AustralieFrV1, Main, Exploration, bibRecord, 001C07

Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome

Identifieur interne : 001C07 ( Main/Exploration ); précédent : 001C06; suivant : 001C08

Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome

Auteurs : Valerie M. Harris [États-Unis] ; Rohan Sharma [États-Unis] ; Joshua Cavett [États-Unis] ; Biji T. Kurien [États-Unis] ; Ke Liu [États-Unis] ; Kristi A. Koelsch [États-Unis] ; Astrid Rasmussen [États-Unis] ; Lida Radfar [États-Unis] ; David Lewis [États-Unis] ; Donald U. Stone [États-Unis] ; C. Erick Kaufman [États-Unis] ; Shibo Li [États-Unis] ; Barbara Segal [États-Unis] ; Daniel J. Wallace [États-Unis] ; Michael H. Weisman [États-Unis] ; Swamy Venuturupalli [États-Unis] ; Jennifer A. Kelly [États-Unis] ; Marta E. Alarcon-Riquelme [États-Unis, Espagne] ; Bernardo Pons-Estel [Argentine] ; Roland Jonsson [Norvège] ; Xianglan Lu [États-Unis] ; Jacques-Eric Gottenberg [France] ; Juan-Manuel Anaya [Colombie] ; Deborah S. Cunninghame-Graham [Royaume-Uni] ; Andrew J. W. Huang [États-Unis] ; Michael T. Brennan [États-Unis] ; Pamela Hughes [États-Unis] ; Ilias Alevizos [États-Unis] ; Corinne Miceli-Richard [France] ; Edward C. Keystone [Canada] ; Vivian P. Bykerk [États-Unis] ; Gideon Hirschfield [Royaume-Uni] ; Gang Xie [Canada] ; Wan-Fai Ng [Royaume-Uni] ; Gunnel Nordmark [Suède] ; Sara Magnusson Bucher [Suède] ; Per Eriksson [Suède] ; Roald Omdal [Norvège] ; Nelson L. Rhodus [États-Unis] ; Maureen Rischmueller [Australie] ; Michael Rohrer [États-Unis] ; Marie Wahren-Herlenius [Suède] ; Torsten Witte [Allemagne] ; Xavier Mariette [France] ; Christopher J. Lessard [États-Unis] ; John B. Harley [États-Unis] ; Kathy L. Sivils [États-Unis] ; R. Hal Scofield [États-Unis]

Source :

Clinical immunology (Orlando, Fla.) [ 1521-6616 ] ; 2016.

RBID : PMC:4940221

Descripteurs français

English descriptors

KwdEn :
- Arthritis, Rheumatoid (genetics), Chromosomes, Human, X (genetics), Chromosomes, Human, Y (genetics), Female, Gene Frequency, Genotype, Humans, Klinefelter Syndrome (genetics), Lupus Erythematosus, Systemic (genetics), Male, Polymorphism, Single Nucleotide, Sjogren's Syndrome (genetics).
MESH :
- genetics : Arthritis, Rheumatoid, Chromosomes, Human, X, Chromosomes, Human, Y, Klinefelter Syndrome, Lupus Erythematosus, Systemic, Sjogren's Syndrome.
- Female, Gene Frequency, Genotype, Humans, Male, Polymorphism, Single Nucleotide.

Abstract

Primary Sjögren's syndrome (pSS) has a strong female bias. We evaluated an X chromosome dose effect by analyzing 47,XXY (Klinefelter's syndrome, 1 in 500 live male births) among subjects with pSS. 47,XXY was determined by examination of fluorescence intensity of single nucleotide polymorphisms from the X and Y chromosomes. Among 136 pSS men there were 4 with 47,XXY. This was significantly different from healthy controls (1 of 1254 had 47,XXY, p=0.0012 by Fisher's exact test) as well men with rheumatoid arthritis (0 of 363 with 47,XXY), but not different compared to men with systemic lupus erythematosus (SLE) (4 of 136 versus 8 of 306, Fisher's exact test p=NS). These results are consistent with the hypothesis that the number of X chromosomes is critical for the female bias of pSS, a property that may be shared with SLE but not RA.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940221

