor <italic>ZEB2</italic>
 as a recurrent genetic lesion in immature/ETP-ALL. Using a conditional gain-of-function mouse model, we demonstrate that sustained <italic>Zeb2</italic>
 expression initiates T-cell leukaemia. Moreover, <italic>Zeb2</italic>
-driven mouse leukaemia exhibit some features of the human immature/ETP-ALL gene expression signature, as well as an enhanced leukaemia-initiation potential and activated Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signalling through transcriptional activation of <italic>IL7R</italic>
. This study reveals ZEB2 as an oncogene in the biology of immature/ETP-ALL and paves the way towards pre-clinical studies of novel compounds for the treatment of this aggressive subtype of human T-ALL using our <italic>Zeb2</italic>
-driven mouse model.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Meijerink, J P" uniqKey="Meijerink J">J. P. Meijerink</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Vlierberghe, P" uniqKey="Van Vlierberghe P">P. Van Vlierberghe</name>
</author>
<author><name sortKey="Ferrando, A" uniqKey="Ferrando A">A. Ferrando</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ferrando, A A" uniqKey="Ferrando A">A. A. Ferrando</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Soulier, J" uniqKey="Soulier J">J. Soulier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Coustan Smith, E" uniqKey="Coustan Smith E">E. Coustan-Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Homminga, I" uniqKey="Homminga I">I. Homminga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Comijn, J" uniqKey="Comijn J">J. Comijn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gheldof, A" uniqKey="Gheldof A">A. Gheldof</name>
</author>
<author><name sortKey="Hulpiau, P" uniqKey="Hulpiau P">P. Hulpiau</name>
</author>
<author><name sortKey="Van Roy, F" uniqKey="Van Roy F">F. van Roy</name>
</author>
<author><name sortKey="De Craene, B" uniqKey="De Craene B">B. De Craene</name>
</author>
<author><name sortKey="Berx, G" uniqKey="Berx G">G. Berx</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wellner, U" uniqKey="Wellner U">U. Wellner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brabletz, S" uniqKey="Brabletz S">S. Brabletz</name>
</author>
<author><name sortKey="Brabletz, T" uniqKey="Brabletz T">T. Brabletz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bernard, O A" uniqKey="Bernard O">O. A. Bernard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Su, X" uniqKey="Su X">X. Su</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nagel, S" uniqKey="Nagel S">S. Nagel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nagel, S" uniqKey="Nagel S">S. Nagel</name>
</author>
<author><name sortKey="Kaufmann, M" uniqKey="Kaufmann M">M. Kaufmann</name>
</author>
<author><name sortKey="Drexler, H G" uniqKey="Drexler H">H. G. Drexler</name>
</author>
<author><name sortKey="Macleod, R A" uniqKey="Macleod R">R. A. MacLeod</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clappier, E" uniqKey="Clappier E">E. Clappier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Vlierberghe, P" uniqKey="Van Vlierberghe P">P. Van Vlierberghe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tatari, M N" uniqKey="Tatari M">M. N. Tatari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kisanuki, Y Y" uniqKey="Kisanuki Y">Y. Y. Kisanuki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Goossens, S" uniqKey="Goossens S">S. Goossens</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jonkers, J" uniqKey="Jonkers J">J. Jonkers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Farhang Ghahremani, M" uniqKey="Farhang Ghahremani M">M. Farhang Ghahremani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, P P" uniqKey="Lee P">P. P. Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mccormack, M P" uniqKey="Mccormack M">M. P. McCormack</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mccormack, M P" uniqKey="Mccormack M">M. P. McCormack</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Akashi, K" uniqKey="Akashi K">K. Akashi</name>
</author>
<author><name sortKey="Kondo, M" uniqKey="Kondo M">M. Kondo</name>
</author>
<author><name sortKey="Von Freeden Jeffry, U" uniqKey="Von Freeden Jeffry U">U. von Freeden-Jeffry</name>
