Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy
Identifieur interne : 002514 ( Main/Exploration ); précédent : 002513; suivant : 002515Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy
Auteurs : Monica Rolando [France] ; Pedro Escoll [France] ; Tamara Nora [France] ; Joëlle Botti [France] ; Valérie Boitez [France] ; Carmen Bedia [France] ; Craig Daniels [Canada] ; Gilu Abraham [Australie] ; Peter J. Stogios [Canada] ; Tatiana Skarina [Canada] ; Charlotte Christophe [France] ; Delphine Dervins-Ravault [France] ; Christel Cazalet [France] ; Hubert Hilbi [Suisse] ; Thusitha W. T. Rupasinghe [Australie] ; Dedreia Tull [Australie] ; Malcolm J. Mcconville [Australie] ; Sze Ying Ong [Australie] ; Elizabeth L. Hartland [Australie] ; Patrice Codogno [France] ; Thierry Levade [France] ; Thomas Naderer [Australie] ; Alexei Savchenko [Canada] ; Carmen Buchrieser [France]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- enzymologie : Legionella pneumophila.
- immunologie : Maladie des légionnaires.
- métabolisme : Aldehyde-lyases, Sphingolipides.
- Aldehyde-lyases, Animaux, Autophagie, Conformation des protéines, Cristallographie aux rayons X, Domaine catalytique, Souris.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Aldehyde-Lyases.
- chemical , metabolism : Aldehyde-Lyases, Sphingolipids.
- enzymology : Legionella pneumophila.
- immunology : Legionnaires' Disease.
- Animals, Autophagy, Catalytic Domain, Crystallography, X-Ray, Mice, Protein Conformation.
Abstract
Url:
DOI: 10.1073/pnas.1522067113
PubMed: 26831115
PubMed Central: 4763766
Affiliations:
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Le document en format XML
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S1P-lyase targets host sphingolipid metabolism and restrains autophagy</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>Legionella pneumophila</italic>
S1P-lyase targets host sphingolipid metabolism and restrains autophagy</title>
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;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Université Paris Descartes-Sorbonne Paris Cité</institution>
, 75993 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bedia, Carmen" sort="Bedia, Carmen" uniqKey="Bedia C" first="Carmen" last="Bedia">Carmen Bedia</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">INSERM UMR1037,<institution>Centre de Recherches en Cancérologie de Toulouse</institution>
, 31432 Toulouse,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Daniels, Craig" sort="Daniels, Craig" uniqKey="Daniels C" first="Craig" last="Daniels">Craig Daniels</name>
<affiliation wicri:level="1"><nlm:aff id="aff6">Department of Chemical Engineering and Applied Chemistry,<institution>University of Toronto</institution>
, Toronto,<country>Canada</country>
M5S 3E5;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Abraham, Gilu" sort="Abraham, Gilu" uniqKey="Abraham G" first="Gilu" last="Abraham">Gilu Abraham</name>
<affiliation wicri:level="1"><nlm:aff id="aff7">Department of Biochemistry and Molecular Biology and the Biomedicine Discovery Institute,<institution>Monash University</institution>
, Clayton, VIC 3800,<country>Australia</country>
;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stogios, Peter J" sort="Stogios, Peter J" uniqKey="Stogios P" first="Peter J." last="Stogios">Peter J. Stogios</name>
<affiliation wicri:level="1"><nlm:aff id="aff6">Department of Chemical Engineering and Applied Chemistry,<institution>University of Toronto</institution>
, Toronto,<country>Canada</country>
M5S 3E5;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Skarina, Tatiana" sort="Skarina, Tatiana" uniqKey="Skarina T" first="Tatiana" last="Skarina">Tatiana Skarina</name>
<affiliation wicri:level="1"><nlm:aff id="aff6">Department of Chemical Engineering and Applied Chemistry,<institution>University of Toronto</institution>
, Toronto,<country>Canada</country>
M5S 3E5;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Christophe, Charlotte" sort="Christophe, Charlotte" uniqKey="Christophe C" first="Charlotte" last="Christophe">Charlotte Christophe</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Institut Pasteur,<institution>Biologie des Bactéries Intracellulaires</institution>
, 75724 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CNRS</institution>
