Intraspinal Sensory Neurons Provide Powerful Inhibition to Motor Circuits Ensuring Postural Control during Locomotion.
Identifieur interne : 001C35 ( Main/Exploration ); précédent : 001C34; suivant : 001C36Intraspinal Sensory Neurons Provide Powerful Inhibition to Motor Circuits Ensuring Postural Control during Locomotion.
Auteurs : Jeffrey Michael Hubbard [France] ; Urs Lucas Böhm [France] ; Andrew Prendergast [France] ; Po-En Brian Tseng [France] ; Morgan Newman [Australie] ; Caleb Stokes [France] ; Claire Wyart [France]Source :
- Current biology : CB [ 1879-0445 ] ; 2016.
Abstract
In the vertebrate spinal cord, cerebrospinal fluid-contacting neurons (CSF-cNs) are GABAergic neurons whose functions are only beginning to unfold. Recent evidence indicates that CSF-cNs detect local spinal bending and relay this mechanosensory feedback information to motor circuits, yet many CSF-cN targets remain unknown. Using optogenetics, patterned illumination, and in vivo electrophysiology, we show here that CSF-cNs provide somatic inhibition to fast motor neurons and excitatory sensory interneurons involved in the escape circuit. Ventral CSF-cNs respond to longitudinal spinal contractions and induce large inhibitory postsynaptic currents (IPSCs) sufficient to silence spiking of their targets. Upon repetitive stimulation, these IPSCs promptly depress, enabling the mechanosensory response to the first bend to be the most effective. When CSF-cNs are silenced, postural control is compromised, resulting in rollovers during escapes. Altogether, our data demonstrate how GABAergic sensory neurons provide powerful inhibitory feedback to the escape circuit to maintain balance during active locomotion.
DOI: 10.1016/j.cub.2016.08.026
PubMed: 27720623
Affiliations:
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INSERM UMRS 1127, 75013 Paris, France; CNRS UMR 7225, 75005 Paris, France; UPMC University Paris 06, 75005 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle Épinière, Hôpital Pitié Salpêtrière, 47 Boulevard de l'Hôpital, 75013 Paris, France; INSERM UMRS 1127, 75013 Paris, France; CNRS UMR 7225, 75005 Paris, France; UPMC University Paris 06, 75005 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bohm, Urs Lucas" sort="Bohm, Urs Lucas" uniqKey="Bohm U" first="Urs Lucas" last="Böhm">Urs Lucas Böhm</name><affiliation wicri:level="3"><nlm:affiliation>Institut du Cerveau et de la Moelle Épinière, Hôpital Pitié Salpêtrière, 47 Boulevard de l'Hôpital, 75013 Paris, France; INSERM UMRS 1127, 75013 Paris, France; CNRS UMR 7225, 75005 Paris, France; UPMC University Paris 06, 75005 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle Épinière, Hôpital Pitié Salpêtrière, 47 Boulevard de l'Hôpital, 75013 Paris, France; INSERM UMRS 1127, 75013 Paris, France; CNRS UMR 7225, 75005 Paris, France; UPMC University Paris 06, 75005 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Prendergast, Andrew" sort="Prendergast, Andrew" uniqKey="Prendergast A" first="Andrew" last="Prendergast">Andrew Prendergast</name><affiliation wicri:level="3"><nlm:affiliation>Institut du Cerveau et de la Moelle Épinière, Hôpital Pitié Salpêtrière, 47 Boulevard de l'Hôpital, 75013 Paris, France; INSERM UMRS 1127, 75013 Paris, France; CNRS UMR 7225, 75005 Paris, France; UPMC University Paris 06, 75005 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle Épinière, Hôpital Pitié Salpêtrière, 47 Boulevard de l'Hôpital, 75013 Paris, France; INSERM UMRS 1127, 75013 Paris, France; CNRS UMR 7225, 75005 Paris, France; UPMC University Paris 06, 75005 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Tseng, Po En Brian" sort="Tseng, Po En Brian" uniqKey="Tseng P" first="Po-En Brian" last="Tseng">Po-En Brian Tseng</name><affiliation wicri:level="3"><nlm:affiliation>Institut du Cerveau et de la Moelle Épinière, Hôpital Pitié Salpêtrière, 47 Boulevard de l'Hôpital, 75013 Paris, France; INSERM UMRS 1127, 75013 Paris, France; CNRS UMR 7225, 75005 Paris, France; UPMC University Paris 06, 75005 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle Épinière, Hôpital Pitié Salpêtrière, 47 Boulevard de l'Hôpital, 75013 Paris, France; INSERM UMRS 1127, 75013 Paris, France; CNRS UMR 7225, 75005 Paris, France; UPMC University Paris 06, 75005 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Newman, Morgan" sort="Newman, Morgan" uniqKey="Newman