Genetic variants linked to education predict longevity
Identifieur interne : 001E46 ( Main/Exploration ); précédent : 001E45; suivant : 001E47Genetic variants linked to education predict longevity
Auteurs : Riccardo E. Marioni [Royaume-Uni, Australie] ; Stuart J. Ritchie [Royaume-Uni] ; Peter K. Joshi [Royaume-Uni] ; Saskia P. Hagenaars [Royaume-Uni] ; Aysu Okbay [Pays-Bas] ; Krista Fischer [Estonie] ; Mark J. Adams [Royaume-Uni] ; W. David Hill [Royaume-Uni] ; Gail Davies [Royaume-Uni] ; Reka Nagy [Royaume-Uni] ; Carmen Amador [Royaume-Uni] ; Kristi L Ll [Estonie] ; Andres Metspalu [Estonie] ; David C. Liewald [Royaume-Uni] ; Archie Campbell [Royaume-Uni] ; James F. Wilson [Royaume-Uni] ; Caroline Hayward [Royaume-Uni] ; T Nu Esko [Estonie] ; David J. Porteous [Royaume-Uni] ; Catharine R. Gale [Royaume-Uni] ; Ian J. Deary [Royaume-Uni]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2016.
Abstract
Individuals with more education tend to live longer. Genetic variants have been discovered that predict educational attainment. We tested whether a “polygenic score” based on these genetic variants could make predictions about people’s lifespan. We used data from three cohort studies (including >130,000 participants) to examine the link between offspring polygenic score for education and parental longevity. Across the studies, we found that participants with more education-linked genetic variants had longer-living parents; compared with those with the lowest genetic education scores, those with the highest scores had parents who lived on average 6 months longer. This finding suggests the hypothesis that part of the ultimate explanation for the extended longevity of better-educated people is an underlying, quantifiable, genetic propensity.
Url:
DOI: 10.1073/pnas.1605334113
PubMed: 27799538
PubMed Central: 5127357
Affiliations:
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Marioni</name><affiliation wicri:level="1"><nlm:aff id="aff188">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff189">Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine,<institution>University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff190">Institute for Molecular Bioscience,<institution>University of Queensland</institution>, Brisbane, QLD 4072,<country>Australia</country>;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ritchie, Stuart J" sort="Ritchie, Stuart J" uniqKey="Ritchie S" first="Stuart J." last="Ritchie">Stuart J. 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Adams</name><affiliation wicri:level="1"><nlm:aff id="aff193">Division of Psychiatry,<institution>University of Edinburgh</institution>, Edinburgh EH8 9YL,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hill, W David" sort="Hill, W David" uniqKey="Hill W" first="W. David" last="Hill">W. David Hill</name><affiliation wicri:level="1"><nlm:aff id="aff188">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff191">Department of Psychology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Davies, Gail" sort="Davies, Gail" uniqKey="Davies G" first="Gail" last="Davies">Gail Davies</name><affiliation wicri:level="1"><nlm:aff id="aff188">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff191">Department of Psychology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nagy, Reka" sort="Nagy, Reka" uniqKey="Nagy R" first="Reka" last="Nagy">Reka Nagy</name><affiliation wicri:level="1"><nlm:aff id="aff198">Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine,<institution>University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Amador, Carmen" sort="Amador, Carmen" uniqKey="Amador C" first="Carmen" last="Amador">Carmen Amador</name><affiliation wicri:level="1"><nlm:aff id="aff198">Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine,<institution>University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="L Ll, Kristi" sort="L Ll, Kristi" uniqKey="L Ll K" first="Kristi" last="L Ll">Kristi L Ll</name><affiliation wicri:level="1"><nlm:aff id="aff197">Estonian Genome Center,<institution>University of Tartu</institution>, Tartu 51010,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff199">Institute of Mathematical Statistics,<institution>University of Tartu</institution>, Tartu 50409,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation wicri:level="1"><nlm:aff id="aff197">Estonian Genome Center,<institution>University of Tartu</institution>, Tartu 51010,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liewald, David C" sort="Liewald, David C" uniqKey="Liewald D" first="David C." last="Liewald">David C. Liewald</name><affiliation wicri:level="1"><nlm:aff id="aff188">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff191">Department of Psychology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Campbell, Archie" sort="Campbell, Archie" uniqKey="Campbell A" first="Archie" last="Campbell">Archie Campbell</name><affiliation wicri:level="1"><nlm:aff id="aff189">Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine,<institution>University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation wicri:level="1"><nlm:aff id="aff192">Usher Institute for Population Health Sciences and Informatics,<institution>University of Edinburgh</institution>, Edinburgh EH16 