Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells
Identifieur interne : 001C80 ( Main/Exploration ); précédent : 001C79; suivant : 001C81Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells
Auteurs : Céline Souilhol [Royaume-Uni] ; Christèle Gonneau [Royaume-Uni] ; Javier G. Lendinez [Royaume-Uni] ; Antoniana Batsivari [Royaume-Uni] ; Stanislav Rybtsov [Royaume-Uni] ; Heather Wilson [Royaume-Uni] ; Lucia Morgado-Palacin [Royaume-Uni] ; David Hills [Royaume-Uni] ; Samir Taoudi [Australie] ; Jennifer Antonchuk [Canada] ; Suling Zhao [Royaume-Uni] ; Alexander Medvinsky [Royaume-Uni]Source :
- Nature Communications [ 2041-1723 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Aorte (embryologie), Aorte (métabolisme), Cellules souches hématopoïétiques (cytologie), Cellules souches hématopoïétiques (métabolisme), Femelle, Gonades (embryologie), Gonades (métabolisme), Mâle, Mésonéphros (embryologie), Mésonéphros (métabolisme), Protéine morphogénétique osseuse de type 4 (génétique), Protéine morphogénétique osseuse de type 4 (métabolisme), Protéines Hedgehog (génétique), Protéines Hedgehog (métabolisme), Souris de lignée C57BL, Transduction du signal, Transplantation de cellules souches hématopoïétiques.
- MESH :
- cytologie : Cellules souches hématopoïétiques.
- embryologie : Aorte, Gonades, Mésonéphros.
- génétique : Protéine morphogénétique osseuse de type 4, Protéines Hedgehog.
- métabolisme : Aorte, Cellules souches hématopoïétiques, Gonades, Mésonéphros, Protéine morphogénétique osseuse de type 4, Protéines Hedgehog.
- Animaux, Femelle, Mâle, Souris de lignée C57BL, Transduction du signal, Transplantation de cellules souches hématopoïétiques.
English descriptors
- KwdEn :
- Animals, Aorta (embryology), Aorta (metabolism), Bone Morphogenetic Protein 4 (genetics), Bone Morphogenetic Protein 4 (metabolism), Female, Gonads (embryology), Gonads (metabolism), Hedgehog Proteins (genetics), Hedgehog Proteins (metabolism), Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cells (cytology), Hematopoietic Stem Cells (metabolism), Male, Mesonephros (embryology), Mesonephros (metabolism), Mice, Inbred C57BL, Signal Transduction.
- MESH :
- chemical , genetics : Bone Morphogenetic Protein 4, Hedgehog Proteins.
- cytology : Hematopoietic Stem Cells.
- embryology : Aorta, Gonads, Mesonephros.
- metabolism : Aorta, Bone Morphogenetic Protein 4, Gonads, Hedgehog Proteins, Hematopoietic Stem Cells, Mesonephros.
- Animals, Female, Hematopoietic Stem Cell Transplantation, Male, Mice, Inbred C57BL, Signal Transduction.
Abstract
During embryonic development, adult haematopoietic stem cells (HSCs) emerge preferentially in the ventral domain of the aorta in the aorta–gonad–mesonephros (AGM) region. Several signalling pathways such as Notch, Wnt, Shh and RA are implicated in this process, yet how these interact to regulate the emergence of HSCs has not previously been described in mammals. Using a combination of
Url:
DOI: 10.1038/ncomms10784
PubMed: 26952187
PubMed Central: 4786750
Affiliations:
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id="a1"><institution>Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, SCRM Bioquarter</institution>, 5 Little France Drive, Edinburgh EH16 4UU, Scotland,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gonneau, Christele" sort="Gonneau, Christele" uniqKey="Gonneau C" first="Christèle" last="Gonneau">Christèle Gonneau</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, SCRM Bioquarter</institution>, 5 Little France Drive, Edinburgh EH16 4UU, Scotland,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lendinez, Javier G" sort="Lendinez, Javier G" uniqKey="Lendinez J" first="Javier G." last="Lendinez">Javier G. Lendinez</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, SCRM Bioquarter</institution>, 5 Little France Drive, Edinburgh EH16 4UU, Scotland,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Batsivari, Antoniana" sort="Batsivari, Antoniana" uniqKey="Batsivari A" first="Antoniana" last="Batsivari">Antoniana Batsivari</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, SCRM Bioquarter</institution>, 5 Little France Drive, Edinburgh EH16 4UU, Scotland,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rybtsov, Stanislav" sort="Rybtsov, Stanislav" uniqKey="Rybtsov S" first="Stanislav" last="Rybtsov">Stanislav Rybtsov</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, SCRM Bioquarter</institution>, 5 Little France Drive, Edinburgh EH16 