M" first="Morgan" last="Newman">Morgan Newman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Evolution, School of Biological Sciences, The University of Adelaide, Adelaide, SA 5005, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Genetics and Evolution, School of Biological Sciences, The University of Adelaide, Adelaide, SA 5005</wicri:regionArea><wicri:noRegion>SA 5005</wicri:noRegion></affiliation></author><author><name sortKey="Stokes, Caleb" sort="Stokes, Caleb" uniqKey="Stokes C" first="Caleb" last="Stokes">Caleb Stokes</name><affiliation wicri:level="1"><nlm:affiliation>Institut du Cerveau et de la Moelle Épinière, Hôpital Pitié Salpêtrière, 47 Boulevard de l'Hôpital, 75013 Paris, France; INSERM UMRS 1127, 75013 Paris, France; CNRS UMR 7225, 75005 Paris, France; UPMC University Paris 06, 75005 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle Épinière, Hôpital Pitié Salpêtrière, 47 Boulevard de l'Hôpital, 75013 Paris, France; INSERM UMRS 1127, 75013 Paris, France; CNRS UMR 7225, 75005 Paris, France; UPMC University Paris 06, 75005 Paris</wicri:regionArea><wicri:noRegion>75005 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Wyart, Claire" sort="Wyart, Claire" uniqKey="Wyart C" first="Claire" last="Wyart">Claire Wyart</name><affiliation wicri:level="1"><nlm:affiliation>Institut du Cerveau et de la Moelle Épinière, Hôpital Pitié Salpêtrière, 47 Boulevard de l'Hôpital, 75013 Paris, France; INSERM UMRS 1127, 75013 Paris, France; CNRS UMR 7225, 75005 Paris, France; UPMC University Paris 06, 75005 Paris, France. Electronic address: claire.wyart@icm-institute.org.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle Épinière, Hôpital Pitié Salpêtrière, 47 Boulevard de l'Hôpital, 75013 Paris, France; INSERM UMRS 1127, 75013 Paris, France; CNRS UMR 7225, 75005 Paris, France; UPMC University Paris 06, 75005 Paris</wicri:regionArea><wicri:noRegion>75005 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author></analytic><series><title level="j">Current biology : CB</title><idno type="eISSN">1879-0445</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In the vertebrate spinal cord, cerebrospinal fluid-contacting neurons (CSF-cNs) are GABAergic neurons whose functions are only beginning to unfold. Recent evidence indicates that CSF-cNs detect local spinal bending and relay this mechanosensory feedback information to motor circuits, yet many CSF-cN targets remain unknown. Using optogenetics, patterned illumination, and in vivo electrophysiology, we show here that CSF-cNs provide somatic inhibition to fast motor neurons and excitatory sensory interneurons involved in the escape circuit. Ventral CSF-cNs respond to longitudinal spinal contractions and induce large inhibitory postsynaptic currents (IPSCs) sufficient to silence spiking of their targets. Upon repetitive stimulation, these IPSCs promptly depress, enabling the mechanosensory response to the first bend to be the most effective. When CSF-cNs are silenced, postural control is compromised, resulting in rollovers during escapes. Altogether, our data demonstrate how GABAergic sensory neurons provide powerful inhibitory feedback to the escape circuit to maintain balance during active locomotion.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Hubbard, Jeffrey Michael" sort="Hubbard, Jeffrey Michael" uniqKey="Hubbard J" first="Jeffrey Michael" last="Hubbard">Jeffrey Michael Hubbard</name></region><name sortKey="Bohm, Urs Lucas" sort="Bohm, Urs Lucas" uniqKey="Bohm U" first="Urs Lucas" last="Böhm">Urs Lucas Böhm</name><name sortKey="Prendergast, Andrew" sort="Prendergast, Andrew" uniqKey="Prendergast A" first="Andrew" last="Prendergast">Andrew Prendergast</name><name sortKey="Stokes, Caleb" sort="Stokes, Caleb" uniqKey="Stokes C" first="Caleb" last="Stokes">Caleb Stokes</name><name sortKey="Tseng, Po En Brian" sort="Tseng, Po En Brian" uniqKey="Tseng P" first="Po-En Brian" last="Tseng">Po-En Brian Tseng</name><name sortKey="Wyart, Claire" sort="Wyart, Claire" uniqKey="Wyart C" first="Claire" last="Wyart">Claire Wyart</name></country><country name="Australie"><noRegion><name sortKey="Newman, Morgan" sort="Newman, Morgan" uniqKey="Newman M" first="Morgan" last="Newman">Morgan Newman</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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