</author>
<author><name sortKey="Murray, R" uniqKey="Murray R">R. Murray</name>
</author>
<author><name sortKey="Weissman, I L" uniqKey="Weissman I">I. L. Weissman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ribeiro, D" uniqKey="Ribeiro D">D. Ribeiro</name>
</author>
<author><name sortKey="Melao, A" uniqKey="Melao A">A. Melao</name>
</author>
<author><name sortKey="Barata, J T" uniqKey="Barata J">J. T. Barata</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lund, A H" uniqKey="Lund A">A. H. Lund</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mikkers, H" uniqKey="Mikkers H">H. Mikkers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Caudell, D" uniqKey="Caudell D">D. Caudell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gregory, P A" uniqKey="Gregory P">P. A. Gregory</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lim, Y Y" uniqKey="Lim Y">Y. Y. Lim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pieraccioli, M" uniqKey="Pieraccioli M">M. Pieraccioli</name>
</author>
<author><name sortKey="Imbastari, F" uniqKey="Imbastari F">F. Imbastari</name>
</author>
<author><name sortKey="Antonov, A" uniqKey="Antonov A">A. Antonov</name>
</author>
<author><name sortKey="Melino, G" uniqKey="Melino G">G. Melino</name>
</author>
<author><name sortKey="Raschella, G" uniqKey="Raschella G">G. Raschella</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seuntjens, E" uniqKey="Seuntjens E">E. Seuntjens</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weng, A P" uniqKey="Weng A">A. P. Weng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Palomero, T" uniqKey="Palomero T">T. Palomero</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mullighan, C G" uniqKey="Mullighan C">C. G. Mullighan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Spaderna, S" uniqKey="Spaderna S">S. Spaderna</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zenatti, P P" uniqKey="Zenatti P">P. P. Zenatti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shochat, C" uniqKey="Shochat C">C. Shochat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Treanor, L M" uniqKey="Treanor L">L. M. Treanor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Silva, A" uniqKey="Silva A">A. Silva</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morse, H C" uniqKey="Morse H">H. C. Morse</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rehg, J E" uniqKey="Rehg J">J. E. Rehg</name>
</author>
<author><name sortKey="Ward, J M" uniqKey="Ward J">J. M. Ward</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rehg, J E" uniqKey="Rehg J">J. E. Rehg</name>
</author>
<author><name sortKey="Bush, D" uniqKey="Bush D">D. Bush</name>
</author>
<author><name sortKey="Ward, J M" uniqKey="Ward J">J. M. Ward</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jinadasa, R" uniqKey="Jinadasa R">R. Jinadasa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bindels, S" uniqKey="Bindels S">S. Bindels</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mets, E" uniqKey="Mets E">E. Mets</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vandewalle, C" uniqKey="Vandewalle C">C. Vandewalle</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="O Neil, J" uniqKey="O Neil J">J. O'Neil</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Belgique</li>
<li>France</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
</list>
<tree><country name="Belgique"><noRegion><name sortKey="Goossens, Steven" sort="Goossens, Steven" uniqKey="Goossens S" first="Steven" last="Goossens">Steven Goossens</name>
</noRegion>
<name sortKey="Bartunkova, Sonia" sort="Bartunkova, Sonia" uniqKey="Bartunkova S" first="Sonia" last="Bartunkova">Sonia Bartunkova</name>
<name sortKey="Berx, Geert" sort="Berx, Geert" uniqKey="Berx G" first="Geert" last="Berx">Geert Berx</name>
<name sortKey="Berx, Geert" sort="Berx, Geert" uniqKey="Berx G" first="Geert" last="Berx">Geert Berx</name>
<name sortKey="Bogaert, Pieter" sort="Bogaert, Pieter" uniqKey="Bogaert P" first="Pieter" last="Bogaert">Pieter Bogaert</name>
<name sortKey="De Medts, Jelle" sort="De Medts, Jelle" uniqKey="De Medts J" first="Jelle" last="De Medts">Jelle De Medts</name>