DOI: 10.1016/j.clim.2016.04.002
PubMed: 27109640
PubMed Central: 4940221

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome</title>
<author><name sortKey="Harris, Valerie M" sort="Harris, Valerie M" uniqKey="Harris V" first="Valerie M." last="Harris">Valerie M. Harris</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sharma, Rohan" sort="Sharma, Rohan" uniqKey="Sharma R" first="Rohan" last="Sharma">Rohan Sharma</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cavett, Joshua" sort="Cavett, Joshua" uniqKey="Cavett J" first="Joshua" last="Cavett">Joshua Cavett</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kurien, Biji T" sort="Kurien, Biji T" uniqKey="Kurien B" first="Biji T." last="Kurien">Biji T. Kurien</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Ke" sort="Liu, Ke" uniqKey="Liu K" first="Ke" last="Liu">Ke Liu</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6">College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>College of Medicine, University of Cincinnati, Cincinnati, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koelsch, Kristi A" sort="Koelsch, Kristi A" uniqKey="Koelsch K" first="Kristi A." last="Koelsch">Kristi A. Koelsch</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rasmussen, Astrid" sort="Rasmussen, Astrid" uniqKey="Rasmussen A" first="Astrid" last="Rasmussen">Astrid Rasmussen</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Radfar, Lida" sort="Radfar, Lida" uniqKey="Radfar L" first="Lida" last="Radfar">Lida Radfar</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City</wicri:regionArea>
<wicri:noRegion>Oklahoma City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lewis, David" sort="Lewis, David" uniqKey="Lewis D" first="David" last="Lewis">David Lewis</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City</wicri:regionArea>
<wicri:noRegion>Oklahoma City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stone, Donald U" sort="Stone, Donald U" uniqKey="Stone D" first="Donald U." last="Stone">Donald U. Stone</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Dean McGee Eye Institute and Department of Ophthalmology, University of Oklahoma College of Medicine, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dean McGee Eye Institute and Department of Ophthalmology, University of Oklahoma College of Medicine, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kaufman, C Erick" sort="Kaufman, C Erick" uniqKey="Kaufman C" first="C. Erick" last="Kaufman">C. Erick Kaufman</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Shibo" sort="Li, Shibo" uniqKey="Li S" first="Shibo" last="Li">Shibo Li</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Segal, Barbara" sort="Segal, Barbara" uniqKey="Segal B" first="Barbara" last="Segal">Barbara Segal</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Minnesota Medical School, Minneapolis, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wallace, Daniel J" sort="Wallace, Daniel J" uniqKey="Wallace D" first="Daniel J" last="Wallace">Daniel J. Wallace</name>
<affiliation wicri:level="2"><nlm:aff id="A11">Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Weisman, Michael H" sort="Weisman, Michael H" uniqKey="Weisman M" first="Michael H." last="Weisman">Michael H. Weisman</name>
<affiliation wicri:level="2"><nlm:aff id="A11">Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Venuturupalli, Swamy" sort="Venuturupalli, Swamy" uniqKey="Venuturupalli S" first="Swamy" last="Venuturupalli">Swamy Venuturupalli</name>
<affiliation wicri:level="2"><nlm:aff id="A11">Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kelly, Jennifer A" sort="Kelly, Jennifer A" uniqKey="Kelly J" first="Jennifer A." last="Kelly">Jennifer A. Kelly</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Alarcon Riquelme, Marta E" sort="Alarcon Riquelme, Marta E" uniqKey="Alarcon Riquelme M" first="Marta E." last="Alarcon-Riquelme">Marta E. Alarcon-Riquelme</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A12">Center Pfizer, University of Granada, Andalusian Government for Genomics and Oncological Research, PTS Granada, 18016, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Center Pfizer, University of Granada, Andalusian Government for Genomics and Oncological Research, PTS Granada, 18016</wicri:regionArea>
<orgName type="university">Université de Grenade</orgName>
<placeName><settlement type="city">Grenade (Espagne)</settlement>
<region nuts="2" type="region">Andalousie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pons Estel, Bernardo" sort="Pons Estel, Bernardo" uniqKey="Pons Estel B" first="Bernardo" last="Pons-Estel">Bernardo Pons-Estel</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Sanatorio Parque, Rosario, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea>Sanatorio Parque, Rosario</wicri:regionArea>
<wicri:noRegion>Rosario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jonsson, Roland" sort="Jonsson, Roland" uniqKey="Jonsson R" first="Roland" last="Jonsson">Roland Jonsson</name>
<affiliation wicri:level="1"><nlm:aff id="A15">Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen 5021, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen 5021</wicri:regionArea>
<wicri:noRegion>Bergen 5021</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A16">Department of Rheumatology, Haukeland University Hospital, Bergen 5021, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Rheumatology, Haukeland University Hospital, Bergen 5021</wicri:regionArea>
<wicri:noRegion>Bergen 5021</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lu, Xianglan" sort="Lu, Xianglan" uniqKey="Lu X" first="Xianglan" last="Lu">Xianglan Lu</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gottenberg, Jacques Eric" sort="Gottenberg, Jacques Eric" uniqKey="Gottenberg J" first="Jacques-Eric" last="Gottenberg">Jacques-Eric Gottenberg</name>
<affiliation wicri:level="3"><nlm:aff id="A17">Strasbourg University, Strasbourg, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Strasbourg University, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Anaya, Juan Manuel" sort="Anaya, Juan Manuel" uniqKey="Anaya J" first="Juan-Manuel" last="Anaya">Juan-Manuel Anaya</name>
<affiliation wicri:level="1"><nlm:aff id="A18">Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia</nlm:aff>