UMR 3525, 75724 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dervins Ravault, Delphine" sort="Dervins Ravault, Delphine" uniqKey="Dervins Ravault D" first="Delphine" last="Dervins-Ravault">Delphine Dervins-Ravault</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Institut Pasteur,<institution>Biologie des Bactéries Intracellulaires</institution>
, 75724 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CNRS</institution>
UMR 3525, 75724 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cazalet, Christel" sort="Cazalet, Christel" uniqKey="Cazalet C" first="Christel" last="Cazalet">Christel Cazalet</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Institut Pasteur,<institution>Biologie des Bactéries Intracellulaires</institution>
, 75724 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CNRS</institution>
UMR 3525, 75724 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hilbi, Hubert" sort="Hilbi, Hubert" uniqKey="Hilbi H" first="Hubert" last="Hilbi">Hubert Hilbi</name>
<affiliation wicri:level="1"><nlm:aff id="aff8">Institute of Medical Microbiology,<institution>University of Zürich</institution>
,<country>8006, Zurich, Switzerland</country>
;</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda</wicri:regionArea>
<wicri:noRegion>Bethesda</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rupasinghe, Thusitha W T" sort="Rupasinghe, Thusitha W T" uniqKey="Rupasinghe T" first="Thusitha W. T." last="Rupasinghe">Thusitha W. T. Rupasinghe</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Metabolomics Australia, Bio21 Molecular Science and Biotechnology Institute,<institution>The University of Melbourne</institution>
, Melbourne, VIC 3010,<country>Australia</country>
;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tull, Dedreia" sort="Tull, Dedreia" uniqKey="Tull D" first="Dedreia" last="Tull">Dedreia Tull</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Metabolomics Australia, Bio21 Molecular Science and Biotechnology Institute,<institution>The University of Melbourne</institution>
, Melbourne, VIC 3010,<country>Australia</country>
;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mcconville, Malcolm J" sort="Mcconville, Malcolm J" uniqKey="Mcconville M" first="Malcolm J." last="Mcconville">Malcolm J. Mcconville</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Metabolomics Australia, Bio21 Molecular Science and Biotechnology Institute,<institution>The University of Melbourne</institution>
, Melbourne, VIC 3010,<country>Australia</country>
;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff10">Department of Biochemistry and Molecular Biology,<institution>The University of Melbourne</institution>
, Melbourne, VIC 3010,<country>Australia</country>
;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ong, Sze Ying" sort="Ong, Sze Ying" uniqKey="Ong S" first="Sze Ying" last="Ong">Sze Ying Ong</name>
<affiliation wicri:level="1"><nlm:aff id="aff11">Department of Microbiology and Immunology,<institution>University of Melbourne at the Peter Doherty Institute for Infection and Immunity</institution>
, Melbourne, VIC 3010,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hartland, Elizabeth L" sort="Hartland, Elizabeth L" uniqKey="Hartland E" first="Elizabeth L." last="Hartland">Elizabeth L. Hartland</name>
<affiliation wicri:level="1"><nlm:aff id="aff11">Department of Microbiology and Immunology,<institution>University of Melbourne at the Peter Doherty Institute for Infection and Immunity</institution>
, Melbourne, VIC 3010,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Codogno, Patrice" sort="Codogno, Patrice" uniqKey="Codogno P" first="Patrice" last="Codogno">Patrice Codogno</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Institut Necker Enfants-Malades</institution>
, INSERM U1151-CNRS UMR 8253, 75993 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Université Paris Descartes-Sorbonne Paris Cité</institution>
, 75993 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Levade, Thierry" sort="Levade, Thierry" uniqKey="Levade T" first="Thierry" last="Levade">Thierry Levade</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">INSERM UMR1037,<institution>Centre de Recherches en Cancérologie de Toulouse</institution>
, 31432 Toulouse,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Naderer, Thomas" sort="Naderer, Thomas" uniqKey="Naderer T" first="Thomas" last="Naderer">Thomas Naderer</name>
<affiliation wicri:level="1"><nlm:aff id="aff7">Department of Biochemistry and Molecular Biology and the Biomedicine Discovery Institute,<institution>Monash University</institution>