4UU, Scotland,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, Heather" sort="Wilson, Heather" uniqKey="Wilson H" first="Heather" last="Wilson">Heather Wilson</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, SCRM Bioquarter</institution>, 5 Little France Drive, Edinburgh EH16 4UU, Scotland,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Morgado Palacin, Lucia" sort="Morgado Palacin, Lucia" uniqKey="Morgado Palacin L" first="Lucia" last="Morgado-Palacin">Lucia Morgado-Palacin</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, SCRM Bioquarter</institution>, 5 Little France Drive, Edinburgh EH16 4UU, Scotland,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hills, David" sort="Hills, David" uniqKey="Hills D" first="David" last="Hills">David Hills</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, SCRM Bioquarter</institution>, 5 Little France Drive, Edinburgh EH16 4UU, Scotland,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Taoudi, Samir" sort="Taoudi, Samir" uniqKey="Taoudi S" first="Samir" last="Taoudi">Samir Taoudi</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research</institution>, Victoria 3052 Melbourne,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Medical Biology, University of Melbourne</institution>, Victoria 3052 Melbourne,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research</institution>, Victoria 3052 Melbourne,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Antonchuk, Jennifer" sort="Antonchuk, Jennifer" uniqKey="Antonchuk J" first="Jennifer" last="Antonchuk">Jennifer Antonchuk</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>STEMCELL Technologies Inc., Vancouver</institution>, British Columbia V5Z 1B3,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Suling" sort="Zhao, Suling" uniqKey="Zhao S" first="Suling" last="Zhao">Suling Zhao</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, SCRM Bioquarter</institution>, 5 Little France Drive, Edinburgh EH16 4UU, Scotland,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Medvinsky, Alexander" sort="Medvinsky, Alexander" uniqKey="Medvinsky A" first="Alexander" last="Medvinsky">Alexander Medvinsky</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, SCRM Bioquarter</institution>, 5 Little France Drive, Edinburgh EH16 4UU, Scotland,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Aorta (embryology)</term><term>Aorta (metabolism)</term><term>Bone Morphogenetic Protein 4 (genetics)</term><term>Bone Morphogenetic Protein 4 (metabolism)</term><term>Female</term><term>Gonads (embryology)</term><term>Gonads (metabolism)</term><term>Hedgehog Proteins (genetics)</term><term>Hedgehog Proteins (metabolism)</term><term>Hematopoietic Stem Cell Transplantation</term><term>Hematopoietic Stem Cells (cytology)</term><term>Hematopoietic Stem Cells (metabolism)</term><term>Male</term><term>Mesonephros (embryology)</term><term>Mesonephros (metabolism)</term><term>Mice, Inbred C57BL</term><term>Signal Transduction</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Aorte (embryologie)</term><term>Aorte (métabolisme)</term><term>Cellules souches hématopoïétiques (cytologie)</term><term>Cellules souches hématopoïétiques (métabolisme)</term><term>Femelle</term><term>Gonades (embryologie)</term><term>Gonades (métabolisme)</term><term>Mâle</term><term>Mésonéphros (embryologie)</term><term>Mésonéphros (métabolisme)</term><term>Protéine morphogénétique osseuse de type 4 (génétique)</term><term>Protéine morphogénétique osseuse de type 4 (métabolisme)</term><term>Protéines Hedgehog (génétique)</term><term>Protéines Hedgehog (métabolisme)</term><term>Souris de lignée C57BL</term><term>Transduction du signal</term><term>Transplantation de cellules souches hématopoïétiques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Bone Morphogenetic Protein 4</term><term>Hedgehog Proteins</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules souches hématopoïétiques</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Hematopoietic Stem Cells</term></keywords><keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Aorte</term><term>Gonades</term><term>Mésonéphros</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Aorta</term><term>Gonads</term><term>Mesonephros</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéine morphogénétique osseuse de type 4</term><term>Protéines Hedgehog</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Aorta</term><term>Bone Morphogenetic Protein 4</term><term>Gonads</term><term>Hedgehog