A Phase II Trial of the Multitargeted Tyrosine Kinase Inhibitor Lenvatinib (E7080) in Advanced Medullary Thyroid Cancer.
Identifieur interne : 002489 ( Main/Exploration ); précédent : 002488; suivant : 002490A Phase II Trial of the Multitargeted Tyrosine Kinase Inhibitor Lenvatinib (E7080) in Advanced Medullary Thyroid Cancer.
Auteurs : Martin Schlumberger [France] ; Barbara Jarzab [Pologne] ; Maria E. Cabanillas [États-Unis] ; Bruce Robinson [Australie] ; Furio Pacini [Italie] ; Douglas W. Ball [États-Unis] ; Judith Mccaffrey [États-Unis] ; Kate Newbold [Royaume-Uni] ; Roger Allison [Australie] ; Renato G. Martins [États-Unis] ; Lisa F. Licitra [Italie] ; Manisha H. Shah [États-Unis] ; Donald Bodenner [États-Unis] ; Rossella Elisei [Italie] ; Lynn Burmeister [États-Unis] ; Yasuhiro Funahashi [États-Unis] ; Min Ren [États-Unis] ; James P. O'Brien [États-Unis] ; Steven I. Sherman [États-Unis]Source :
- Clinical cancer research : an official journal of the American Association for Cancer Research [ 1078-0432 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Antinéoplasiques (pharmacologie), Antinéoplasiques (usage thérapeutique), Carcinome neuroendocrine (anatomopathologie), Carcinome neuroendocrine (sang), Carcinome neuroendocrine (traitement médicamenteux), Femelle, Humains, Inhibiteurs de protéines kinases (pharmacologie), Inhibiteurs de protéines kinases (usage thérapeutique), Jeune adulte, Marqueurs biologiques, Mâle, Métastase tumorale, Phénylurées (pharmacologie), Phénylurées (usage thérapeutique), Quinoléines (pharmacologie), Quinoléines (usage thérapeutique), Reprise du traitement, Résultat thérapeutique, Stade de la tumeur, Sujet âgé, Thérapie moléculaire ciblée, Tumeurs de la thyroïde (anatomopathologie), Tumeurs de la thyroïde (sang), Tumeurs de la thyroïde (traitement médicamenteux), Évolution de la maladie.
- MESH :
- anatomopathologie : Carcinome neuroendocrine, Tumeurs de la thyroïde.
- pharmacologie : Antinéoplasiques, Inhibiteurs de protéines kinases, Phénylurées, Quinoléines.
- sang : Carcinome neuroendocrine, Tumeurs de la thyroïde.
- traitement médicamenteux : Carcinome neuroendocrine, Tumeurs de la thyroïde.
- usage thérapeutique : Antinéoplasiques, Inhibiteurs de protéines kinases, Phénylurées, Quinoléines.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Jeune adulte, Marqueurs biologiques, Mâle, Métastase tumorale, Reprise du traitement, Résultat thérapeutique, Stade de la tumeur, Sujet âgé, Thérapie moléculaire ciblée, Évolution de la maladie.
English descriptors
- KwdEn :
- Adult, Aged, Antineoplastic Agents (pharmacology), Antineoplastic Agents (therapeutic use), Biomarkers, Carcinoma, Neuroendocrine (blood), Carcinoma, Neuroendocrine (drug therapy), Carcinoma, Neuroendocrine (pathology), Disease Progression, Female, Humans, Male, Middle Aged, Molecular Targeted Therapy, Neoplasm Metastasis, Neoplasm Staging, Phenylurea Compounds (pharmacology), Phenylurea Compounds (therapeutic use), Protein Kinase Inhibitors (pharmacology), Protein Kinase Inhibitors (therapeutic use), Quinolines (pharmacology), Quinolines (therapeutic use), Retreatment, Thyroid Neoplasms (blood), Thyroid Neoplasms (drug therapy), Thyroid Neoplasms (pathology), Treatment Outcome, Young Adult.
- MESH :
- chemical , pharmacology : Antineoplastic Agents, Phenylurea Compounds, Protein Kinase Inhibitors, Quinolines.
- chemical , therapeutic use : Antineoplastic Agents, Phenylurea Compounds, Protein Kinase Inhibitors, Quinolines.