<country xml:lang="fr">Colombie</country>
<wicri:regionArea>Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota</wicri:regionArea>
<wicri:noRegion>Bogota</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cunninghame Graham, Deborah S" sort="Cunninghame Graham, Deborah S" uniqKey="Cunninghame Graham D" first="Deborah S." last="Cunninghame-Graham">Deborah S. Cunninghame-Graham</name>
<affiliation wicri:level="3"><nlm:aff id="A19">Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huang, Andrew J W" sort="Huang, Andrew J W" uniqKey="Huang A" first="Andrew J. W." last="Huang">Andrew J. W. Huang</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brennan, Michael T" sort="Brennan, Michael T" uniqKey="Brennan M" first="Michael T." last="Brennan">Michael T. Brennan</name>
<affiliation wicri:level="2"><nlm:aff id="A20">Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hughes, Pamela" sort="Hughes, Pamela" uniqKey="Hughes P" first="Pamela" last="Hughes">Pamela Hughes</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Alevizos, Ilias" sort="Alevizos, Ilias" uniqKey="Alevizos I" first="Ilias" last="Alevizos">Ilias Alevizos</name>
<affiliation wicri:level="2"><nlm:aff id="A21">Molecular Physiology & Therapeutic Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Molecular Physiology & Therapeutic Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Miceli Richard, Corinne" sort="Miceli Richard, Corinne" uniqKey="Miceli Richard C" first="Corinne" last="Miceli-Richard">Corinne Miceli-Richard</name>
<affiliation wicri:level="4"><nlm:aff id="A22">Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre</wicri:regionArea>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
<orgName type="university">Université Paris-Sud</orgName>
<placeName><settlement type="city">Orsay</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Ontario</nlm:aff>
<country>Canada</country>
<placeName><region type="province">Ontario</region>
</placeName>
<wicri:cityArea>Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bykerk, Vivian P" sort="Bykerk, Vivian P" uniqKey="Bykerk V" first="Vivian P." last="Bykerk">Vivian P. Bykerk</name>
<affiliation wicri:level="2"><nlm:aff id="A24">Hospital for Special Surgery, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Hospital for Special Surgery, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hirschfield, Gideon" sort="Hirschfield, Gideon" uniqKey="Hirschfield G" first="Gideon" last="Hirschfield">Gideon Hirschfield</name>
<affiliation wicri:level="4"><nlm:aff id="A25">NIHR Biomedical Research Unit, University of Birmingham, Birmingham, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>NIHR Biomedical Research Unit, University of Birmingham, Birmingham</wicri:regionArea>
<placeName><settlement type="city">Birmingham</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Midlands de l'Ouest</region>
<settlement type="city">Birmingham</settlement>
</placeName>
<orgName type="university">Université de Birmingham</orgName>
</affiliation>
</author>
<author><name sortKey="Xie, Gang" sort="Xie, Gang" uniqKey="Xie G" first="Gang" last="Xie">Gang Xie</name>
<affiliation wicri:level="4"><nlm:aff id="A26">Samuel Lunenfeld and Toronto General Research Institutes, Departments of Medicine, Immunology and Molecular Genetics, University of Toronto, Toronto Ontario</nlm:aff>
<orgName type="university">Université de Toronto</orgName>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ng, Wan Fai" sort="Ng, Wan Fai" uniqKey="Ng W" first="Wan-Fai" last="Ng">Wan-Fai Ng</name>
<affiliation wicri:level="1"><nlm:aff id="A27">Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nordmark, Gunnel" sort="Nordmark, Gunnel" uniqKey="Nordmark G" first="Gunnel" last="Nordmark">Gunnel Nordmark</name>
<affiliation wicri:level="4"><nlm:aff id="A28">Section of Rheumatology, Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Section of Rheumatology, Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala</wicri:regionArea>
<orgName type="university">Université d'Uppsala</orgName>
<placeName><settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bucher, Sara Magnusson" sort="Bucher, Sara Magnusson" uniqKey="Bucher S" first="Sara Magnusson" last="Bucher">Sara Magnusson Bucher</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Department of Rheumatology, Örebro University Hospital, Örebro, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Rheumatology, Örebro University Hospital, Örebro</wicri:regionArea>
<wicri:noRegion>Örebro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eriksson, Per" sort="Eriksson, Per" uniqKey="Eriksson P" first="Per" last="Eriksson">Per Eriksson</name>
<affiliation wicri:level="1"><nlm:aff id="A30">Rheumatology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Rheumatology, Department of Clinical and Experimental Medicine, Linköping University, Linköping</wicri:regionArea>
<wicri:noRegion>Linköping</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Omdal, Roald" sort="Omdal, Roald" uniqKey="Omdal R" first="Roald" last="Omdal">Roald Omdal</name>
<affiliation wicri:level="1"><nlm:aff id="A31">Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger</wicri:regionArea>
<wicri:noRegion>Stavanger</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rhodus, Nelson L" sort="Rhodus, Nelson L" uniqKey="Rhodus N" first="Nelson L." last="Rhodus">Nelson L. Rhodus</name>
<affiliation wicri:level="1"><nlm:aff id="A32">Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis</wicri:regionArea>
<wicri:noRegion>Minneapolis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rischmueller, Maureen" sort="Rischmueller, Maureen" uniqKey="Rischmueller M" first="Maureen" last="Rischmueller">Maureen Rischmueller</name>
<affiliation wicri:level="1"><nlm:aff id="A33">Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA 5011, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA 5011</wicri:regionArea>
<wicri:noRegion>SA 5011</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A34">Discipline of Medicine, University of Adelaide, Adelaide, SA 5000, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Discipline of Medicine, University of Adelaide, Adelaide, SA 5000</wicri:regionArea>