<name sortKey="Deswarte, Kim" sort="Deswarte, Kim" uniqKey="Deswarte K" first="Kim" last="Deswarte">Kim Deswarte</name>
<name sortKey="Durinck, Kaat" sort="Durinck, Kaat" uniqKey="Durinck K" first="Kaat" last="Durinck">Kaat Durinck</name>
<name sortKey="Farla, Natalie" sort="Farla, Natalie" uniqKey="Farla N" first="Natalie" last="Farla">Natalie Farla</name>
<name sortKey="Farla, Natalie" sort="Farla, Natalie" uniqKey="Farla N" first="Natalie" last="Farla">Natalie Farla</name>
<name sortKey="Farla, Natalie" sort="Farla, Natalie" uniqKey="Farla N" first="Natalie" last="Farla">Natalie Farla</name>
<name sortKey="Ghahremani, Morvarid Farhang" sort="Ghahremani, Morvarid Farhang" uniqKey="Ghahremani M" first="Morvarid Farhang" last="Ghahremani">Morvarid Farhang Ghahremani</name>
<name sortKey="Ghahremani, Morvarid Farhang" sort="Ghahremani, Morvarid Farhang" uniqKey="Ghahremani M" first="Morvarid Farhang" last="Ghahremani">Morvarid Farhang Ghahremani</name>
<name sortKey="Goossens, Steven" sort="Goossens, Steven" uniqKey="Goossens S" first="Steven" last="Goossens">Steven Goossens</name>
<name sortKey="Goossens, Steven" sort="Goossens, Steven" uniqKey="Goossens S" first="Steven" last="Goossens">Steven Goossens</name>
<name sortKey="Haenebalcke, Lieven" sort="Haenebalcke, Lieven" uniqKey="Haenebalcke L" first="Lieven" last="Haenebalcke">Lieven Haenebalcke</name>
<name sortKey="Haenebalcke, Lieven" sort="Haenebalcke, Lieven" uniqKey="Haenebalcke L" first="Lieven" last="Haenebalcke">Lieven Haenebalcke</name>
<name sortKey="Haigh, Jody J" sort="Haigh, Jody J" uniqKey="Haigh J" first="Jody J." last="Haigh">Jody J. Haigh</name>
<name sortKey="Haigh, Jody J" sort="Haigh, Jody J" uniqKey="Haigh J" first="Jody J." last="Haigh">Jody J. Haigh</name>
<name sortKey="Haigh, Katharina" sort="Haigh, Katharina" uniqKey="Haigh K" first="Katharina" last="Haigh">Katharina Haigh</name>
<name sortKey="Haigh, Katharina" sort="Haigh, Katharina" uniqKey="Haigh K" first="Katharina" last="Haigh">Katharina Haigh</name>
<name sortKey="Huylebroeck, Danny" sort="Huylebroeck, Danny" uniqKey="Huylebroeck D" first="Danny" last="Huylebroeck">Danny Huylebroeck</name>
<name sortKey="Matthijssens, Filip" sort="Matthijssens, Filip" uniqKey="Matthijssens F" first="Filip" last="Matthijssens">Filip Matthijssens</name>
<name sortKey="Peirs, Sofie" sort="Peirs, Sofie" uniqKey="Peirs S" first="Sofie" last="Peirs">Sofie Peirs</name>
<name sortKey="Pieters, Tim" sort="Pieters, Tim" uniqKey="Pieters T" first="Tim" last="Pieters">Tim Pieters</name>
<name sortKey="Pieters, Tim" sort="Pieters, Tim" uniqKey="Pieters T" first="Tim" last="Pieters">Tim Pieters</name>
<name sortKey="Pieters, Tim" sort="Pieters, Tim" uniqKey="Pieters T" first="Tim" last="Pieters">Tim Pieters</name>
<name sortKey="Pieters, Tim" sort="Pieters, Tim" uniqKey="Pieters T" first="Tim" last="Pieters">Tim Pieters</name>
<name sortKey="Radaelli, Enrico" sort="Radaelli, Enrico" uniqKey="Radaelli E" first="Enrico" last="Radaelli">Enrico Radaelli</name>
<name sortKey="Rondou, Pieter" sort="Rondou, Pieter" uniqKey="Rondou P" first="Pieter" last="Rondou">Pieter Rondou</name>
<name sortKey="Slowicka, Karolina" sort="Slowicka, Karolina" uniqKey="Slowicka K" first="Karolina" last="Slowicka">Karolina Slowicka</name>
<name sortKey="Slowicka, Karolina" sort="Slowicka, Karolina" uniqKey="Slowicka K" first="Karolina" last="Slowicka">Karolina Slowicka</name>
<name sortKey="Taghon, Tom" sort="Taghon, Tom" uniqKey="Taghon T" first="Tom" last="Taghon">Tom Taghon</name>
<name sortKey="Van Der Meulen, Joni" sort="Van Der Meulen, Joni" uniqKey="Van Der Meulen J" first="Joni" last="Van Der Meulen">Joni Van Der Meulen</name>
<name sortKey="Van Roy, Nadine" sort="Van Roy, Nadine" uniqKey="Van Roy N" first="Nadine" last="Van Roy">Nadine Van Roy</name>
<name sortKey="Van Vlierberghe, Pieter" sort="Van Vlierberghe, Pieter" uniqKey="Van Vlierberghe P" first="Pieter" last="Van Vlierberghe">Pieter Van Vlierberghe</name>
</country>
<country name="Australie"><noRegion><name sortKey="Goossens, Steven" sort="Goossens, Steven" uniqKey="Goossens S" first="Steven" last="Goossens">Steven Goossens</name>
</noRegion>
<name sortKey="Alserihi, Raed" sort="Alserihi, Raed" uniqKey="Alserihi R" first="Raed" last="Alserihi">Raed Alserihi</name>