Proteins</term><term>Hematopoietic Stem Cells</term><term>Mesonephros</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Aorte</term><term>Cellules souches hématopoïétiques</term><term>Gonades</term><term>Mésonéphros</term><term>Protéine morphogénétique osseuse de type 4</term><term>Protéines Hedgehog</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Hematopoietic Stem Cell Transplantation</term><term>Male</term><term>Mice, Inbred C57BL</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Mâle</term><term>Souris de lignée C57BL</term><term>Transduction du signal</term><term>Transplantation de cellules souches hématopoïétiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>During embryonic development, adult haematopoietic stem cells (HSCs) emerge preferentially in the ventral domain of the aorta in the aorta–gonad–mesonephros (AGM) region. Several signalling pathways such as Notch, Wnt, Shh and RA are implicated in this process, yet how these interact to regulate the emergence of HSCs has not previously been described in mammals. Using a combination of <italic>ex vivo</italic> and <italic>in vivo</italic> approaches, we report here that stage-specific reciprocal dorso–ventral inductive interactions and lateral input from the urogenital ridges are required to drive HSC development in the aorta. Our study strongly suggests that these inductive interactions in the AGM region are mediated by the interplay between spatially polarized signalling pathways. Specifically, Shh produced in the dorsal region of the AGM, stem cell factor in the ventral and lateral regions, and BMP inhibitory signals in the ventral tissue are integral parts of the regulatory system involved in the development of HSCs.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Medvinsky, A" uniqKey="Medvinsky A">A. Medvinsky</name></author><author><name sortKey="Dzierzak, E" uniqKey="Dzierzak E">E. Dzierzak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Bruijn, M F" uniqKey="De Bruijn M">M. F. de Bruijn</name></author><author><name sortKey="Speck, N A" uniqKey="Speck N">N. A. Speck</name></author><author><name sortKey="Peeters, M C" uniqKey="Peeters M">M. C. Peeters</name></author><author><name sortKey="Dzierzak, E" uniqKey="Dzierzak E">E. Dzierzak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muller, A M" uniqKey="Muller A">A. M. 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Niwa</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Souilhol, Celine" sort="Souilhol, Celine" uniqKey="Souilhol C" first="Céline" last="Souilhol">Céline Souilhol</name></noRegion><name sortKey="Batsivari, Antoniana" sort="Batsivari, Antoniana" uniqKey="Batsivari A" first="Antoniana" last="Batsivari">Antoniana Batsivari</name><name sortKey="Gonneau, Christele" sort="Gonneau, Christele" uniqKey="Gonneau C" first="Christèle" last="Gonneau">Christèle Gonneau</name><name sortKey="Hills, David" sort="Hills, David" uniqKey="Hills D" first="David" last="Hills">David Hills</name><name sortKey="Lendinez, Javier G" sort="Lendinez, Javier G" uniqKey="Lendinez J" first="Javier G." last="Lendinez">Javier G. Lendinez</name><name sortKey="Medvinsky, Alexander" sort="Medvinsky, Alexander" uniqKey="Medvinsky A" first="Alexander" last="Medvinsky">Alexander Medvinsky</name><name sortKey="Morgado Palacin, Lucia" sort="Morgado Palacin, Lucia" uniqKey="Morgado Palacin L" first="Lucia" last="Morgado-Palacin">Lucia Morgado-Palacin</name><name sortKey="Rybtsov, Stanislav" sort="Rybtsov, Stanislav" uniqKey="Rybtsov S" first="Stanislav" last="Rybtsov">Stanislav Rybtsov</name><name sortKey="Wilson, Heather" sort="Wilson, Heather" uniqKey="Wilson H" first="Heather" last="Wilson">Heather Wilson</name><name sortKey="Zhao, Suling" sort="Zhao, Suling" uniqKey="Zhao S" first="Suling" last="Zhao">Suling Zhao</name></country><country name="Australie"><noRegion><name sortKey="Taoudi, Samir" sort="Taoudi, Samir" uniqKey="Taoudi S" first="Samir" last="Taoudi">Samir Taoudi</name></noRegion><name sortKey="Taoudi, Samir" sort="Taoudi, Samir" uniqKey="Taoudi S" first="Samir" last="Taoudi">Samir Taoudi</name><name sortKey="Taoudi, Samir" sort="Taoudi, Samir" uniqKey="Taoudi S" first="Samir" last="Taoudi">Samir Taoudi</name></country><country name="Canada"><noRegion><name sortKey="Antonchuk, Jennifer" sort="Antonchuk, Jennifer" uniqKey="Antonchuk J" first="Jennifer" last="Antonchuk">Jennifer Antonchuk</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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