<wicri:noRegion>SA 5000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rohrer, Michael" sort="Rohrer, Michael" uniqKey="Rohrer M" first="Michael" last="Rohrer">Michael Rohrer</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wahren Herlenius, Marie" sort="Wahren Herlenius, Marie" uniqKey="Wahren Herlenius M" first="Marie" last="Wahren-Herlenius">Marie Wahren-Herlenius</name>
<affiliation wicri:level="3"><nlm:aff id="A35">Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Witte, Torsten" sort="Witte, Torsten" uniqKey="Witte T" first="Torsten" last="Witte">Torsten Witte</name>
<affiliation wicri:level="3"><nlm:aff id="A36">Clinic for Immunology and Rheumatology, Hannover Medical School, 30625 Hannover, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Clinic for Immunology and Rheumatology, Hannover Medical School, 30625 Hannover</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name>
<affiliation wicri:level="4"><nlm:aff id="A22">Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre</wicri:regionArea>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
<orgName type="university">Université Paris-Sud</orgName>
<placeName><settlement type="city">Orsay</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lessard, Christopher J" sort="Lessard, Christopher J" uniqKey="Lessard C" first="Christopher J." last="Lessard">Christopher J. Lessard</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harley, John B" sort="Harley, John B" uniqKey="Harley J" first="John B" last="Harley">John B. Harley</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6">College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>College of Medicine, University of Cincinnati, Cincinnati, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A37">Medical Service, Department of Veterans Affairs Medical Center, Cincinnati, Ohio, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Service, Department of Veterans Affairs Medical Center, Cincinnati, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sivils, Kathy L" sort="Sivils, Kathy L" uniqKey="Sivils K" first="Kathy L" last="Sivils">Kathy L. Sivils</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Scofield, R Hal" sort="Scofield, R Hal" uniqKey="Scofield R" first="R. Hal" last="Scofield">R. Hal Scofield</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">27109640</idno>
<idno type="pmc">4940221</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940221</idno>
<idno type="RBID">PMC:4940221</idno>
<idno type="doi">10.1016/j.clim.2016.04.002</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">001D61</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D61</idno>
<idno type="wicri:Area/Pmc/Curation">001C17</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001C17</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000817</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000817</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001C56</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001C56</idno>
<idno type="wicri:Area/PubMed/Curation">001C32</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001C32</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001C32</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001C32</idno>
<idno type="wicri:Area/Ncbi/Merge">003460</idno>
<idno type="wicri:Area/Ncbi/Curation">003460</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003460</idno>
<idno type="wicri:doubleKey">1521-6616:2016:Harris V:klinefelter:s:syndrome</idno>
<idno type="wicri:Area/Main/Merge">001C04</idno>
<idno type="wicri:Area/Main/Curation">001C07</idno>
<idno type="wicri:Area/Main/Exploration">001C07</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome</title>
<author><name sortKey="Harris, Valerie M" sort="Harris, Valerie M" uniqKey="Harris V" first="Valerie M." last="Harris">Valerie M. Harris</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sharma, Rohan" sort="Sharma, Rohan" uniqKey="Sharma R" first="Rohan" last="Sharma">Rohan Sharma</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cavett, Joshua" sort="Cavett, Joshua" uniqKey="Cavett J" first="Joshua" last="Cavett">Joshua Cavett</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kurien, Biji T" sort="Kurien, Biji T" uniqKey="Kurien B" first="Biji T." last="Kurien">Biji T. Kurien</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Ke" sort="Liu, Ke" uniqKey="Liu K" first="Ke" last="Liu">Ke Liu</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6">College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>College of Medicine, University of Cincinnati, Cincinnati, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koelsch, Kristi A" sort="Koelsch, Kristi A" uniqKey="Koelsch K" first="Kristi A." last="Koelsch">Kristi A. Koelsch</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rasmussen, Astrid" sort="Rasmussen, Astrid" uniqKey="Rasmussen A" first="Astrid" last="Rasmussen">Astrid Rasmussen</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Radfar, Lida" sort="Radfar, Lida" uniqKey="Radfar L" first="Lida" last="Radfar">Lida Radfar</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City</wicri:regionArea>
<wicri:noRegion>Oklahoma City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lewis, David" sort="Lewis, David" uniqKey="Lewis D" first="David" last="Lewis">David Lewis</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City</wicri:regionArea>
<wicri:noRegion>Oklahoma City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stone, Donald U" sort="Stone, Donald U" uniqKey="Stone D" first="Donald U." last="Stone">Donald U. Stone</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Dean McGee Eye Institute and Department of Ophthalmology, University of Oklahoma College of Medicine, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dean McGee Eye Institute and Department of Ophthalmology, University of Oklahoma College of Medicine, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kaufman, C Erick" sort="Kaufman, C Erick" uniqKey="Kaufman C" first="C. Erick" last="Kaufman">C. Erick Kaufman</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Shibo" sort="Li, Shibo" uniqKey="Li S" first="Shibo" last="Li">Shibo Li</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Segal, Barbara" sort="Segal, Barbara" uniqKey="Segal B" first="Barbara" last="Segal">Barbara Segal</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Minnesota Medical School, Minneapolis, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wallace, Daniel J" sort="Wallace, Daniel J" uniqKey="Wallace D" first="Daniel J" last="Wallace">Daniel J. Wallace</name>