<name sortKey="Bracken, Lauryn S" sort="Bracken, Lauryn S" uniqKey="Bracken L" first="Lauryn S." last="Bracken">Lauryn S. Bracken</name>
<name sortKey="Carmichael, Catherine" sort="Carmichael, Catherine" uniqKey="Carmichael C" first="Catherine" last="Carmichael">Catherine Carmichael</name>
<name sortKey="Costa, Magdaline" sort="Costa, Magdaline" uniqKey="Costa M" first="Magdaline" last="Costa">Magdaline Costa</name>
<name sortKey="Curtis, David J" sort="Curtis, David J" uniqKey="Curtis D" first="David J." last="Curtis">David J. Curtis</name>
<name sortKey="Haigh, Jody J" sort="Haigh, Jody J" uniqKey="Haigh J" first="Jody J." last="Haigh">Jody J. Haigh</name>
<name sortKey="Haigh, Katharina" sort="Haigh, Katharina" uniqKey="Haigh K" first="Katharina" last="Haigh">Katharina Haigh</name>
<name sortKey="Lock, Richard B" sort="Lock, Richard B" uniqKey="Lock R" first="Richard B." last="Lock">Richard B. Lock</name>
<name sortKey="Mccormack, Matthew P" sort="Mccormack, Matthew P" uniqKey="Mccormack M" first="Matthew P." last="Mccormack">Matthew P. Mccormack</name>
<name sortKey="Rickard, Adam" sort="Rickard, Adam" uniqKey="Rickard A" first="Adam" last="Rickard">Adam Rickard</name>
<name sortKey="Suryani, Santi" sort="Suryani, Santi" uniqKey="Suryani S" first="Santi" last="Suryani">Santi Suryani</name>
<name sortKey="Tremblay, Cedric S" sort="Tremblay, Cedric S" uniqKey="Tremblay C" first="Cedric S." last="Tremblay">Cedric S. Tremblay</name>
</country>
<country name="Italie"><noRegion><name sortKey="Radaelli, Enrico" sort="Radaelli, Enrico" uniqKey="Radaelli E" first="Enrico" last="Radaelli">Enrico Radaelli</name>
</noRegion>
</country>
<country name="France"><noRegion><name sortKey="Blanchet, Odile" sort="Blanchet, Odile" uniqKey="Blanchet O" first="Odile" last="Blanchet">Odile Blanchet</name>
</noRegion>
<name sortKey="Blanchet, Odile" sort="Blanchet, Odile" uniqKey="Blanchet O" first="Odile" last="Blanchet">Odile Blanchet</name>
<name sortKey="Clappier, Emmanuelle" sort="Clappier, Emmanuelle" uniqKey="Clappier E" first="Emmanuelle" last="Clappier">Emmanuelle Clappier</name>
<name sortKey="Clappier, Emmanuelle" sort="Clappier, Emmanuelle" uniqKey="Clappier E" first="Emmanuelle" last="Clappier">Emmanuelle Clappier</name>
<name sortKey="Soulier, Jean" sort="Soulier, Jean" uniqKey="Soulier J" first="Jean" last="Soulier">Jean Soulier</name>
<name sortKey="Soulier, Jean" sort="Soulier, Jean" uniqKey="Soulier J" first="Jean" last="Soulier">Jean Soulier</name>
<name sortKey="Speleman, Frank" sort="Speleman, Frank" uniqKey="Speleman F" first="Frank" last="Speleman">Frank Speleman</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Schwab, Claire" sort="Schwab, Claire" uniqKey="Schwab C" first="Claire" last="Schwab">Claire Schwab</name>
</noRegion>
<name sortKey="Harrison, Christine" sort="Harrison, Christine" uniqKey="Harrison C" first="Christine" last="Harrison">Christine Harrison</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Best, J Adam" sort="Best, J Adam" uniqKey="Best J" first="J. Adam" last="Best">J. Adam Best</name>
</noRegion>
<name sortKey="Goldrath, Ananda W" sort="Goldrath, Ananda W" uniqKey="Goldrath A" first="Ananda W." last="Goldrath">Ananda W. Goldrath</name>
</country>
<country name="Pays-Bas"><noRegion><name sortKey="Cante Barrett, Kirsten" sort="Cante Barrett, Kirsten" uniqKey="Cante Barrett K" first="Kirsten" last="Canté-Barrett">Kirsten Canté-Barrett</name>
</noRegion>
<name sortKey="Huylebroeck, Danny" sort="Huylebroeck, Danny" uniqKey="Huylebroeck D" first="Danny" last="Huylebroeck">Danny Huylebroeck</name>
<name sortKey="Meijerink, Jules P P" sort="Meijerink, Jules P P" uniqKey="Meijerink J" first="Jules P. P." last="Meijerink">Jules P. P. Meijerink</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Janzen, Viktor" sort="Janzen, Viktor" uniqKey="Janzen V" first="Viktor" last="Janzen">Viktor Janzen</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002629 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002629 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4354161
   |texte=   ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:25565005" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.