AustralieFrV1, Main, Exploration, bibRecord, 001508

Transcranial direct current stimulation for acute major depressive episodes: meta-analysis of individual patient data

Identifieur interne : 001508 ( Main/Exploration ); précédent : 001507; suivant : 001509

Transcranial direct current stimulation for acute major depressive episodes: meta-analysis of individual patient data

Auteurs : André R. Brunoni ; Adriano H. Moffa ; Felipe Fregni ; Ulrich Palm ; Frank Padberg ; Daniel M. Blumberger ; Zafiris J. Daskalakis ; Djamila Bennabi ; Emmanuel Haffen ; Angelo Alonzo ; Colleen K. Loo

Source :

The British Journal of Psychiatry [ 0007-1250 ] ; 2016.

RBID : PMC:4887722

Descripteurs français

English descriptors

KwdEn :
- Depressive Disorder, Major (therapy), Humans, Patient Outcome Assessment, Transcranial Direct Current Stimulation (methods).
MESH :
- methods : Transcranial Direct Current Stimulation.
- therapy : Depressive Disorder, Major.
- Humans, Patient Outcome Assessment.

Abstract

Background

Transcranial direct current stimulation (tDCS) is a non-pharmacological intervention for depression. It has mixed results, possibly caused by study heterogeneity.

Aims

To assess tDCS efficacy and to explore individual response predictors.

Method

Systematic review and individual patient data meta-analysis.

Results

Data were gathered from six randomised sham-controlled trials, enrolling 289 patients. Active tDCS was significantly superior to sham for response (34% v. 19% respectively, odds ratio (OR) = 2.44, 95% CI 1.38–4.32, number needed to treat (NNT) = 7), remission (23.1% v. 12.7% respectively, OR = 2.38, 95% CI 1.22–4.64, NNT = 9) and depression improvement (B coefficient 0.35, 95% CI 0.12–0.57). Mixed-effects models showed that, after adjustment for other predictors and confounders, treatment-resistant depression and higher tDCS ‘doses’ were, respectively, negatively and positively associated with tDCS efficacy.

Conclusions

The effect size of tDCS treatment was comparable with those reported for repetitive transcranial magnetic stimulation and antidepressant drug treatment in primary care. The most important parameters for optimisation in future trials are depression refractoriness and tDCS dose.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887722

DOI: 10.1192/bjp.bp.115.164715
PubMed: 27056623
PubMed Central: 4887722

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p id="P1"><bold>Background</bold>
</p>
<p id="P2">Transcranial direct current stimulation (tDCS) is a non-pharmacological intervention for depression. It has mixed results, possibly caused by study heterogeneity.</p>
<p id="P3"><bold>Aims</bold>
</p>
<p id="P4">To assess tDCS efficacy and to explore individual response predictors.</p>
<p id="P5"><bold>Method</bold>
</p>
<p id="P6">Systematic review and individual patient data meta-analysis.</p>
<p id="P7"><bold>Results</bold>
</p>
<p id="P8">Data were gathered from six randomised sham-controlled trials, enrolling 289 patients. Active tDCS was significantly superior to sham for response (34% <italic>v.</italic>
 19% respectively, odds ratio (OR) = 2.44, 95% CI 1.38–4.32, number needed to treat (NNT) = 7), remission (23.1% <italic>v.</italic>
 12.7% respectively, OR = 2.38, 95% CI 1.22–4.64, NNT = 9) and depression improvement (<italic>B</italic>
 coefficient 0.35, 95% CI 0.12–0.57). Mixed-effects models showed that, after adjustment for other predictors and confounders, treatment-resistant depression and higher tDCS ‘doses’ were, respectively, negatively and positively associated with tDCS efficacy.</p>
<p id="P9"><bold>Conclusions</bold>
</p>
<p id="P10">The effect size of tDCS treatment was comparable with those reported for repetitive transcranial magnetic stimulation and antidepressant drug treatment in primary care. The most important parameters for optimisation in future trials are depression refractoriness and tDCS dose.</p>
</div>
</front>
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<name sortKey="Blumberger, Daniel M" sort="Blumberger, Daniel M" uniqKey="Blumberger D" first="Daniel M." last="Blumberger">Daniel M. Blumberger</name>
<name sortKey="Brunoni, Andre R" sort="Brunoni, Andre R" uniqKey="Brunoni A" first="André R." last="Brunoni">André R. Brunoni</name>
<name sortKey="Daskalakis, Zafiris J" sort="Daskalakis, Zafiris J" uniqKey="Daskalakis Z" first="Zafiris J." last="Daskalakis">Zafiris J. Daskalakis</name>
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Transcranial direct current stimulation for acute major depressive episodes: meta-analysis of individual patient data

Transcranial direct current stimulation for acute major depressive episodes: meta-analysis of individual patient data

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
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