<affiliation wicri:level="2"><nlm:aff id="A11">Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Weisman, Michael H" sort="Weisman, Michael H" uniqKey="Weisman M" first="Michael H." last="Weisman">Michael H. Weisman</name>
<affiliation wicri:level="2"><nlm:aff id="A11">Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Venuturupalli, Swamy" sort="Venuturupalli, Swamy" uniqKey="Venuturupalli S" first="Swamy" last="Venuturupalli">Swamy Venuturupalli</name>
<affiliation wicri:level="2"><nlm:aff id="A11">Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kelly, Jennifer A" sort="Kelly, Jennifer A" uniqKey="Kelly J" first="Jennifer A." last="Kelly">Jennifer A. Kelly</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Alarcon Riquelme, Marta E" sort="Alarcon Riquelme, Marta E" uniqKey="Alarcon Riquelme M" first="Marta E." last="Alarcon-Riquelme">Marta E. Alarcon-Riquelme</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A12">Center Pfizer, University of Granada, Andalusian Government for Genomics and Oncological Research, PTS Granada, 18016, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Center Pfizer, University of Granada, Andalusian Government for Genomics and Oncological Research, PTS Granada, 18016</wicri:regionArea>
<orgName type="university">Université de Grenade</orgName>
<placeName><settlement type="city">Grenade (Espagne)</settlement>
<region nuts="2" type="region">Andalousie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pons Estel, Bernardo" sort="Pons Estel, Bernardo" uniqKey="Pons Estel B" first="Bernardo" last="Pons-Estel">Bernardo Pons-Estel</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Sanatorio Parque, Rosario, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea>Sanatorio Parque, Rosario</wicri:regionArea>
<wicri:noRegion>Rosario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jonsson, Roland" sort="Jonsson, Roland" uniqKey="Jonsson R" first="Roland" last="Jonsson">Roland Jonsson</name>
<affiliation wicri:level="1"><nlm:aff id="A15">Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen 5021, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen 5021</wicri:regionArea>
<wicri:noRegion>Bergen 5021</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A16">Department of Rheumatology, Haukeland University Hospital, Bergen 5021, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Rheumatology, Haukeland University Hospital, Bergen 5021</wicri:regionArea>
<wicri:noRegion>Bergen 5021</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lu, Xianglan" sort="Lu, Xianglan" uniqKey="Lu X" first="Xianglan" last="Lu">Xianglan Lu</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gottenberg, Jacques Eric" sort="Gottenberg, Jacques Eric" uniqKey="Gottenberg J" first="Jacques-Eric" last="Gottenberg">Jacques-Eric Gottenberg</name>
<affiliation wicri:level="3"><nlm:aff id="A17">Strasbourg University, Strasbourg, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Strasbourg University, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Anaya, Juan Manuel" sort="Anaya, Juan Manuel" uniqKey="Anaya J" first="Juan-Manuel" last="Anaya">Juan-Manuel Anaya</name>
<affiliation wicri:level="1"><nlm:aff id="A18">Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia</nlm:aff>
<country xml:lang="fr">Colombie</country>
<wicri:regionArea>Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota</wicri:regionArea>
<wicri:noRegion>Bogota</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cunninghame Graham, Deborah S" sort="Cunninghame Graham, Deborah S" uniqKey="Cunninghame Graham D" first="Deborah S." last="Cunninghame-Graham">Deborah S. Cunninghame-Graham</name>
<affiliation wicri:level="3"><nlm:aff id="A19">Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huang, Andrew J W" sort="Huang, Andrew J W" uniqKey="Huang A" first="Andrew J. W." last="Huang">Andrew J. W. Huang</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brennan, Michael T" sort="Brennan, Michael T" uniqKey="Brennan M" first="Michael T." last="Brennan">Michael T. Brennan</name>
<affiliation wicri:level="2"><nlm:aff id="A20">Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hughes, Pamela" sort="Hughes, Pamela" uniqKey="Hughes P" first="Pamela" last="Hughes">Pamela Hughes</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Alevizos, Ilias" sort="Alevizos, Ilias" uniqKey="Alevizos I" first="Ilias" last="Alevizos">Ilias Alevizos</name>
<affiliation wicri:level="2"><nlm:aff id="A21">Molecular Physiology & Therapeutic Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Molecular Physiology & Therapeutic Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Miceli Richard, Corinne" sort="Miceli Richard, Corinne" uniqKey="Miceli Richard C" first="Corinne" last="Miceli-Richard">Corinne Miceli-Richard</name>
<affiliation wicri:level="4"><nlm:aff id="A22">Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre</wicri:regionArea>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
<orgName type="university">Université Paris-Sud</orgName>
<placeName><settlement type="city">Orsay</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Ontario</nlm:aff>
<country>Canada</country>
<placeName><region type="province">Ontario</region>
</placeName>
<wicri:cityArea>Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bykerk, Vivian P" sort="Bykerk, Vivian P" uniqKey="Bykerk V" first="Vivian P." last="Bykerk">Vivian P. Bykerk</name>
<affiliation wicri:level="2"><nlm:aff id="A24">Hospital for Special Surgery, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Hospital for Special Surgery, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hirschfield, Gideon" sort="Hirschfield, Gideon" uniqKey="Hirschfield G" first="Gideon" last="Hirschfield">Gideon Hirschfield</name>
<affiliation wicri:level="4"><nlm:aff id="A25">NIHR Biomedical Research Unit, University of Birmingham, Birmingham, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>NIHR Biomedical Research Unit, University of Birmingham, Birmingham</wicri:regionArea>
<placeName><settlement type="city">Birmingham</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Midlands de l'Ouest</region>