- blood : Carcinoma, Neuroendocrine, Thyroid Neoplasms.
- drug therapy : Carcinoma, Neuroendocrine, Thyroid Neoplasms.
- pathology : Carcinoma, Neuroendocrine, Thyroid Neoplasms.
- Adult, Aged, Biomarkers, Disease Progression, Female, Humans, Male, Middle Aged, Molecular Targeted Therapy, Neoplasm Metastasis, Neoplasm Staging, Retreatment, Treatment Outcome, Young Adult.
Abstract
Positive results of phase I studies evaluating lenvatinib in solid tumors, including thyroid cancer, prompted a phase II trial in advanced medullary thyroid carcinoma (MTC).
DOI: 10.1158/1078-0432.CCR-15-1127
PubMed: 26311725
Affiliations:
- Australie, France, Italie, Pologne, Royaume-Uni, États-Unis
- Angleterre, Arkansas, Floride, Grand Londres, Lombardie, Maryland, Massachusetts, Minnesota, New Jersey, Nouvelle-Galles du Sud, Ohio, Texas, Toscane, Washington (État)
- Londres, Milan, Pise, Sydney
- Université de Pise
Links toward previous steps (curation, corpus...)
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- to stream PubMed, to step Checkpoint: 002386
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- to stream Main, to step Curation: 002489
Le document en format XML
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Lee Moffitt Cancer Center and Research Institute, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Newbold, Kate" sort="Newbold, Kate" uniqKey="Newbold K" first="Kate" last="Newbold">Kate Newbold</name><affiliation wicri:level="3"><nlm:affiliation>NIHR Royal Marsden Hospital and Institute of Cancer Research BRC, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Royal Marsden Hospital and Institute of Cancer Research BRC, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Allison, Roger" sort="Allison, Roger" uniqKey="Allison R" first="Roger" last="Allison">Roger Allison</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Care Services, The Royal Brisbane and Women's Hospital, Herston, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Care Services, The Royal Brisbane and Women's Hospital, Herston</wicri:regionArea><wicri:noRegion>Herston</wicri:noRegion></affiliation></author><author><name sortKey="Martins, Renato G" sort="Martins, Renato G" uniqKey="Martins R" first="Renato G" last="Martins">Renato G. 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Sherman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26311725</idno><idno type="pmid">26311725</idno><idno type="doi">10.1158/1078-0432.CCR-15-1127</idno><idno type="wicri:Area/PubMed/Corpus">002432</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002432</idno><idno type="wicri:Area/PubMed/Curation">002386</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002386</idno><idno type="wicri:Area/PubMed/Checkpoint">002386</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002386</idno><idno type="wicri:Area/Ncbi/Merge">002986</idno><idno type="wicri:Area/Ncbi/Curation">002986</idno><idno type="wicri:Area/Ncbi/Checkpoint">002986</idno><idno type="wicri:doubleKey">1078-0432:2016:Schlumberger M:a:phase:ii</idno><idno type="wicri:Area/Main/Merge">002488</idno><idno type="wicri:Area/Main/Curation">002489</idno><idno type="wicri:Area/Main/Exploration">002489</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A Phase II Trial of the Multitargeted Tyrosine Kinase Inhibitor Lenvatinib (E7080) in Advanced Medullary Thyroid Cancer.</title><author><name sortKey="Schlumberger, Martin" sort="Schlumberger, Martin" uniqKey="Schlumberger M" first="Martin" last="Schlumberger">Martin Schlumberger</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nuclear Medicine and Endocrine Oncology, Institut Gustave-Roussy and University Paris-Sud, Villejuif, France. martin.schlumberger@gustaveroussy.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nuclear Medicine and Endocrine Oncology, Institut Gustave-Roussy and University Paris-Sud, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Jarzab, Barbara" sort="Jarzab, Barbara" uniqKey="Jarzab B" first="Barbara" last="Jarzab">Barbara Jarzab</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nuclear Medicine and Endocrine Oncology, Centrum Onkologii Instytut im. M. Sklodowskiei-Curie, Gliwice, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Nuclear Medicine and Endocrine Oncology, Centrum Onkologii Instytut im. M. Sklodowskiei-Curie, Gliwice</wicri:regionArea><wicri:noRegion>Gliwice</wicri:noRegion></affiliation></author><author><name sortKey="Cabanillas, Maria