, Clayton, VIC 3800,<country>Australia</country>
;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Savchenko, Alexei" sort="Savchenko, Alexei" uniqKey="Savchenko A" first="Alexei" last="Savchenko">Alexei Savchenko</name>
<affiliation wicri:level="1"><nlm:aff id="aff6">Department of Chemical Engineering and Applied Chemistry,<institution>University of Toronto</institution>
, Toronto,<country>Canada</country>
M5S 3E5;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Buchrieser, Carmen" sort="Buchrieser, Carmen" uniqKey="Buchrieser C" first="Carmen" last="Buchrieser">Carmen Buchrieser</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Institut Pasteur,<institution>Biologie des Bactéries Intracellulaires</institution>
, 75724 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CNRS</institution>
UMR 3525, 75724 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title>
<idno type="ISSN">0027-8424</idno>
<idno type="eISSN">1091-6490</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aldehyde-Lyases (chemistry)</term>
<term>Aldehyde-Lyases (metabolism)</term>
<term>Animals</term>
<term>Autophagy</term>
<term>Catalytic Domain</term>
<term>Crystallography, X-Ray</term>
<term>Legionella pneumophila (enzymology)</term>
<term>Legionnaires' Disease (immunology)</term>
<term>Mice</term>
<term>Protein Conformation</term>
<term>Sphingolipids (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Aldehyde-lyases ()</term>
<term>Aldehyde-lyases (métabolisme)</term>
<term>Animaux</term>
<term>Autophagie</term>
<term>Conformation des protéines</term>
<term>Cristallographie aux rayons X</term>
<term>Domaine catalytique</term>
<term>Legionella pneumophila (enzymologie)</term>
<term>Maladie des légionnaires (immunologie)</term>
<term>Souris</term>
<term>Sphingolipides (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Aldehyde-Lyases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Aldehyde-Lyases</term>
<term>Sphingolipids</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Legionella pneumophila</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Legionella pneumophila</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Maladie des légionnaires</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Legionnaires' Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Aldehyde-lyases</term>
<term>Sphingolipides</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Autophagy</term>
<term>Catalytic Domain</term>
<term>Crystallography, X-Ray</term>
<term>Mice</term>
<term>Protein Conformation</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Aldehyde-lyases</term>
<term>Animaux</term>
<term>Autophagie</term>
<term>Conformation des protéines</term>
<term>Cristallographie aux rayons X</term>
<term>Domaine catalytique</term>
<term>Souris</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Significance</title>
<p><italic>Legionella pneumophila</italic>
is the causative agent of Legionnaires’ disease. It translocates a large repertoire of effectors into the host cell through a specialized secretion system to subvert cellular defenses. A key characteristic of this pathogen is that the majority of its effectors are encoded by eukaryotic-like genes acquired through horizontal gene transfer. We determined the crystal structure of one of these effectors, sphingosine-1 phosphate lyase (<italic>Lp</italic>
Spl), and show that it has high similarity with its eukaryotic homologue. We demonstrate that <italic>Lp</italic>
Spl possesses lyase activity and that it disrupts sphingolipid metabolism in the host cells. <italic>Lp</italic>
Spl plays a critical and previously unknown role in decreasing autophagy and is a unique virulence factor facilitating intracellular replication of <italic>L. pneumophila</italic>
.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Canada</li>
<li>France</li>
<li>Suisse</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Rolando, Monica" sort="Rolando, Monica" uniqKey="Rolando M" first="Monica" last="Rolando">Monica Rolando</name>
</noRegion>
<name sortKey="Bedia, Carmen" sort="Bedia, Carmen" uniqKey="Bedia C" first="Carmen" last="Bedia">Carmen Bedia</name>
<name sortKey="Boitez, Valerie" sort="Boitez, Valerie" uniqKey="Boitez V" first="Valérie" last="Boitez">Valérie Boitez</name>
<name sortKey="Boitez, Valerie" sort="Boitez, Valerie" uniqKey="Boitez V" first="Valérie" last="Boitez">Valérie Boitez</name>