<settlement type="city">Birmingham</settlement>
</placeName>
<orgName type="university">Université de Birmingham</orgName>
</affiliation>
</author>
<author><name sortKey="Xie, Gang" sort="Xie, Gang" uniqKey="Xie G" first="Gang" last="Xie">Gang Xie</name>
<affiliation wicri:level="4"><nlm:aff id="A26">Samuel Lunenfeld and Toronto General Research Institutes, Departments of Medicine, Immunology and Molecular Genetics, University of Toronto, Toronto Ontario</nlm:aff>
<orgName type="university">Université de Toronto</orgName>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ng, Wan Fai" sort="Ng, Wan Fai" uniqKey="Ng W" first="Wan-Fai" last="Ng">Wan-Fai Ng</name>
<affiliation wicri:level="1"><nlm:aff id="A27">Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nordmark, Gunnel" sort="Nordmark, Gunnel" uniqKey="Nordmark G" first="Gunnel" last="Nordmark">Gunnel Nordmark</name>
<affiliation wicri:level="4"><nlm:aff id="A28">Section of Rheumatology, Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Section of Rheumatology, Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala</wicri:regionArea>
<orgName type="university">Université d'Uppsala</orgName>
<placeName><settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bucher, Sara Magnusson" sort="Bucher, Sara Magnusson" uniqKey="Bucher S" first="Sara Magnusson" last="Bucher">Sara Magnusson Bucher</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Department of Rheumatology, Örebro University Hospital, Örebro, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Rheumatology, Örebro University Hospital, Örebro</wicri:regionArea>
<wicri:noRegion>Örebro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eriksson, Per" sort="Eriksson, Per" uniqKey="Eriksson P" first="Per" last="Eriksson">Per Eriksson</name>
<affiliation wicri:level="1"><nlm:aff id="A30">Rheumatology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Rheumatology, Department of Clinical and Experimental Medicine, Linköping University, Linköping</wicri:regionArea>
<wicri:noRegion>Linköping</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Omdal, Roald" sort="Omdal, Roald" uniqKey="Omdal R" first="Roald" last="Omdal">Roald Omdal</name>
<affiliation wicri:level="1"><nlm:aff id="A31">Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger</wicri:regionArea>
<wicri:noRegion>Stavanger</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rhodus, Nelson L" sort="Rhodus, Nelson L" uniqKey="Rhodus N" first="Nelson L." last="Rhodus">Nelson L. Rhodus</name>
<affiliation wicri:level="1"><nlm:aff id="A32">Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis</wicri:regionArea>
<wicri:noRegion>Minneapolis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rischmueller, Maureen" sort="Rischmueller, Maureen" uniqKey="Rischmueller M" first="Maureen" last="Rischmueller">Maureen Rischmueller</name>
<affiliation wicri:level="1"><nlm:aff id="A33">Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA 5011, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA 5011</wicri:regionArea>
<wicri:noRegion>SA 5011</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A34">Discipline of Medicine, University of Adelaide, Adelaide, SA 5000, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Discipline of Medicine, University of Adelaide, Adelaide, SA 5000</wicri:regionArea>
<wicri:noRegion>SA 5000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rohrer, Michael" sort="Rohrer, Michael" uniqKey="Rohrer M" first="Michael" last="Rohrer">Michael Rohrer</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wahren Herlenius, Marie" sort="Wahren Herlenius, Marie" uniqKey="Wahren Herlenius M" first="Marie" last="Wahren-Herlenius">Marie Wahren-Herlenius</name>
<affiliation wicri:level="3"><nlm:aff id="A35">Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Witte, Torsten" sort="Witte, Torsten" uniqKey="Witte T" first="Torsten" last="Witte">Torsten Witte</name>
<affiliation wicri:level="3"><nlm:aff id="A36">Clinic for Immunology and Rheumatology, Hannover Medical School, 30625 Hannover, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Clinic for Immunology and Rheumatology, Hannover Medical School, 30625 Hannover</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name>
<affiliation wicri:level="4"><nlm:aff id="A22">Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre</wicri:regionArea>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
<orgName type="university">Université Paris-Sud</orgName>
<placeName><settlement type="city">Orsay</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lessard, Christopher J" sort="Lessard, Christopher J" uniqKey="Lessard C" first="Christopher J." last="Lessard">Christopher J. Lessard</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harley, John B" sort="Harley, John B" uniqKey="Harley J" first="John B" last="Harley">John B. Harley</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6">College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>College of Medicine, University of Cincinnati, Cincinnati, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A37">Medical Service, Department of Veterans Affairs Medical Center, Cincinnati, Ohio, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Service, Department of Veterans Affairs Medical Center, Cincinnati, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sivils, Kathy L" sort="Sivils, Kathy L" uniqKey="Sivils K" first="Kathy L" last="Sivils">Kathy L. Sivils</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Scofield, R Hal" sort="Scofield, R Hal" uniqKey="Scofield R" first="R. Hal" last="Scofield">R. Hal Scofield</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Clinical immunology (Orlando, Fla.)</title>
<idno type="ISSN">1521-6616</idno>
<idno type="eISSN">1521-7035</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arthritis, Rheumatoid (genetics)</term>
<term>Chromosomes, Human, X (genetics)</term>
<term>Chromosomes, Human, Y (genetics)</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genotype</term>
<term>Humans</term>
<term>Klinefelter Syndrome (genetics)</term>
<term>Lupus Erythematosus, Systemic (genetics)</term>
<term>Male</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Sjogren's Syndrome (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Chromosomes X humains (génétique)</term>