E" sort="Cabanillas, Maria E" uniqKey="Cabanillas M" first="Maria E" last="Cabanillas">Maria E. Cabanillas</name><affiliation wicri:level="2"><nlm:affiliation>Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Robinson, Bruce" sort="Robinson, Bruce" uniqKey="Robinson B" first="Bruce" last="Robinson">Bruce Robinson</name><affiliation wicri:level="3"><nlm:affiliation>Department of Endocrinology, Royal North Shore Hospital, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Endocrinology, Royal North Shore Hospital, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Pacini, Furio" sort="Pacini, Furio" uniqKey="Pacini F" first="Furio" last="Pacini">Furio Pacini</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical, Surgical and Neurological Sciences, Azienda Ospedaliera Universitaria Senese, Siena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical, Surgical and Neurological Sciences, Azienda Ospedaliera Universitaria Senese, Siena</wicri:regionArea><wicri:noRegion>Siena</wicri:noRegion></affiliation></author><author><name sortKey="Ball, Douglas W" sort="Ball, Douglas W" uniqKey="Ball D" first="Douglas W" last="Ball">Douglas W. Ball</name><affiliation wicri:level="2"><nlm:affiliation>Division of Endocrinology and Metabolism, Johns Hopkins Medical Institute, Baltimore, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Endocrinology and Metabolism, Johns Hopkins Medical Institute, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Mccaffrey, Judith" sort="Mccaffrey, Judith" uniqKey="Mccaffrey J" first="Judith" last="Mccaffrey">Judith Mccaffrey</name><affiliation wicri:level="2"><nlm:affiliation>Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Newbold, Kate" sort="Newbold, Kate" uniqKey="Newbold K" first="Kate" last="Newbold">Kate Newbold</name><affiliation wicri:level="3"><nlm:affiliation>NIHR Royal Marsden Hospital and Institute of Cancer Research BRC, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Royal Marsden Hospital and Institute of Cancer Research BRC, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Allison, Roger" sort="Allison, Roger" uniqKey="Allison R" first="Roger" last="Allison">Roger Allison</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Care Services, The Royal Brisbane and Women's Hospital, Herston, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Care Services, The Royal Brisbane and Women's Hospital, Herston</wicri:regionArea><wicri:noRegion>Herston</wicri:noRegion></affiliation></author><author><name sortKey="Martins, Renato G" sort="Martins, Renato G" uniqKey="Martins R" first="Renato G" last="Martins">Renato G. Martins</name><affiliation wicri:level="2"><nlm:affiliation>Division of Clinical Research, Seattle Cancer Care Alliance, Seattle, Washington.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Division of Clinical Research, Seattle Cancer Care Alliance, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Licitra, Lisa F" sort="Licitra, Lisa F" uniqKey="Licitra L" first="Lisa F" last="Licitra">Lisa F. Licitra</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Shah, Manisha H" sort="Shah, Manisha H" uniqKey="Shah M" first="Manisha H" last="Shah">Manisha H. Shah</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medical Oncology, The Ohio State University School of Medicine, Columbus, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Medical Oncology, The Ohio State University School of Medicine, Columbus</wicri:cityArea></affiliation></author><author><name sortKey="Bodenner, Donald" sort="Bodenner, Donald" uniqKey="Bodenner D" first="Donald" last="Bodenner">Donald Bodenner</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, University of Arkansas, Little Rock, Arkansas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arkansas</region></placeName><wicri:cityArea>Department of Otolaryngology-Head and Neck Surgery, University of Arkansas, Little Rock</wicri:cityArea></affiliation></author><author><name sortKey="Elisei, Rossella" sort="Elisei, Rossella" uniqKey="Elisei R" first="Rossella" last="Elisei">Rossella Elisei</name><affiliation wicri:level="4"><nlm:affiliation>Endocrine Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Endocrine Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region nuts="2">Toscane</region><settlement type="city">Pise</settlement></placeName><orgName type="university">Université de Pise</orgName></affiliation></author><author><name