4UX,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff198">Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine,<institution>University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation wicri:level="1"><nlm:aff id="aff198">Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine,<institution>University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation wicri:level="1"><nlm:aff id="aff197">Estonian Genome Center,<institution>University of Tartu</institution>, Tartu 51010,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff199">Institute of Mathematical Statistics,<institution>University of Tartu</institution>, Tartu 50409,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="aff200"><institution>Broad Institute</institution>, Cambridge,<addr-line>MA</addr-line> 02142;</nlm:aff></affiliation><affiliation><nlm:aff id="aff201">Department of Endocrinology,<institution>Children’s Hospital Boston</institution>, Boston,<addr-line>MA</addr-line> 02115;</nlm:aff></affiliation></author><author><name sortKey="Porteous, David J" sort="Porteous, David J" uniqKey="Porteous D" first="David J." last="Porteous">David J. Porteous</name><affiliation wicri:level="1"><nlm:aff id="aff188">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff189">Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine,<institution>University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gale, Catharine R" sort="Gale, Catharine R" uniqKey="Gale C" first="Catharine R." last="Gale">Catharine R. Gale</name><affiliation wicri:level="1"><nlm:aff id="aff188">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff191">Department of Psychology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff202">Medical Research Council Lifecourse Epidemiology Unit,<institution>University of Southampton</institution>, Southampton SO17 1BJ,<country>United Kingdom</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><affiliation wicri:level="1"><nlm:aff id="aff188">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff191">Department of Psychology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27799538</idno><idno type="pmc">5127357</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127357</idno><idno type="RBID">PMC:5127357</idno><idno type="doi">10.1073/pnas.1605334113</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001C09</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C09</idno><idno type="wicri:Area/Pmc/Curation">001A67</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001A67</idno><idno type="wicri:Area/Pmc/Checkpoint">000912</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000912</idno><idno type="wicri:Area/Ncbi/Merge">003E04</idno><idno type="wicri:Area/Ncbi/Curation">003E04</idno><idno type="wicri:Area/Ncbi/Checkpoint">003E04</idno><idno type="wicri:doubleKey">0027-8424:2016:Marioni R:genetic:variants:linked</idno><idno type="wicri:Area/Main/Merge">001E44</idno><idno type="wicri:Area/Main/Curation">001E46</idno><idno type="wicri:Area/Main/Exploration">001E46</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genetic variants linked to education predict longevity</title><author><name sortKey="Marioni, Riccardo E" sort="Marioni, Riccardo E" uniqKey="Marioni R" first="Riccardo E." last="Marioni">Riccardo E. Marioni</name><affiliation wicri:level="1"><nlm:aff id="aff188">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff189">Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine,<institution>University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff190">Institute for Molecular Bioscience,<institution>University of Queensland</institution>, Brisbane, QLD 4072,<country>Australia</country>;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ritchie, Stuart J" sort="Ritchie, Stuart J" uniqKey="Ritchie S" first="Stuart J." last="Ritchie">Stuart J. Ritchie</name><affiliation wicri:level="1"><nlm:aff id="aff188">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff191">Department of Psychology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Joshi, Peter K" sort="Joshi, Peter K" uniqKey="Joshi P" first="Peter K." last="Joshi">Peter K. Joshi</name><affiliation wicri:level="1"><nlm:aff id="aff192">Usher Institute for Population Health Sciences and Informatics,<institution>University of Edinburgh</institution>, Edinburgh EH16 4UX,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hagenaars, Saskia P" sort="Hagenaars, Saskia P" uniqKey="Hagenaars S" first="Saskia P." last="Hagenaars">Saskia P. Hagenaars</name><affiliation wicri:level="1"><nlm:aff id="aff188">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff191">Department of Psychology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff193">Division of Psychiatry,<institution>University of Edinburgh</institution>, Edinburgh EH8 9YL,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Okbay, Aysu" sort="Okbay, Aysu" uniqKey="Okbay A" first="Aysu" last="Okbay">Aysu Okbay</name><affiliation wicri:level="1"><nlm:aff id="aff194">Department of Applied Economics, Erasmus School of Economics,<institution>Erasmus University</institution>, 3062 PA Rotterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff195">Department of Epidemiology,<institution>Erasmus Medical Center</institution>, 3015 CE Rotterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff196"><institution>Erasmus