<term>Chromosomes Y humains (génétique)</term>
<term>Femelle</term>
<term>Fréquence d'allèle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Lupus érythémateux disséminé (génétique)</term>
<term>Mâle</term>
<term>Polyarthrite rhumatoïde (génétique)</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Syndrome de Gougerot-Sjögren (génétique)</term>
<term>Syndrome de Klinefelter (génétique)</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Arthritis, Rheumatoid</term>
<term>Chromosomes, Human, X</term>
<term>Chromosomes, Human, Y</term>
<term>Klinefelter Syndrome</term>
<term>Lupus Erythematosus, Systemic</term>
<term>Sjogren's Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Chromosomes X humains</term>
<term>Chromosomes Y humains</term>
<term>Lupus érythémateux disséminé</term>
<term>Polyarthrite rhumatoïde</term>
<term>Syndrome de Gougerot-Sjögren</term>
<term>Syndrome de Klinefelter</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Gene Frequency</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Femelle</term>
<term>Fréquence d'allèle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Mâle</term>
<term>Polymorphisme de nucléotide simple</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Primary Sjögren's syndrome (pSS) has a strong female bias. We evaluated an X chromosome dose effect by analyzing 47,XXY (Klinefelter's syndrome, 1 in 500 live male births) among subjects with pSS. 47,XXY was determined by examination of fluorescence intensity of single nucleotide polymorphisms from the X and Y chromosomes. Among 136 pSS men there were 4 with 47,XXY. This was significantly different from healthy controls (1 of 1254 had 47,XXY, p=0.0012 by Fisher's exact test) as well men with rheumatoid arthritis (0 of 363 with 47,XXY), but not different compared to men with systemic lupus erythematosus (SLE) (4 of 136 versus 8 of 306, Fisher's exact test p=NS). These results are consistent with the hypothesis that the number of X chromosomes is critical for the female bias of pSS, a property that may be shared with SLE but not RA.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Argentine</li>
<li>Australie</li>
<li>Canada</li>
<li>Colombie</li>
<li>Espagne</li>
<li>France</li>
<li>Norvège</li>
<li>Royaume-Uni</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Alsace (région administrative)</li>
<li>Andalousie</li>
<li>Angleterre</li>
<li>Basse-Saxe</li>
<li>Californie</li>
<li>Caroline du Nord</li>
<li>East Middle Sweden</li>
<li>Grand Est</li>
<li>Grand Londres</li>
<li>Maryland</li>
<li>Midlands de l'Ouest</li>
<li>Minnesota</li>
<li>Ohio</li>
<li>Oklahoma</li>
<li>Ontario</li>
<li>Svealand</li>
<li>État de New York</li>
<li>Île-de-France</li>
</region>
<settlement><li>Birmingham</li>
<li>Grenade (Espagne)</li>
<li>Hanovre</li>
<li>Londres</li>
<li>Orsay</li>
<li>Stockholm</li>
<li>Strasbourg</li>
<li>Toronto</li>
<li>Uppsala</li>
</settlement>
<orgName><li>Université Paris-Sud</li>
<li>Université d'Uppsala</li>
<li>Université de Birmingham</li>
<li>Université de Grenade</li>
<li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Oklahoma"><name sortKey="Harris, Valerie M" sort="Harris, Valerie M" uniqKey="Harris V" first="Valerie M." last="Harris">Valerie M. Harris</name>
</region>
<name sortKey="Alarcon Riquelme, Marta E" sort="Alarcon Riquelme, Marta E" uniqKey="Alarcon Riquelme M" first="Marta E." last="Alarcon-Riquelme">Marta E. Alarcon-Riquelme</name>
<name sortKey="Alevizos, Ilias" sort="Alevizos, Ilias" uniqKey="Alevizos I" first="Ilias" last="Alevizos">Ilias Alevizos</name>
<name sortKey="Brennan, Michael T" sort="Brennan, Michael T" uniqKey="Brennan M" first="Michael T." last="Brennan">Michael T. Brennan</name>
<name sortKey="Bykerk, Vivian P" sort="Bykerk, Vivian P" uniqKey="Bykerk V" first="Vivian P." last="Bykerk">Vivian P. Bykerk</name>
<name sortKey="Cavett, Joshua" sort="Cavett, Joshua" uniqKey="Cavett J" first="Joshua" last="Cavett">Joshua Cavett</name>
<name sortKey="Cavett, Joshua" sort="Cavett, Joshua" uniqKey="Cavett J" first="Joshua" last="Cavett">Joshua Cavett</name>
<name sortKey="Harley, John B" sort="Harley, John B" uniqKey="Harley J" first="John B" last="Harley">John B. Harley</name>
<name sortKey="Harley, John B" sort="Harley, John B" uniqKey="Harley J" first="John B" last="Harley">John B. Harley</name>
<name sortKey="Harley, John B" sort="Harley, John B" uniqKey="Harley J" first="John B" last="Harley">John B. Harley</name>
<name sortKey="Harris, Valerie M" sort="Harris, Valerie M" uniqKey="Harris V" first="Valerie M." last="Harris">Valerie M. Harris</name>
<name sortKey="Huang, Andrew J W" sort="Huang, Andrew J W" uniqKey="Huang A" first="Andrew J. W." last="Huang">Andrew J. W. Huang</name>
<name sortKey="Hughes, Pamela" sort="Hughes, Pamela" uniqKey="Hughes P" first="Pamela" last="Hughes">Pamela Hughes</name>
<name sortKey="Kaufman, C Erick" sort="Kaufman, C Erick" uniqKey="Kaufman C" first="C. Erick" last="Kaufman">C. Erick Kaufman</name>
<name sortKey="Kelly, Jennifer A" sort="Kelly, Jennifer A" uniqKey="Kelly J" first="Jennifer A." last="Kelly">Jennifer A. Kelly</name>
<name sortKey="Koelsch, Kristi A" sort="Koelsch, Kristi A" uniqKey="Koelsch K" first="Kristi A." last="Koelsch">Kristi A. Koelsch</name>
<name sortKey="Koelsch, Kristi A" sort="Koelsch, Kristi A" uniqKey="Koelsch K" first="Kristi A." last="Koelsch">Kristi A. Koelsch</name>
<name sortKey="Koelsch, Kristi A" sort="Koelsch, Kristi A" uniqKey="Koelsch K" first="Kristi A." last="Koelsch">Kristi A. Koelsch</name>
<name sortKey="Kurien, Biji T" sort="Kurien, Biji T" uniqKey="Kurien B" first="Biji T." last="Kurien">Biji T. Kurien</name>
<name sortKey="Kurien, Biji T" sort="Kurien, Biji T" uniqKey="Kurien B" first="Biji T." last="Kurien">Biji T. Kurien</name>
<name sortKey="Kurien, Biji T" sort="Kurien, Biji T" uniqKey="Kurien B" first="Biji T." last="Kurien">Biji T. Kurien</name>
<name sortKey="Lessard, Christopher J" sort="Lessard, Christopher J" uniqKey="Lessard C" first="Christopher J." last="Lessard">Christopher J. Lessard</name>
<name sortKey="Lewis, David" sort="Lewis, David" uniqKey="Lewis D" first="David" last="Lewis">David Lewis</name>
<name sortKey="Li, Shibo" sort="Li, Shibo" uniqKey="Li S" first="Shibo" last="Li">Shibo Li</name>