<name sortKey="Botti, Joelle" sort="Botti, Joelle" uniqKey="Botti J" first="Joëlle" last="Botti">Joëlle Botti</name>
<name sortKey="Botti, Joelle" sort="Botti, Joelle" uniqKey="Botti J" first="Joëlle" last="Botti">Joëlle Botti</name>
<name sortKey="Buchrieser, Carmen" sort="Buchrieser, Carmen" uniqKey="Buchrieser C" first="Carmen" last="Buchrieser">Carmen Buchrieser</name>
<name sortKey="Buchrieser, Carmen" sort="Buchrieser, Carmen" uniqKey="Buchrieser C" first="Carmen" last="Buchrieser">Carmen Buchrieser</name>
<name sortKey="Cazalet, Christel" sort="Cazalet, Christel" uniqKey="Cazalet C" first="Christel" last="Cazalet">Christel Cazalet</name>
<name sortKey="Cazalet, Christel" sort="Cazalet, Christel" uniqKey="Cazalet C" first="Christel" last="Cazalet">Christel Cazalet</name>
<name sortKey="Christophe, Charlotte" sort="Christophe, Charlotte" uniqKey="Christophe C" first="Charlotte" last="Christophe">Charlotte Christophe</name>
<name sortKey="Christophe, Charlotte" sort="Christophe, Charlotte" uniqKey="Christophe C" first="Charlotte" last="Christophe">Charlotte Christophe</name>
<name sortKey="Codogno, Patrice" sort="Codogno, Patrice" uniqKey="Codogno P" first="Patrice" last="Codogno">Patrice Codogno</name>
<name sortKey="Codogno, Patrice" sort="Codogno, Patrice" uniqKey="Codogno P" first="Patrice" last="Codogno">Patrice Codogno</name>
<name sortKey="Dervins Ravault, Delphine" sort="Dervins Ravault, Delphine" uniqKey="Dervins Ravault D" first="Delphine" last="Dervins-Ravault">Delphine Dervins-Ravault</name>
<name sortKey="Dervins Ravault, Delphine" sort="Dervins Ravault, Delphine" uniqKey="Dervins Ravault D" first="Delphine" last="Dervins-Ravault">Delphine Dervins-Ravault</name>
<name sortKey="Escoll, Pedro" sort="Escoll, Pedro" uniqKey="Escoll P" first="Pedro" last="Escoll">Pedro Escoll</name>
<name sortKey="Escoll, Pedro" sort="Escoll, Pedro" uniqKey="Escoll P" first="Pedro" last="Escoll">Pedro Escoll</name>
<name sortKey="Levade, Thierry" sort="Levade, Thierry" uniqKey="Levade T" first="Thierry" last="Levade">Thierry Levade</name>
<name sortKey="Nora, Tamara" sort="Nora, Tamara" uniqKey="Nora T" first="Tamara" last="Nora">Tamara Nora</name>
<name sortKey="Nora, Tamara" sort="Nora, Tamara" uniqKey="Nora T" first="Tamara" last="Nora">Tamara Nora</name>
<name sortKey="Rolando, Monica" sort="Rolando, Monica" uniqKey="Rolando M" first="Monica" last="Rolando">Monica Rolando</name>
</country>
<country name="Canada"><noRegion><name sortKey="Daniels, Craig" sort="Daniels, Craig" uniqKey="Daniels C" first="Craig" last="Daniels">Craig Daniels</name>
</noRegion>
<name sortKey="Savchenko, Alexei" sort="Savchenko, Alexei" uniqKey="Savchenko A" first="Alexei" last="Savchenko">Alexei Savchenko</name>
<name sortKey="Skarina, Tatiana" sort="Skarina, Tatiana" uniqKey="Skarina T" first="Tatiana" last="Skarina">Tatiana Skarina</name>
<name sortKey="Stogios, Peter J" sort="Stogios, Peter J" uniqKey="Stogios P" first="Peter J." last="Stogios">Peter J. Stogios</name>
</country>
<country name="Australie"><noRegion><name sortKey="Abraham, Gilu" sort="Abraham, Gilu" uniqKey="Abraham G" first="Gilu" last="Abraham">Gilu Abraham</name>
</noRegion>
<name sortKey="Hartland, Elizabeth L" sort="Hartland, Elizabeth L" uniqKey="Hartland E" first="Elizabeth L." last="Hartland">Elizabeth L. Hartland</name>
<name sortKey="Mcconville, Malcolm J" sort="Mcconville, Malcolm J" uniqKey="Mcconville M" first="Malcolm J." last="Mcconville">Malcolm J. Mcconville</name>
<name sortKey="Mcconville, Malcolm J" sort="Mcconville, Malcolm J" uniqKey="Mcconville M" first="Malcolm J." last="Mcconville">Malcolm J. Mcconville</name>
<name sortKey="Naderer, Thomas" sort="Naderer, Thomas" uniqKey="Naderer T" first="Thomas" last="Naderer">Thomas Naderer</name>
<name sortKey="Ong, Sze Ying" sort="Ong, Sze Ying" uniqKey="Ong S" first="Sze Ying" last="Ong">Sze Ying Ong</name>
<name sortKey="Rupasinghe, Thusitha W T" sort="Rupasinghe, Thusitha W T" uniqKey="Rupasinghe T" first="Thusitha W. T." last="Rupasinghe">Thusitha W. T. Rupasinghe</name>
<name sortKey="Tull, Dedreia" sort="Tull, Dedreia" uniqKey="Tull D" first="Dedreia" last="Tull">Dedreia Tull</name>
</country>
<country name="Suisse"><noRegion><name sortKey="Hilbi, Hubert" sort="Hilbi, Hubert" uniqKey="Hilbi H" first="Hubert" last="Hilbi">Hubert Hilbi</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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