University Rotterdam Institute for Behavior and Biology</institution>, Rotterdam 3062 PA,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><affiliation wicri:level="1"><nlm:aff id="aff197">Estonian Genome Center,<institution>University of Tartu</institution>, Tartu 51010,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Adams, Mark J" sort="Adams, Mark J" uniqKey="Adams M" first="Mark J." last="Adams">Mark J. Adams</name><affiliation wicri:level="1"><nlm:aff id="aff193">Division of Psychiatry,<institution>University of Edinburgh</institution>, Edinburgh EH8 9YL,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hill, W David" sort="Hill, W David" uniqKey="Hill W" first="W. David" last="Hill">W. David Hill</name><affiliation wicri:level="1"><nlm:aff id="aff188">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff191">Department of Psychology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Davies, Gail" sort="Davies, Gail" uniqKey="Davies G" first="Gail" last="Davies">Gail Davies</name><affiliation wicri:level="1"><nlm:aff id="aff188">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff191">Department of Psychology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nagy, Reka" sort="Nagy, Reka" uniqKey="Nagy R" first="Reka" last="Nagy">Reka Nagy</name><affiliation wicri:level="1"><nlm:aff id="aff198">Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine,<institution>University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Amador, Carmen" sort="Amador, Carmen" uniqKey="Amador C" first="Carmen" last="Amador">Carmen Amador</name><affiliation wicri:level="1"><nlm:aff id="aff198">Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine,<institution>University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="L Ll, Kristi" sort="L Ll, Kristi" uniqKey="L Ll K" first="Kristi" last="L Ll">Kristi L Ll</name><affiliation wicri:level="1"><nlm:aff id="aff197">Estonian Genome Center,<institution>University of Tartu</institution>, Tartu 51010,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff199">Institute of Mathematical Statistics,<institution>University of Tartu</institution>, Tartu 50409,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation wicri:level="1"><nlm:aff id="aff197">Estonian Genome Center,<institution>University of Tartu</institution>, Tartu 51010,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liewald, David C" sort="Liewald, David C" uniqKey="Liewald D" first="David C." last="Liewald">David C. Liewald</name><affiliation wicri:level="1"><nlm:aff id="aff188">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff191">Department of Psychology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Campbell, Archie" sort="Campbell, Archie" uniqKey="Campbell A" first="Archie" last="Campbell">Archie Campbell</name><affiliation wicri:level="1"><nlm:aff id="aff189">Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine,<institution>University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation wicri:level="1"><nlm:aff id="aff192">Usher Institute for Population Health Sciences and Informatics,<institution>University of Edinburgh</institution>, Edinburgh EH16 4UX,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff198">Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine,<institution>University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation wicri:level="1"><nlm:aff id="aff198">Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine,<institution>University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation wicri:level="1"><nlm:aff id="aff197">Estonian Genome Center,<institution>University of Tartu</institution>, Tartu 51010,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff199">Institute of Mathematical Statistics,<institution>University of Tartu</institution>, Tartu 50409,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="aff200"><institution>Broad Institute</institution>, Cambridge,<addr-line>MA</addr-line> 02142;</nlm:aff></affiliation><affiliation><nlm:aff id="aff201">Department of Endocrinology,<institution>Children’s Hospital Boston</institution>, Boston,<addr-line>MA</addr-line> 02115;</nlm:aff></affiliation></author><author><name sortKey="Porteous, David J" sort="Porteous, David J" uniqKey="Porteous D" first="David J." last="Porteous">David J. Porteous</name><affiliation wicri:level="1"><nlm:aff id="aff188">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff189">Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine,<institution>University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gale, Catharine R" sort="Gale, Catharine R" uniqKey="Gale C" first="Catharine R." last="Gale">Catharine R. Gale</name><affiliation wicri:level="1"><nlm:aff id="aff188">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff191">Department of Psychology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff202">Medical Research Council Lifecourse Epidemiology Unit,<institution>University of Southampton</institution>, Southampton SO17 1BJ,<country>United Kingdom</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><affiliation wicri:level="1"><nlm:aff id="aff188">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff191">Department of