sortKey="Burmeister, Lynn" sort="Burmeister, Lynn" uniqKey="Burmeister L" first="Lynn" last="Burmeister">Lynn Burmeister</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Minnesota, Minneapolis, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Medicine, University of Minnesota, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Funahashi, Yasuhiro" sort="Funahashi, Yasuhiro" uniqKey="Funahashi Y" first="Yasuhiro" last="Funahashi">Yasuhiro Funahashi</name><affiliation wicri:level="2"><nlm:affiliation>Eisai, Andover, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Eisai, Andover</wicri:cityArea></affiliation></author><author><name sortKey="Ren, Min" sort="Ren, Min" uniqKey="Ren M" first="Min" last="Ren">Min Ren</name><affiliation wicri:level="2"><nlm:affiliation>Eisai Inc., Woodcliff Lake, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Eisai Inc., Woodcliff Lake</wicri:cityArea></affiliation></author><author><name sortKey="O Brien, James P" sort="O Brien, James P" uniqKey="O Brien J" first="James P" last="O'Brien">James P. O'Brien</name><affiliation wicri:level="2"><nlm:affiliation>Eisai Inc., Woodcliff Lake, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Eisai Inc., Woodcliff Lake</wicri:cityArea></affiliation></author><author><name sortKey="Sherman, Steven I" sort="Sherman, Steven I" uniqKey="Sherman S" first="Steven I" last="Sherman">Steven I. Sherman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author></analytic><series><title level="j">Clinical cancer research : an official journal of the American Association for Cancer Research</title><idno type="ISSN">1078-0432</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Antineoplastic Agents (pharmacology)</term><term>Antineoplastic Agents (therapeutic use)</term><term>Biomarkers</term><term>Carcinoma, Neuroendocrine (blood)</term><term>Carcinoma, Neuroendocrine (drug therapy)</term><term>Carcinoma, Neuroendocrine (pathology)</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Molecular Targeted Therapy</term><term>Neoplasm Metastasis</term><term>Neoplasm Staging</term><term>Phenylurea Compounds (pharmacology)</term><term>Phenylurea Compounds (therapeutic use)</term><term>Protein Kinase Inhibitors (pharmacology)</term><term>Protein Kinase Inhibitors (therapeutic use)</term><term>Quinolines (pharmacology)</term><term>Quinolines (therapeutic use)</term><term>Retreatment</term><term>Thyroid Neoplasms (blood)</term><term>Thyroid Neoplasms (drug therapy)</term><term>Thyroid Neoplasms (pathology)</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antinéoplasiques (pharmacologie)</term><term>Antinéoplasiques (usage thérapeutique)</term><term>Carcinome neuroendocrine (anatomopathologie)</term><term>Carcinome neuroendocrine (sang)</term><term>Carcinome neuroendocrine (traitement médicamenteux)</term><term>Femelle</term><term>Humains</term><term>Inhibiteurs de protéines kinases (pharmacologie)</term><term>Inhibiteurs de protéines kinases (usage thérapeutique)</term><term>Jeune adulte</term><term>Marqueurs biologiques</term><term>Mâle</term><term>Métastase tumorale</term><term>Phénylurées (pharmacologie)</term><term>Phénylurées (usage thérapeutique)</term><term>Quinoléines (pharmacologie)</term><term>Quinoléines (usage thérapeutique)</term><term>Reprise du traitement</term><term>Résultat thérapeutique</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Thérapie moléculaire ciblée</term><term>Tumeurs de la thyroïde (anatomopathologie)</term><term>Tumeurs de la thyroïde (sang)</term><term>Tumeurs de la thyroïde (traitement médicamenteux)</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antineoplastic Agents</term><term>Phenylurea Compounds</term><term>Protein Kinase Inhibitors</term><term>Quinolines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Agents</term><term>Phenylurea Compounds</term><term>Protein Kinase Inhibitors</term><term>Quinolines</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome neuroendocrine</term><term>Tumeurs de la thyroïde</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Carcinoma, Neuroendocrine</term><term>Thyroid Neoplasms</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Carcinoma, Neuroendocrine</term><term>Thyroid Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Neuroendocrine</term><term>Thyroid Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antinéoplasiques</term><term>Inhibiteurs de protéines kinases</term><term>Phénylurées</term><term>Quinoléines</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Carcinome