<name sortKey="Liu, Ke" sort="Liu, Ke" uniqKey="Liu K" first="Ke" last="Liu">Ke Liu</name>
<name sortKey="Liu, Ke" sort="Liu, Ke" uniqKey="Liu K" first="Ke" last="Liu">Ke Liu</name>
<name sortKey="Lu, Xianglan" sort="Lu, Xianglan" uniqKey="Lu X" first="Xianglan" last="Lu">Xianglan Lu</name>
<name sortKey="Radfar, Lida" sort="Radfar, Lida" uniqKey="Radfar L" first="Lida" last="Radfar">Lida Radfar</name>
<name sortKey="Rasmussen, Astrid" sort="Rasmussen, Astrid" uniqKey="Rasmussen A" first="Astrid" last="Rasmussen">Astrid Rasmussen</name>
<name sortKey="Rhodus, Nelson L" sort="Rhodus, Nelson L" uniqKey="Rhodus N" first="Nelson L." last="Rhodus">Nelson L. Rhodus</name>
<name sortKey="Rohrer, Michael" sort="Rohrer, Michael" uniqKey="Rohrer M" first="Michael" last="Rohrer">Michael Rohrer</name>
<name sortKey="Scofield, R Hal" sort="Scofield, R Hal" uniqKey="Scofield R" first="R. Hal" last="Scofield">R. Hal Scofield</name>
<name sortKey="Scofield, R Hal" sort="Scofield, R Hal" uniqKey="Scofield R" first="R. Hal" last="Scofield">R. Hal Scofield</name>
<name sortKey="Scofield, R Hal" sort="Scofield, R Hal" uniqKey="Scofield R" first="R. Hal" last="Scofield">R. Hal Scofield</name>
<name sortKey="Scofield, R Hal" sort="Scofield, R Hal" uniqKey="Scofield R" first="R. Hal" last="Scofield">R. Hal Scofield</name>
<name sortKey="Segal, Barbara" sort="Segal, Barbara" uniqKey="Segal B" first="Barbara" last="Segal">Barbara Segal</name>
<name sortKey="Sharma, Rohan" sort="Sharma, Rohan" uniqKey="Sharma R" first="Rohan" last="Sharma">Rohan Sharma</name>
<name sortKey="Sharma, Rohan" sort="Sharma, Rohan" uniqKey="Sharma R" first="Rohan" last="Sharma">Rohan Sharma</name>
<name sortKey="Sivils, Kathy L" sort="Sivils, Kathy L" uniqKey="Sivils K" first="Kathy L" last="Sivils">Kathy L. Sivils</name>
<name sortKey="Sivils, Kathy L" sort="Sivils, Kathy L" uniqKey="Sivils K" first="Kathy L" last="Sivils">Kathy L. Sivils</name>
<name sortKey="Stone, Donald U" sort="Stone, Donald U" uniqKey="Stone D" first="Donald U." last="Stone">Donald U. Stone</name>
<name sortKey="Venuturupalli, Swamy" sort="Venuturupalli, Swamy" uniqKey="Venuturupalli S" first="Swamy" last="Venuturupalli">Swamy Venuturupalli</name>
<name sortKey="Wallace, Daniel J" sort="Wallace, Daniel J" uniqKey="Wallace D" first="Daniel J" last="Wallace">Daniel J. Wallace</name>
<name sortKey="Weisman, Michael H" sort="Weisman, Michael H" uniqKey="Weisman M" first="Michael H." last="Weisman">Michael H. Weisman</name>
</country>
<country name="Espagne"><region name="Andalousie"><name sortKey="Alarcon Riquelme, Marta E" sort="Alarcon Riquelme, Marta E" uniqKey="Alarcon Riquelme M" first="Marta E." last="Alarcon-Riquelme">Marta E. Alarcon-Riquelme</name>
</region>
</country>
<country name="Argentine"><noRegion><name sortKey="Pons Estel, Bernardo" sort="Pons Estel, Bernardo" uniqKey="Pons Estel B" first="Bernardo" last="Pons-Estel">Bernardo Pons-Estel</name>
</noRegion>
</country>
<country name="Norvège"><noRegion><name sortKey="Jonsson, Roland" sort="Jonsson, Roland" uniqKey="Jonsson R" first="Roland" last="Jonsson">Roland Jonsson</name>
</noRegion>
<name sortKey="Jonsson, Roland" sort="Jonsson, Roland" uniqKey="Jonsson R" first="Roland" last="Jonsson">Roland Jonsson</name>
<name sortKey="Omdal, Roald" sort="Omdal, Roald" uniqKey="Omdal R" first="Roald" last="Omdal">Roald Omdal</name>
</country>
<country name="France"><region name="Grand Est"><name sortKey="Gottenberg, Jacques Eric" sort="Gottenberg, Jacques Eric" uniqKey="Gottenberg J" first="Jacques-Eric" last="Gottenberg">Jacques-Eric Gottenberg</name>
</region>
<name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name>
<name sortKey="Miceli Richard, Corinne" sort="Miceli Richard, Corinne" uniqKey="Miceli Richard C" first="Corinne" last="Miceli-Richard">Corinne Miceli-Richard</name>
</country>
<country name="Colombie"><noRegion><name sortKey="Anaya, Juan Manuel" sort="Anaya, Juan Manuel" uniqKey="Anaya J" first="Juan-Manuel" last="Anaya">Juan-Manuel Anaya</name>
</noRegion>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Cunninghame Graham, Deborah S" sort="Cunninghame Graham, Deborah S" uniqKey="Cunninghame Graham D" first="Deborah S." last="Cunninghame-Graham">Deborah S. Cunninghame-Graham</name>
</region>
<name sortKey="Hirschfield, Gideon" sort="Hirschfield, Gideon" uniqKey="Hirschfield G" first="Gideon" last="Hirschfield">Gideon Hirschfield</name>
<name sortKey="Ng, Wan Fai" sort="Ng, Wan Fai" uniqKey="Ng W" first="Wan-Fai" last="Ng">Wan-Fai Ng</name>
</country>
<country name="Canada"><region name="Ontario"><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
</region>
<name sortKey="Xie, Gang" sort="Xie, Gang" uniqKey="Xie G" first="Gang" last="Xie">Gang Xie</name>
</country>
<country name="Suède"><region name="Svealand"><name sortKey="Nordmark, Gunnel" sort="Nordmark, Gunnel" uniqKey="Nordmark G" first="Gunnel" last="Nordmark">Gunnel Nordmark</name>
</region>
<name sortKey="Bucher, Sara Magnusson" sort="Bucher, Sara Magnusson" uniqKey="Bucher S" first="Sara Magnusson" last="Bucher">Sara Magnusson Bucher</name>
<name sortKey="Eriksson, Per" sort="Eriksson, Per" uniqKey="Eriksson P" first="Per" last="Eriksson">Per Eriksson</name>
<name sortKey="Wahren Herlenius, Marie" sort="Wahren Herlenius, Marie" uniqKey="Wahren Herlenius M" first="Marie" last="Wahren-Herlenius">Marie Wahren-Herlenius</name>
</country>
<country name="Australie"><noRegion><name sortKey="Rischmueller, Maureen" sort="Rischmueller, Maureen" uniqKey="Rischmueller M" first="Maureen" last="Rischmueller">Maureen Rischmueller</name>
</noRegion>
<name sortKey="Rischmueller, Maureen" sort="Rischmueller, Maureen" uniqKey="Rischmueller M" first="Maureen" last="Rischmueller">Maureen Rischmueller</name>
</country>
<country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Witte, Torsten" sort="Witte, Torsten" uniqKey="Witte T" first="Torsten" last="Witte">Torsten Witte</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C07 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001C07 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4940221
   |texte=   Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:27109640" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome

Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.