Psychology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Significance</title><p>Individuals with more education tend to live longer. Genetic variants have been discovered that predict educational attainment. We tested whether a “polygenic score” based on these genetic variants could make predictions about people’s lifespan. We used data from three cohort studies (including >130,000 participants) to examine the link between offspring polygenic score for education and parental longevity. Across the studies, we found that participants with more education-linked genetic variants had longer-living parents; compared with those with the lowest genetic education scores, those with the highest scores had parents who lived on average 6 months longer. This finding suggests the hypothesis that part of the ultimate explanation for the extended longevity of better-educated people is an underlying, quantifiable, genetic propensity.</p></div></front></TEI><affiliations><list><country><li>Australie</li><li>Estonie</li><li>Pays-Bas</li><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Marioni, Riccardo E" sort="Marioni, Riccardo E" uniqKey="Marioni R" first="Riccardo E." last="Marioni">Riccardo E. Marioni</name></noRegion><name sortKey="Adams, Mark J" sort="Adams, Mark J" uniqKey="Adams M" first="Mark J." last="Adams">Mark J. Adams</name><name sortKey="Amador, Carmen" sort="Amador, Carmen" uniqKey="Amador C" first="Carmen" last="Amador">Carmen Amador</name><name sortKey="Campbell, Archie" sort="Campbell, Archie" uniqKey="Campbell A" first="Archie" last="Campbell">Archie Campbell</name><name sortKey="Davies, Gail" sort="Davies, Gail" uniqKey="Davies G" first="Gail" last="Davies">Gail Davies</name><name sortKey="Davies, Gail" sort="Davies, Gail" uniqKey="Davies G" first="Gail" last="Davies">Gail Davies</name><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><name sortKey="Gale, Catharine R" sort="Gale, Catharine R" uniqKey="Gale C" first="Catharine R." last="Gale">Catharine R. Gale</name><name sortKey="Gale, Catharine R" sort="Gale, Catharine R" uniqKey="Gale C" first="Catharine R." last="Gale">Catharine R. Gale</name><name sortKey="Gale, Catharine R" sort="Gale, Catharine R" uniqKey="Gale C" first="Catharine R." last="Gale">Catharine R. Gale</name><name sortKey="Hagenaars, Saskia P" sort="Hagenaars, Saskia P" uniqKey="Hagenaars S" first="Saskia P." last="Hagenaars">Saskia P. Hagenaars</name><name sortKey="Hagenaars, Saskia P" sort="Hagenaars, Saskia P" uniqKey="Hagenaars S" first="Saskia P." last="Hagenaars">Saskia P. Hagenaars</name><name sortKey="Hagenaars, Saskia P" sort="Hagenaars, Saskia P" uniqKey="Hagenaars S" first="Saskia P." last="Hagenaars">Saskia P. Hagenaars</name><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><name sortKey="Hill, W David" sort="Hill, W David" uniqKey="Hill W" first="W. David" last="Hill">W. David Hill</name><name sortKey="Hill, W David" sort="Hill, W David" uniqKey="Hill W" first="W. David" last="Hill">W. David Hill</name><name sortKey="Joshi, Peter K" sort="Joshi, Peter K" uniqKey="Joshi P" first="Peter K." last="Joshi">Peter K. Joshi</name><name sortKey="Liewald, David C" sort="Liewald, David C" uniqKey="Liewald D" first="David C." last="Liewald">David C. Liewald</name><name sortKey="Liewald, David C" sort="Liewald, David C" uniqKey="Liewald D" first="David C." last="Liewald">David C. Liewald</name><name sortKey="Marioni, Riccardo E" sort="Marioni, Riccardo E" uniqKey="Marioni R" first="Riccardo E." last="Marioni">Riccardo E. Marioni</name><name sortKey="Nagy, Reka" sort="Nagy, Reka" uniqKey="Nagy R" first="Reka" last="Nagy">Reka Nagy</name><name sortKey="Porteous, David J" sort="Porteous, David J" uniqKey="Porteous D" first="David J." last="Porteous">David J. Porteous</name><name sortKey="Porteous, David J" sort="Porteous, David J" uniqKey="Porteous D" first="David J." last="Porteous">David J. Porteous</name><name sortKey="Ritchie, Stuart J" sort="Ritchie, Stuart J" uniqKey="Ritchie S" first="Stuart J." last="Ritchie">Stuart J. Ritchie</name><name sortKey="Ritchie, Stuart J" sort="Ritchie, Stuart J" uniqKey="Ritchie S" first="Stuart J." last="Ritchie">Stuart J. Ritchie</name><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name></country><country name="Australie"><noRegion><name sortKey="Marioni, Riccardo E" sort="Marioni, Riccardo E" uniqKey="Marioni R" first="Riccardo E." last="Marioni">Riccardo E. Marioni</name></noRegion></country><country name="Pays-Bas"><noRegion><name sortKey="Okbay, Aysu" sort="Okbay, Aysu" uniqKey="Okbay A" first="Aysu" last="Okbay">Aysu Okbay</name></noRegion><name sortKey="Okbay, Aysu" sort="Okbay, Aysu" uniqKey="Okbay A" first="Aysu" last="Okbay">Aysu Okbay</name><name sortKey="Okbay, Aysu" sort="Okbay, Aysu" uniqKey="Okbay A" first="Aysu" last="Okbay">Aysu Okbay</name></country><country name="Estonie"><noRegion><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name></noRegion><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><name sortKey="L Ll, Kristi" sort="L Ll, Kristi" uniqKey="L Ll K" first="Kristi" last="L Ll">Kristi L Ll</name><name sortKey="L Ll, Kristi" sort="L Ll, Kristi" uniqKey="L Ll K" first="Kristi" last="L Ll">Kristi L Ll</name><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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