neuroendocrine</term><term>Tumeurs de la thyroïde</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Carcinome neuroendocrine</term><term>Tumeurs de la thyroïde</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antinéoplasiques</term><term>Inhibiteurs de protéines kinases</term><term>Phénylurées</term><term>Quinoléines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Biomarkers</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Molecular Targeted Therapy</term><term>Neoplasm Metastasis</term><term>Neoplasm Staging</term><term>Retreatment</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Marqueurs biologiques</term><term>Mâle</term><term>Métastase tumorale</term><term>Reprise du traitement</term><term>Résultat thérapeutique</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Thérapie moléculaire ciblée</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Positive results of phase I studies evaluating lenvatinib in solid tumors, including thyroid cancer, prompted a phase II trial in advanced medullary thyroid carcinoma (MTC).</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Italie</li><li>Pologne</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Arkansas</li><li>Floride</li><li>Grand Londres</li><li>Lombardie</li><li>Maryland</li><li>Massachusetts</li><li>Minnesota</li><li>New Jersey</li><li>Nouvelle-Galles du Sud</li><li>Ohio</li><li>Texas</li><li>Toscane</li><li>Washington (État)</li></region><settlement><li>Londres</li><li>Milan</li><li>Pise</li><li>Sydney</li></settlement><orgName><li>Université de Pise</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Schlumberger, Martin" sort="Schlumberger, Martin" uniqKey="Schlumberger M" first="Martin" last="Schlumberger">Martin Schlumberger</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Jarzab, Barbara" sort="Jarzab, Barbara" uniqKey="Jarzab B" first="Barbara" last="Jarzab">Barbara Jarzab</name></noRegion></country><country name="États-Unis"><region name="Texas"><name sortKey="Cabanillas, Maria E" sort="Cabanillas, Maria E" uniqKey="Cabanillas M" first="Maria E" last="Cabanillas">Maria E. Cabanillas</name></region><name sortKey="Ball, Douglas W" sort="Ball, Douglas W" uniqKey="Ball D" first="Douglas W" last="Ball">Douglas W. Ball</name><name sortKey="Bodenner, Donald" sort="Bodenner, Donald" uniqKey="Bodenner D" first="Donald" last="Bodenner">Donald Bodenner</name><name sortKey="Burmeister, Lynn" sort="Burmeister, Lynn" uniqKey="Burmeister L" first="Lynn" last="Burmeister">Lynn Burmeister</name><name sortKey="Funahashi, Yasuhiro" sort="Funahashi, Yasuhiro" uniqKey="Funahashi Y" first="Yasuhiro" last="Funahashi">Yasuhiro Funahashi</name><name sortKey="Martins, Renato G" sort="Martins, Renato G" uniqKey="Martins R" first="Renato G" last="Martins">Renato G. Martins</name><name sortKey="Mccaffrey, Judith" sort="Mccaffrey, Judith" uniqKey="Mccaffrey J" first="Judith" last="Mccaffrey">Judith Mccaffrey</name><name sortKey="O Brien, James P" sort="O Brien, James P" uniqKey="O Brien J" first="James P" last="O'Brien">James P. O'Brien</name><name sortKey="Ren, Min" sort="Ren, Min" uniqKey="Ren M" first="Min" last="Ren">Min Ren</name><name sortKey="Shah, Manisha H" sort="Shah, Manisha H" uniqKey="Shah M" first="Manisha H" last="Shah">Manisha H. Shah</name><name sortKey="Sherman, Steven I" sort="Sherman, Steven I" uniqKey="Sherman S" first="Steven I" last="Sherman">Steven I. Sherman</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Robinson, Bruce" sort="Robinson, Bruce" uniqKey="Robinson B" first="Bruce" last="Robinson">Bruce Robinson</name></region><name sortKey="Allison, Roger" sort="Allison, Roger" uniqKey="Allison R" first="Roger" last="Allison">Roger Allison</name></country><country name="Italie"><noRegion><name sortKey="Pacini, Furio" sort="Pacini, Furio" uniqKey="Pacini F" first="Furio" last="Pacini">Furio Pacini</name></noRegion><name sortKey="Elisei, Rossella" sort="Elisei, Rossella" uniqKey="Elisei R" first="Rossella" last="Elisei">Rossella Elisei</name><name sortKey="Licitra, Lisa F" sort="Licitra, Lisa F" uniqKey="Licitra L" first="Lisa F" last="Licitra">Lisa F. Licitra</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Newbold, Kate" sort="Newbold, Kate" uniqKey="Newbold K" first="Kate" last="Newbold">Kate Newbold</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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